Dsg1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsg1b
Entrez Gene ID	225256
Full Name	desmoglein 1 beta
Synonyms	Dsg5,dsg1-beta
General protein information	Preferred Names desmoglein 1 beta Names desmoglein-1-beta desmoglein 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 A2\|18 11.32 cM
Summary	This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006525821.1	XP_006525884.1	desmoglein-1-beta isoform X1
NM_181682.2	NP_859010.1	desmoglein-1-beta preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dsg1b	NP_859010.1
Pan troglodytes (chimpanzee)	DSG1	XP_523899.2
Rattus norvegicus (Norway rat)	Dsg1	XP_214616.5
Homo sapiens (human)	DSG1	NP_001933.2
Canis lupus familiaris (dog)	DSG1	NP_001002939.1
	DSG1	XP_001098203.1
Bos taurus (cattle)	DSG1	NP_776470.1
Mus musculus (house mouse)	Dsg1a	NP_034209.2

Gene Ontology
Bibliography

Related articles in PubMed

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R
PLoS genetics13(1)e1006566(2017 Jan)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

?Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.
Romano RA, Smalley K, Magraw C, Serna VA, Kurita T, Raghavan S, Sinha S
Development (Cambridge, England)139(4)772-82(2012 Feb)

Glucocorticoid receptor is required for skin barrier competence.
Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, Tuckermann J, Sch?tz G, P?rez P
Endocrinology149(3)1377-88(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Desmogleins 4, 5, and 6 are all expressed in the epidermis but are expressed during different times of mouse development.
Title: Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.

Cloned and characterized a novel member of the mouse desmoglein gene family, Dsg1-beta.
Title: Novel member of the mouse desmoglein gene family: Dsg1-beta.

