COLQ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COLQ
Entrez Gene ID	8292
Full Name	collagen like tail subunit of asymmetric acetylcholinesterase
Synonyms	CMS5,EAD
General protein information	Preferred Names collagen like tail subunit of asymmetric acetylcholinesterase Names acetylcholinesterase collagenic tail peptide AChE Q subunit acetylcholinesterase-associated collagen collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase collagenic tail of endplate acetylcholinesterase single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.1
Summary	This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	603033
Disorder Html:	Myasthenic syndrome, congenital, 5, 603034 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_080539.3	NP_536800.2	acetylcholinesterase collagenic tail peptide isoform III precursor
NM_080539.4	NP_536800.2	acetylcholinesterase collagenic tail peptide isoform III precursor
NM_005677.4	NP_005668.2	acetylcholinesterase collagenic tail peptide isoform I precursor
NM_080538.2	NP_536799.1	acetylcholinesterase collagenic tail peptide isoform II precursor
NM_005677.3	NP_005668.2	acetylcholinesterase collagenic tail peptide isoform I precursor

Pathways from BioSystems

Homologies

	COLQ	XP_001083025.2
Bos taurus (cattle)	COLQ	NP_001030374.2
Rattus norvegicus (Norway rat)	Colq	NP_062147.1
Xenopus tropicalis (tropical clawed frog)	colq	XP_004915447.1
Pan troglodytes (chimpanzee)	COLQ	XP_001159864.1
Gallus gallus (chicken)	COLQ	XP_001235720.2
Homo sapiens (human)	COLQ	NP_005668.2
Canis lupus familiaris (dog)	COLQ	XP_863371.1
Mus musculus (house mouse)	Colq	NP_034067.2

Gene Ontology
Bibliography

Related articles in PubMed

Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Sigurdsson S, Alexandersson KF, Sulem P, Feenstra B, Gudmundsdottir S, Halldorsson GH, Olafsson S, Sigurdsson A, Rafnar T, Thorgeirsson T, S?rensen E, Nordholm-Carstensen A, Burcharth J, Andersen J, J?rgensen HS, Possfelt-M?ller E, Ullum H, Thorleifsson G, Masson G, Thorsteinsdottir U, Melbye M, Gudbjartsson DF, Stefansson T, Jonsdottir I, Stefansson K
Nature communications815789(2017 Jun)

Congenital myasthenic syndrome in Israel: Genetic and clinical characterization.
Aharoni S, Sadeh M, Shapira Y, Edvardson S, Daana M, Dor-Wollman T, Mimouni-Bloch A, Halevy A, Cohen R, Sagie L, Argov Z, Rabie M, Spiegel R, Chervinsky I, Orenstein N, Engel AG, Nevo Y
Neuromuscular disorders : NMD27(2)136-140(2017 Feb)

SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome.
Rahman MA, Azuma Y, Nasrin F, Takeda J, Nazim M, Bin Ahsan K, Masuda A, Engel AG, Ohno K
Scientific reports513208(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains.
Title: SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome.

study identified the molecular cause underlying congenital myasthenic syndrome in two patients in a Syrian family, a novel missense mutation, homozygous single nucleotide substitution (c.1010T>C) in the COLQ gene
Title: Clinical and molecular analysis of a novel COLQ missense mutation causing congenital myasthenic syndrome in a Syrian family.

findings suggest that the impaired attachment of COOH-terminal mutants causing EP AChE deficiency is in part independent of MuSK, and that the COOH-terminus of ColQ may interact with other proteins at the BL
Title: COOH-terminal collagen Q (COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of ColQ with proteins of the basal lamina.

We proved that the missense mutations in ColQ-CTD cause endplate AChE deficiency by compromising ColQ-MuSK interaction at the NMJ.
Title: Mutations in the C-terminal domain of ColQ in endplate acetylcholinesterase deficiency compromise ColQ-MuSK interaction.

This study presented that four cases illustrate the clinical spectrum of the recurrent homozygous W148X mutation in the COLQ gene.
Title: Recurrent COLQ mutation in congenital myasthenic syndrome.

The following COLQ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COLQ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19054	NM_005677.4 Latest version!	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant I, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
OHu16232	NM_080538.2 Latest version!	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant II, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu16271	NM_080539.4 Latest version!	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant III, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$244.30 $349.00
View Old Accession Versions >>
OHu16271	NM_080539.3	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant III, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$244.30 $349.00
OHu19054	NM_005677.3	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant I, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COLQ ( NM_005677.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005668.2 Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant I, mRNA.

