DUSP11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DUSP11
Entrez Gene ID	8446
Full Name	dual specificity phosphatase 11
Synonyms	PIR1
General protein information	Preferred Names dual specificity phosphatase 11 Names RNA/RNP complex-1-interacting phosphatase RNA/RNP complex 1-interacting RNA/RNP complex-interacting phosphatase dual specificity protein phosphatase 11 phosphatase that interacts with RNA/RNP complex 1 serine/threonine specific protein phosphatase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.1
Summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008].
Disorder MIM:	603092

mRNA and Protein(s)

mRNA	Protein	Name
NM_003584.2	NP_003575.2	RNA/RNP complex-1-interacting phosphatase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DUSP11	XP_515550.2
	DUSP11	XP_001105622.2
Danio rerio (zebrafish)	dusp11	NP_001017722.1
Canis lupus familiaris (dog)	DUSP11	XP_005630616.1
Rattus norvegicus (Norway rat)	LOC100911499	XP_006236878.1
Bos taurus (cattle)	LOC786531	XP_005212571.1
Caenorhabditis elegans (roundworm)	pir-1	NP_495959.1
Homo sapiens (human)	DUSP11	NP_003575.2
Mus musculus (house mouse)	Dusp11	NP_082375.4
Rattus norvegicus (Norway rat)	Dusp11	NP_001020821.1

Gene Ontology
Bibliography

Related articles in PubMed

Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells.
Carrillo D, Mu?oz JP, Huerta H, Leal G, Corval?n A, Le?n O, Calaf GM, Urz?a U, