DSG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSG1
Entrez Gene ID	1828
Full Name	desmoglein 1
Synonyms	CDHF4,DG1,DSG,EPKHE,EPKHIA,PPKS1,SPPK1
General protein information	Preferred Names desmoglein 1 Names desmoglein-1 cadherin family member 4 desmosomal glycoprotein 1 pemphigus foliaceus antigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015].
Disorder MIM:	125670
Disorder Html:	Keratosis palmoplantaris striata I, AD, 148700 (3); Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE, 615508 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001942.3	NP_001933.2	desmoglein-1 preproprotein
NM_001942.4	NP_001933.2	desmoglein-1 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dsg1b	NP_859010.1
Pan troglodytes (chimpanzee)	DSG1	XP_523899.2
Rattus norvegicus (Norway rat)	Dsg1	XP_214616.5
Homo sapiens (human)	DSG1	NP_001933.2
Canis lupus familiaris (dog)	DSG1	NP_001002939.1
	DSG1	XP_001098203.1
Bos taurus (cattle)	DSG1	NP_776470.1
Mus musculus (house mouse)	Dsg1a	NP_034209.2

Gene Ontology
Bibliography

Related articles in PubMed

Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
Najor NA, Fitz GN, Koetsier JL, Godsel LM, Albrecht LV, Harmon R, Green KJ
eLife6(2017 Sep)

Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Walter E, Vielmuth F, Rotkopf L, S?rdy M, Horv?th ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke J
Scientific reports7(1)3579(2017 Jun)

Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7.
Fukaura R, Takeichi T, Okuno Y, Kojima D, Kono M, Sugiura K, Suga Y, Akiyama M
Acta dermato-venereologica97(3)399-401(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Case Report: striate palmoplantar keratoderma showing transgrediens in a patient with heterozygote nonsense mutations in DSG1 and SERPINB7.
Title: Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7.

Authors report a new family of severe dermatitis, multiple allergies and metabolic wasting syndrome of Asian decent and expand the spectrum of mutations in the DSG1 gene.
Title: Report of Chinese family with severe dermatitis, multiple allergies and metabolic wasting syndrome caused by novel homozygous desmoglein-1 gene mutation.

The results of this study describes the fourth family with a biallelic mutation in the DSG1 gene associated with SAM syndrome, and emphasizes that the presence of PPK and skin fragility with or without additional symptoms should alert clinicians to consider DSG1 deficiency.
Title: Whole-exome sequencing identifies novel autosomal recessive DSG1 mutations associated with mild SAM syndrome.

Genetic deletion of sdrD in S. aureus NCTC8325-4 through allelic replacement resulted in decreased bacterial adherence to Dsg1- expressing HaCaT cells in vitro.
Title: The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells.

Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression in human umbilical vein endothelial cells.
Title: Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression via LOX-1/Ca(2+)/PKC-? signal in human umbilical vein endothelial cells.

The following DSG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu57380	NM_001942.4 Latest version!	Homo sapiens desmoglein 1 (DSG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$741.30 $1059.00
View Old Accession Versions >>
OHu57380	NM_001942.3	Homo sapiens desmoglein 1 (DSG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$741.30 $1059.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSG1 ( NM_001942.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001933.2 Homo sapiens desmoglein 1 (DSG1), mRNA.

