MPZ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MPZ
Entrez Gene ID	4359
Full Name	myelin protein zero
Synonyms	CHM,CMT1,CMT1B,CMT2I,CMT2J,CMT4E,CMTDI3,CMTDID,DSS,HMSNIB,MPP,P0
General protein information	Preferred Names myelin protein zero Names myelin protein P0 Charcot-Marie-Tooth neuropathy 1B myelin peripheral protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015].
Disorder MIM:	159440
Disorder Html:	Charcot-Marie-Tooth disease, type 1B, 118200 (3); Dejerine-Sottas disease, 145900 (3); Neuropathy, congenital hypomyelinating, 605253 (3); Charcot-Marie-Tooth disease, type 2J, 607736 (3); Roussy-Levy syndrome, 180800 (3); Charcot-Marie-Tooth disease, type 2I, 607677 (3); Charcot-Marie-Tooth disease, dominant intermediate D, 607791 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001315491.2	NP_001302420.1	myelin protein P0 isoform L-MPZ precursor
NM_000530.8	NP_000521.2	myelin protein P0 isoform MPZ precursor
NM_000530.6	NP_000521.2	myelin protein P0 precursor
XM_017001321.2	XP_016856810.1	myelin protein P0 isoform X1
NM_001315491.1	NP_001302420.1	myelin protein P0 isoform L-MPZ precursor
NM_000530.7	NP_000521.2	myelin protein P0 isoform MPZ precursor
XM_017001321.1	XP_016856810.1	myelin protein P0 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC100859605	XP_003643863.1
Danio rerio (zebrafish)	mpz	NP_919342.1
Canis lupus familiaris (dog)	MPZ	XP_545771.1
Pan troglodytes (chimpanzee)	MPZ	XP_001173975.1
Mus musculus (house mouse)	Mpz	NP_032649.2
Homo sapiens (human)	MPZ	NP_000521.2
	LOC719969	XP_001118030.1
Xenopus tropicalis (tropical clawed frog)	mpz	NP_001072741.1
Bos taurus (cattle)	MPZ	NP_001072975.1
Rattus norvegicus (Norway rat)	Mpz	NP_058723.1

Gene Ontology
Bibliography

Related articles in PubMed

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.
Yamaguchi Y, Baba H
Neurochemical research43(1)227-237(2018 Jan)

L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.
Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H
The Journal of biological chemistry287(21)17765-76(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genotype of MPZ mutations and phenotype of Charcot Marie Tooth Disease are correlated.
Title: Genotype-phenotype characteristics and baseline natural history of heritable neuropathies caused by mutations in the MPZ gene.

The obtained results depict that the protein with I30T mutation had variable structural conformation and dynamic behavior than native and mutant I30M of MPZ protein.
Title: Impact of I30T and I30M substitution in MPZ gene associated with Dejerine-Sottas syndrome type B (DSSB): A molecular modeling and dynamics.

interaction with neurofascins impaired by mutations D6Y, D32G, and H52Y responsible for late onset forms of the human disease
Title: HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.

As a result of the haplotype analysis, based on ten markers (seven SNPs, two microsatellites and an intronic polyA stretch), the founder effect hypothesis for this allele migration is suggestive.
Title: A Costa Rican family affected with Charcot-Marie-Tooth disease due to the myelin protein zero (MPZ) p.Thr124Met mutation shares the Belgian haplotype.

2 heterozygous missense mutations were identified among 38 Italian CMT2 patients.
Title: Mutation analysis of MFN2, GJB1, MPZ and PMP22 in Italian patients with axonal Charcot-Marie-Tooth disease.

The following MPZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MPZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26713	NM_000530.8 Latest version!	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu82766	NM_001315491.2 Latest version!	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu87427	XM_017001321.2 Latest version!	Homo sapiens myelin protein zero (MPZ), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu26713	NM_000530.6	Homo sapiens myelin protein zero (MPZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu82766	NM_001315491.1	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26713	NM_000530.7	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu87427	XM_017001321.1	Homo sapiens myelin protein zero (MPZ), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MPZ ( NM_000530.8 ) cDNA ORF clone, Homo sapiens(human) -> NP_000521.2 Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26713
Clone ID Related Accession (Same CDS sequence)	NM_000530.8 , NM_000530.6 , NM_000530.7
Accession Version	NM_000530.8 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myelin protein P0 isoform MPZ precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210759.1, D10537.1, CD172418.1 and BM663255.1. On Nov 22, 2018 this sequence version replaced NM_000530.7. Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313555.1, D10537.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:16414078) MANE Ensembl match :: ENST00000533357.5/ ENSP00000432943.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000521.2
CDS	64..810
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK

Target ORF information:

RefSeq Version	NM_000530.8
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000530.8

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( NM_000530.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000521.2 Homo sapiens myelin protein zero (MPZ), mRNA.