The following Dsg1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsg1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu54503	XM_006525821.1 Latest version!	Mus musculus desmoglein 1 beta (Dsg1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu08145	NM_181682.2 Latest version!	Mus musculus desmoglein 1 beta (Dsg1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsg1b ( XM_006525821.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006525884.1 Mus musculus desmoglein 1 beta (Dsg1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu54503
Clone ID Related Accession (Same CDS sequence)	XM_006525821.1
Accession Version	XM_006525821.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	desmoglein-1-beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTAGATT CCCTTCAGAG GACCTGCACG GGGACAATCG TCATTGAACT TAGTGGCACT 
GGCTGGGTAC CAGGTTCAGA TGGTGGTGGC AGTTCCAGTG GCAGTGGTGG TAATCGTGAC 
CCAGTGACTA ATGGATATCA AGGCACTTCT ACTGTGGGCC CGCAACGCGT CACAGGATCA 
GGGGGAGTCA CTTCAAGTGG TGGAGGCAGT GGAGTTAACA ACACTCCCGG TAGGCAAAAT 
CCCTTAGACG AACCGGAACC CGAGCCCTTT GACATCACAG AAGACAACGT TCACTTCGGT 
CCTGCAGGCA TCGGGCTGCT CATCATGGGG TTCCTAGTCT TAGGATTGGT TCCATTCCTG 
CTGATCTGCT GTGATTGTGG AGGGGCCCCT GGTGGTGGAG CTGGATTTGA ACCTGTTCCA 
GAATGTTCTG ATGGAGCAAT TCACACGTGG GCCATAGAAG GGCCACAGCC TGAACCCCAC 
GATGGGATAA CCACCATCTG TGTGCCACAA ATGCCACCTG GTAATGCCAA TGTTATAGAA 
TATATTGACA ACTCAGGAGT TTACACAAAT GAATATTGTG GCAGAGAAAT GCAAGATCTG 
GGAGGAGGAG AAAGAACCAC AGGATTTGAA CTAATGGATG GAGTTAAAAC ATCAGCTGCA 
CCTGAGATAT GCCAAGAATA TTCAGGAACA TTAAGAAGAA ATTCAATGAG AGAATGTAGA 
GATGGGGGTC TCAACATGAA TTTCATGGAA AGTTACTTCT GCCAGAAAGC CTATGCTTAT 
GCGGATGAAG ATGAAGGACG TCCATCCAAT GACTGTTTGC TCATCTATGA CATCGAAGGT 
GTGGGTTCCC CTGCAGGCTC CGTGGGCTGT TGCAGTTTCA TTGGAGAAGA TCTAGATGAG 
AGCTTCCTGG ATACCTTGGG GCCCAAGTTT AAGAAGTTGG CAGATATCAG CCTGGGAAAA 
GAAATAGACT CATACCCAGA TCCTGATTCT TCTTGGCCTC CTCAGAGCAC TGAACCGATG 
TGTCCCCAGA GTACAGAGCC CCTGGGTAGT GGATATCCAC CTATATCCCC ACATTTTGGT 
ACGACCACAG TAATTTCTGA GAATGCCTAC CCTTCTGGCC CTGGAGTACA GCATCCTTTG 
CCAATTCCTG ATCCTCTGGG CTATGGCAAT GTCACTGTAA GGGAGTCCTA TGCCACCTCT 
GGCACTCTGA AGCCCTCTGT CCACTTTCAT GATAACCAGC AGGCTTCAAA TGTGGTGGTG 
ACAGAGAGGG TGGTGGGCCC CGTCCCTGGT GCTGATTTGC ATGGCATGTT AGAGATACCT 
GACTTAAGAG ATGGAACAAA TGTTATAGTG ACAGAAAGGG TAATAGCACC AGGCTCAAGT 
CTACCCACTT CTCTGACCAT TCCTAACCCT CGAGAGACCT CAAATGTAGT TGTGACAGAA 
AGAGTGATCC AACCAACCTC TGGCATGATA GGCAATCTGA GCATGACCCC TGAGTTATCA 
AGTGCCCAAA ACGTGATTGT GACAGAGAGA GTGGTTTCTG GTGCTGGTAT GAGTGGAATT 
GCTGGCACTG CCGGGTTAGG TGGGGTTGGA GGCATAGGCA GCAGTGGCCT TGTTAGCACC 
ACCATGGGTG CTGCTGGCAC TGGGCTGAAT ATGGGAGGAA CAGCCACTAT TGGCCACATG 
AGGAGTTCCT CTGACCATCA CTTTAGTCAG ACAATTGGAT CTGCCTCCCC CAACATGGCT 
CGAAGTCGAA TCACAAAGTA CAGTACGGTA CAGTATAGCA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006525884.1
CDS	58..1842
Translation	MLDSLQRTCTGTIVIELSGTGWVPGSDGGGSSSGSGGNRDPVTNGYQGTSTVGPQRVTGSGGVTSSGGGSGVNNTPGRQNPLDEPEPEPFDITEDNVHFGPAGIGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAIEGPQPEPHDGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDSSWPPQSTEPMCPQSTEPLGSGYPPISPHFGTTTVISENAYPSGPGVQHPLPIPDPLGYGNVTVRESYATSGTLKPSVHFHDNQQASNVVVTERVVGPVPGADLHGMLEIPDLRDGTNVIVTERVIAPGSSLPTSLTIPNPRETSNVVVTERVIQPTSGMIGNLSMTPELSSAQNVIVTERVVSGAGMSGIAGTAGLGGVGGIGSSGLVSTTMGAAGTGLNMGGTATIGHMRSSSDHHFSQTIGSASPNMARSRITKYSTVQYSK

Target ORF information:

RefSeq Version	XM_006525821.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmoglein 1 beta (Dsg1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006525821.1

ORF Insert Sequence:

ATGTTAGATT CCCTTCAGAG GACCTGCACG GGGACAATCG TCATTGAACT TAGTGGCACT 
GGCTGGGTAC CAGGTTCAGA TGGTGGTGGC AGTTCCAGTG GCAGTGGTGG TAATCGTGAC 
CCAGTGACTA ATGGATATCA AGGCACTTCT ACTGTGGGCC CGCAACGCGT CACAGGATCA 
GGGGGAGTCA CTTCAAGTGG TGGAGGCAGT GGAGTTAACA ACACTCCCGG TAGGCAAAAT 
CCCTTAGACG AACCGGAACC CGAGCCCTTT GACATCACAG AAGACAACGT TCACTTCGGT 
CCTGCAGGCA TCGGGCTGCT CATCATGGGG TTCCTAGTCT TAGGATTGGT TCCATTCCTG 
CTGATCTGCT GTGATTGTGG AGGGGCCCCT GGTGGTGGAG CTGGATTTGA ACCTGTTCCA 
GAATGTTCTG ATGGAGCAAT TCACACGTGG GCCATAGAAG GGCCACAGCC TGAACCCCAC 
GATGGGATAA CCACCATCTG TGTGCCACAA ATGCCACCTG GTAATGCCAA TGTTATAGAA 
TATATTGACA ACTCAGGAGT TTACACAAAT GAATATTGTG GCAGAGAAAT GCAAGATCTG 
GGAGGAGGAG AAAGAACCAC AGGATTTGAA CTAATGGATG GAGTTAAAAC ATCAGCTGCA 
CCTGAGATAT GCCAAGAATA TTCAGGAACA TTAAGAAGAA ATTCAATGAG AGAATGTAGA 
GATGGGGGTC TCAACATGAA TTTCATGGAA AGTTACTTCT GCCAGAAAGC CTATGCTTAT 
GCGGATGAAG ATGAAGGACG TCCATCCAAT GACTGTTTGC TCATCTATGA CATCGAAGGT 
GTGGGTTCCC CTGCAGGCTC CGTGGGCTGT TGCAGTTTCA TTGGAGAAGA TCTAGATGAG 
AGCTTCCTGG ATACCTTGGG GCCCAAGTTT AAGAAGTTGG CAGATATCAG CCTGGGAAAA 
GAAATAGACT CATACCCAGA TCCTGATTCT TCTTGGCCTC CTCAGAGCAC TGAACCGATG 
TGTCCCCAGA GTACAGAGCC CCTGGGTAGT GGATATCCAC CTATATCCCC ACATTTTGGT 
ACGACCACAG TAATTTCTGA GAATGCCTAC CCTTCTGGCC CTGGAGTACA GCATCCTTTG 
CCAATTCCTG ATCCTCTGGG CTATGGCAAT GTCACTGTAA GGGAGTCCTA TGCCACCTCT 
GGCACTCTGA AGCCCTCTGT CCACTTTCAT GATAACCAGC AGGCTTCAAA TGTGGTGGTG 
ACAGAGAGGG TGGTGGGCCC CGTCCCTGGT GCTGATTTGC ATGGCATGTT AGAGATACCT 
GACTTAAGAG ATGGAACAAA TGTTATAGTG ACAGAAAGGG TAATAGCACC AGGCTCAAGT 
CTACCCACTT CTCTGACCAT TCCTAACCCT CGAGAGACCT CAAATGTAGT TGTGACAGAA 
AGAGTGATCC AACCAACCTC TGGCATGATA GGCAATCTGA GCATGACCCC TGAGTTATCA 
AGTGCCCAAA ACGTGATTGT GACAGAGAGA GTGGTTTCTG GTGCTGGTAT GAGTGGAATT 
GCTGGCACTG CCGGGTTAGG TGGGGTTGGA GGCATAGGCA GCAGTGGCCT TGTTAGCACC 
ACCATGGGTG CTGCTGGCAC TGGGCTGAAT ATGGGAGGAA CAGCCACTAT TGGCCACATG 
AGGAGTTCCT CTGACCATCA CTTTAGTCAG ACAATTGGAT CTGCCTCCCC CAACATGGCT 
CGAAGTCGAA TCACAAAGTA CAGTACGGTA CAGTATAGCA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dsg1b ( NM_181682.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_859010.1 Mus musculus desmoglein 1 beta (Dsg1b), mRNA.

Price & Availability↑

CloneID	OMu08145
Clone ID Related Accession (Same CDS sequence)	NM_181682.2
Accession Version	NM_181682.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3183bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	desmoglein-1-beta preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK036986.1 and AC164648.3. On Jan 29, 2016 this sequence version replaced NM_181682.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036986.1, AY192158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGGACTGGC ACTCCTTCAG GATAGCTGCC CTGCTGCTCA CTTCCCTGGT GGTGCTTGAA 
GTTAACAGTG AATTTCAAAT CCAGGTAAGA GATCATAACG CCAAAAATGG TACCATCAAG 
TGGCACTCCA TCAGAAGGCA GAAAAGAGAA TGGATCAAGT TTGCTGCAGC CTGTCGCGAA 
GGTGAAGACA ACTCAAAGAG AAACCCAATT GCCAAAATTC ATTCAGATTG TGCTGCAAAC 
CAACCAGTAA CATACCGCAT CTCGGGAGTG GGAATTGACC AGCCACCTTA TGGAATCTTC 
ATTATTAACC AAAAAACTGG TGAAATCAAT ATAACATCCA TTGTTGATCG TGAAGTCACC 
CCCTTTTTCA TTATCTACTG CCGAGCACTG AATGCACAAG GTCAAGACTT GGAGAATCCA 
CTGGAGCTTA GAGTCAGAGT GATGGATATA AACGACAACC CTCCTGTGTT TTCAATGACT 
ACATTTCTAG GACAAATAGA AGAAAATTCT AATGCAAACA CACTGGTAAT GAAACTCAAT 
GCTACCGATG CCGATGAGCC AAATAACTTG AACTCAATGA TAGCCTTCAA GATCATAAGA 
CAGGAGCCTT CTGACTCACC AATGTTCATC ATCAACAGGA AAACTGGAGA AATCAGAACA 
ATGAATAACT TTCTAGACAG AGAGCAATAT AGCCAGTATT CCCTTGTGGT GAGAGGCTCA 
GACCGGGACG GTGGAGCAGA CGGCATGTCT GCAGAGAGCG AGTGCAGCAT CACCATCCTG 
GATGTCAATG ACAACATCCC ATACTTGGAG CAGTCATCTT ATGACATCGA AATTGAAGAA 
AATGCACTTC ACTCACAGCT AGTGCAGATC AGAGTCATTG ATTTGGATGA AGAATTCTCA 
GACAACTGGA AGGCAATCAT TTTCTTTATC TCTGGAAATG AGGGAAATTG GTTTGAAATA 
GAAATGAATG AAAGAACAAA TGTAGGAACT CTGAAGGTTG TCAAGCCCCT AGATTATGAA 
GCCATGAAGA ATCTACAGCT TAGTATTGGT GTTCGAAATG TAGCTGAATT CCACCAGTCA 
ATTATTTCTC AATACAGACT CACAGCAACT ATGGTCACTG TGACTGTGTT AAATGTCATC 
GAGGGCTCTG TGTTCCGTCC AGGTTCAAAG ACATTTGTAG TAGACAGTAG AATGGAAGCA 
AATCACAGAG TGGGAGAGTT TGTAGCTACA GACCTGGACA CAGGTCGAGC TTCCACAAAT 
GTTAGATATG AAATGGGAAA TAACCCAGAG AACCTGCTGG TTGTTGACTC AAGAACAGGC 
ATAATAACGT TAAGAAACAG AGTTACTATG GAACAATACC AAAGGCTTAA TGGGGAATAT 
AAAGGAACAG TGCTATCAAT AGATGATTCC CTTCAGAGGA CCTGCACGGG GACAATCGTC 
ATTGAACTTA GTGGCACTGG CTGGGTACCA GGTTCAGATG GTGGTGGCAG TTCCAGTGGC 
AGTGGTGGTA ATCGTGACCC AGTGACTAAT GGATATCAAG GCACTTCTAC TGTGGGCCCG 
CAACGCGTCA CAGGATCAGG GGGAGTCACT TCAAGTGGTG GAGGCAGTGG AGTTAACAAC 
ACTCCCGGTA GGCAAAATCC CTTAGACGAA CCGGAACCCG AGCCCTTTGA CATCACAGAA 
GACAACGTTC ACTTCGGTCC TGCAGGCATC GGGCTGCTCA TCATGGGGTT CCTAGTCTTA 