Price & Availability↑

CloneID	OHu57380
Clone ID Related Accession (Same CDS sequence)	NM_001942.3 , NM_001942.4
Accession Version	NM_001942.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3150bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	desmoglein-1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF097935.1, BX476267.1, CU456411.1 and AC009717.15. This sequence is a reference standard in the RefSeqGene project. On Feb 19, 2015 this sequence version replaced NM_001942.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF097935.1, X56654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTGGA GTTTCTTCAG AGTAGTTGCA ATGCTGTTCA TTTTTCTGGT GGTGGTAGAA 
GTTAACAGTG AATTCCGAAT CCAGGTAAGA GATTATAACA CTAAAAATGG CACCATCAAA 
TGGCATTCAA TCCGAAGGCA GAAACGTGAA TGGATCAAGT TCGCAGCAGC CTGTCGTGAA 
GGTGAAGACA ACTCAAAGAG GAACCCAATC GCCAAAATTC ACTCAGATTG TGCTGCAAAC 
CAGCAAGTTA CATACCGCAT CTCTGGAGTA GGAATTGATC AGCCACCATA TGGGATCTTT 
GTCATTAATC AGAAAACTGG TGAAATTAAT ATAACATCCA TAGTTGATCG AGAGGTCACT 
CCTTTCTTCA TTATCTACTG CCGAGCTCTG AACTCAATGG GCCAAGATTT AGAGAGGCCT 
CTAGAGCTCA GAGTCAGGGT TTTGGATATA AATGACAACC CTCCAGTGTT TTCAATGGCT 
ACATTTGCAG GACAAATAGA AGAAAATTCT AATGCAAATA CACTGGTGAT GATACTCAAT 
GCTACTGACG CAGATGAACC GAACAATTTG AACTCAAAAA TAGCCTTCAA GATTATAAGA 
CAAGAACCTT CAGATTCACC AATGTTTATT ATCAACAGAA ATACTGGAGA AATTCGAACG 
ATGAATAATT TTCTAGACAG AGAGCAATAC GGCCAGTATG CTCTTGCTGT AAGAGGCTCT 
GACCGAGATG GCGGGGCAGA TGGCATGTCA GCGGAATGTG AGTGCAACAT TAAAATCCTC 
GATGTCAATG ATAATATCCC TTACATGGAA CAGTCTTCAT ATACCATAGA AATTCAAGAA 
AATACTCTAA ATTCAAATTT GCTCGAGATT AGAGTAATTG ATTTGGATGA AGAGTTCTCA 
GCTAACTGGA TGGCAGTAAT TTTCTTTATC TCTGGAAATG AAGGAAATTG GTTTGAGATA 
GAAATGAATG AAAGAACAAA TGTGGGAATT TTAAAGGTTG TTAAGCCCTT AGATTATGAA 
GCTATGCAGA GTCTGCAACT CAGTATTGGT GTCAGAAATA AAGCTGAATT TCATCATTCA 
ATTATGTCTC AATATAAACT GAAAGCATCT GCAATTTCTG TGACTGTGTT AAATGTAATT 
GAAGGCCCAG TGTTTCGTCC AGGTTCAAAG ACATATGTTG TAACTGGTAA TATGGGATCA 
AATGATAAAG TGGGAGACTT TGTAGCTACT GACCTGGACA CAGGTAGACC TTCAACGACT 
GTTAGGTATG TAATGGGAAA TAATCCAGCT GACCTGCTAG CTGTTGATTC AAGAACAGGC 
AAACTCACTT TGAAAAATAA AGTTACCAAG GAACAGTACA ATATGCTCGG AGGAAAATAC 
