GNRH1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNRH1
Entrez Gene ID	2796
Full Name	gonadotropin releasing hormone 1
Synonyms	GNRH,GRH,LHRH,LNRH
General protein information	Preferred Names gonadotropin releasing hormone 1 Names progonadoliberin-1 GnRH-associated peptide 1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) leuteinizing-releasing hormone luliberin I prolactin release-inhibiting factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p21.2
Summary	This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015].
Disorder MIM:	152760
Disorder Html:	?Hypogonadotropic hypogonadism 12 with or without anosmia, 614841 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001083111.1	NP_001076580.1	progonadoliberin-1 isoform 2 preproprotein
NM_000825.3	NP_000816.4	progonadoliberin-1 isoform 1 precursor
NM_001083111.2	NP_001076580.1	progonadoliberin-1 isoform 2 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GNRH1	XP_001160489.1
Mus musculus (house mouse)	Gnrh1	NP_032171.1
Homo sapiens (human)	GNRH1	NP_001076580.1
	GNRH1	XP_001107290.1
Canis lupus familiaris (dog)	GNRH1	XP_850859.2
Rattus norvegicus (Norway rat)	Gnrh1	NP_036899.1
Bos taurus (cattle)	GNRH1	NP_001071605.1

Gene Ontology
Bibliography

Related articles in PubMed

Modeling and high-throughput experimental data uncover the mechanisms underlying
Stern E, Ruf-Zamojski F, Zalepa-King L, Pincas H, Choi SG, Peskin CS, Hayot F, Turgeon JL, Sealfon SC
The Journal of biological chemistry292(23)9815-9829(2017 06)

LHRH receptor expression in sarcomas of bone and soft tissue.
Deivaraju C, Temple HT, Block N, Robinson P, Schally AV
Hormone molecular biology and clinical investigation28(2)105-111(2016 Nov)

Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer.
Ye H, Liu X, Sun J, Zhu S, Zhu Y, Chang S
BMC cancer16(1)831(2016 10)

Characterization of cDNA for precursor of human luteinizing hormone releasing hormone.
Seeburg PH, Adelman JP
Nature311(5987)666-8(1984 Oct 18-24)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency
Title: Modeling and high-throughput experimental data uncover the mechanisms underlying

High LHRH expression is associated with sarcomas of bone and soft tissue.
Title: LHRH receptor expression in sarcomas of bone and soft tissue.

High expression of LHRH is associated with ovarian cancer.
Title: Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer.

GNRH (and GNRHR) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.
Title: Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor are expressed at tubal ectopic pregnancy implantation sites.

GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/MMP9 expression.
Title: GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.

The following GNRH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNRH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16907	NM_000825.3 Latest version!	Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18122	NM_001083111.2 Latest version!	Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18122	NM_001083111.1	Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNRH1 ( NM_000825.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000816.4 Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16907
Clone ID Related Accession (Same CDS sequence)	NM_000825.3
Accession Version	NM_000825.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	progonadoliberin-1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL047164.1, BC067290.1 and CB243067.1. On Mar 21, 2007 this sequence version replaced NM_000825.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB243067.1, SRR1660805.241747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267775 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCCTTA GAATGAAGCC AATTCAAAAA CTCCTAGCTG GCCTTATTCT ACTGACTTGG 
TGCGTGGAAG GCTGCTCCAG CCAGCACTGG TCCTATGGAC TGCGCCCTGG AGGAAAGAGA 
GATGCCGAAA ATTTGATTGA TTCTTTCCAA GAGATAGTCA AAGAGGTTGG TCAACTGGCA 
GAAACCCAAC GCTTCGAATG CACCACGCAC CAGCCACGTT CTCCCCTCCG AGACCTGAAA 
GGAGCTCTGG AAAGTCTGAT TGAAGAGGAA ACTGGGCAGA AGAAGATTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000816.4
CDS	1699..1989
Translation	MCLRMKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI

Target ORF information:

RefSeq Version	NM_000825.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000825.3

ORF Insert Sequence:

ATGTGCCTTA GAATGAAGCC AATTCAAAAA CTCCTAGCTG GCCTTATTCT ACTGACTTGG 
TGCGTGGAAG GCTGCTCCAG CCAGCACTGG TCCTATGGAC TGCGCCCTGG AGGAAAGAGA 
GATGCCGAAA ATTTGATTGA TTCTTTCCAA GAGATAGTCA AAGAGGTTGG TCAACTGGCA 
GAAACCCAAC GCTTCGAATG CACCACGCAC CAGCCACGTT CTCCCCTCCG AGACCTGAAA 
GGAGCTCTGG AAAGTCTGAT TGAAGAGGAA ACTGGGCAGA AGAAGATTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNRH1 ( NM_001083111.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001076580.1 Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18122
Clone ID Related Accession (Same CDS sequence)	NM_001083111.1 , NM_001083111.2
Accession Version	NM_001083111.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	progonadoliberin-1 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL047164.1, BC067290.1, M12578.1 and CB243067.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, which results in translation initiation from an in-frame downstream start codon, and an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.132937.1, SRR1803611.483537.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCAA TTCAAAAACT CCTAGCTGGC CTTATTCTAC TGACTTGGTG CGTGGAAGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGCCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATTGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACGC 
TTCGAATGCA CCACGCACCA GCCACGTTCT CCCCTCCGAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001076580.1
CDS	842..1120
Translation	MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI

Target ORF information:

RefSeq Version	NM_001083111.1
Organism	Homo sapiens(human)
Definition	Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001083111.1

ORF Insert Sequence:

ATGAAGCCAA TTCAAAAACT CCTAGCTGGC CTTATTCTAC TGACTTGGTG CGTGGAAGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGCCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATTGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACGC 
TTCGAATGCA CCACGCACCA GCCACGTTCT CCCCTCCGAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNRH1 ( NM_001083111.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001076580.1 Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18122
Clone ID Related Accession (Same CDS sequence)	NM_001083111.1 , NM_001083111.2
Accession Version	NM_001083111.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	progonadoliberin-1 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC067290.1, M12578.1 and CB243067.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_001083111.1. Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, which results in translation initiation from an in-frame downstream start codon, and an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.132937.1, M12578.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000421054.7/ ENSP00000391280.2 RefSeq Select criteria :: based on manual assertion, conservation ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCCAA TTCAAAAACT CCTAGCTGGC CTTATTCTAC TGACTTGGTG CGTGGAAGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGCCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATTGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACGC 
TTCGAATGCA CCACGCACCA GCCACGTTCT CCCCTCCGAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001076580.1
CDS	63..341
Translation	MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI

Target ORF information:

RefSeq Version	NM_001083111.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gonadotropin releasing hormone 1 (GNRH1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001083111.2

ORF Insert Sequence:

ATGAAGCCAA TTCAAAAACT CCTAGCTGGC CTTATTCTAC TGACTTGGTG CGTGGAAGGC 
TGCTCCAGCC AGCACTGGTC CTATGGACTG CGCCCTGGAG GAAAGAGAGA TGCCGAAAAT 
TTGATTGATT CTTTCCAAGA GATAGTCAAA GAGGTTGGTC AACTGGCAGA AACCCAACGC 
TTCGAATGCA CCACGCACCA GCCACGTTCT CCCCTCCGAG ACCTGAAAGG AGCTCTGGAA 
AGTCTGATTG AAGAGGAAAC TGGGCAGAAG AAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Modeling and high-throughput experimental data uncover the mechanisms underlying
The Journal of biological chemistry292(23)9815-9829(2017 06)
Stern E,Ruf-Zamojski F,Zalepa-King L,Pincas H,Choi SG,Peskin CS,Hayot F,Turgeon JL,Sealfon SC

LHRH receptor expression in sarcomas of bone and soft tissue.
Hormone molecular biology and clinical investigation28(2)105-111(2016 Nov)
Deivaraju C,Temple HT,Block N,Robinson P,Schally AV

Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer.
BMC cancer16(1)831(2016 10)
Ye H,Liu X,Sun J,Zhu S,Zhu Y,Chang S

Characterization of cDNA for precursor of human luteinizing hormone releasing hormone.
Nature311(5987)666-8(1984 Oct 18-24)
Seeburg PH,Adelman JP

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GNRH1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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