GGATTGGTTC CATTCCTGCT GATCTGCTGT GATTGTGGAG GGGCCCCTGG TGGTGGAGCT 
GGATTTGAAC CTGTTCCAGA ATGTTCTGAT GGAGCAATTC ACACGTGGGC CATAGAAGGG 
CCACAGCCTG AACCCCACGA TGGGATAACC ACCATCTGTG TGCCACAAAT GCCACCTGGT 
AATGCCAATG TTATAGAATA TATTGACAAC TCAGGAGTTT ACACAAATGA ATATTGTGGC 
AGAGAAATGC AAGATCTGGG AGGAGGAGAA AGAACCACAG GATTTGAACT AATGGATGGA 
GTTAAAACAT CAGCTGCACC TGAGATATGC CAAGAATATT CAGGAACATT AAGAAGAAAT 
TCAATGAGAG AATGTAGAGA TGGGGGTCTC AACATGAATT TCATGGAAAG TTACTTCTGC 
CAGAAAGCCT ATGCTTATGC GGATGAAGAT GAAGGACGTC CATCCAATGA CTGTTTGCTC 
ATCTATGACA TCGAAGGTGT GGGTTCCCCT GCAGGCTCCG TGGGCTGTTG CAGTTTCATT 
GGAGAAGATC TAGATGAGAG CTTCCTGGAT ACCTTGGGGC CCAAGTTTAA GAAGTTGGCA 
GATATCAGCC TGGGAAAAGA AATAGACTCA TACCCAGATC CTGATTCTTC TTGGCCTCCT 
CAGAGCACTG AACCGATGTG TCCCCAGAGT ACAGAGCCCC TGGGTAGTGG ATATCCACCT 
ATATCCCCAC ATTTTGGTAC GACCACAGTA ATTTCTGAGA ATGCCTACCC TTCTGGCCCT 
GGAGTACAGC ATCCTTTGCC AATTCCTGAT CCTCTGGGCT ATGGCAATGT CACTGTAAGG 
GAGTCCTATG CCACCTCTGG CACTCTGAAG CCCTCTGTCC ACTTTCATGA TAACCAGCAG 
GCTTCAAATG TGGTGGTGAC AGAGAGGGTG GTGGGCCCCG TCCCTGGTGC TGATTTGCAT 
GGCATGTTAG AGATACCTGA CTTAAGAGAT GGAACAAATG TTATAGTGAC AGAAAGGGTA 
ATAGCACCAG GCTCAAGTCT ACCCACTTCT CTGACCATTC CTAACCCTCG AGAGACCTCA 
AATGTAGTTG TGACAGAAAG AGTGATCCAA CCAACCTCTG GCATGATAGG CAATCTGAGC 
ATGACCCCTG AGTTATCAAG TGCCCAAAAC GTGATTGTGA CAGAGAGAGT GGTTTCTGGT 
GCTGGTATGA GTGGAATTGC TGGCACTGCC GGGTTAGGTG GGGTTGGAGG CATAGGCAGC 
AGTGGCCTTG TTAGCACCAC CATGGGTGCT GCTGGCACTG GGCTGAATAT GGGAGGAACA 
GCCACTATTG GCCACATGAG GAGTTCCTCT GACCATCACT TTAGTCAGAC AATTGGATCT 
GCCTCCCCCA ACATGGCTCG AAGTCGAATC ACAAAGTACA GTACGGTACA GTATAGCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859010.1
CDS	207..3389
Translation	MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDIEIEENALHSQLVQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAMKNLQLSIGVRNVAEFHQSIISQYRLTATMVTVTVLNVIEGSVFRPGSKTFVVDSRMEANHRVGEFVATDLDTGRASTNVRYEMGNNPENLLVVDSRTGIITLRNRVTMEQYQRLNGEYKGTVLSIDDSLQRTCTGTIVIELSGTGWVPGSDGGGSSSGSGGNRDPVTNGYQGTSTVGPQRVTGSGGVTSSGGGSGVNNTPGRQNPLDEPEPEPFDITEDNVHFGPAGIGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAIEGPQPEPHDGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDSSWPPQSTEPMCPQSTEPLGSGYPPISPHFGTTTVISENAYPSGPGVQHPLPIPDPLGYGNVTVRESYATSGTLKPSVHFHDNQQASNVVVTERVVGPVPGADLHGMLEIPDLRDGTNVIVTERVIAPGSSLPTSLTIPNPRETSNVVVTERVIQPTSGMIGNLSMTPELSSAQNVIVTERVVSGAGMSGIAGTAGLGGVGGIGSSGLVSTTMGAAGTGLNMGGTATIGHMRSSSDHHFSQTIGSASPNMARSRITKYSTVQYSK