CAAGGAACGA TTCTCTCTAT AGATGATAAT CTTCAAAGAA CTTGCACTGG TACAATTAAT 
ATTAACATTC AAAGTTTTGG TAATGACGAC AGGACTAATA CAGAGCCGAA CACTAAAATT 
ACTACCAATA CTGGCAGACA AGAAAGTACT TCTTCCACTA ACTATGATAC CAGCACAACT 
TCTACTGACT CTAGCCAAGT ATATTCTTCT GAACCCGGAA ACGGAGCCAA AGATTTGTTA 
TCAGACAATG TACATTTTGG TCCTGCTGGC ATTGGACTCC TCATCATGGG ATTCTTGGTC 
TTAGGATTGG TCCCATTTTT GATGATCTGT TGTGATTGTG GAGGTGCTCC TCGTAGTGCA 
GCTGGCTTTG AGCCTGTTCC CGAATGTTCA GATGGAGCAA TTCATTCATG GGCAGTAGAA 
GGACCACAGC CTGAACCCAG GGATATAACC ACTGTCATAC CACAAATACC ACCTGATAAC 
GCAAATATAA TTGAATGCAT TGACAACTCA GGAGTTTATA CAAATGAGTA TGGTGGCAGA 
GAAATGCAAG ATCTGGGAGG AGGAGAGAGA ATGACAGGAT TTGAACTAAC AGAGGGAGTT 
AAAACTTCAG GAATGCCTGA GATATGTCAA GAATACTCTG GAACATTAAG AAGAAATTCT 
ATGAGGGAAT GTAGAGAAGG AGGTCTGAAT ATGAATTTCA TGGAAAGCTA CTTCTGTCAG 
AAAGCATATG CTTACGCAGA TGAAGATGAA GGACGCCCAT CTAATGACTG TTTGCTCATA 
TATGACATCG AAGGTGTAGG TTCCCCTGCT GGCTCTGTGG GTTGTTGTAG CTTCATTGGA 
GAAGACCTGG ATGACAGCTT CTTGGATACC CTGGGACCTA AATTTAAGAA GTTGGCAGAC 
ATCAGCCTAG GAAAAGAATC ATATCCAGAC CTTGATCCTT CTTGGCCACC ACAAAGCACT 
GAACCAGTTT GCCTTCCTCA GGAAACAGAG CCCGTTGTTA GTGGACACCC ACCAATCTCC 
CCACATTTCG GCACTACCAC AGTAATTTCT GAGAGCACCT ATCCCTCGGG ACCTGGTGTA 
CTGCATCCTA AGCCTATTCT CGATCCTCTG GGCTATGGTA ATGTCACTGT GACCGAGTCT 
TACACCACCT CTGACACTCT GAAGCCCTCT GTGCACGTTC ACGATAACCG ACCAGCATCA 
AACGTGGTAG TGACAGAGAG AGTGGTCGGC CCAATCTCTG GCGCTGATTT GCATGGAATG 
TTAGAGATGC CTGACTTGCG AGATGGGTCG AATGTTATAG TGACAGAAAG GGTAATAGCA 
CCAAGCTCTA GTCTACCCAC CTCTCTGACT ATCCATCATC CTAGAGAGTC TTCAAATGTG 
GTAGTGACAG AAAGAGTAAT CCAACCAACT TCCGGCATGA TAGGTAGTCT GAGTATGCAC 
CCCGAGTTAG CCAATGCCCA CAATGTCATT GTGACAGAGA GGGTTGTTTC TGGTGCTGGC 
GTAACTGGAA TTAGTGGCAC CACTGGGATC AGCGGTGGCA TAGGCAGCAG TGGCCTGGTT 
GGCACCAGCA TGGGTGCTGG GAGCGGTGCC CTGAGTGGAG CTGGCATAAG TGGTGGTGGC 
ATTGGCCTGA GCAGCTTGGG AGGGACAGCC AGCATTGGCC ACATGAGGAG TTCCTCTGAC 
CATCACTTTA ACCAAACCAT TGGGTCCGCC TCCCCTAGCA CAGCTCGAAG TCGAATCACA 
AAGTATAGTA CCGTGCAATA TAGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001933.2
CDS	213..3362
Translation	MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK

Target ORF information:

RefSeq Version	NM_001942.3
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 1 (DSG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001942.3

ORF Insert Sequence:

ATGGACTGGA GTTTCTTCAG AGTAGTTGCA ATGCTGTTCA TTTTTCTGGT GGTGGTAGAA 
GTTAACAGTG AATTCCGAAT CCAGGTAAGA GATTATAACA CTAAAAATGG CACCATCAAA 
TGGCATTCAA TCCGAAGGCA GAAACGTGAA TGGATCAAGT TCGCAGCAGC CTGTCGTGAA 
GGTGAAGACA ACTCAAAGAG GAACCCAATC GCCAAAATTC ACTCAGATTG TGCTGCAAAC 
CAGCAAGTTA CATACCGCAT CTCTGGAGTA GGAATTGATC AGCCACCATA TGGGATCTTT 
GTCATTAATC AGAAAACTGG TGAAATTAAT ATAACATCCA TAGTTGATCG AGAGGTCACT 
CCTTTCTTCA TTATCTACTG CCGAGCTCTG AACTCAATGG GCCAAGATTT AGAGAGGCCT 
CTAGAGCTCA GAGTCAGGGT TTTGGATATA AATGACAACC CTCCAGTGTT TTCAATGGCT 
ACATTTGCAG GACAAATAGA AGAAAATTCT AATGCAAATA CACTGGTGAT GATACTCAAT 
GCTACTGACG CAGATGAACC GAACAATTTG AACTCAAAAA TAGCCTTCAA GATTATAAGA 
CAAGAACCTT CAGATTCACC AATGTTTATT ATCAACAGAA ATACTGGAGA AATTCGAACG 
ATGAATAATT TTCTAGACAG AGAGCAATAC GGCCAGTATG CTCTTGCTGT AAGAGGCTCT 
GACCGAGATG GCGGGGCAGA TGGCATGTCA GCGGAATGTG AGTGCAACAT TAAAATCCTC 
GATGTCAATG ATAATATCCC TTACATGGAA CAGTCTTCAT ATACCATAGA AATTCAAGAA 
AATACTCTAA ATTCAAATTT GCTCGAGATT AGAGTAATTG ATTTGGATGA AGAGTTCTCA 
GCTAACTGGA TGGCAGTAAT TTTCTTTATC TCTGGAAATG AAGGAAATTG GTTTGAGATA 
GAAATGAATG AAAGAACAAA TGTGGGAATT TTAAAGGTTG TTAAGCCCTT AGATTATGAA 
GCTATGCAGA GTCTGCAACT CAGTATTGGT GTCAGAAATA AAGCTGAATT TCATCATTCA 
ATTATGTCTC AATATAAACT GAAAGCATCT GCAATTTCTG TGACTGTGTT AAATGTAATT 
GAAGGCCCAG TGTTTCGTCC AGGTTCAAAG ACATATGTTG TAACTGGTAA TATGGGATCA 
AATGATAAAG TGGGAGACTT TGTAGCTACT GACCTGGACA CAGGTAGACC TTCAACGACT 
GTTAGGTATG TAATGGGAAA TAATCCAGCT GACCTGCTAG CTGTTGATTC AAGAACAGGC 
AAACTCACTT TGAAAAATAA AGTTACCAAG GAACAGTACA ATATGCTCGG AGGAAAATAC 
CAAGGAACGA TTCTCTCTAT AGATGATAAT CTTCAAAGAA CTTGCACTGG TACAATTAAT 
ATTAACATTC AAAGTTTTGG TAATGACGAC AGGACTAATA CAGAGCCGAA CACTAAAATT 
ACTACCAATA CTGGCAGACA AGAAAGTACT TCTTCCACTA ACTATGATAC CAGCACAACT 
TCTACTGACT CTAGCCAAGT ATATTCTTCT GAACCCGGAA ACGGAGCCAA AGATTTGTTA 
TCAGACAATG TACATTTTGG TCCTGCTGGC ATTGGACTCC TCATCATGGG ATTCTTGGTC 
TTAGGATTGG TCCCATTTTT GATGATCTGT TGTGATTGTG GAGGTGCTCC TCGTAGTGCA 
GCTGGCTTTG AGCCTGTTCC CGAATGTTCA GATGGAGCAA TTCATTCATG GGCAGTAGAA 
GGACCACAGC CTGAACCCAG GGATATAACC ACTGTCATAC CACAAATACC ACCTGATAAC 
GCAAATATAA TTGAATGCAT TGACAACTCA GGAGTTTATA CAAATGAGTA TGGTGGCAGA 
GAAATGCAAG ATCTGGGAGG AGGAGAGAGA ATGACAGGAT TTGAACTAAC AGAGGGAGTT 
AAAACTTCAG GAATGCCTGA GATATGTCAA GAATACTCTG GAACATTAAG AAGAAATTCT 
ATGAGGGAAT GTAGAGAAGG AGGTCTGAAT ATGAATTTCA TGGAAAGCTA CTTCTGTCAG 
AAAGCATATG CTTACGCAGA TGAAGATGAA GGACGCCCAT CTAATGACTG TTTGCTCATA 
TATGACATCG AAGGTGTAGG TTCCCCTGCT GGCTCTGTGG GTTGTTGTAG CTTCATTGGA 
GAAGACCTGG ATGACAGCTT CTTGGATACC CTGGGACCTA AATTTAAGAA GTTGGCAGAC 
ATCAGCCTAG GAAAAGAATC ATATCCAGAC CTTGATCCTT CTTGGCCACC ACAAAGCACT 
GAACCAGTTT GCCTTCCTCA GGAAACAGAG CCCGTTGTTA GTGGACACCC ACCAATCTCC 
CCACATTTCG GCACTACCAC AGTAATTTCT GAGAGCACCT ATCCCTCGGG ACCTGGTGTA 
CTGCATCCTA AGCCTATTCT CGATCCTCTG GGCTATGGTA ATGTCACTGT GACCGAGTCT 
TACACCACCT CTGACACTCT GAAGCCCTCT GTGCACGTTC ACGATAACCG ACCAGCATCA 
AACGTGGTAG TGACAGAGAG AGTGGTCGGC CCAATCTCTG GCGCTGATTT GCATGGAATG 
TTAGAGATGC CTGACTTGCG AGATGGGTCG AATGTTATAG TGACAGAAAG GGTAATAGCA 
CCAAGCTCTA GTCTACCCAC CTCTCTGACT ATCCATCATC CTAGAGAGTC TTCAAATGTG 
GTAGTGACAG AAAGAGTAAT CCAACCAACT TCCGGCATGA TAGGTAGTCT GAGTATGCAC 
CCCGAGTTAG CCAATGCCCA CAATGTCATT GTGACAGAGA GGGTTGTTTC TGGTGCTGGC 
GTAACTGGAA TTAGTGGCAC CACTGGGATC AGCGGTGGCA TAGGCAGCAG TGGCCTGGTT 
GGCACCAGCA TGGGTGCTGG GAGCGGTGCC CTGAGTGGAG CTGGCATAAG TGGTGGTGGC 
ATTGGCCTGA GCAGCTTGGG AGGGACAGCC AGCATTGGCC ACATGAGGAG TTCCTCTGAC 
CATCACTTTA ACCAAACCAT TGGGTCCGCC TCCCCTAGCA CAGCTCGAAG TCGAATCACA 
AAGTATAGTA CCGTGCAATA TAGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG1 ( NM_001942.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001933.2 Homo sapiens desmoglein 1 (DSG1), mRNA.