Price & Availability↑

CloneID	OHu19054
Clone ID Related Accession (Same CDS sequence)	NM_005677.4 , NM_005677.3
Accession Version	NM_005677.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	acetylcholinesterase collagenic tail peptide isoform I precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF057036.1, AK128401.1 and AI554171.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005677.3. Transcript Variant: This variant (I) encodes the longest protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF057036.1, SRR1803611.51101.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000383788.10/ ENSP00000373298.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGC TTCTCTCCCC AGACATGAAG 
AATCTCATGC TGGAACTGGA GACCTCGCAG TCCCCGTGCA TGCAAGGCTC GCTAGGCTCC 
CCTGGGCCTC CCGGCCCCCA GGGTCCACCG GGGCTTCCTG GCAAGACAGG ACCAAAGGGA 
GAAAAGGGGG AGCTTGGCCG ACCAGGAAGG AAGGGTAGAC CTGGCCCCCC AGGTGTTCCT 
GGCATGCCTG GGCCCATCGG TTGGCCAGGC CCTGAAGGAC CCAGGGGTGA AAAAGGTGAC 
CTGGGTATGA TGGGCTTGCC AGGGTCAAGA GGACCAATGG GCTCCAAGGG CTACCCTGGA 
TCCAGAGGGG AAAAGGGATC CAGAGGTGAA AAGGGTGACC TGGGTCCCAA AGGAGAAAAG 
GGTTTCCCAG GATTTCCTGG AATGTTGGGG CAGAAAGGTG AAATGGGTCC AAAAGGTGAA 
CCTGGGATAG CAGGACACCG AGGACCCACA GGAAGACCAG GAAAACGAGG CAAGCAGGGA 
CAGAAAGGGG ATAGTGGAGT TATGGGCCCA CCAGGCAAGC CTGGGCCTTC TGGTCAACCT 
GGCCGTCCGG GGCCCCCAGG CCCCCCACCT GCAGGACAAC TTATAATGGG ACCCAAAGGG 
GAAAGAGGAT TTCCCGGGCC TCCAGGAAGA TGTCTTTGTG GACCCACTAT GAATGTGAAT 
AACCCTTCCT ACGGGGAATC TGTGTATGGG CCCAGTTCCC CGCGAGTTCC TGTGATTTTT 
GTGGTCAACA ACCAGGAGGA GCTTGAGAGG CTGAACACCC AAAACGCCAT TGCCTTCCGC 
AGAGACCAGA GATCTCTGTA CTTCAAGGAC AGCCTTGGCT GGCTCCCCAT CCAGCTGACC 
CCTTTCTACC CTGTGGATTA CACTGCAGAC CAGCACGGCA CCTGTGGGGA TGGGCTCCTG 
CAGCCTGGGG AGGAGTGTGA CGACGGTAAC AGCGATGTGG GTGACGACTG CATCCGCTGT 
CACCGTGCCT ACTGTGGAGA TGGTCACCGG CATGAGGGTG TGGAGGACTG TGACGGCTCT 
GACTTTGGCT ACCTGACATG CGAGACCTAT CTCCCTGGGT CATATGGAGA CCTGCAATGC 
ACCCAGTACT GCTACATCGA CTCCACGCCC TGCCGCTACT TCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005668.2
CDS	82..1449
Translation	MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT

Target ORF information:

RefSeq Version	NM_005677.4
Organism	Homo sapiens(human)
Definition	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant I, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005677.4

ORF Insert Sequence:

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGC TTCTCTCCCC AGACATGAAG 
AATCTCATGC TGGAACTGGA GACCTCGCAG TCCCCGTGCA TGCAAGGCTC GCTAGGCTCC 
CCTGGGCCTC CCGGCCCCCA GGGTCCACCG GGGCTTCCTG GCAAGACAGG ACCAAAGGGA 
GAAAAGGGGG AGCTTGGCCG ACCAGGAAGG AAGGGTAGAC CTGGCCCCCC AGGTGTTCCT 
GGCATGCCTG GGCCCATCGG TTGGCCAGGC CCTGAAGGAC CCAGGGGTGA AAAAGGTGAC 
CTGGGTATGA TGGGCTTGCC AGGGTCAAGA GGACCAATGG GCTCCAAGGG CTACCCTGGA 
TCCAGAGGGG AAAAGGGATC CAGAGGTGAA AAGGGTGACC TGGGTCCCAA AGGAGAAAAG 
GGTTTCCCAG GATTTCCTGG AATGTTGGGG CAGAAAGGTG AAATGGGTCC AAAAGGTGAA 
CCTGGGATAG CAGGACACCG AGGACCCACA GGAAGACCAG GAAAACGAGG CAAGCAGGGA 
CAGAAAGGGG ATAGTGGAGT TATGGGCCCA CCAGGCAAGC CTGGGCCTTC TGGTCAACCT 
GGCCGTCCGG GGCCCCCAGG CCCCCCACCT GCAGGACAAC TTATAATGGG ACCCAAAGGG 
GAAAGAGGAT TTCCCGGGCC TCCAGGAAGA TGTCTTTGTG GACCCACTAT GAATGTGAAT 
AACCCTTCCT ACGGGGAATC TGTGTATGGG CCCAGTTCCC CGCGAGTTCC TGTGATTTTT 
GTGGTCAACA ACCAGGAGGA GCTTGAGAGG CTGAACACCC AAAACGCCAT TGCCTTCCGC 
AGAGACCAGA GATCTCTGTA CTTCAAGGAC AGCCTTGGCT GGCTCCCCAT CCAGCTGACC 
CCTTTCTACC CTGTGGATTA CACTGCAGAC CAGCACGGCA CCTGTGGGGA TGGGCTCCTG 
CAGCCTGGGG AGGAGTGTGA CGACGGTAAC AGCGATGTGG GTGACGACTG CATCCGCTGT 
CACCGTGCCT ACTGTGGAGA TGGTCACCGG CATGAGGGTG TGGAGGACTG TGACGGCTCT 
GACTTTGGCT ACCTGACATG CGAGACCTAT CTCCCTGGGT CATATGGAGA CCTGCAATGC 
ACCCAGTACT GCTACATCGA CTCCACGCCC TGCCGCTACT TCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLQ ( NM_005677.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005668.2 Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant I, mRNA.

