Atp1a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp1a3
Entrez Gene ID	24213
Full Name	ATPase Na+/K+ transporting subunit alpha 3
Synonyms	Atpa1a3
General protein information	Preferred Names ATPase Na+/K+ transporting subunit alpha 3 Names sodium/potassium-transporting ATPase subunit alpha-3 ATPase, Na+/K+ transporting, alpha 3 polypeptide ATPase, Na+K+ transporting, alpha 3 subunit NA,K-ATPase alpha subunit 3 Na(+)/K(+) ATPase alpha(III) subunit Na(+)/K(+) ATPase alpha-3 subunit Na+/K+ -ATPase alpha 3 subunit sodium pump subunit alpha-3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	contains 4.5 kb and 6 kb transcripts that display differential tissue expression [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017588775.1	XP_017444264.1	sodium/potassium-transporting ATPase subunit alpha-3 isoform X1
NM_012506.1	NP_036638.1	sodium/potassium-transporting ATPase subunit alpha-3

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATP1A3	NP_001243143.1
Xenopus tropicalis (tropical clawed frog)	atp1a3	NP_001120366.1
Pan troglodytes (chimpanzee)	ATP1A3	XP_003316427.1
	ATP1A3	XP_002801302.1
Bos taurus (cattle)	ATP1A3	XP_002695120.2
Rattus norvegicus (Norway rat)	Atp1a3	NP_036638.1
Drosophila melanogaster (fruit fly)	Atpalpha	NP_732572.1
Danio rerio (zebrafish)	atp1a3b	NP_571760.2
Gallus gallus (chicken)	ATP1A3	NP_990806.1
Caenorhabditis elegans (roundworm)	eat-6	NP_506269.1
Canis lupus familiaris (dog)	ATP1A3	XP_005616573.1
Mus musculus (house mouse)	Atp1a3	NP_659170.1
Danio rerio (zebrafish)	atp1a3a	NP_571759.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002858	XP_003436267.1

Gene Ontology
Bibliography

Related articles in PubMed

Na, K-ATPase ?3 is a death target of Alzheimer patient amyloid-? assembly.
Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M
Proceedings of the National Academy of Sciences of the United States of America112(32)E4465-74(2015 Aug)

The (Na(+)/K (+))-ATPase activity in the developing rat retina: the role of insulin-like growth factor-I (IGF-I).
Maturana-Teixeira S, Braga LE, Carpi Santos R, Calaza Kda C, Giestal-de-Araujo E, Le?o-Ferreira LR
Cellular and molecular neurobiology35(2)243-54(2015 Mar)

Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly.
Paciorkowski AR, McDaniel SS, Jansen LA, Tully H, Tuttle E, Ghoneim DH, Tupal S, Gunter SA, Vasta V, Zhang Q, Tran T, Liu YB, Ozelius LJ, Brashear A, Sweadner KJ, Dobyns WB, Hahn S
Epilepsia56(3)422-30(2015 Mar)

Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only.
Wilcox R, Br?nne I, Br?ggemann N, Winkler S, Wiegers K, Bertram L, Anderson T, Lohmann K
Journal of neurology262(1)187-93(2015 Jan)

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A, Teunissen CE, de Wit H, Jim?nez CR
Journal of proteomics106191-204(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The amylospheroids target is neuron-specific Na(+)/K(+)-ATPase alpha3 subunit (NAKalpha3).
Title: Na, K-ATPase ?3 is a death target of Alzheimer patient amyloid-? assembly.

the PI 3-kinase/PKB signaling pathway is involved in the IGF-I-sustained basal (Na(+)/K(+))-ATPase activity during the first 7 days of the postnatal development of rat retina.
Title: The (Na(+)/K (+))-ATPase activity in the developing rat retina: the role of insulin-like growth factor-I (IGF-I).

Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease
Title: Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.

Mild hyperhomocysteinemia significantly decreases the activity and the content of the alpha 1 and alpha 2 subunits of the Na(+),K(+)-ATPase in cerebral cortex and hippocampus of adult rats.
Title: Mild hyperhomocysteinemia reduces the activity and immunocontent, but does not alter the gene expression, of catalytic ? subunits of cerebral Na+,K+-ATPase.

there is a specific and essential role for Na,K-ATPase alpha3 in neurons co-expressing alpha1 and alpha3
Title: A specific and essential role for Na,K-ATPase ?3 in neurons co-expressing ?1 and ?3.

The following Atp1a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp1a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12775	NM_012506.1 Latest version!	Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3 (Atp1a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
ORa56379	XM_017588775.1 Latest version!	Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3 (Atp1a3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp1a3 ( NM_012506.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036638.1 Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3 (Atp1a3), mRNA.