Price & Availability↑

CloneID	OHu26713
Clone ID Related Accession (Same CDS sequence)	NM_000530.8 , NM_000530.6 , NM_000530.7
Accession Version	NM_000530.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	myelin protein P0 precursor
Comment

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000521.2
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK

Target ORF information:

RefSeq Version	NM_000530.6
Organism	Homo sapiens(Human)
Definition	Homo sapiens myelin protein zero (MPZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000530.6

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( NM_000530.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_000521.2 Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26713
Clone ID Related Accession (Same CDS sequence)	NM_000530.8 , NM_000530.6 , NM_000530.7
Accession Version	NM_000530.7	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-15
Organism	Homo sapiens(human)
Product	myelin protein P0 isoform MPZ precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210759.1, D10537.1, CD172418.1 and BM663255.1. On Oct 6, 2015 this sequence version replaced NM_000530.6. Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10537.1, BU838551.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:16414078) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000521.2
CDS	68..814
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK

Target ORF information:

RefSeq Version	NM_000530.7
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000530.7

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( NM_001315491.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001302420.1 Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu82766
Clone ID Related Accession (Same CDS sequence)	NM_001315491.2 , NM_001315491.1
Accession Version	NM_001315491.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	myelin protein P0 isoform L-MPZ precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210759.1, D10537.1, CD172418.1 and BM663255.1. On May 31, 2019 this sequence version replaced NM_001315491.1. Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (L-MPZ). As the UAG stop codon has been reported to specify several alternative amino acids (glutamine, tyrosine and leucine), its location in the longer isoform is denoted by an 'X'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.112476.1, D10537.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:16414078) stop codon readthrough :: PMID: 22457349, 29081003 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAGCGG TTAGCGGGCC GGGCGGGGGA TCGGGGGTTA 
GGGGTGGAGT CCGCCAAAGG CCCAAAGGTG ATGGTCATCG AGATGGAGCT ACGAAAGGAT 
GAGCAGAGCC CGGAGCTCCG GCCTGCTGTC AAGTCCCCCA GCAGAACCAG CCTCAAAAAC 
GCCCTCAAGA ACATGATGGG CCTGAACTCG GACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001302420.1
CDS	64..1002
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK*RLAGRAGDRGLGVESAKGPKVMVIEMELRKDEQSPELRPAVKSPSRTSLKNALKNMMGLNSDK

Target ORF information:

RefSeq Version	NM_001315491.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001315491.2

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAGCGG TTAGCGGGCC GGGCGGGGGA TCGGGGGTTA 
GGGGTGGAGT CCGCCAAAGG CCCAAAGGTG ATGGTCATCG AGATGGAGCT ACGAAAGGAT 
GAGCAGAGCC CGGAGCTCCG GCCTGCTGTC AAGTCCCCCA GCAGAACCAG CCTCAAAAAC 
GCCCTCAAGA ACATGATGGG CCTGAACTCG GACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( NM_001315491.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001302420.1 Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

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CloneID	OHu82766
Clone ID Related Accession (Same CDS sequence)	NM_001315491.2 , NM_001315491.1
Accession Version	NM_001315491.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	myelin protein P0 isoform L-MPZ precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210759.1, D10537.1, CD172418.1 and BM663255.1. Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (L-MPZ). As the UAG stop codon has been reported to specify several alternative amino acids (glutamine, tyrosine and leucine), its location in the longer isoform is denoted by an 'X'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10537.1, BU838551.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:16414078) stop codon readthrough :: PMID: 22457349, 29081003 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAGCGG TTAGCGGGCC GGGCGGGGGA TCGGGGGTTA 
GGGGTGGAGT CCGCCAAAGG CCCAAAGGTG ATGGTCATCG AGATGGAGCT ACGAAAGGAT 
GAGCAGAGCC CGGAGCTCCG GCCTGCTGTC AAGTCCCCCA GCAGAACCAG CCTCAAAAAC 
GCCCTCAAGA ACATGATGGG CCTGAACTCG GACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001302420.1
CDS	68..1006
Translation	MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK*RLAGRAGDRGLGVESAKGPKVMVIEMELRKDEQSPELRPAVKSPSRTSLKNALKNMMGLNSDK

Target ORF information:

RefSeq Version	NM_001315491.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero (MPZ), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001315491.1

ORF Insert Sequence:

ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC AGCCCTATCC TGGCTGTGCT GCTCTTCTCT 
TCTTTGGTGC TGTCCCCGGC CCAGGCCATC GTGGTTTACA CCGACAGGGA GGTCCATGGT 
GCTGTGGGCT CCCGGGTGAC CCTGCACTGC TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT 
GACATCTCCT TCACCTGGCG CTACCAGCCC GAAGGGGGCA GAGATGCCAT TTCGATCTTC 
CACTATGCCA AGGGACAACC CTACATTGAC GAGGTGGGGA CCTTCAAAGA GCGCATCCAG 
TGGGTAGGGG ACCCTCGCTG GAAGGATGGC TCCATTGTCA TACACAACCT AGACTACAGT 
GACAATGGCA CGTTCACTTG TGACGTCAAA AACCCTCCAG ACATAGTGGG CAAGACCTCT 
CAGGTCACGC TGTATGTCTT TGAAAAAGTG CCAACTAGGT ACGGGGTCGT TCTGGGAGCT 
GTGATCGGGG GTGTCCTCGG GGTGGTGCTG TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG 
TACTGCTGGC TACGCAGGCA GGCGGCCCTG CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG 
AAATTGCACA AGCCAGGAAA GGACGCGTCG AAGCGCGGGC GGCAGACGCC AGTGCTGTAT 
GCAATGCTGG ACCACAGCAG AAGCACCAAA GCTGTCAGTG AGAAGAAGGC CAAGGGGCTG 
GGGGAGTCTC GCAAGGATAA GAAATAGCGG TTAGCGGGCC GGGCGGGGGA TCGGGGGTTA 
GGGGTGGAGT CCGCCAAAGG CCCAAAGGTG ATGGTCATCG AGATGGAGCT ACGAAAGGAT 
GAGCAGAGCC CGGAGCTCCG GCCTGCTGTC AAGTCCCCCA GCAGAACCAG CCTCAAAAAC 
GCCCTCAAGA ACATGATGGG CCTGAACTCG GACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( XM_017001321.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856810.1 Homo sapiens myelin protein zero (MPZ), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu87427
Clone ID Related Accession (Same CDS sequence)	XM_017001321.2 , XM_017001321.1
Accession Version	XM_017001321.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	myelin protein P0 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017001321.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCGGG CCCCTGCCCC TGCCCCAGCT ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC 
AGCCCTATCC TGGCTGTGCT GCTCTTCTCT TCTTTGGTGC TGTCCCCGGC CCAGGCCATC 
GTGGTTTACA CCGACAGGGA GGTCCATGGT GCTGTGGGCT CCCGGGTGAC CCTGCACTGC 
TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT GACATCTCCT TCACCTGGCG CTACCAGCCC 
GAAGGGGGCA GAGATGCCAT TTCGATCTTC CACTATGCCA AGGGACAACC CTACATTGAC 
GAGGTGGGGA CCTTCAAAGA GCGCATCCAG TGGGTAGGGG ACCCTCGCTG GAAGGATGGC 
TCCATTGTCA TACACAACCT AGACTACAGT GACAATGGCA CGTTCACTTG TGACGTCAAA 
AACCCTCCAG ACATAGTGGG CAAGACCTCT CAGGTCACGC TGTATGTCTT TGAAAAAGTG 
CCAACTAGGT ACGGGGTCGT TCTGGGAGCT GTGATCGGGG GTGTCCTCGG GGTGGTGCTG 
TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG TACTGCTGGC TACGCAGGCA GGCGGCCCTG 
CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG AAATTGCACA AGCCAGGAAA GGACGCGTCG 
AAGCGCGGGC GGCAGGGATT TTATAATAAT CAAATGAGAT CCTGTGTATG GAAAACTTTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856810.1
CDS	35..757
Translation	MLRAPAPAPAMAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQGFYNNQMRSCVWKTL

Target ORF information:

RefSeq Version	XM_017001321.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero (MPZ), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001321.2

ORF Insert Sequence:

ATGCTCCGGG CCCCTGCCCC TGCCCCAGCT ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC 
AGCCCTATCC TGGCTGTGCT GCTCTTCTCT TCTTTGGTGC TGTCCCCGGC CCAGGCCATC 
GTGGTTTACA CCGACAGGGA GGTCCATGGT GCTGTGGGCT CCCGGGTGAC CCTGCACTGC 
TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT GACATCTCCT TCACCTGGCG CTACCAGCCC 
GAAGGGGGCA GAGATGCCAT TTCGATCTTC CACTATGCCA AGGGACAACC CTACATTGAC 
GAGGTGGGGA CCTTCAAAGA GCGCATCCAG TGGGTAGGGG ACCCTCGCTG GAAGGATGGC 
TCCATTGTCA TACACAACCT AGACTACAGT GACAATGGCA CGTTCACTTG TGACGTCAAA 
AACCCTCCAG ACATAGTGGG CAAGACCTCT CAGGTCACGC TGTATGTCTT TGAAAAAGTG 
CCAACTAGGT ACGGGGTCGT TCTGGGAGCT GTGATCGGGG GTGTCCTCGG GGTGGTGCTG 
TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG TACTGCTGGC TACGCAGGCA GGCGGCCCTG 
CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG AAATTGCACA AGCCAGGAAA GGACGCGTCG 
AAGCGCGGGC GGCAGGGATT TTATAATAAT CAAATGAGAT CCTGTGTATG GAAAACTTTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZ ( XM_017001321.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856810.1 Homo sapiens myelin protein zero (MPZ), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu87427
Clone ID Related Accession (Same CDS sequence)	XM_017001321.2 , XM_017001321.1
Accession Version	XM_017001321.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	myelin protein P0 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCGGG CCCCTGCCCC TGCCCCAGCT ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC 
AGCCCTATCC TGGCTGTGCT GCTCTTCTCT TCTTTGGTGC TGTCCCCGGC CCAGGCCATC 
GTGGTTTACA CCGACAGGGA GGTCCATGGT GCTGTGGGCT CCCGGGTGAC CCTGCACTGC 
TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT GACATCTCCT TCACCTGGCG CTACCAGCCC 
GAAGGGGGCA GAGATGCCAT TTCGATCTTC CACTATGCCA AGGGACAACC CTACATTGAC 
GAGGTGGGGA CCTTCAAAGA GCGCATCCAG TGGGTAGGGG ACCCTCGCTG GAAGGATGGC 
TCCATTGTCA TACACAACCT AGACTACAGT GACAATGGCA CGTTCACTTG TGACGTCAAA 
AACCCTCCAG ACATAGTGGG CAAGACCTCT CAGGTCACGC TGTATGTCTT TGAAAAAGTG 
CCAACTAGGT ACGGGGTCGT TCTGGGAGCT GTGATCGGGG GTGTCCTCGG GGTGGTGCTG 
TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG TACTGCTGGC TACGCAGGCA GGCGGCCCTG 
CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG AAATTGCACA AGCCAGGAAA GGACGCGTCG 
AAGCGCGGGC GGCAGGGATT TTATAATAAT CAAATGAGAT CCTGTGTATG GAAAACTTTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856810.1
CDS	35..757
Translation	MLRAPAPAPAMAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQGFYNNQMRSCVWKTL

Target ORF information:

RefSeq Version	XM_017001321.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero (MPZ), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001321.1

ORF Insert Sequence:

ATGCTCCGGG CCCCTGCCCC TGCCCCAGCT ATGGCTCCTG GGGCTCCCTC ATCCAGCCCC 
AGCCCTATCC TGGCTGTGCT GCTCTTCTCT TCTTTGGTGC TGTCCCCGGC CCAGGCCATC 
GTGGTTTACA CCGACAGGGA GGTCCATGGT GCTGTGGGCT CCCGGGTGAC CCTGCACTGC 
TCCTTCTGGT CCAGTGAGTG GGTCTCAGAT GACATCTCCT TCACCTGGCG CTACCAGCCC 
GAAGGGGGCA GAGATGCCAT TTCGATCTTC CACTATGCCA AGGGACAACC CTACATTGAC 
GAGGTGGGGA CCTTCAAAGA GCGCATCCAG TGGGTAGGGG ACCCTCGCTG GAAGGATGGC 
TCCATTGTCA TACACAACCT AGACTACAGT GACAATGGCA CGTTCACTTG TGACGTCAAA 
AACCCTCCAG ACATAGTGGG CAAGACCTCT CAGGTCACGC TGTATGTCTT TGAAAAAGTG 
CCAACTAGGT ACGGGGTCGT TCTGGGAGCT GTGATCGGGG GTGTCCTCGG GGTGGTGCTG 
TTGCTGCTGC TGCTTTTCTA CGTGGTTCGG TACTGCTGGC TACGCAGGCA GGCGGCCCTG 
CAGAGGAGGC TCAGTGCTAT GGAGAAGGGG AAATTGCACA AGCCAGGAAA GGACGCGTCG 
AAGCGCGGGC GGCAGGGATT TTATAATAAT CAAATGAGAT CCTGTGTATG GAAAACTTTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.
Neurochemical research43(1)227-237(2018 Jan)
Yamaguchi Y,Baba H

L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.
The Journal of biological chemistry287(21)17765-76(2012 May)
Yamaguchi Y,Hayashi A,Campagnoni CW,Kimura A,Inuzuka T,Baba H

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MPZ cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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