Target ORF information:

RefSeq Version	NM_181682.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmoglein 1 beta (Dsg1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181682.2

ORF Insert Sequence:

ATGGACTGGC ACTCCTTCAG GATAGCTGCC CTGCTGCTCA CTTCCCTGGT GGTGCTTGAA 
GTTAACAGTG AATTTCAAAT CCAGGTAAGA GATCATAACG CCAAAAATGG TACCATCAAG 
TGGCACTCCA TCAGAAGGCA GAAAAGAGAA TGGATCAAGT TTGCTGCAGC CTGTCGCGAA 
GGTGAAGACA ACTCAAAGAG AAACCCAATT GCCAAAATTC ATTCAGATTG TGCTGCAAAC 
CAACCAGTAA CATACCGCAT CTCGGGAGTG GGAATTGACC AGCCACCTTA TGGAATCTTC 
ATTATTAACC AAAAAACTGG TGAAATCAAT ATAACATCCA TTGTTGATCG TGAAGTCACC 
CCCTTTTTCA TTATCTACTG CCGAGCACTG AATGCACAAG GTCAAGACTT GGAGAATCCA 
CTGGAGCTTA GAGTCAGAGT GATGGATATA AACGACAACC CTCCTGTGTT TTCAATGACT 
ACATTTCTAG GACAAATAGA AGAAAATTCT AATGCAAACA CACTGGTAAT GAAACTCAAT 
GCTACCGATG CCGATGAGCC AAATAACTTG AACTCAATGA TAGCCTTCAA GATCATAAGA 
CAGGAGCCTT CTGACTCACC AATGTTCATC ATCAACAGGA AAACTGGAGA AATCAGAACA 
ATGAATAACT TTCTAGACAG AGAGCAATAT AGCCAGTATT CCCTTGTGGT GAGAGGCTCA 
GACCGGGACG GTGGAGCAGA CGGCATGTCT GCAGAGAGCG AGTGCAGCAT CACCATCCTG 
GATGTCAATG ACAACATCCC ATACTTGGAG CAGTCATCTT ATGACATCGA AATTGAAGAA 
AATGCACTTC ACTCACAGCT AGTGCAGATC AGAGTCATTG ATTTGGATGA AGAATTCTCA 
GACAACTGGA AGGCAATCAT TTTCTTTATC TCTGGAAATG AGGGAAATTG GTTTGAAATA 
GAAATGAATG AAAGAACAAA TGTAGGAACT CTGAAGGTTG TCAAGCCCCT AGATTATGAA 
GCCATGAAGA ATCTACAGCT TAGTATTGGT GTTCGAAATG TAGCTGAATT CCACCAGTCA 
ATTATTTCTC AATACAGACT CACAGCAACT ATGGTCACTG TGACTGTGTT AAATGTCATC 
GAGGGCTCTG TGTTCCGTCC AGGTTCAAAG ACATTTGTAG TAGACAGTAG AATGGAAGCA 
AATCACAGAG TGGGAGAGTT TGTAGCTACA GACCTGGACA CAGGTCGAGC TTCCACAAAT 
GTTAGATATG AAATGGGAAA TAACCCAGAG AACCTGCTGG TTGTTGACTC AAGAACAGGC 
ATAATAACGT TAAGAAACAG AGTTACTATG GAACAATACC AAAGGCTTAA TGGGGAATAT 
AAAGGAACAG TGCTATCAAT AGATGATTCC CTTCAGAGGA CCTGCACGGG GACAATCGTC 
ATTGAACTTA GTGGCACTGG CTGGGTACCA GGTTCAGATG GTGGTGGCAG TTCCAGTGGC 
AGTGGTGGTA ATCGTGACCC AGTGACTAAT GGATATCAAG GCACTTCTAC TGTGGGCCCG 
CAACGCGTCA CAGGATCAGG GGGAGTCACT TCAAGTGGTG GAGGCAGTGG AGTTAACAAC 
ACTCCCGGTA GGCAAAATCC CTTAGACGAA CCGGAACCCG AGCCCTTTGA CATCACAGAA 
GACAACGTTC ACTTCGGTCC TGCAGGCATC GGGCTGCTCA TCATGGGGTT CCTAGTCTTA 
GGATTGGTTC CATTCCTGCT GATCTGCTGT GATTGTGGAG GGGCCCCTGG TGGTGGAGCT 
GGATTTGAAC CTGTTCCAGA ATGTTCTGAT GGAGCAATTC ACACGTGGGC CATAGAAGGG 