Price & Availability↑

CloneID	ORa12775
Clone ID Related Accession (Same CDS sequence)	NM_012506.1
Accession Version	NM_012506.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3042bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	sodium/potassium-transporting ATPase subunit alpha-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M14513.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M14513.1, X05883.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGACA AAAAAGATGA CAAGAGCTCG CCCAAGAAGA GCAAGGCCAA AGAGCGCCGG 
GACCTGGATG ACCTCAAGAA GGAAGTGGCT ATGACAGAGC ACAAGATGTC AGTAGAAGAG 
GTCTGCCGGA AATACAATAC CGACTGCGTG CAGGGTCTGA CACACAGTAA AGCCCAGGAG 
ATCCTAGCCC GGGATGGGCC TAACGCCCTC ACACCACCGC CCACCACCCC AGAATGGGTC 
AAGTTCTGCC GACAGCTATT TGGTGGCTTC TCCATCCTGC TGTGGATCGG GGCGATCCTT 
TGCTTCCTGG CCTATGGCAT CCAGGCAGGG ACTGAGGATG ACCCTTCCGG TGACAATCTG 
TACCTGGGCA TAGTGCTGGC CGCTGTGGTG ATCATCACCG GCTGCTTCTC CTACTACCAA 
GAAGCCAAGA GCTCTAAGAT TATGGAGTCC TTCAAGAACA TGGTTCCCCA GCAAGCCCTT 
GTGATCCGGG AAGGTGAAAA GATGCAGGTG AATGCGGAGG AGGTGGTGGT CGGGGACCTG 
GTGGAGATCA AGGGTGGCGA CCGGGTGCCC GCTGACCTGC GCATCATCTC GGCCCATGGC 
TGCAAGGTGG ACAACTCTTC CCTGACTGGC GAATCTGAGC CTCAGACCCG CTCCCCGGAC 
TGCACACACG ACAACCCACT GGAGACCCGG AACATCACCT TCTTTTCCAC CAACTGTGTG 
GAAGGCACCG CTCGTGGTGT GGTGGTAGCC ACAGGTGACC GCACCGTCAT GGGCCGCATT 
GCCACCCTGG CCTCAGGCCT GGAGGTGGGC AAGACGCCCA TCGCCATTGA GATCGAGCAC 
TTCATCCAGC TCATCACTGG CGTGGCCGTG TTCCTGGGCG TCTCCTTCTT CATCCTCTCC 
CTCATTCTGG GCTACACCTG GCTGGAGGCT GTCATCTTCC TCATCGGTAT CATTGTGGCC 
AATGTCCCAG AGGGGCTGCT GGCTACTGTC ACGGTGTGTC TGACGCTGAC CGCCAAGCGC 
ATGGCTCGGA AGAACTGTCT GGTAAAGAAC CTGGAGGCGG TGGAGACGCT AGGCTCCACA 
TCCACCATCT GCTCCGACAA GACCGGCACC CTCACCCAGA ACCGCATGAC CGTCGCCCAC 
ATGTGGTTTG ACAACCAGAT CCACGAGGCC GACACTACTG AGGATCAGTC AGGGACCTCT 
TTCGACAAGA GCTCACACAC CTGGGTGGCC CTGTCCCACA TCGCCGGTCT CTGCAACCGG 
GCTGTCTTCA AGGGCGGGCA GGATAACATC CCTGTACTCA AGAGGGACGT GGCGGGTGAT 
GCCTCAGAGT CCGCCCTGCT TAAGTGCATC GAGCTGTCCT CGGGTTCCGT AAAGCTGATG 