Price & Availability↑

CloneID	OHu57380
Clone ID Related Accession (Same CDS sequence)	NM_001942.3 , NM_001942.4
Accession Version	NM_001942.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3150bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	desmoglein-1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF097935.1, BX476267.1, CU456411.1 and AC009717.15. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001942.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF097935.1, X56654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000257192.5/ ENSP00000257192.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTGGA GTTTCTTCAG AGTAGTTGCA ATGCTGTTCA TTTTTCTGGT GGTGGTAGAA 
GTTAACAGTG AATTCCGAAT CCAGGTAAGA GATTATAACA CTAAAAATGG CACCATCAAA 
TGGCATTCAA TCCGAAGGCA GAAACGTGAA TGGATCAAGT TCGCAGCAGC CTGTCGTGAA 
GGTGAAGACA ACTCAAAGAG GAACCCAATC GCCAAAATTC ACTCAGATTG TGCTGCAAAC 
CAGCAAGTTA CATACCGCAT CTCTGGAGTA GGAATTGATC AGCCACCATA TGGGATCTTT 
GTCATTAATC AGAAAACTGG TGAAATTAAT ATAACATCCA TAGTTGATCG AGAGGTCACT 
CCTTTCTTCA TTATCTACTG CCGAGCTCTG AACTCAATGG GCCAAGATTT AGAGAGGCCT 
CTAGAGCTCA GAGTCAGGGT TTTGGATATA AATGACAACC CTCCAGTGTT TTCAATGGCT 
ACATTTGCAG GACAAATAGA AGAAAATTCT AATGCAAATA CACTGGTGAT GATACTCAAT 
GCTACTGACG CAGATGAACC GAACAATTTG AACTCAAAAA TAGCCTTCAA GATTATAAGA 
CAAGAACCTT CAGATTCACC AATGTTTATT ATCAACAGAA ATACTGGAGA AATTCGAACG 
ATGAATAATT TTCTAGACAG AGAGCAATAC GGCCAGTATG CTCTTGCTGT AAGAGGCTCT 
GACCGAGATG GCGGGGCAGA TGGCATGTCA GCGGAATGTG AGTGCAACAT TAAAATCCTC 
GATGTCAATG ATAATATCCC TTACATGGAA CAGTCTTCAT ATACCATAGA AATTCAAGAA 
AATACTCTAA ATTCAAATTT GCTCGAGATT AGAGTAATTG ATTTGGATGA AGAGTTCTCA 
GCTAACTGGA TGGCAGTAAT TTTCTTTATC TCTGGAAATG AAGGAAATTG GTTTGAGATA 
GAAATGAATG AAAGAACAAA TGTGGGAATT TTAAAGGTTG TTAAGCCCTT AGATTATGAA 
GCTATGCAGA GTCTGCAACT CAGTATTGGT GTCAGAAATA AAGCTGAATT TCATCATTCA 
ATTATGTCTC AATATAAACT GAAAGCATCT GCAATTTCTG TGACTGTGTT AAATGTAATT 
GAAGGCCCAG TGTTTCGTCC AGGTTCAAAG ACATATGTTG TAACTGGTAA TATGGGATCA 
AATGATAAAG TGGGAGACTT TGTAGCTACT GACCTGGACA CAGGTAGACC TTCAACGACT 
GTTAGGTATG TAATGGGAAA TAATCCAGCT GACCTGCTAG CTGTTGATTC AAGAACAGGC 
AAACTCACTT TGAAAAATAA AGTTACCAAG GAACAGTACA ATATGCTCGG AGGAAAATAC 
