Colq cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Colq
Entrez Gene ID	29755
Full Name	collagen like tail subunit of asymmetric acetylcholinesterase
General protein information	Preferred Names collagen like tail subunit of asymmetric acetylcholinesterase Names acetylcholinesterase collagenic tail peptide AChE Q subunit acetylcholinesterase-associated collagen collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16
Summary	binds heparin; links asymmetric acetylcholinesterase to the basal lamina of the neuromuscular junction [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019274.2	NP_062147.1	acetylcholinesterase collagenic tail peptide precursor

Pathways from BioSystems

Homologies

	COLQ	XP_001083025.2
Bos taurus (cattle)	COLQ	NP_001030374.2
Rattus norvegicus (Norway rat)	Colq	NP_062147.1
Xenopus tropicalis (tropical clawed frog)	colq	XP_004915447.1
Pan troglodytes (chimpanzee)	COLQ	XP_001159864.1
Gallus gallus (chicken)	COLQ	XP_001235720.2
Homo sapiens (human)	COLQ	NP_005668.2
Canis lupus familiaris (dog)	COLQ	XP_863371.1
Mus musculus (house mouse)	Colq	NP_034067.2

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of collagen Q expression in the extrajunctional regions of rat fast muscles is encoded in their stem cells (satellite cells).
Gli?ovi? ?, Pregelj P, Dolenc I, Sketelj J
Chemico-biological interactions203(1)292-6(2013 Mar)

Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction.
Choi RC, Chen VP, Luk WK, Yung AW, Ng AH, Dong TT, Tsim KW
Chemico-biological interactions203(1)282-6(2013 Mar)

Cholinesterases regulation in the absence of ColQ.
Sigoillot SM, Bourgeois F, Legay C
Chemico-biological interactions187(1-3)84-9(2010 Sep)

The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat muscles.
Glisovi? S, Trinkaus M, Pregelj P, Sketelj J
Chemico-biological interactions187(1-3)90-5(2010 Sep)

ColQ controls postsynaptic differentiation at the neuromuscular junction.
Sigoillot SM, Bourgeois F, Lambergeon M, Strochlic L, Legay C
The Journal of neuroscience : the official journal of the Society for Neuroscience30(1)13-23(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Extensive neural suppression of the extrajunctional ColQ expression in regenerating fast muscles during maturation is a very slow process requiring 30-60 days.
Title: Suppression of collagen Q expression in the extrajunctional regions of rat fast muscles is encoded in their stem cells (satellite cells).

differential distribution of P-CREB in fast-and slow-twitch muscles might support the crucial role of cAMP-dependent signaling in controlling the synapse-specific expression of ColQ-1a in fast-twitch muscles
Title: Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction.

AChE, BChE and PRiMA mRNA level modifications found in the absence of ColQ cannot compensate for the physiological defects observed at the ColQ-deficient neuromuscular junction.
Title: Cholinesterases regulation in the absence of ColQ.

extrajunctional levels of ColQ mRNA in non-innervated regenerating fast and slow muscles
Title: The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat muscles.

In addition to its structural role, ColQ has important regulatory functions at the synapse by controlling acetylcholine receptor clustering through its interaction with MuSK.
Title: ColQ controls postsynaptic differentiation at the neuromuscular junction.

The following Colq gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Colq cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42826	NM_019274.2 Latest version!	Rattus norvegicus collagen like tail subunit of asymmetric acetylcholinesterase (Colq), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Colq ( NM_019274.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062147.1 Rattus norvegicus collagen like tail subunit of asymmetric acetylcholinesterase (Colq), mRNA.

