B3GALT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	B3GALT2
Entrez Gene ID	8707
Full Name	beta-1,3-galactosyltransferase 2
Synonyms	BETA3GALT2,GLCT2,beta3Gal-T2
General protein information	Preferred Names beta-1,3-galactosyltransferase 2 Names beta-1,3-galactosyltransferase 2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2 beta-1,3-GalTase 2 beta-3-galt2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.2
Summary	This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008].
Disorder MIM:	603018

mRNA and Protein(s)

mRNA	Protein	Name
NM_003783.3	NP_003774.1	beta-1,3-galactosyltransferase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	B3galt2	NP_001102962.1
Arabidopsis thaliana (thale cress)	GALT1	NP_174003.1
	B3GALT2	XP_001112579.1
Bos taurus (cattle)	B3GALT2	NP_001069656.1
Homo sapiens (human)	B3GALT2	NP_003774.1
Mus musculus (house mouse)	B3galt2	NP_064409.3
Danio rerio (zebrafish)	b3galt2	NP_996984.1
Xenopus tropicalis (tropical clawed frog)	LOC100487440	XP_002932191.1
Canis lupus familiaris (dog)	B3GALT2	XP_849233.1
Gallus gallus (chicken)	B3GALT2	XP_001231894.1
Pan troglodytes (chimpanzee)	B3GALT2	XP_001167219.1
Oryza sativa (rice)	Os06g0229200	NP_001057213.1

Gene Ontology
Bibliography

Related articles in PubMed

Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.
Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD
Genomics73(2)211-22(2001 Apr)

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
Amado M, Almeida R, Schwientek T, Clausen H
Biochimica et biophysica acta1473(1)35-53(1999 Dec)

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.
Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H
The Journal of biological chemistry273(21)12770-8(1998 May)

Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.
Kolbinger F, Streiff MB, Katopodis AG
The Journal of biological chemistry273(1)433-40(1998 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following B3GALT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B3GALT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31815	NM_003783.3 Latest version!	Homo sapiens beta-1,3-galactosyltransferase 2 (B3GALT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B3GALT2 ( NM_003783.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003774.1 Homo sapiens beta-1,3-galactosyltransferase 2 (B3GALT2), mRNA.

Price & Availability↑

CloneID	OHu31815
Clone ID Related Accession (Same CDS sequence)	NM_003783.3
Accession Version	NM_003783.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	beta-1,3-galactosyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA116294.1, AK314116.1 and AL390863.9. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2008 this sequence version replaced NM_003783.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.190253.1, SRR1660805.230968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367434.5/ ENSP00000356404.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTTCAGT GGAGGAGAAG ACACTGCTGC TTTGCAAAGA TGACCTGGAA TGCCAAAAGG 
TCTCTGTTCC GCACTCATCT TATTGGAGTA CTTTCTCTAG TGTTTCTTTT TGCTATGTTT 
TTGTTTTTCA ATCATCATGA CTGGCTGCCA GGCAGAGCTG GATTCAAAGA AAACCCTGTG 
ACATACACTT TCCGAGGATT TCGGTCAACA AAAAGTGAGA CAAACCACAG CTCCCTTCGG 
AACATTTGGA AAGAAACAGT CCCTCAAACC CTGAGGCCTC AAACAGCAAC TAACTCTAAT 
AACACAGACC TGTCACCACA AGGAGTTACA GGCCTGGAGA ATACACTTAG TGCCAATGGA 
AGTATTTACA ATGAAAAAGG TACTGGACAT CCAAATTCTT ACCATTTCAA ATATATTATT 
AATGAGCCTG AAAAATGCCA AGAGAAAAGT CCTTTTTTAA TACTACTAAT AGCTGCAGAG 
CCTGGACAAA TAGAAGCTAG AAGAGCTATT CGGCAAACTT GGGGCAATGA AAGTCTAGCA 
CCTGGTATTC AAATCACAAG AATATTTTTG TTGGGCTTAA GTATTAAGCT AAATGGCTAC 
CTTCAACGTG CAATACTGGA AGAAAGCAGA CAATATCATG ATATAATTCA ACAGGAATAC 
TTAGATACGT ACTATAATTT GACCATTAAA ACACTAATGG GCATGAACTG GGTTGCAACA 
TACTGTCCAC ATATTCCATA TGTTATGAAA ACTGACAGTG ACATGTTTGT CAACACTGAA 
TATTTAATCA ATAAGTTACT GAAGCCAGAT CTGCCTCCCA GACATAACTA TTTCACTGGT 
TACCTAATGC GAGGATATGC ACCCAATCGA AACAAAGATA GCAAGTGGTA CATGCCACCA 
GACCTCTACC CAAGTGAGCG TTATCCTGTC TTCTGTTCTG GAACTGGTTA TGTTTTTTCT 
GGAGATCTGG CAGAAAAGAT TTTTAAAGTT TCTTTAGGTA TCCGCCGTTT GCACTTGGAA 
GATGTATATG TAGGGATCTG TCTTGCCAAG TTGAGAATTG ATCCTGTACC CCCTCCCAAT 
GAGTTTGTGT TCAATCACTG GCGAGTCTCT TATTCGAGCT GTAAATACAG CCACCTAATT 
ACCTCTCATC AGTTCCAGCC TAGTGAACTG ATAAAATACT GGAACCATTT ACAACAAAAT 
AAGCACAATG CCTGTGCCAA CGCAGCAAAA GAAAAGGCAG GCAGGTATCG CCACCGTAAA 
CTACATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003774.1
CDS	716..1984
Translation	MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPVTYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLAPGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVATYCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRKLH

Target ORF information:

RefSeq Version	NM_003783.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,3-galactosyltransferase 2 (B3GALT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003783.3

ORF Insert Sequence:

ATGCTTCAGT GGAGGAGAAG ACACTGCTGC TTTGCAAAGA TGACCTGGAA TGCCAAAAGG 
TCTCTGTTCC GCACTCATCT TATTGGAGTA CTTTCTCTAG TGTTTCTTTT TGCTATGTTT 
TTGTTTTTCA ATCATCATGA CTGGCTGCCA GGCAGAGCTG GATTCAAAGA AAACCCTGTG 
ACATACACTT TCCGAGGATT TCGGTCAACA AAAAGTGAGA CAAACCACAG CTCCCTTCGG 
AACATTTGGA AAGAAACAGT CCCTCAAACC CTGAGGCCTC AAACAGCAAC TAACTCTAAT 
AACACAGACC TGTCACCACA AGGAGTTACA GGCCTGGAGA ATACACTTAG TGCCAATGGA 
AGTATTTACA ATGAAAAAGG TACTGGACAT CCAAATTCTT ACCATTTCAA ATATATTATT 
AATGAGCCTG AAAAATGCCA AGAGAAAAGT CCTTTTTTAA TACTACTAAT AGCTGCAGAG 
CCTGGACAAA TAGAAGCTAG AAGAGCTATT CGGCAAACTT GGGGCAATGA AAGTCTAGCA 
CCTGGTATTC AAATCACAAG AATATTTTTG TTGGGCTTAA GTATTAAGCT AAATGGCTAC 
CTTCAACGTG CAATACTGGA AGAAAGCAGA CAATATCATG ATATAATTCA ACAGGAATAC 
TTAGATACGT ACTATAATTT GACCATTAAA ACACTAATGG GCATGAACTG GGTTGCAACA 
TACTGTCCAC ATATTCCATA TGTTATGAAA ACTGACAGTG ACATGTTTGT CAACACTGAA 
TATTTAATCA ATAAGTTACT GAAGCCAGAT CTGCCTCCCA GACATAACTA TTTCACTGGT 
TACCTAATGC GAGGATATGC ACCCAATCGA AACAAAGATA GCAAGTGGTA CATGCCACCA 
GACCTCTACC CAAGTGAGCG TTATCCTGTC TTCTGTTCTG GAACTGGTTA TGTTTTTTCT 
GGAGATCTGG CAGAAAAGAT TTTTAAAGTT TCTTTAGGTA TCCGCCGTTT GCACTTGGAA 
GATGTATATG TAGGGATCTG TCTTGCCAAG TTGAGAATTG ATCCTGTACC CCCTCCCAAT 
GAGTTTGTGT TCAATCACTG GCGAGTCTCT TATTCGAGCT GTAAATACAG CCACCTAATT 
ACCTCTCATC AGTTCCAGCC TAGTGAACTG ATAAAATACT GGAACCATTT ACAACAAAAT 
AAGCACAATG CCTGTGCCAA CGCAGCAAAA GAAAAGGCAG GCAGGTATCG CCACCGTAAA 
CTACATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.
Genomics73(2)211-22(2001 Apr)
Sood R,Bonner TI,Makalowska I,Stephan DA,Robbins CM,Connors TD,Morgenbesser SD,Su K,Faruque MU,Pinkett H,Graham C,Baxevanis AD,Klinger KW,Landes GM,Trent JM,Carpten JD

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
Biochimica et biophysica acta1473(1)35-53(1999 Dec)
Amado M,Almeida R,Schwientek T,Clausen H

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.
The Journal of biological chemistry273(21)12770-8(1998 May)
Amado M,Almeida R,Carneiro F,Levery SB,Holmes EH,Nomoto M,Hollingsworth MA,Hassan H,Schwientek T,Nielsen PA,Bennett EP,Clausen H

Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.
The Journal of biological chemistry273(1)433-40(1998 Jan)
Kolbinger F,Streiff MB,Katopodis AG

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B3GALT2 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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