CAAGGAACGA TTCTCTCTAT AGATGATAAT CTTCAAAGAA CTTGCACTGG TACAATTAAT 
ATTAACATTC AAAGTTTTGG TAATGACGAC AGGACTAATA CAGAGCCGAA CACTAAAATT 
ACTACCAATA CTGGCAGACA AGAAAGTACT TCTTCCACTA ACTATGATAC CAGCACAACT 
TCTACTGACT CTAGCCAAGT ATATTCTTCT GAACCCGGAA ACGGAGCCAA AGATTTGTTA 
TCAGACAATG TACATTTTGG TCCTGCTGGC ATTGGACTCC TCATCATGGG ATTCTTGGTC 
TTAGGATTGG TCCCATTTTT GATGATCTGT TGTGATTGTG GAGGTGCTCC TCGTAGTGCA 
GCTGGCTTTG AGCCTGTTCC CGAATGTTCA GATGGAGCAA TTCATTCATG GGCAGTAGAA 
GGACCACAGC CTGAACCCAG GGATATAACC ACTGTCATAC CACAAATACC ACCTGATAAC 
GCAAATATAA TTGAATGCAT TGACAACTCA GGAGTTTATA CAAATGAGTA TGGTGGCAGA 
GAAATGCAAG ATCTGGGAGG AGGAGAGAGA ATGACAGGAT TTGAACTAAC AGAGGGAGTT 
AAAACTTCAG GAATGCCTGA GATATGTCAA GAATACTCTG GAACATTAAG AAGAAATTCT 
ATGAGGGAAT GTAGAGAAGG AGGTCTGAAT ATGAATTTCA TGGAAAGCTA CTTCTGTCAG 
AAAGCATATG CTTACGCAGA TGAAGATGAA GGACGCCCAT CTAATGACTG TTTGCTCATA 
TATGACATCG AAGGTGTAGG TTCCCCTGCT GGCTCTGTGG GTTGTTGTAG CTTCATTGGA 
GAAGACCTGG ATGACAGCTT CTTGGATACC CTGGGACCTA AATTTAAGAA GTTGGCAGAC 
ATCAGCCTAG GAAAAGAATC ATATCCAGAC CTTGATCCTT CTTGGCCACC ACAAAGCACT 
GAACCAGTTT GCCTTCCTCA GGAAACAGAG CCCGTTGTTA GTGGACACCC ACCAATCTCC 
CCACATTTCG GCACTACCAC AGTAATTTCT GAGAGCACCT ATCCCTCGGG ACCTGGTGTA 
CTGCATCCTA AGCCTATTCT CGATCCTCTG GGCTATGGTA ATGTCACTGT GACCGAGTCT 
TACACCACCT CTGACACTCT GAAGCCCTCT GTGCACGTTC ACGATAACCG ACCAGCATCA 
AACGTGGTAG TGACAGAGAG AGTGGTCGGC CCAATCTCTG GCGCTGATTT GCATGGAATG 
TTAGAGATGC CTGACTTGCG AGATGGGTCG AATGTTATAG TGACAGAAAG GGTAATAGCA 
CCAAGCTCTA GTCTACCCAC CTCTCTGACT ATCCATCATC CTAGAGAGTC TTCAAATGTG 
GTAGTGACAG AAAGAGTAAT CCAACCAACT TCCGGCATGA TAGGTAGTCT GAGTATGCAC 
CCCGAGTTAG CCAATGCCCA CAATGTCATT GTGACAGAGA GGGTTGTTTC TGGTGCTGGC 
GTAACTGGAA TTAGTGGCAC CACTGGGATC AGCGGTGGCA TAGGCAGCAG TGGCCTGGTT 
GGCACCAGCA TGGGTGCTGG GAGCGGTGCC CTGAGTGGAG CTGGCATAAG TGGTGGTGGC 
ATTGGCCTGA GCAGCTTGGG AGGGACAGCC AGCATTGGCC ACATGAGGAG TTCCTCTGAC 
CATCACTTTA ACCAAACCAT TGGGTCCGCC TCCCCTAGCA CAGCTCGAAG TCGAATCACA 
AAGTATAGTA CCGTGCAATA TAGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001933.2
CDS	142..3291
Translation	MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK

Target ORF information:

RefSeq Version	NM_001942.4
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 1 (DSG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001942.4

ORF Insert Sequence:

ATGGACTGGA GTTTCTTCAG AGTAGTTGCA ATGCTGTTCA TTTTTCTGGT GGTGGTAGAA 
GTTAACAGTG AATTCCGAAT CCAGGTAAGA GATTATAACA CTAAAAATGG CACCATCAAA 
TGGCATTCAA TCCGAAGGCA GAAACGTGAA TGGATCAAGT TCGCAGCAGC CTGTCGTGAA 
GGTGAAGACA ACTCAAAGAG GAACCCAATC GCCAAAATTC ACTCAGATTG TGCTGCAAAC 
CAGCAAGTTA CATACCGCAT CTCTGGAGTA GGAATTGATC AGCCACCATA TGGGATCTTT 
GTCATTAATC AGAAAACTGG TGAAATTAAT ATAACATCCA TAGTTGATCG AGAGGTCACT 
CCTTTCTTCA TTATCTACTG CCGAGCTCTG AACTCAATGG GCCAAGATTT AGAGAGGCCT 
CTAGAGCTCA GAGTCAGGGT TTTGGATATA AATGACAACC CTCCAGTGTT TTCAATGGCT 
ACATTTGCAG GACAAATAGA AGAAAATTCT AATGCAAATA CACTGGTGAT GATACTCAAT 
GCTACTGACG CAGATGAACC GAACAATTTG AACTCAAAAA TAGCCTTCAA GATTATAAGA 
CAAGAACCTT CAGATTCACC AATGTTTATT ATCAACAGAA ATACTGGAGA AATTCGAACG 
ATGAATAATT TTCTAGACAG AGAGCAATAC GGCCAGTATG CTCTTGCTGT AAGAGGCTCT 
GACCGAGATG GCGGGGCAGA TGGCATGTCA GCGGAATGTG AGTGCAACAT TAAAATCCTC 
GATGTCAATG ATAATATCCC TTACATGGAA CAGTCTTCAT ATACCATAGA AATTCAAGAA 
AATACTCTAA ATTCAAATTT GCTCGAGATT AGAGTAATTG ATTTGGATGA AGAGTTCTCA 
GCTAACTGGA TGGCAGTAAT TTTCTTTATC TCTGGAAATG AAGGAAATTG GTTTGAGATA 
GAAATGAATG AAAGAACAAA TGTGGGAATT TTAAAGGTTG TTAAGCCCTT AGATTATGAA 
GCTATGCAGA GTCTGCAACT CAGTATTGGT GTCAGAAATA AAGCTGAATT TCATCATTCA 
ATTATGTCTC AATATAAACT GAAAGCATCT GCAATTTCTG TGACTGTGTT AAATGTAATT 
GAAGGCCCAG TGTTTCGTCC AGGTTCAAAG ACATATGTTG TAACTGGTAA TATGGGATCA 
AATGATAAAG TGGGAGACTT TGTAGCTACT GACCTGGACA CAGGTAGACC TTCAACGACT 
GTTAGGTATG TAATGGGAAA TAATCCAGCT GACCTGCTAG CTGTTGATTC AAGAACAGGC 
AAACTCACTT TGAAAAATAA AGTTACCAAG GAACAGTACA ATATGCTCGG AGGAAAATAC 
CAAGGAACGA TTCTCTCTAT AGATGATAAT CTTCAAAGAA CTTGCACTGG TACAATTAAT 
ATTAACATTC AAAGTTTTGG TAATGACGAC AGGACTAATA CAGAGCCGAA CACTAAAATT 
ACTACCAATA CTGGCAGACA AGAAAGTACT TCTTCCACTA ACTATGATAC CAGCACAACT 
TCTACTGACT CTAGCCAAGT ATATTCTTCT GAACCCGGAA ACGGAGCCAA AGATTTGTTA 
TCAGACAATG TACATTTTGG TCCTGCTGGC ATTGGACTCC TCATCATGGG ATTCTTGGTC 
TTAGGATTGG TCCCATTTTT GATGATCTGT TGTGATTGTG GAGGTGCTCC TCGTAGTGCA 
GCTGGCTTTG AGCCTGTTCC CGAATGTTCA GATGGAGCAA TTCATTCATG GGCAGTAGAA 