Price & Availability↑

CloneID	ORa42826
Clone ID Related Accession (Same CDS sequence)	NM_019274.2
Accession Version	NM_019274.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	acetylcholinesterase collagenic tail peptide precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF007583.1. On Jun 13, 2011 this sequence version replaced NM_019274.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF007583.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTCC AACTCTTCTT CTGCTCCATC 
GTGTCGCAGC CAACTTTCAT CAACAGTGTC CTCCCAATCT CAGCAGCCCT TCCTGGCCTG 
GATCAGAAGA AACGAGGCAA CCACAAAGCA TGCTGCCTAC TGATGCCCCC GCCACCCCCA 
CTCTTCCCAC CGCCATTCTT CAGAGGCAGC CGAAGCCCGC TTCTCTCCCC AGACATGAAG 
AATCTTCTGG AACTTGAGGC CTCCCCATCA CCCTGCATGC AAGGCTCTCT AGGCTCTCCT 
GGCCCCCCTG GGCCCCAGGG TCCACCTGGG CTTCCTGGCA AGGCAGGACC AAAGGGAGAA 
AAGGGGGATC TTGGCCGCCC AGGAAGGAAG GGTAGACCTG GACCCCCAGG TGTTCCTGGC 
GAGCCCGGGC CCGTTGGCTG GCCAGGCCCT GAAGGACCCA GGGGCGAAAA AGGCGACGTG 
GGTATGATGG GTCTGCCAGG GTCAAGAGGA CCGATGGGCT CTAAGGGCTT CCCTGGATCC 
AGAGGGGAAA AGGGATCCAG AGGTGAAAGA GGGGACTTGG GTCCCAAAGG AGAAAAGGGT 
TTCCCTGGAT TTCCTGGAAT GCTGGGGCAG AAAGGTGAAA TGGGTCCAAA GGGAGAATCT 
GGGATAGCAG GACATCGGGG CCCCACAGGA AGACCAGGGA AACGAGGCAA GCAGGGTCAG 
AAGGGAGACA GTGGAATTAT GGGCCCACCA GGCAAACCTG GGCCTTCTGG TCAACCTGGC 
CGTCAAGGTC CTCCCGGGCC CCCAGGACCC CCATCTGCAG GACAACTTGT AATGGGACTC 
AAAGGGGAAA GAGGATTTCC AGGGCCCCCG GGAAGATGCC TTTGCGGACC CCCTGCGAAT 
GTGAATAACC CCTCCTATGG GGACCCCATG TATGGGCGCG GCTCCCCTCG AGTTCCTGCG 
ATTTTTGTGG TCAACAACCA GGAGGAGCTT GAGAAGCTGA ACACTCAAAA TGCCATTGCC 
TTTCGAAGAG ACCAGCGATC TCTGTACTTC AAAGATAGCC TTGGCTGGCT CCCCATCCAG 
CTAACCCCTT TCTACCCAGT GGGTTTACAC CATAAAGCAG CATGGCACCT GTGTGGGGAT 
GGGGTCCTGC AGCCTGGGGA GGAATGTGAC GATGGTAACC CGGATGTGAG TGACGGCTGC 
ATTGACTGTC ATCGGGCCTA CTGTGGAGAC GGTTATCGGC ACCGGGGCGT GGAGGACTGT 
GACGGCTCTG ACTTTGGCTA CCTGAAGTGC GAGACCTATC TCCCTGGATC ATACGGAGAA 
CTTCGGTGCA CCCAGTATTG CTCCATCGAC TCCACACCCT GCCGATACTT CACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062147.1
CDS	46..1422
Translation	MAVLNPMTLGIYLQLFFCSIVSQPTFINSVLPISAALPGLDQKKRGNHKACCLLMPPPPPLFPPPFFRGSRSPLLSPDMKNLLELEASPSPCMQGSLGSPGPPGPQGPPGLPGKAGPKGEKGDLGRPGRKGRPGPPGVPGEPGPVGWPGPEGPRGEKGDVGMMGLPGSRGPMGSKGFPGSRGEKGSRGERGDLGPKGEKGFPGFPGMLGQKGEMGPKGESGIAGHRGPTGRPGKRGKQGQKGDSGIMGPPGKPGPSGQPGRQGPPGPPGPPSAGQLVMGLKGERGFPGPPGRCLCGPPANVNNPSYGDPMYGRGSPRVPAIFVVNNQEELEKLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVGLHHKAAWHLCGDGVLQPGEECDDGNPDVSDGCIDCHRAYCGDGYRHRGVEDCDGSDFGYLKCETYLPGSYGELRCTQYCSIDSTPCRYFT

Target ORF information:

RefSeq Version	NM_019274.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus collagen like tail subunit of asymmetric acetylcholinesterase (Colq), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019274.2

ORF Insert Sequence:

ATGGCTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTCC AACTCTTCTT CTGCTCCATC 
GTGTCGCAGC CAACTTTCAT CAACAGTGTC CTCCCAATCT CAGCAGCCCT TCCTGGCCTG 
GATCAGAAGA AACGAGGCAA CCACAAAGCA TGCTGCCTAC TGATGCCCCC GCCACCCCCA 
CTCTTCCCAC CGCCATTCTT CAGAGGCAGC CGAAGCCCGC TTCTCTCCCC AGACATGAAG 
AATCTTCTGG AACTTGAGGC CTCCCCATCA CCCTGCATGC AAGGCTCTCT AGGCTCTCCT 
GGCCCCCCTG GGCCCCAGGG TCCACCTGGG CTTCCTGGCA AGGCAGGACC AAAGGGAGAA 
AAGGGGGATC TTGGCCGCCC AGGAAGGAAG GGTAGACCTG GACCCCCAGG TGTTCCTGGC 
GAGCCCGGGC CCGTTGGCTG GCCAGGCCCT GAAGGACCCA GGGGCGAAAA AGGCGACGTG 
GGTATGATGG GTCTGCCAGG GTCAAGAGGA CCGATGGGCT CTAAGGGCTT CCCTGGATCC 
AGAGGGGAAA AGGGATCCAG AGGTGAAAGA GGGGACTTGG GTCCCAAAGG AGAAAAGGGT 
TTCCCTGGAT TTCCTGGAAT GCTGGGGCAG AAAGGTGAAA TGGGTCCAAA GGGAGAATCT 
GGGATAGCAG GACATCGGGG CCCCACAGGA AGACCAGGGA AACGAGGCAA GCAGGGTCAG 
AAGGGAGACA GTGGAATTAT GGGCCCACCA GGCAAACCTG GGCCTTCTGG TCAACCTGGC 
CGTCAAGGTC CTCCCGGGCC CCCAGGACCC CCATCTGCAG GACAACTTGT AATGGGACTC 
AAAGGGGAAA GAGGATTTCC AGGGCCCCCG GGAAGATGCC TTTGCGGACC CCCTGCGAAT 
GTGAATAACC CCTCCTATGG GGACCCCATG TATGGGCGCG GCTCCCCTCG AGTTCCTGCG 
ATTTTTGTGG TCAACAACCA GGAGGAGCTT GAGAAGCTGA ACACTCAAAA TGCCATTGCC 
TTTCGAAGAG ACCAGCGATC TCTGTACTTC AAAGATAGCC TTGGCTGGCT CCCCATCCAG 
CTAACCCCTT TCTACCCAGT GGGTTTACAC CATAAAGCAG CATGGCACCT GTGTGGGGAT 
GGGGTCCTGC AGCCTGGGGA GGAATGTGAC GATGGTAACC CGGATGTGAG TGACGGCTGC 
ATTGACTGTC ATCGGGCCTA CTGTGGAGAC GGTTATCGGC ACCGGGGCGT GGAGGACTGT 
GACGGCTCTG ACTTTGGCTA CCTGAAGTGC GAGACCTATC TCCCTGGATC ATACGGAGAA 
CTTCGGTGCA CCCAGTATTG CTCCATCGAC TCCACACCCT GCCGATACTT CACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of collagen Q expression in the extrajunctional regions of rat fast muscles is encoded in their stem cells (satellite cells).
Chemico-biological interactions203(1)292-6(2013 Mar)
Gli?ovi? ?,Pregelj P,Dolenc I,Sketelj J

Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction.
Chemico-biological interactions203(1)282-6(2013 Mar)
Choi RC,Chen VP,Luk WK,Yung AW,Ng AH,Dong TT,Tsim KW

Cholinesterases regulation in the absence of ColQ.
Chemico-biological interactions187(1-3)84-9(2010 Sep)
Sigoillot SM,Bourgeois F,Legay C

The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat muscles.
Chemico-biological interactions187(1-3)90-5(2010 Sep)
Glisovi? S,Trinkaus M,Pregelj P,Sketelj J

ColQ controls postsynaptic differentiation at the neuromuscular junction.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(1)13-23(2010 Jan)
Sigoillot SM,Bourgeois F,Lambergeon M,Strochlic L,Legay C

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Colq cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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