Price & Availability↑

CloneID	OHu19054
Clone ID Related Accession (Same CDS sequence)	NM_005677.4 , NM_005677.3
Accession Version	NM_005677.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	acetylcholinesterase collagenic tail peptide isoform I precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF057036.1, AK128401.1 and AI554171.1. This sequence is a reference standard in the RefSeqGene project. On Oct 27, 2006 this sequence version replaced NM_005677.2. Transcript Variant: This variant (I) encodes the longest protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF057036.1, SRR1803611.51101.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGC TTCTCTCCCC AGACATGAAG 
AATCTCATGC TGGAACTGGA GACCTCGCAG TCCCCGTGCA TGCAAGGCTC GCTAGGCTCC 
CCTGGGCCTC CCGGCCCCCA GGGTCCACCG GGGCTTCCTG GCAAGACAGG ACCAAAGGGA 
GAAAAGGGGG AGCTTGGCCG ACCAGGAAGG AAGGGTAGAC CTGGCCCCCC AGGTGTTCCT 
GGCATGCCTG GGCCCATCGG TTGGCCAGGC CCTGAAGGAC CCAGGGGTGA AAAAGGTGAC 
CTGGGTATGA TGGGCTTGCC AGGGTCAAGA GGACCAATGG GCTCCAAGGG CTACCCTGGA 
TCCAGAGGGG AAAAGGGATC CAGAGGTGAA AAGGGTGACC TGGGTCCCAA AGGAGAAAAG 
GGTTTCCCAG GATTTCCTGG AATGTTGGGG CAGAAAGGTG AAATGGGTCC AAAAGGTGAA 
CCTGGGATAG CAGGACACCG AGGACCCACA GGAAGACCAG GAAAACGAGG CAAGCAGGGA 
CAGAAAGGGG ATAGTGGAGT TATGGGCCCA CCAGGCAAGC CTGGGCCTTC TGGTCAACCT 
GGCCGTCCGG GGCCCCCAGG CCCCCCACCT GCAGGACAAC TTATAATGGG ACCCAAAGGG 
GAAAGAGGAT TTCCCGGGCC TCCAGGAAGA TGTCTTTGTG GACCCACTAT GAATGTGAAT 
AACCCTTCCT ACGGGGAATC TGTGTATGGG CCCAGTTCCC CGCGAGTTCC TGTGATTTTT 
GTGGTCAACA ACCAGGAGGA GCTTGAGAGG CTGAACACCC AAAACGCCAT TGCCTTCCGC 
AGAGACCAGA GATCTCTGTA CTTCAAGGAC AGCCTTGGCT GGCTCCCCAT CCAGCTGACC 
CCTTTCTACC CTGTGGATTA CACTGCAGAC CAGCACGGCA CCTGTGGGGA TGGGCTCCTG 
CAGCCTGGGG AGGAGTGTGA CGACGGTAAC AGCGATGTGG GTGACGACTG CATCCGCTGT 
CACCGTGCCT ACTGTGGAGA TGGTCACCGG CATGAGGGTG TGGAGGACTG TGACGGCTCT 
GACTTTGGCT ACCTGACATG CGAGACCTAT CTCCCTGGGT CATATGGAGA CCTGCAATGC 
ACCCAGTACT GCTACATCGA CTCCACGCCC TGCCGCTACT TCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005668.2
CDS	127..1494
Translation	MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT

Target ORF information:

RefSeq Version	NM_005677.3
Organism	Homo sapiens(human)
Definition	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant I, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005677.3

ORF Insert Sequence:

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGC TTCTCTCCCC AGACATGAAG 
AATCTCATGC TGGAACTGGA GACCTCGCAG TCCCCGTGCA TGCAAGGCTC GCTAGGCTCC 
CCTGGGCCTC CCGGCCCCCA GGGTCCACCG GGGCTTCCTG GCAAGACAGG ACCAAAGGGA 
GAAAAGGGGG AGCTTGGCCG ACCAGGAAGG AAGGGTAGAC CTGGCCCCCC AGGTGTTCCT 
GGCATGCCTG GGCCCATCGG TTGGCCAGGC CCTGAAGGAC CCAGGGGTGA AAAAGGTGAC 
CTGGGTATGA TGGGCTTGCC AGGGTCAAGA GGACCAATGG GCTCCAAGGG CTACCCTGGA 
TCCAGAGGGG AAAAGGGATC CAGAGGTGAA AAGGGTGACC TGGGTCCCAA AGGAGAAAAG 
GGTTTCCCAG GATTTCCTGG AATGTTGGGG CAGAAAGGTG AAATGGGTCC AAAAGGTGAA 
CCTGGGATAG CAGGACACCG AGGACCCACA GGAAGACCAG GAAAACGAGG CAAGCAGGGA 
CAGAAAGGGG ATAGTGGAGT TATGGGCCCA CCAGGCAAGC CTGGGCCTTC TGGTCAACCT 
GGCCGTCCGG GGCCCCCAGG CCCCCCACCT GCAGGACAAC TTATAATGGG ACCCAAAGGG 
GAAAGAGGAT TTCCCGGGCC TCCAGGAAGA TGTCTTTGTG GACCCACTAT GAATGTGAAT 
AACCCTTCCT ACGGGGAATC TGTGTATGGG CCCAGTTCCC CGCGAGTTCC TGTGATTTTT 
GTGGTCAACA ACCAGGAGGA GCTTGAGAGG CTGAACACCC AAAACGCCAT TGCCTTCCGC 
AGAGACCAGA GATCTCTGTA CTTCAAGGAC AGCCTTGGCT GGCTCCCCAT CCAGCTGACC 
CCTTTCTACC CTGTGGATTA CACTGCAGAC CAGCACGGCA CCTGTGGGGA TGGGCTCCTG 
CAGCCTGGGG AGGAGTGTGA CGACGGTAAC AGCGATGTGG GTGACGACTG CATCCGCTGT 
CACCGTGCCT ACTGTGGAGA TGGTCACCGG CATGAGGGTG TGGAGGACTG TGACGGCTCT 
GACTTTGGCT ACCTGACATG CGAGACCTAT CTCCCTGGGT CATATGGAGA CCTGCAATGC 
ACCCAGTACT GCTACATCGA CTCCACGCCC TGCCGCTACT TCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLQ ( NM_080538.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_536799.1 Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant II, mRNA.