CGCGAACGAA ACAAGAAAGT GGCCGAGATT CCCTTCAACT CCACTAACAA ATACCAGCTA 
TCCATCCATG AGACTGAGGA CCCCAATGAC AACCGATACC TGTTAGTGAT GAAGGGCGCC 
CCTGAACGCA TTCTGGACCG CTGTGCGACC ATCCTCCTGC AGGGCAAGGA GCAGCCTCTG 
GATGAGGAGA TGAAGGAGGC CTTCCAGAAC GCCTACCTGG AGCTTGGTGG CCTGGGCGAG 
CGTGTGCTGG GTTTCTGCCA TTACTACCTG CCGGAGGAAC AGTTCCCCAA GGGCTTTGCC 
TTTGACTGTG ATGACGTGAA CTTCACCACA GACAACCTTT GCTTCGTGGG TCTCATGTCC 
ATGATCGACC CTCCCCGGGC AGCTGTCCCT GATGCTGTGG GCAAATGCCG CAGTGCAGGC 
ATCAAGGTCA TCATGGTCAC CGGCGATCAC CCCATCACTG CGAAGGCCAT CGCCAAAGGT 
GTAGGCATCA TCTCCGAGGG TAACGAGACT GTGGAGGACA TCGCTGCCCG GCTCAACATC 
CCTGTCAGCC AGGTCAACCC CAGGGATGCC AAAGCCTGTG TGATTCATGG CACCGACCTC 
AAGGACTTCA CCTCTGAGCA GATTGACGAG ATCCTACAGA ACCACACTGA GATCGTCTTT 
GCCCGAACCT CCCCTCAGCA GAAGCTCATC ATCGTGGAGG GCTGTCAGAG ACAGGGAGCA 
ATTGTGGCTG TGACTGGCGA TGGTGTGAAT GACTCCCCTG CTCTGAAGAA GGCTGATATT 
GGGGTGGCCA TGGGCATTGC TGGCTCTGAT GTCTCTAAGC AGGCTGCCGA CATGATTCTG 
CTGGATGACA ATTTTGCTTC CATTGTCACT GGTGTGGAGG AAGGCCGCCT GATCTTTGAC 
AACCTGAAGA AATCCATCGC CTACACTCTG ACCAGCAACA TCCCTGAGAT CACACCCTTC 
CTTCTCTTCA TCATGGCCAA CATCCCACTG CCCCTTGGCA CCATCACCAT CCTCTGCATT 
GACCTGGGCA CCGACATGGT CCCTGCAATC TCCTTGGCCT ACGAGGCTGC AGAGAGTGAC 
ATCATGAAGA GGCAGCCCAG GAACCCACGC ACAGACAAAC TGGTCAACGA AAGGCTCATC 
AGCATGGCCT ATGGGCAGAT CGGGATGATC CAGGCCCTCG GTGGTTTCTT CTCCTACTTT 
GTCATCCTGG CAGAAAATGG TTTCTTGCCC GGTAACCTGG TGGGCATCCG GCTCAACTGG 
GATGACCGCA CTGTCAACGA CCTGGAAGAC AGCTACGGGC AGCAGTGGAC TTATGAGCAG 
AGGAAGGTGG TTGAGTTCAC GTTCCACACA GCCTTCTTCG TGAGCATAGT GGTGGTCCAG 
TGGGCTGACC TGATCATTTG CAAGACCAGG AGGAATTCCG TCTTCCAGCA GGGCATGAAG 
AATAAGATCT TGATCTTCGG ACTGTTTGAG GAAACGGCCC TCGCTGCCTT CCTGTCCTAC 
TGCCCAGGCA TGGATGTGGC CCTTCGCATG TACCCGCTCA AGCCCAGCTG GTGGTTCTGT 
GCCTTCCCCT ACAGTTTCCT CATCTTCGTC TATGATGAGA TTCGCAAACT CATCCTGCGC 
AGGAACCCCG GGGGTTGGGT GGAGAAAGAG ACCTACTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036638.1
CDS	144..3185
Translation	MGDKKDDKSSPKKSKAKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTFHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY

Target ORF information:

RefSeq Version	NM_012506.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3 (Atp1a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012506.1

ORF Insert Sequence:

ATGGGGGACA AAAAAGATGA CAAGAGCTCG CCCAAGAAGA GCAAGGCCAA AGAGCGCCGG 
GACCTGGATG ACCTCAAGAA GGAAGTGGCT ATGACAGAGC ACAAGATGTC AGTAGAAGAG 
GTCTGCCGGA AATACAATAC CGACTGCGTG CAGGGTCTGA CACACAGTAA AGCCCAGGAG 
ATCCTAGCCC GGGATGGGCC TAACGCCCTC ACACCACCGC CCACCACCCC AGAATGGGTC 
AAGTTCTGCC GACAGCTATT TGGTGGCTTC TCCATCCTGC TGTGGATCGG GGCGATCCTT 
TGCTTCCTGG CCTATGGCAT CCAGGCAGGG ACTGAGGATG ACCCTTCCGG TGACAATCTG 
TACCTGGGCA TAGTGCTGGC CGCTGTGGTG ATCATCACCG GCTGCTTCTC CTACTACCAA 
GAAGCCAAGA GCTCTAAGAT TATGGAGTCC TTCAAGAACA TGGTTCCCCA GCAAGCCCTT 
GTGATCCGGG AAGGTGAAAA GATGCAGGTG AATGCGGAGG AGGTGGTGGT CGGGGACCTG 
GTGGAGATCA AGGGTGGCGA CCGGGTGCCC GCTGACCTGC GCATCATCTC GGCCCATGGC 
TGCAAGGTGG ACAACTCTTC CCTGACTGGC GAATCTGAGC CTCAGACCCG CTCCCCGGAC 
TGCACACACG ACAACCCACT GGAGACCCGG AACATCACCT TCTTTTCCAC CAACTGTGTG 
GAAGGCACCG CTCGTGGTGT GGTGGTAGCC ACAGGTGACC GCACCGTCAT GGGCCGCATT 
GCCACCCTGG CCTCAGGCCT GGAGGTGGGC AAGACGCCCA TCGCCATTGA GATCGAGCAC 
TTCATCCAGC TCATCACTGG CGTGGCCGTG TTCCTGGGCG TCTCCTTCTT CATCCTCTCC 
CTCATTCTGG GCTACACCTG GCTGGAGGCT GTCATCTTCC TCATCGGTAT CATTGTGGCC 
AATGTCCCAG AGGGGCTGCT GGCTACTGTC ACGGTGTGTC TGACGCTGAC CGCCAAGCGC 
ATGGCTCGGA AGAACTGTCT GGTAAAGAAC CTGGAGGCGG TGGAGACGCT AGGCTCCACA 
TCCACCATCT GCTCCGACAA GACCGGCACC CTCACCCAGA ACCGCATGAC CGTCGCCCAC 
ATGTGGTTTG ACAACCAGAT CCACGAGGCC GACACTACTG AGGATCAGTC AGGGACCTCT 
TTCGACAAGA GCTCACACAC CTGGGTGGCC CTGTCCCACA TCGCCGGTCT CTGCAACCGG 
GCTGTCTTCA AGGGCGGGCA GGATAACATC CCTGTACTCA AGAGGGACGT GGCGGGTGAT 
GCCTCAGAGT CCGCCCTGCT TAAGTGCATC GAGCTGTCCT CGGGTTCCGT AAAGCTGATG 
CGCGAACGAA ACAAGAAAGT GGCCGAGATT CCCTTCAACT CCACTAACAA ATACCAGCTA 
TCCATCCATG AGACTGAGGA CCCCAATGAC AACCGATACC TGTTAGTGAT GAAGGGCGCC 
CCTGAACGCA TTCTGGACCG CTGTGCGACC ATCCTCCTGC AGGGCAAGGA GCAGCCTCTG 
GATGAGGAGA TGAAGGAGGC CTTCCAGAAC GCCTACCTGG AGCTTGGTGG CCTGGGCGAG 
CGTGTGCTGG GTTTCTGCCA TTACTACCTG CCGGAGGAAC AGTTCCCCAA GGGCTTTGCC 
TTTGACTGTG ATGACGTGAA CTTCACCACA GACAACCTTT GCTTCGTGGG TCTCATGTCC 
ATGATCGACC CTCCCCGGGC AGCTGTCCCT GATGCTGTGG GCAAATGCCG CAGTGCAGGC 
ATCAAGGTCA TCATGGTCAC CGGCGATCAC CCCATCACTG CGAAGGCCAT CGCCAAAGGT 
GTAGGCATCA TCTCCGAGGG TAACGAGACT GTGGAGGACA TCGCTGCCCG GCTCAACATC 
CCTGTCAGCC AGGTCAACCC CAGGGATGCC AAAGCCTGTG TGATTCATGG CACCGACCTC 
AAGGACTTCA CCTCTGAGCA GATTGACGAG ATCCTACAGA ACCACACTGA GATCGTCTTT 
GCCCGAACCT CCCCTCAGCA GAAGCTCATC ATCGTGGAGG GCTGTCAGAG ACAGGGAGCA 
ATTGTGGCTG TGACTGGCGA TGGTGTGAAT GACTCCCCTG CTCTGAAGAA GGCTGATATT 