GGACCACAGC CTGAACCCAG GGATATAACC ACTGTCATAC CACAAATACC ACCTGATAAC 
GCAAATATAA TTGAATGCAT TGACAACTCA GGAGTTTATA CAAATGAGTA TGGTGGCAGA 
GAAATGCAAG ATCTGGGAGG AGGAGAGAGA ATGACAGGAT TTGAACTAAC AGAGGGAGTT 
AAAACTTCAG GAATGCCTGA GATATGTCAA GAATACTCTG GAACATTAAG AAGAAATTCT 
ATGAGGGAAT GTAGAGAAGG AGGTCTGAAT ATGAATTTCA TGGAAAGCTA CTTCTGTCAG 
AAAGCATATG CTTACGCAGA TGAAGATGAA GGACGCCCAT CTAATGACTG TTTGCTCATA 
TATGACATCG AAGGTGTAGG TTCCCCTGCT GGCTCTGTGG GTTGTTGTAG CTTCATTGGA 
GAAGACCTGG ATGACAGCTT CTTGGATACC CTGGGACCTA AATTTAAGAA GTTGGCAGAC 
ATCAGCCTAG GAAAAGAATC ATATCCAGAC CTTGATCCTT CTTGGCCACC ACAAAGCACT 
GAACCAGTTT GCCTTCCTCA GGAAACAGAG CCCGTTGTTA GTGGACACCC ACCAATCTCC 
CCACATTTCG GCACTACCAC AGTAATTTCT GAGAGCACCT ATCCCTCGGG ACCTGGTGTA 
CTGCATCCTA AGCCTATTCT CGATCCTCTG GGCTATGGTA ATGTCACTGT GACCGAGTCT 
TACACCACCT CTGACACTCT GAAGCCCTCT GTGCACGTTC ACGATAACCG ACCAGCATCA 
AACGTGGTAG TGACAGAGAG AGTGGTCGGC CCAATCTCTG GCGCTGATTT GCATGGAATG 
TTAGAGATGC CTGACTTGCG AGATGGGTCG AATGTTATAG TGACAGAAAG GGTAATAGCA 
CCAAGCTCTA GTCTACCCAC CTCTCTGACT ATCCATCATC CTAGAGAGTC TTCAAATGTG 
GTAGTGACAG AAAGAGTAAT CCAACCAACT TCCGGCATGA TAGGTAGTCT GAGTATGCAC 
CCCGAGTTAG CCAATGCCCA CAATGTCATT GTGACAGAGA GGGTTGTTTC TGGTGCTGGC 
GTAACTGGAA TTAGTGGCAC CACTGGGATC AGCGGTGGCA TAGGCAGCAG TGGCCTGGTT 
GGCACCAGCA TGGGTGCTGG GAGCGGTGCC CTGAGTGGAG CTGGCATAAG TGGTGGTGGC 
ATTGGCCTGA GCAGCTTGGG AGGGACAGCC AGCATTGGCC ACATGAGGAG TTCCTCTGAC 
CATCACTTTA ACCAAACCAT TGGGTCCGCC TCCCCTAGCA CAGCTCGAAG TCGAATCACA 
AAGTATAGTA CCGTGCAATA TAGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
eLife6(2017 Sep)
Najor NA,Fitz GN,Koetsier JL,Godsel LM,Albrecht LV,Harmon R,Green KJ

Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Scientific reports7(1)3579(2017 Jun)
Walter E,Vielmuth F,Rotkopf L,S?rdy M,Horv?th ON,Goebeler M,Schmidt E,Eming R,Hertl M,Spindler V,Waschke J

Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7.
Acta dermato-venereologica97(3)399-401(2017 03)
Fukaura R,Takeichi T,Okuno Y,Kojima D,Kono M,Sugiura K,Suga Y,Akiyama M

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DSG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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