Price & Availability↑

CloneID	OHu16232
Clone ID Related Accession (Same CDS sequence)	NM_080538.2
Accession Version	NM_080538.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	acetylcholinesterase collagenic tail peptide isoform II precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK128401.1, AF057036.1 and AI554171.1. On Oct 27, 2006 this sequence version replaced NM_080538.1. Transcript Variant: This variant (II) utilizes alternate exon 1A that is not present in variant I. The use of this exon results in a unique N-terminus compared to isoform I. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK128401.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACGGGCT CATCATTCAG CCTCGCTCAT CTGCTCATCA TTTCAGGACT GCTCTGTTAC 
TCGGCAGGCT GCTTGGCCCT TCCCAGCCTG GATCAGAAGA AGCGTGGTGG CCACAAAGCA 
TGCTGCCTGC TGACGCCTCC TCCACCACCA CTGTTCCCAC CACCATTCTT CAGAGGTGGC 
CGAAGTCCGC TTCTCTCCCC AGACATGAAG AATCTCATGC TGGAACTGGA GACCTCGCAG 
TCCCCGTGCA TGCAAGGCTC GCTAGGCTCC CCTGGGCCTC CCGGCCCCCA GGGTCCACCG 
GGGCTTCCTG GCAAGACAGG ACCAAAGGGA GAAAAGGGGG AGCTTGGCCG ACCAGGAAGG 
AAGGGTAGAC CTGGCCCCCC AGGTGTTCCT GGCATGCCTG GGCCCATCGG TTGGCCAGGC 
CCTGAAGGAC CCAGGGGTGA AAAAGGTGAC CTGGGTATGA TGGGCTTGCC AGGGTCAAGA 
GGACCAATGG GCTCCAAGGG CTACCCTGGA TCCAGAGGGG AAAAGGGATC CAGAGGTGAA 
AAGGGTGACC TGGGTCCCAA AGGAGAAAAG GGTTTCCCAG GATTTCCTGG AATGTTGGGG 
CAGAAAGGTG AAATGGGTCC AAAAGGTGAA CCTGGGATAG CAGGACACCG AGGACCCACA 
GGAAGACCAG GAAAACGAGG CAAGCAGGGA CAGAAAGGGG ATAGTGGAGT TATGGGCCCA 
CCAGGCAAGC CTGGGCCTTC TGGTCAACCT GGCCGTCCGG GGCCCCCAGG CCCCCCACCT 
GCAGGACAAC TTATAATGGG ACCCAAAGGG GAAAGAGGAT TTCCCGGGCC TCCAGGAAGA 
TGTCTTTGTG GACCCACTAT GAATGTGAAT AACCCTTCCT ACGGGGAATC TGTGTATGGG 
CCCAGTTCCC CGCGAGTTCC TGTGATTTTT GTGGTCAACA ACCAGGAGGA GCTTGAGAGG 
CTGAACACCC AAAACGCCAT TGCCTTCCGC AGAGACCAGA GATCTCTGTA CTTCAAGGAC 
AGCCTTGGCT GGCTCCCCAT CCAGCTGACC CCTTTCTACC CTGTGGATTA CACTGCAGAC 
CAGCACGGCA CCTGTGGGGA TGGGCTCCTG CAGCCTGGGG AGGAGTGTGA CGACGGTAAC 
AGCGATGTGG GTGACGACTG CATCCGCTGT CACCGTGCCT ACTGTGGAGA TGGTCACCGG 
CATGAGGGTG TGGAGGACTG TGACGGCTCT GACTTTGGCT ACCTGACATG CGAGACCTAT 
CTCCCTGGGT CATATGGAGA CCTGCAATGC ACCCAGTACT GCTACATCGA CTCCACGCCC 
TGCCGCTACT TCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536799.1
CDS	286..1623
Translation	MTGSSFSLAHLLIISGLLCYSAGCLALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT

Target ORF information:

RefSeq Version	NM_080538.2
Organism	Homo sapiens(human)
Definition	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant II, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080538.2

ORF Insert Sequence:

ATGACGGGCT CATCATTCAG CCTCGCTCAT CTGCTCATCA TTTCAGGACT GCTCTGTTAC 
TCGGCAGGCT GCTTGGCCCT TCCCAGCCTG GATCAGAAGA AGCGTGGTGG CCACAAAGCA 
TGCTGCCTGC TGACGCCTCC TCCACCACCA CTGTTCCCAC CACCATTCTT CAGAGGTGGC 
CGAAGTCCGC TTCTCTCCCC AGACATGAAG AATCTCATGC TGGAACTGGA GACCTCGCAG 
TCCCCGTGCA TGCAAGGCTC GCTAGGCTCC CCTGGGCCTC CCGGCCCCCA GGGTCCACCG 
GGGCTTCCTG GCAAGACAGG ACCAAAGGGA GAAAAGGGGG AGCTTGGCCG ACCAGGAAGG 
AAGGGTAGAC CTGGCCCCCC AGGTGTTCCT GGCATGCCTG GGCCCATCGG TTGGCCAGGC 
CCTGAAGGAC CCAGGGGTGA AAAAGGTGAC CTGGGTATGA TGGGCTTGCC AGGGTCAAGA 
GGACCAATGG GCTCCAAGGG CTACCCTGGA TCCAGAGGGG AAAAGGGATC CAGAGGTGAA 
AAGGGTGACC TGGGTCCCAA AGGAGAAAAG GGTTTCCCAG GATTTCCTGG AATGTTGGGG 
CAGAAAGGTG AAATGGGTCC AAAAGGTGAA CCTGGGATAG CAGGACACCG AGGACCCACA 
GGAAGACCAG GAAAACGAGG CAAGCAGGGA CAGAAAGGGG ATAGTGGAGT TATGGGCCCA 
CCAGGCAAGC CTGGGCCTTC TGGTCAACCT GGCCGTCCGG GGCCCCCAGG CCCCCCACCT 
GCAGGACAAC TTATAATGGG ACCCAAAGGG GAAAGAGGAT TTCCCGGGCC TCCAGGAAGA 
TGTCTTTGTG GACCCACTAT GAATGTGAAT AACCCTTCCT ACGGGGAATC TGTGTATGGG 
CCCAGTTCCC CGCGAGTTCC TGTGATTTTT GTGGTCAACA ACCAGGAGGA GCTTGAGAGG 
CTGAACACCC AAAACGCCAT TGCCTTCCGC AGAGACCAGA GATCTCTGTA CTTCAAGGAC 
AGCCTTGGCT GGCTCCCCAT CCAGCTGACC CCTTTCTACC CTGTGGATTA CACTGCAGAC 
CAGCACGGCA CCTGTGGGGA TGGGCTCCTG CAGCCTGGGG AGGAGTGTGA CGACGGTAAC 
AGCGATGTGG GTGACGACTG CATCCGCTGT CACCGTGCCT ACTGTGGAGA TGGTCACCGG 
CATGAGGGTG TGGAGGACTG TGACGGCTCT GACTTTGGCT ACCTGACATG CGAGACCTAT 
CTCCCTGGGT CATATGGAGA CCTGCAATGC ACCCAGTACT GCTACATCGA CTCCACGCCC 
TGCCGCTACT TCACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLQ ( NM_080539.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_536800.2 Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant III, mRNA.