GGGGTGGCCA TGGGCATTGC TGGCTCTGAT GTCTCTAAGC AGGCTGCCGA CATGATTCTG 
CTGGATGACA ATTTTGCTTC CATTGTCACT GGTGTGGAGG AAGGCCGCCT GATCTTTGAC 
AACCTGAAGA AATCCATCGC CTACACTCTG ACCAGCAACA TCCCTGAGAT CACACCCTTC 
CTTCTCTTCA TCATGGCCAA CATCCCACTG CCCCTTGGCA CCATCACCAT CCTCTGCATT 
GACCTGGGCA CCGACATGGT CCCTGCAATC TCCTTGGCCT ACGAGGCTGC AGAGAGTGAC 
ATCATGAAGA GGCAGCCCAG GAACCCACGC ACAGACAAAC TGGTCAACGA AAGGCTCATC 
AGCATGGCCT ATGGGCAGAT CGGGATGATC CAGGCCCTCG GTGGTTTCTT CTCCTACTTT 
GTCATCCTGG CAGAAAATGG TTTCTTGCCC GGTAACCTGG TGGGCATCCG GCTCAACTGG 
GATGACCGCA CTGTCAACGA CCTGGAAGAC AGCTACGGGC AGCAGTGGAC TTATGAGCAG 
AGGAAGGTGG TTGAGTTCAC GTTCCACACA GCCTTCTTCG TGAGCATAGT GGTGGTCCAG 
TGGGCTGACC TGATCATTTG CAAGACCAGG AGGAATTCCG TCTTCCAGCA GGGCATGAAG 
AATAAGATCT TGATCTTCGG ACTGTTTGAG GAAACGGCCC TCGCTGCCTT CCTGTCCTAC 
TGCCCAGGCA TGGATGTGGC CCTTCGCATG TACCCGCTCA AGCCCAGCTG GTGGTTCTGT 
GCCTTCCCCT ACAGTTTCCT CATCTTCGTC TATGATGAGA TTCGCAAACT CATCCTGCGC 
AGGAACCCCG GGGGTTGGGT GGAGAAAGAG ACCTACTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Atp1a3 ( XM_017588775.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444264.1 Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3 (Atp1a3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56379
Clone ID Related Accession (Same CDS sequence)	XM_017588775.1
Accession Version	XM_017588775.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3081bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sodium/potassium-transporting ATPase subunit alpha-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGTCTG GTGGTTCTGA CAGCTACCGT GTCGCCACCT CGCAGGACAA AAAAGATGAC 
AAGAGCTCGC CCAAGAAGAG CAAGGCCAAA GAGCGCCGGG ACCTGGATGA CCTCAAGAAG 
GAAGTGGCTA TGACAGAGCA CAAGATGTCA GTAGAAGAGG TCTGCCGGAA ATACAATACC 
GACTGCGTGC AGGGTCTGAC ACACAGTAAA GCCCAGGAGA TCCTAGCCCG GGATGGGCCT 
AACGCCCTCA CACCACCGCC CACCACCCCA GAATGGGTCA AGTTCTGCCG ACAGCTATTT 
GGTGGCTTCT CCATCCTGCT GTGGATCGGG GCGATCCTTT GCTTCCTGGC CTATGGCATC 
CAGGCAGGGA CTGAGGATGA CCCTTCCGGT GACAATCTGT ACCTGGGCAT AGTGCTGGCC 
GCTGTGGTGA TCATCACCGG CTGCTTCTCC TACTACCAAG AAGCCAAGAG CTCTAAGATT 
ATGGAGTCCT TCAAGAACAT GGTTCCCCAG CAAGCCCTTG TGATCCGGGA AGGTGAAAAG 
ATGCAGGTGA ATGCGGAGGA GGTGGTGGTC GGGGACCTGG TGGAGATCAA GGGTGGCGAC 
CGGGTGCCCG CTGACCTGCG CATCATCTCG GCCCATGGCT GCAAGGTGGA CAACTCTTCC 
CTGACTGGCG AATCTGAGCC TCAGACCCGC TCCCCGGACT GCACACACGA CAACCCACTG 
GAGACCCGGA ACATCACCTT CTTTTCCACC AACTGTGTGG AAGGCACCGC TCGTGGTGTG 
GTGGTAGCCA CAGGTGACCG CACCGTCATG GGCCGCATTG CCACCCTGGC CTCAGGCCTG 
GAGGTGGGCA AGACGCCCAT CGCCATTGAG ATCGAGCACT TCATCCAGCT CATCACTGGC 
