CARTPT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CARTPT
Entrez Gene ID	9607
Full Name	CART prepropeptide
Synonyms	CART
General protein information	Preferred Names CART prepropeptide Names cocaine- and amphetamine-regulated transcript protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q13.2
Summary	This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016].
Disorder MIM:	602606
Disorder Html:	{?Obesity, susceptibility to}, 601665 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004291.3	NP_004282.1	cocaine- and amphetamine-regulated transcript protein preproprotein
NM_004291.4	NP_004282.1	cocaine- and amphetamine-regulated transcript protein preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cartpt	NP_058806.1
Xenopus tropicalis (tropical clawed frog)	cartpt	XP_002934864.1
Bos taurus (cattle)	CARTPT	NP_001007821.1
Mus musculus (house mouse)	Cartpt	NP_038760.3
	CARTPT	XP_001096906.1
Canis lupus familiaris (dog)	CARTPT	XP_852772.1
Pan troglodytes (chimpanzee)	CARTPT	XP_001155069.1
Homo sapiens (human)	CARTPT	NP_004282.1

Gene Ontology
Bibliography

Related articles in PubMed

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, S?rhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahr?n B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renstr?m E, Groop L, Lyssenko V, Wierup N
Diabetologia59(9)1928-37(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin secretion and reduce glucagon secretion, CART-based agents could be a therapeutic modality in type 2 diabetes.
Title: CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

In samples from patients undergoing IVF, there is a significant positive correlation between patient BMI, CART mRNA expression in granulosa cells, and CART peptide levels in follicular fluid.
Title: Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females.

polymorphisms in the gene may be useful in identifying women at risk for osteoporosis.
Title: Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.

In schizophrenia patients on clozapine monotherapy, CART levels did not correlate with age, weight, BMI, abdominal, waist and hip circumferences, WHR, blood pressure, clozapine dose or treatment duration, body composition, or markers of insulin resistance
Title: Blood serum levels of CART peptide in patients with schizophrenia on clozapine monotherapy.

Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities.
Title: Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region.

The following CARTPT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CARTPT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22817	NM_004291.4 Latest version!	Homo sapiens CART prepropeptide (CARTPT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22817	NM_004291.3	Homo sapiens CART prepropeptide (CARTPT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CARTPT ( NM_004291.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004282.1 Homo sapiens CART prepropeptide (CARTPT), mRNA.

Price & Availability↑

CloneID	OHu22817
Clone ID Related Accession (Same CDS sequence)	NM_004291.3 , NM_004291.4
Accession Version	NM_004291.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	cocaine- and amphetamine-regulated transcript protein preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC143336.1, BC029882.1, AI417979.1 and CK300473.1. This sequence is a reference standard in the RefSeqGene project. On Nov 6, 2009 this sequence version replaced NM_004291.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB485130.1, SRR1660803.291833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAGCT CCCGCGTGAG GCTGCTGCCC CTCCTGGGCG CCGCCCTGCT GCTGATGCTA 
CCTCTGTTGG GTACCCGTGC CCAGGAGGAC GCCGAGCTCC AGCCCCGAGC CCTGGACATC 
TACTCTGCCG TGGATGATGC CTCCCACGAG AAGGAGCTGA TCGAAGCGCT GCAAGAAGTC 
TTGAAGAAGC TCAAGAGTAA ACGTGTTCCC ATCTATGAGA AGAAGTATGG CCAAGTCCCC 
ATGTGTGACG CCGGTGAGCA GTGTGCAGTG AGGAAAGGGG CAAGGATCGG GAAGCTGTGT 
GACTGTCCCC GAGGAACCTC CTGCAATTCC TTCCTCCTGA AGTGCTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004282.1
CDS	132..482
Translation	MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEVLKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL

Target ORF information:

RefSeq Version	NM_004291.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CART prepropeptide (CARTPT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004291.3

ORF Insert Sequence:

ATGGAGAGCT CCCGCGTGAG GCTGCTGCCC CTCCTGGGCG CCGCCCTGCT GCTGATGCTA 
CCTCTGTTGG GTACCCGTGC CCAGGAGGAC GCCGAGCTCC AGCCCCGAGC CCTGGACATC 
TACTCTGCCG TGGATGATGC CTCCCACGAG AAGGAGCTGA TCGAAGCGCT GCAAGAAGTC 
TTGAAGAAGC TCAAGAGTAA ACGTGTTCCC ATCTATGAGA AGAAGTATGG CCAAGTCCCC 
ATGTGTGACG CCGGTGAGCA GTGTGCAGTG AGGAAAGGGG CAAGGATCGG GAAGCTGTGT 
GACTGTCCCC GAGGAACCTC CTGCAATTCC TTCCTCCTGA AGTGCTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CARTPT ( NM_004291.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004282.1 Homo sapiens CART prepropeptide (CARTPT), mRNA.

Price & Availability↑

CloneID	OHu22817
Clone ID Related Accession (Same CDS sequence)	NM_004291.3 , NM_004291.4
Accession Version	NM_004291.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	cocaine- and amphetamine-regulated transcript protein preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029882.1 and AI417979.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004291.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U16826.1, SRR5189652.169127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296777.5/ ENSP00000296777.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAGCT CCCGCGTGAG GCTGCTGCCC CTCCTGGGCG CCGCCCTGCT GCTGATGCTA 
CCTCTGTTGG GTACCCGTGC CCAGGAGGAC GCCGAGCTCC AGCCCCGAGC CCTGGACATC 
TACTCTGCCG TGGATGATGC CTCCCACGAG AAGGAGCTGA TCGAAGCGCT GCAAGAAGTC 
TTGAAGAAGC TCAAGAGTAA ACGTGTTCCC ATCTATGAGA AGAAGTATGG CCAAGTCCCC 
ATGTGTGACG CCGGTGAGCA GTGTGCAGTG AGGAAAGGGG CAAGGATCGG GAAGCTGTGT 
GACTGTCCCC GAGGAACCTC CTGCAATTCC TTCCTCCTGA AGTGCTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004282.1
CDS	20..370
Translation	MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEVLKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL

Target ORF information:

RefSeq Version	NM_004291.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CART prepropeptide (CARTPT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004291.4

ORF Insert Sequence:

ATGGAGAGCT CCCGCGTGAG GCTGCTGCCC CTCCTGGGCG CCGCCCTGCT GCTGATGCTA 
CCTCTGTTGG GTACCCGTGC CCAGGAGGAC GCCGAGCTCC AGCCCCGAGC CCTGGACATC 
TACTCTGCCG TGGATGATGC CTCCCACGAG AAGGAGCTGA TCGAAGCGCT GCAAGAAGTC 
TTGAAGAAGC TCAAGAGTAA ACGTGTTCCC ATCTATGAGA AGAAGTATGG CCAAGTCCCC 
ATGTGTGACG CCGGTGAGCA GTGTGCAGTG AGGAAAGGGG CAAGGATCGG GAAGCTGTGT 
GACTGTCCCC GAGGAACCTC CTGCAATTCC TTCCTCCTGA AGTGCTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Diabetologia59(9)1928-37(2016 Sep)
Abels M,Riva M,Bennet H,Ahlqvist E,Dyachok O,Nagaraj V,Shcherbina L,Fred RG,Poon W,S?rhede-Winzell M,Fadista J,Lindqvist A,Kask L,Sathanoori R,Dekker-Nitert M,Kuhar MJ,Ahr?n B,Wollheim CB,Hansson O,Tengholm A,Fex M,Renstr?m E,Groop L,Lyssenko V,Wierup N

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CARTPT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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