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CloneID	OHu16271
Clone ID Related Accession (Same CDS sequence)	NM_080539.3 , NM_080539.4
Accession Version	NM_080539.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	acetylcholinesterase collagenic tail peptide isoform III precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF057036.1, BX500613.1, AK128401.1 and AI554171.1. On Apr 25, 2007 this sequence version replaced NM_080539.2. Transcript Variant: This variant (III) is the only variant missing exon 3. Exon 3 encodes the proline-rich attachment domain; as a result, isoform III is the only isoform lacking this domain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGG GTCCACCGGG GCTTCCTGGC 
AAGACAGGAC CAAAGGGAGA AAAGGGGGAG CTTGGCCGAC CAGGAAGGAA GGGTAGACCT 
GGCCCCCCAG GTGTTCCTGG CATGCCTGGG CCCATCGGTT GGCCAGGCCC TGAAGGACCC 
AGGGGTGAAA AAGGTGACCT GGGTATGATG GGCTTGCCAG GGTCAAGAGG ACCAATGGGC 
TCCAAGGGCT ACCCTGGATC CAGAGGGGAA AAGGGATCCA GAGGTGAAAA GGGTGACCTG 
GGTCCCAAAG GAGAAAAGGG TTTCCCAGGA TTTCCTGGAA TGTTGGGGCA GAAAGGTGAA 
ATGGGTCCAA AAGGTGAACC TGGGATAGCA GGACACCGAG GACCCACAGG AAGACCAGGA 
AAACGAGGCA AGCAGGGACA GAAAGGGGAT AGTGGAGTTA TGGGCCCACC AGGCAAGCCT 
GGGCCTTCTG GTCAACCTGG CCGTCCGGGG CCCCCAGGCC CCCCACCTGC AGGACAACTT 
ATAATGGGAC CCAAAGGGGA AAGAGGATTT CCCGGGCCTC CAGGAAGATG TCTTTGTGGA 
CCCACTATGA ATGTGAATAA CCCTTCCTAC GGGGAATCTG TGTATGGGCC CAGTTCCCCG 
CGAGTTCCTG TGATTTTTGT GGTCAACAAC CAGGAGGAGC TTGAGAGGCT GAACACCCAA 
AACGCCATTG CCTTCCGCAG AGACCAGAGA TCTCTGTACT TCAAGGACAG CCTTGGCTGG 
CTCCCCATCC AGCTGACCCC TTTCTACCCT GTGGATTACA CTGCAGACCA GCACGGCACC 
TGTGGGGATG GGCTCCTGCA GCCTGGGGAG GAGTGTGACG ACGGTAACAG CGATGTGGGT 
GACGACTGCA TCCGCTGTCA CCGTGCCTAC TGTGGAGATG GTCACCGGCA TGAGGGTGTG 
GAGGACTGTG ACGGCTCTGA CTTTGGCTAC CTGACATGCG AGACCTATCT CCCTGGGTCA 
TATGGAGACC TGCAATGCAC CCAGTACTGC TACATCGACT CCACGCCCTG CCGCTACTTC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536800.2
CDS	127..1392
Translation	MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT

Target ORF information:

RefSeq Version	NM_080539.3
Organism	Homo sapiens(human)
Definition	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant III, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080539.3

ORF Insert Sequence:

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGG GTCCACCGGG GCTTCCTGGC 
AAGACAGGAC CAAAGGGAGA AAAGGGGGAG CTTGGCCGAC CAGGAAGGAA GGGTAGACCT 
GGCCCCCCAG GTGTTCCTGG CATGCCTGGG CCCATCGGTT GGCCAGGCCC TGAAGGACCC 
AGGGGTGAAA AAGGTGACCT GGGTATGATG GGCTTGCCAG GGTCAAGAGG ACCAATGGGC 
TCCAAGGGCT ACCCTGGATC CAGAGGGGAA AAGGGATCCA GAGGTGAAAA GGGTGACCTG 
GGTCCCAAAG GAGAAAAGGG TTTCCCAGGA TTTCCTGGAA TGTTGGGGCA GAAAGGTGAA 
ATGGGTCCAA AAGGTGAACC TGGGATAGCA GGACACCGAG GACCCACAGG AAGACCAGGA 
AAACGAGGCA AGCAGGGACA GAAAGGGGAT AGTGGAGTTA TGGGCCCACC AGGCAAGCCT 
GGGCCTTCTG GTCAACCTGG CCGTCCGGGG CCCCCAGGCC CCCCACCTGC AGGACAACTT 
ATAATGGGAC CCAAAGGGGA AAGAGGATTT CCCGGGCCTC CAGGAAGATG TCTTTGTGGA 
CCCACTATGA ATGTGAATAA CCCTTCCTAC GGGGAATCTG TGTATGGGCC CAGTTCCCCG 
CGAGTTCCTG TGATTTTTGT GGTCAACAAC CAGGAGGAGC TTGAGAGGCT GAACACCCAA 
AACGCCATTG CCTTCCGCAG AGACCAGAGA TCTCTGTACT TCAAGGACAG CCTTGGCTGG 
CTCCCCATCC AGCTGACCCC TTTCTACCCT GTGGATTACA CTGCAGACCA GCACGGCACC 
TGTGGGGATG GGCTCCTGCA GCCTGGGGAG GAGTGTGACG ACGGTAACAG CGATGTGGGT 
GACGACTGCA TCCGCTGTCA CCGTGCCTAC TGTGGAGATG GTCACCGGCA TGAGGGTGTG 
GAGGACTGTG ACGGCTCTGA CTTTGGCTAC CTGACATGCG AGACCTATCT CCCTGGGTCA 
TATGGAGACC TGCAATGCAC CCAGTACTGC TACATCGACT CCACGCCCTG CCGCTACTTC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLQ ( NM_080539.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_536800.2 Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant III, mRNA.

Price & Availability↑

CloneID	OHu16271
Clone ID Related Accession (Same CDS sequence)	NM_080539.3 , NM_080539.4
Accession Version	NM_080539.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	acetylcholinesterase collagenic tail peptide isoform III precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX500613.1, AF057036.1, AK128401.1 and AI554171.1. On May 31, 2019 this sequence version replaced NM_080539.3. Transcript Variant: This variant (III) is the only variant missing exon 3. Exon 3 encodes the proline-rich attachment domain; as a result, isoform III is the only isoform lacking this domain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGG GTCCACCGGG GCTTCCTGGC 
AAGACAGGAC CAAAGGGAGA AAAGGGGGAG CTTGGCCGAC CAGGAAGGAA GGGTAGACCT 
GGCCCCCCAG GTGTTCCTGG CATGCCTGGG CCCATCGGTT GGCCAGGCCC TGAAGGACCC 
AGGGGTGAAA AAGGTGACCT GGGTATGATG GGCTTGCCAG GGTCAAGAGG ACCAATGGGC 
TCCAAGGGCT ACCCTGGATC CAGAGGGGAA AAGGGATCCA GAGGTGAAAA GGGTGACCTG 
GGTCCCAAAG GAGAAAAGGG TTTCCCAGGA TTTCCTGGAA TGTTGGGGCA GAAAGGTGAA 
ATGGGTCCAA AAGGTGAACC TGGGATAGCA GGACACCGAG GACCCACAGG AAGACCAGGA 
AAACGAGGCA AGCAGGGACA GAAAGGGGAT AGTGGAGTTA TGGGCCCACC AGGCAAGCCT 
GGGCCTTCTG GTCAACCTGG CCGTCCGGGG CCCCCAGGCC CCCCACCTGC AGGACAACTT 
ATAATGGGAC CCAAAGGGGA AAGAGGATTT CCCGGGCCTC CAGGAAGATG TCTTTGTGGA 
CCCACTATGA ATGTGAATAA CCCTTCCTAC GGGGAATCTG TGTATGGGCC CAGTTCCCCG 
CGAGTTCCTG TGATTTTTGT GGTCAACAAC CAGGAGGAGC TTGAGAGGCT GAACACCCAA 
AACGCCATTG CCTTCCGCAG AGACCAGAGA TCTCTGTACT TCAAGGACAG CCTTGGCTGG 
CTCCCCATCC AGCTGACCCC TTTCTACCCT GTGGATTACA CTGCAGACCA GCACGGCACC 
TGTGGGGATG GGCTCCTGCA GCCTGGGGAG GAGTGTGACG ACGGTAACAG CGATGTGGGT 
GACGACTGCA TCCGCTGTCA CCGTGCCTAC TGTGGAGATG GTCACCGGCA TGAGGGTGTG 
GAGGACTGTG ACGGCTCTGA CTTTGGCTAC CTGACATGCG AGACCTATCT CCCTGGGTCA 
TATGGAGACC TGCAATGCAC CCAGTACTGC TACATCGACT CCACGCCCTG CCGCTACTTC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536800.2
CDS	82..1347
Translation	MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT

Target ORF information:

RefSeq Version	NM_080539.4
Organism	Homo sapiens(human)
Definition	Homo sapiens collagen like tail subunit of asymmetric acetylcholinesterase (COLQ), transcript variant III, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080539.4

ORF Insert Sequence:

ATGGTTGTCC TGAATCCAAT GACTTTGGGA ATTTATCTTC AGCTTTTCTT CCTCTCTATC 
GTGTCTCAGC CGACTTTCAT CAACAGCGTT CTTCCAATCT CAGCAGCCCT TCCCAGCCTG 
GATCAGAAGA AGCGTGGTGG CCACAAAGCA TGCTGCCTGC TGACGCCTCC TCCACCACCA 
CTGTTCCCAC CACCATTCTT CAGAGGTGGC CGAAGTCCGG GTCCACCGGG GCTTCCTGGC 
AAGACAGGAC CAAAGGGAGA AAAGGGGGAG CTTGGCCGAC CAGGAAGGAA GGGTAGACCT 
GGCCCCCCAG GTGTTCCTGG CATGCCTGGG CCCATCGGTT GGCCAGGCCC TGAAGGACCC 
AGGGGTGAAA AAGGTGACCT GGGTATGATG GGCTTGCCAG GGTCAAGAGG ACCAATGGGC 
TCCAAGGGCT ACCCTGGATC CAGAGGGGAA AAGGGATCCA GAGGTGAAAA GGGTGACCTG 
GGTCCCAAAG GAGAAAAGGG TTTCCCAGGA TTTCCTGGAA TGTTGGGGCA GAAAGGTGAA 
ATGGGTCCAA AAGGTGAACC TGGGATAGCA GGACACCGAG GACCCACAGG AAGACCAGGA 
AAACGAGGCA AGCAGGGACA GAAAGGGGAT AGTGGAGTTA TGGGCCCACC AGGCAAGCCT 
GGGCCTTCTG GTCAACCTGG CCGTCCGGGG CCCCCAGGCC CCCCACCTGC AGGACAACTT 
ATAATGGGAC CCAAAGGGGA AAGAGGATTT CCCGGGCCTC CAGGAAGATG TCTTTGTGGA 
CCCACTATGA ATGTGAATAA CCCTTCCTAC GGGGAATCTG TGTATGGGCC CAGTTCCCCG 
CGAGTTCCTG TGATTTTTGT GGTCAACAAC CAGGAGGAGC TTGAGAGGCT GAACACCCAA 
AACGCCATTG CCTTCCGCAG AGACCAGAGA TCTCTGTACT TCAAGGACAG CCTTGGCTGG 
CTCCCCATCC AGCTGACCCC TTTCTACCCT GTGGATTACA CTGCAGACCA GCACGGCACC 
TGTGGGGATG GGCTCCTGCA GCCTGGGGAG GAGTGTGACG ACGGTAACAG CGATGTGGGT 
GACGACTGCA TCCGCTGTCA CCGTGCCTAC TGTGGAGATG GTCACCGGCA TGAGGGTGTG 
GAGGACTGTG ACGGCTCTGA CTTTGGCTAC CTGACATGCG AGACCTATCT CCCTGGGTCA 
TATGGAGACC TGCAATGCAC CCAGTACTGC TACATCGACT CCACGCCCTG CCGCTACTTC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Nature communications815789(2017 Jun)
Sigurdsson S,Alexandersson KF,Sulem P,Feenstra B,Gudmundsdottir S,Halldorsson GH,Olafsson S,Sigurdsson A,Rafnar T,Thorgeirsson T,S?rensen E,Nordholm-Carstensen A,Burcharth J,Andersen J,J?rgensen HS,Possfelt-M?ller E,Ullum H,Thorleifsson G,Masson G,Thorsteinsdottir U,Melbye M,Gudbjartsson DF,Stefansson T,Jonsdottir I,Stefansson K

Congenital myasthenic syndrome in Israel: Genetic and clinical characterization.
Neuromuscular disorders : NMD27(2)136-140(2017 Feb)
Aharoni S,Sadeh M,Shapira Y,Edvardson S,Daana M,Dor-Wollman T,Mimouni-Bloch A,Halevy A,Cohen R,Sagie L,Argov Z,Rabie M,Spiegel R,Chervinsky I,Orenstein N,Engel AG,Nevo Y

SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome.
Scientific reports513208(2015 Aug)
Rahman MA,Azuma Y,Nasrin F,Takeda J,Nazim M,Bin Ahsan K,Masuda A,Engel AG,Ohno K

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COLQ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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