CCACAGCCTG AACCCCACGA TGGGATAACC ACCATCTGTG TGCCACAAAT GCCACCTGGT 
AATGCCAATG TTATAGAATA TATTGACAAC TCAGGAGTTT ACACAAATGA ATATTGTGGC 
AGAGAAATGC AAGATCTGGG AGGAGGAGAA AGAACCACAG GATTTGAACT AATGGATGGA 
GTTAAAACAT CAGCTGCACC TGAGATATGC CAAGAATATT CAGGAACATT AAGAAGAAAT 
TCAATGAGAG AATGTAGAGA TGGGGGTCTC AACATGAATT TCATGGAAAG TTACTTCTGC 
CAGAAAGCCT ATGCTTATGC GGATGAAGAT GAAGGACGTC CATCCAATGA CTGTTTGCTC 
ATCTATGACA TCGAAGGTGT GGGTTCCCCT GCAGGCTCCG TGGGCTGTTG CAGTTTCATT 
GGAGAAGATC TAGATGAGAG CTTCCTGGAT ACCTTGGGGC CCAAGTTTAA GAAGTTGGCA 
GATATCAGCC TGGGAAAAGA AATAGACTCA TACCCAGATC CTGATTCTTC TTGGCCTCCT 
CAGAGCACTG AACCGATGTG TCCCCAGAGT ACAGAGCCCC TGGGTAGTGG ATATCCACCT 
ATATCCCCAC ATTTTGGTAC GACCACAGTA ATTTCTGAGA ATGCCTACCC TTCTGGCCCT 
GGAGTACAGC ATCCTTTGCC AATTCCTGAT CCTCTGGGCT ATGGCAATGT CACTGTAAGG 
GAGTCCTATG CCACCTCTGG CACTCTGAAG CCCTCTGTCC ACTTTCATGA TAACCAGCAG 
GCTTCAAATG TGGTGGTGAC AGAGAGGGTG GTGGGCCCCG TCCCTGGTGC TGATTTGCAT 
GGCATGTTAG AGATACCTGA CTTAAGAGAT GGAACAAATG TTATAGTGAC AGAAAGGGTA 
ATAGCACCAG GCTCAAGTCT ACCCACTTCT CTGACCATTC CTAACCCTCG AGAGACCTCA 
AATGTAGTTG TGACAGAAAG AGTGATCCAA CCAACCTCTG GCATGATAGG CAATCTGAGC 
ATGACCCCTG AGTTATCAAG TGCCCAAAAC GTGATTGTGA CAGAGAGAGT GGTTTCTGGT 
GCTGGTATGA GTGGAATTGC TGGCACTGCC GGGTTAGGTG GGGTTGGAGG CATAGGCAGC 
AGTGGCCTTG TTAGCACCAC CATGGGTGCT GCTGGCACTG GGCTGAATAT GGGAGGAACA 
GCCACTATTG GCCACATGAG GAGTTCCTCT GACCATCACT TTAGTCAGAC AATTGGATCT 
GCCTCCCCCA ACATGGCTCG AAGTCGAATC ACAAAGTACA GTACGGTACA GTATAGCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
PLoS genetics13(1)e1006566(2017 Jan)
Kasparek P,Ileninova Z,Zbodakova O,Kanchev I,Benada O,Chalupsky K,Brattsand M,Beck IM,Sedlacek R

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

?Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.
Development (Cambridge, England)139(4)772-82(2012 Feb)
Romano RA,Smalley K,Magraw C,Serna VA,Kurita T,Raghavan S,Sinha S

Glucocorticoid receptor is required for skin barrier competence.
Endocrinology149(3)1377-88(2008 Mar)
Bayo P,Sanchis A,Bravo A,Cascallana JL,Buder K,Tuckermann J,Sch?tz G,P?rez P

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Dsg1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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