GNRH1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNRH1
Entrez Gene ID	613033
Full Name	gonadotropin releasing hormone 1
Synonyms	GNRH,LHRH
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001195436.1	NP_001182365.1	progonadoliberin-1 precursor
NM_001195436.2	NP_001182365.1	progonadoliberin-1 precursor
XM_015144976.1	XP_015000462.1	progonadoliberin-1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GNRH1	XP_001160489.1
Mus musculus (house mouse)	Gnrh1	NP_032171.1
Homo sapiens (human)	GNRH1	NP_001076580.1
	GNRH1	XP_001107290.1
Canis lupus familiaris (dog)	GNRH1	XP_850859.2
Rattus norvegicus (Norway rat)	Gnrh1	NP_036899.1
Bos taurus (cattle)	GNRH1	NP_001071605.1

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Luteinizing hormone regulates inhibin-? subunit expression through multiple signaling pathways involving steroidogenic factor-1 and beta-catenin in the macaque corpus luteum.
Suresh PS, Medhamurthy R
Growth factors (Chur, Switzerland)30(3)192-206(2012 Jun)

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.
Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J
Nature biotechnology29(11)1019-23(2011 Oct)

Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons.
Noel SD, Keen KL, Baumann DI, Filardo EJ, Terasawa E
Molecular endocrinology (Baltimore, Md.)23(3)349-59(2009 Mar)

An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta).
Windsor-Engnell BM, Kasuya E, Mizuno M, Keen KL, Terasawa E
American journal of physiology. Endocrinology and metabolism292(4)E1000-9(2007 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings report the changes in inhibin-alpha subunit gene expression in the corpus luteum is regulated by LH; results suggest a possible multiple crosstalk of Wnt, cAMP, and SF-1 in the regulation of luteal inhibin secretion
Title: Luteinizing hormone regulates inhibin-? subunit expression through multiple signaling pathways involving steroidogenic factor-1 and beta-catenin in the macaque corpus luteum.

Estradiol(E2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E2 appears to be mediated, in part, through GPR30.
Title: Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons.

Posterior hypothalamic lesion animals had elevated LHRH levels and higher evening glutamate levels after lesions, whereas LHRH changes did not occur in sham/controls until later.
Title: An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta).

The following GNRH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNRH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMb02142	XM_015144976.1 Latest version!	Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OMb02142	NM_001195436.2 Latest version!	Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMb02142	NM_001195436.1	Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNRH1 ( NM_001195436.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001182365.1 Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), mRNA.

Price & Availability↑

CloneID	OMb02142
Clone ID Related Accession (Same CDS sequence)	NM_001195436.1 , NM_001195436.2 , XM_015144976.1
Accession Version	NM_001195436.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	progonadoliberin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JSUE03041058.1 and S75918.1. On Sep 10, 2010 this sequence version replaced XM_001107290.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: JU323469.1, JU472587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00765442 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCAA TTCCAAAACT CCTAGCTGGC CTTATTCTGC TGACTCTGTG TGTGGAGGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGTCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATGGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACAC 
TTCGAATGCA CCATGCACCA GCCACGTTCT CCCCTCCAAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182365.1
CDS	1..279
Translation	MEPIPKLLAGLILLTLCVEGCSSQHWSYGLRPGGKRDAENLMDSFQEIVKEVGQLAETQHFECTMHQPRSPLQDLKGALESLIEEETGQKKI

Target ORF information:

RefSeq Version	NM_001195436.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195436.1

ORF Insert Sequence:

ATGGAGCCAA TTCCAAAACT CCTAGCTGGC CTTATTCTGC TGACTCTGTG TGTGGAGGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGTCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATGGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACAC 
TTCGAATGCA CCATGCACCA GCCACGTTCT CCCCTCCAAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNRH1 ( XM_015144976.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> XP_015000462.1 Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMb02142
Clone ID Related Accession (Same CDS sequence)	NM_001195436.1 , NM_001195436.2 , XM_015144976.1
Accession Version	XM_015144976.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-20
Organism	Macaca mulatta(Rhesus monkey)
Product	progonadoliberin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014805094.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Macaca mulatta Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAA TTCCAAAACT CCTAGCTGGC CTTATTCTGC TGACTCTGTG TGTGGAGGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGTCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATGGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACAC 
TTCGAATGCA CCATGCACCA GCCACGTTCT CCCCTCCAAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015000462.1
CDS	33..311
Translation	MEPIPKLLAGLILLTLCVEGCSSQHWSYGLRPGGKRDAENLMDSFQEIVKEVGQLAETQHFECTMHQPRSPLQDLKGALESLIEEETGQKKI

Target ORF information:

RefSeq Version	XM_015144976.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015144976.1

ORF Insert Sequence:

ATGGAGCCAA TTCCAAAACT CCTAGCTGGC CTTATTCTGC TGACTCTGTG TGTGGAGGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGTCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATGGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACAC 
TTCGAATGCA CCATGCACCA GCCACGTTCT CCCCTCCAAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNRH1 ( NM_001195436.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001182365.1 Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), mRNA.

Price & Availability↑

CloneID	OMb02142
Clone ID Related Accession (Same CDS sequence)	NM_001195436.1 , NM_001195436.2 , XM_015144976.1
Accession Version	NM_001195436.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Macaca mulatta(Rhesus monkey)
Product	progonadoliberin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from QNVO02000443.1. On Sep 24, 2019 this sequence version replaced NM_001195436.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: JU472587.1, JU323469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00765442 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCAA TTCCAAAACT CCTAGCTGGC CTTATTCTGC TGACTCTGTG TGTGGAGGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGTCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATGGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACAC 
TTCGAATGCA CCATGCACCA GCCACGTTCT CCCCTCCAAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182365.1
CDS	1..279
Translation	MEPIPKLLAGLILLTLCVEGCSSQHWSYGLRPGGKRDAENLMDSFQEIVKEVGQLAETQHFECTMHQPRSPLQDLKGALESLIEEETGQKKI

Target ORF information:

RefSeq Version	NM_001195436.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta gonadotropin releasing hormone 1 (GNRH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195436.2

ORF Insert Sequence:

ATGGAGCCAA TTCCAAAACT CCTAGCTGGC CTTATTCTGC TGACTCTGTG TGTGGAGGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGTCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATGGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACAC 
TTCGAATGCA CCATGCACCA GCCACGTTCT CCCCTCCAAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Luteinizing hormone regulates inhibin-? subunit expression through multiple signaling pathways involving steroidogenic factor-1 and beta-catenin in the macaque corpus luteum.
Growth factors (Chur, Switzerland)30(3)192-206(2012 Jun)
Suresh PS,Medhamurthy R

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.
Nature biotechnology29(11)1019-23(2011 Oct)
Yan G,Zhang G,Fang X,Zhang Y,Li C,Ling F,Cooper DN,Li Q,Li Y,van Gool AJ,Du H,Chen J,Chen R,Zhang P,Huang Z,Thompson JR,Meng Y,Bai Y,Wang J,Zhuo M,Wang T,Huang Y,Wei L,Li J,Wang Z,Hu H,Yang P,Le L,Stenson PD,Li B,Liu X,Ball EV,An N,Huang Q,Zhang Y,Fan W,Zhang X,Li Y,Wang W,Katze MG,Su B,Nielsen R,Yang H,Wang J,Wang X,Wang J

Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons.
Molecular endocrinology (Baltimore, Md.)23(3)349-59(2009 Mar)
Noel SD,Keen KL,Baumann DI,Filardo EJ,Terasawa E

An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta).
American journal of physiology. Endocrinology and metabolism292(4)E1000-9(2007 Apr)
Windsor-Engnell BM,Kasuya E,Mizuno M,Keen KL,Terasawa E

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GNRH1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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