MPZ cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	MPZ
Entrez Gene ID	719969
Full Name	myelin protein zero
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Mar 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001321056.1	NP_001307985.1	myelin protein P0 isoform L-MPZ precursor
NM_001321055.1	NP_001307984.1	myelin protein P0 isoform MPZ precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC100859605	XP_003643863.1
Danio rerio (zebrafish)	mpz	NP_919342.1
Canis lupus familiaris (dog)	MPZ	XP_545771.1
Pan troglodytes (chimpanzee)	MPZ	XP_001173975.1
Mus musculus (house mouse)	Mpz	NP_032649.2
Homo sapiens (human)	MPZ	NP_000521.2
	LOC719969	XP_001118030.1
Xenopus tropicalis (tropical clawed frog)	mpz	NP_001072741.1
Bos taurus (cattle)	MPZ	NP_001072975.1
Rattus norvegicus (Norway rat)	Mpz	NP_058723.1

Gene Ontology
Bibliography

Related articles in PubMed

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.
Yamaguchi Y, Baba H
Neurochemical research43(1)227-237(2018 Jan)

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.
Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H
The Journal of biological chemistry287(21)17765-76(2012 May)

Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs.
Beier H, Grimm M
Nucleic acids research29(23)4767-82(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MPZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MPZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb57544	NM_001321055.1 Latest version!	Macaca mulatta myelin protein zero (MPZ), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
OMb57545	NM_001321056.1 Latest version!	Macaca mulatta myelin protein zero (MPZ), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MPZ ( NM_001321055.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001307984.1 Macaca mulatta myelin protein zero (MPZ), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMb57544
Clone ID Related Accession (Same CDS sequence)	NM_001321055.1
Accession Version	NM_001321055.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	myelin protein P0 isoform MPZ precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JSUE03002665.1, JV684562.1, JV617229.1 and JV545533.1. On Mar 28, 2016 this sequence version replaced XM_001118030.3. Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688321, SAMEA4688322 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCACGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCT GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTGGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCCAT GGAGAAGGGG 
AAATTGCACA AGCCAGCAAA GGACTCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCCATGCTGG ACCACAGCAG AAGCACCAAA GCTGCCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307984.1
CDS	62..808
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPAKDSSKRGRQTPVLYAMLDHSRSTKAASEKKAKGLGESRKDKK

Target ORF information:

RefSeq Version	NM_001321055.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta myelin protein zero (MPZ), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321055.1

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCACGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCT GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTGGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCCAT GGAGAAGGGG 
AAATTGCACA AGCCAGCAAA GGACTCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCCATGCTGG ACCACAGCAG AAGCACCAAA GCTGCCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( NM_001321056.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001307985.1 Macaca mulatta myelin protein zero (MPZ), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMb57545
Clone ID Related Accession (Same CDS sequence)	NM_001321056.1
Accession Version	NM_001321056.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	myelin protein P0 isoform L-MPZ precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JSUE03002665.1, JV684562.1, JV617229.1 and JV545533.1. Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (L-MPZ). As the UAG stop codon has been reported to specify several alternative amino acids (glutamine, tyrosine and leucine), its location in the longer isoform is denoted by an 'X'. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688321, SAMEA4688322 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal stop codon readthrough :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCACGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCT GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTGGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCCAT GGAGAAGGGG 
AAATTGCACA AGCCAGCAAA GGACTCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCCATGCTGG ACCACAGCAG AAGCACCAAA GCTGCCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAGCGG TTAGCGGGCC GGGCGGGGGA TCGGGGGTTA 
GGGGTGGAGT CCGCCAAAGG CGCAAAGGTG GTGGTCATCG AGATGGAGCT ACGAAAGGAT 
GAGCAGAGCT CGGAGCTCCG GCCTGCTGTC AAGTCCCCCA GCAGAACTAG CCTCAAAAAC 
GCCCTCAAGA ACATGATGGG CCTGGACTCG GACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307985.1
CDS	62..1000
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPAKDSSKRGRQTPVLYAMLDHSRSTKAASEKKAKGLGESRKDKK*RLAGRAGDRGLGVESAKGAKVVVIEMELRKDEQSSELRPAVKSPSRTSLKNALKNMMGLDSDK

Target ORF information:

RefSeq Version	NM_001321056.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta myelin protein zero (MPZ), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321056.1

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCACGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCT GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTGGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCCAT GGAGAAGGGG 
AAATTGCACA AGCCAGCAAA GGACTCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCCATGCTGG ACCACAGCAG AAGCACCAAA GCTGCCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAGCGG TTAGCGGGCC GGGCGGGGGA TCGGGGGTTA 
GGGGTGGAGT CCGCCAAAGG CGCAAAGGTG GTGGTCATCG AGATGGAGCT ACGAAAGGAT 
GAGCAGAGCT CGGAGCTCCG GCCTGCTGTC AAGTCCCCCA GCAGAACTAG CCTCAAAAAC 
GCCCTCAAGA ACATGATGGG CCTGGACTCG GACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.
Neurochemical research43(1)227-237(2018 Jan)
Yamaguchi Y,Baba H

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.
The Journal of biological chemistry287(21)17765-76(2012 May)
Yamaguchi Y,Hayashi A,Campagnoni CW,Kimura A,Inuzuka T,Baba H

Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs.
Nucleic acids research29(23)4767-82(2001 Dec)
Beier H,Grimm M

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MPZ cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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