GTGGCCGTGT TCCTGGGCGT CTCCTTCTTC ATCCTCTCCC TCATTCTGGG CTACACCTGG 
CTGGAGGCTG TCATCTTCCT CATCGGTATC ATTGTGGCCA ATGTCCCAGA GGGGCTGCTG 
GCTACTGTCA CGGTGTGTCT GACGCTGACC GCCAAGCGCA TGGCTCGGAA GAACTGTCTG 
GTAAAGAACC TGGAGGCGGT GGAGACGCTA GGCTCCACAT CCACCATCTG CTCCGACAAG 
ACCGGCACCC TCACCCAGAA CCGCATGACC GTCGCCCACA TGTGGTTTGA CAACCAGATC 
CACGAGGCCG ACACTACTGA GGATCAGTCA GGGACCTCTT TCGACAAGAG CTCACACACC 
TGGGTGGCCC TGTCCCACAT CGCCGGTCTC TGCAACCGGG CTGTCTTCAA GGGCGGGCAG 
GATAACATCC CTGTACTCAA GAGGGACGTG GCGGGTGATG CCTCAGAGTC CGCCCTGCTT 
AAGTGCATCG AGCTGTCCTC GGGTTCCGTA AAGCTGATGC GCGAACGAAA CAAGAAAGTG 
GCCGAGATTC CCTTCAACTC CACTAACAAA TACCAGCTAT CCATCCATGA GACTGAGGAC 
CCCAATGACA ACCGATACCT GTTAGTGATG AAGGGCGCCC CTGAACGCAT TCTGGACCGC 
TGTGCGACCA TCCTCCTGCA GGGCAAGGAG CAGCCTCTGG ATGAGGAGAT GAAGGAGGCC 
TTCCAGAACG CCTACCTGGA GCTTGGTGGC CTGGGCGAGC GTGTGCTGGG TTTCTGCCAT 
TACTACCTGC CGGAGGAACA GTTCCCCAAG GGCTTTGCCT TTGACTGTGA TGACGTGAAC 
TTCACCACAG ACAACCTTTG CTTCGTGGGT CTCATGTCCA TGATCGACCC TCCCCGGGCA 
GCTGTCCCTG ATGCTGTGGG CAAATGCCGC AGTGCAGGCA TCAAGGTCAT CATGGTCACC 
GGCGATCACC CCATCACTGC GAAGGCCATC GCCAAAGGTG TAGGCATCAT CTCCGAGGGT 
AACGAGACTG TGGAGGACAT CGCTGCCCGG CTCAACATCC CTGTCAGCCA GGTCAACCCC 
AGGGATGCCA AAGCCTGTGT GATTCATGGC ACCGACCTCA AGGACTTCAC CTCTGAGCAG 
ATTGACGAGA TCCTACAGAA CCACACTGAG ATCGTCTTTG CCCGAACCTC CCCTCAGCAG 
AAGCTCATCA TCGTGGAGGG CTGTCAGAGA CAGGGAGCAA TTGTGGCTGT GACTGGCGAT 
GGTGTGAATG ACTCCCCTGC TCTGAAGAAG GCTGATATTG GGGTGGCCAT GGGCATTGCT 
GGCTCTGATG TCTCTAAGCA GGCTGCCGAC ATGATTCTGC TGGATGACAA TTTTGCTTCC 
ATTGTCACTG GTGTGGAGGA AGGCCGCCTG ATCTTTGACA ACCTGAAGAA ATCCATCGCC 
TACACTCTGA CCAGCAACAT CCCTGAGATC ACACCCTTCC TTCTCTTCAT CATGGCCAAC 
ATCCCACTGC CCCTTGGCAC CATCACCATC CTCTGCATTG ACCTGGGCAC CGACATGGTC 
CCTGCAATCT CCTTGGCCTA CGAGGCTGCA GAGAGTGACA TCATGAAGAG GCAGCCCAGG 
AACCCACGCA CAGACAAACT GGTCAACGAA AGGCTCATCA GCATGGCCTA TGGGCAGATC 
GGGATGATCC AGGCCCTCGG TGGTTTCTTC TCCTACTTTG TCATCCTGGC AGAAAATGGT 
TTCTTGCCCG GTAACCTGGT GGGCATCCGG CTCAACTGGG ATGACCGCAC TGTCAACGAC 
CTGGAAGACA GCTACGGGCA GCAGTGGACT TATGAGCAGA GGAAGGTGGT TGAGTTCACG 
TGCCACACAG CCTTCTTCGT GAGCATAGTG GTGGTCCAGT GGGCTGACCT GATCATTTGC 
AAGACCAGGA GGAATTCCGT CTTCCAGCAG GGCATGAAGA ATAAGATCTT GATCTTCGGA 
CTGTTTGAGG AAACGGCCCT CGCTGCCTTC CTGTCCTACT GCCCAGGCAT GGATGTGGCC 
CTTCGCATGT ACCCGCTCAA GCCCAGCTGG TGGTTCTGTG CCTTCCCCTA CAGTTTCCTC 
ATCTTCGTCT ATGATGAGAT TCGCAAACTC ATCCTGCGCA GGAACCCCGG GGGTTGGGTG 
GAGAAAGAGA CCTACTATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444264.1
CDS	160..3240
Translation	MGSGGSDSYRVATSQDKKDDKSSPKKSKAKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY

Target ORF information:

RefSeq Version	XM_017588775.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3 (Atp1a3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588775.1

ORF Insert Sequence:

ATGGGGTCTG GTGGTTCTGA CAGCTACCGT GTCGCCACCT CGCAGGACAA AAAAGATGAC 
AAGAGCTCGC CCAAGAAGAG CAAGGCCAAA GAGCGCCGGG ACCTGGATGA CCTCAAGAAG 
GAAGTGGCTA TGACAGAGCA CAAGATGTCA GTAGAAGAGG TCTGCCGGAA ATACAATACC 
GACTGCGTGC AGGGTCTGAC ACACAGTAAA GCCCAGGAGA TCCTAGCCCG GGATGGGCCT 
AACGCCCTCA CACCACCGCC CACCACCCCA GAATGGGTCA AGTTCTGCCG ACAGCTATTT 
GGTGGCTTCT CCATCCTGCT GTGGATCGGG GCGATCCTTT GCTTCCTGGC CTATGGCATC 
CAGGCAGGGA CTGAGGATGA CCCTTCCGGT GACAATCTGT ACCTGGGCAT AGTGCTGGCC 
GCTGTGGTGA TCATCACCGG CTGCTTCTCC TACTACCAAG AAGCCAAGAG CTCTAAGATT 
ATGGAGTCCT TCAAGAACAT GGTTCCCCAG CAAGCCCTTG TGATCCGGGA AGGTGAAAAG 
ATGCAGGTGA ATGCGGAGGA GGTGGTGGTC GGGGACCTGG TGGAGATCAA GGGTGGCGAC 
CGGGTGCCCG CTGACCTGCG CATCATCTCG GCCCATGGCT GCAAGGTGGA CAACTCTTCC 
CTGACTGGCG AATCTGAGCC TCAGACCCGC TCCCCGGACT GCACACACGA CAACCCACTG 
GAGACCCGGA ACATCACCTT CTTTTCCACC AACTGTGTGG AAGGCACCGC TCGTGGTGTG 
GTGGTAGCCA CAGGTGACCG CACCGTCATG GGCCGCATTG CCACCCTGGC CTCAGGCCTG 
GAGGTGGGCA AGACGCCCAT CGCCATTGAG ATCGAGCACT TCATCCAGCT CATCACTGGC 
GTGGCCGTGT TCCTGGGCGT CTCCTTCTTC ATCCTCTCCC TCATTCTGGG CTACACCTGG 
CTGGAGGCTG TCATCTTCCT CATCGGTATC ATTGTGGCCA ATGTCCCAGA GGGGCTGCTG 
GCTACTGTCA CGGTGTGTCT GACGCTGACC GCCAAGCGCA TGGCTCGGAA GAACTGTCTG 
GTAAAGAACC TGGAGGCGGT GGAGACGCTA GGCTCCACAT CCACCATCTG CTCCGACAAG 
ACCGGCACCC TCACCCAGAA CCGCATGACC GTCGCCCACA TGTGGTTTGA CAACCAGATC 
CACGAGGCCG ACACTACTGA GGATCAGTCA GGGACCTCTT TCGACAAGAG CTCACACACC 
TGGGTGGCCC TGTCCCACAT CGCCGGTCTC TGCAACCGGG CTGTCTTCAA GGGCGGGCAG 
GATAACATCC CTGTACTCAA GAGGGACGTG GCGGGTGATG CCTCAGAGTC CGCCCTGCTT 
AAGTGCATCG AGCTGTCCTC GGGTTCCGTA AAGCTGATGC GCGAACGAAA CAAGAAAGTG 
GCCGAGATTC CCTTCAACTC CACTAACAAA TACCAGCTAT CCATCCATGA GACTGAGGAC 
CCCAATGACA ACCGATACCT GTTAGTGATG AAGGGCGCCC CTGAACGCAT TCTGGACCGC 
TGTGCGACCA TCCTCCTGCA GGGCAAGGAG CAGCCTCTGG ATGAGGAGAT GAAGGAGGCC 
TTCCAGAACG CCTACCTGGA GCTTGGTGGC CTGGGCGAGC GTGTGCTGGG TTTCTGCCAT 
TACTACCTGC CGGAGGAACA GTTCCCCAAG GGCTTTGCCT TTGACTGTGA TGACGTGAAC 
TTCACCACAG ACAACCTTTG CTTCGTGGGT CTCATGTCCA TGATCGACCC TCCCCGGGCA 
GCTGTCCCTG ATGCTGTGGG CAAATGCCGC AGTGCAGGCA TCAAGGTCAT CATGGTCACC 
GGCGATCACC CCATCACTGC GAAGGCCATC GCCAAAGGTG TAGGCATCAT CTCCGAGGGT 
AACGAGACTG TGGAGGACAT CGCTGCCCGG CTCAACATCC CTGTCAGCCA GGTCAACCCC 
AGGGATGCCA AAGCCTGTGT GATTCATGGC ACCGACCTCA AGGACTTCAC CTCTGAGCAG 
ATTGACGAGA TCCTACAGAA CCACACTGAG ATCGTCTTTG CCCGAACCTC CCCTCAGCAG 
AAGCTCATCA TCGTGGAGGG CTGTCAGAGA CAGGGAGCAA TTGTGGCTGT GACTGGCGAT 
GGTGTGAATG ACTCCCCTGC TCTGAAGAAG GCTGATATTG GGGTGGCCAT GGGCATTGCT 
GGCTCTGATG TCTCTAAGCA GGCTGCCGAC ATGATTCTGC TGGATGACAA TTTTGCTTCC 
ATTGTCACTG GTGTGGAGGA AGGCCGCCTG ATCTTTGACA ACCTGAAGAA ATCCATCGCC 
TACACTCTGA CCAGCAACAT CCCTGAGATC ACACCCTTCC TTCTCTTCAT CATGGCCAAC 
ATCCCACTGC CCCTTGGCAC CATCACCATC CTCTGCATTG ACCTGGGCAC CGACATGGTC 
CCTGCAATCT CCTTGGCCTA CGAGGCTGCA GAGAGTGACA TCATGAAGAG GCAGCCCAGG 
AACCCACGCA CAGACAAACT GGTCAACGAA AGGCTCATCA GCATGGCCTA TGGGCAGATC 
GGGATGATCC AGGCCCTCGG TGGTTTCTTC TCCTACTTTG TCATCCTGGC AGAAAATGGT 
TTCTTGCCCG GTAACCTGGT GGGCATCCGG CTCAACTGGG ATGACCGCAC TGTCAACGAC 
CTGGAAGACA GCTACGGGCA GCAGTGGACT TATGAGCAGA GGAAGGTGGT TGAGTTCACG 
TGCCACACAG CCTTCTTCGT GAGCATAGTG GTGGTCCAGT GGGCTGACCT GATCATTTGC 
AAGACCAGGA GGAATTCCGT CTTCCAGCAG GGCATGAAGA ATAAGATCTT GATCTTCGGA 
CTGTTTGAGG AAACGGCCCT CGCTGCCTTC CTGTCCTACT GCCCAGGCAT GGATGTGGCC 
CTTCGCATGT ACCCGCTCAA GCCCAGCTGG TGGTTCTGTG CCTTCCCCTA CAGTTTCCTC 
ATCTTCGTCT ATGATGAGAT TCGCAAACTC ATCCTGCGCA GGAACCCCGG GGGTTGGGTG 
GAGAAAGAGA CCTACTATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Na, K-ATPase ?3 is a death target of Alzheimer patient amyloid-? assembly.
Proceedings of the National Academy of Sciences of the United States of America112(32)E4465-74(2015 Aug)
Ohnishi T,Yanazawa M,Sasahara T,Kitamura Y,Hiroaki H,Fukazawa Y,Kii I,Nishiyama T,Kakita A,Takeda H,Takeuchi A,Arai Y,Ito A,Komura H,Hirao H,Satomura K,Inoue M,Muramatsu S,Matsui K,Tada M,Sato M,Saijo E,Shigemitsu Y,Sakai S,Umetsu Y,Goda N,Takino N,Takahashi H,Hagiwara M,Sawasaki T,Iwasaki G,Nakamura Y,Nabeshima Y,Teplow DB,Hoshi M

The (Na(+)/K (+))-ATPase activity in the developing rat retina: the role of insulin-like growth factor-I (IGF-I).
Cellular and molecular neurobiology35(2)243-54(2015 Mar)
Maturana-Teixeira S,Braga LE,Carpi Santos R,Calaza Kda C,Giestal-de-Araujo E,Le?o-Ferreira LR

Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly.
Epilepsia56(3)422-30(2015 Mar)
Paciorkowski AR,McDaniel SS,Jansen LA,Tully H,Tuttle E,Ghoneim DH,Tupal S,Gunter SA,Vasta V,Zhang Q,Tran T,Liu YB,Ozelius LJ,Brashear A,Sweadner KJ,Dobyns WB,Hahn S

Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only.
Journal of neurology262(1)187-93(2015 Jan)
Wilcox R,Br?nne I,Br?ggemann N,Winkler S,Wiegers K,Bertram L,Anderson T,Lohmann K

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Journal of proteomics106191-204(2014 Jun)
Chiasserini D,van Weering JR,Piersma SR,Pham TV,Malekzadeh A,Teunissen CE,de Wit H,Jim?nez CR

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Atp1a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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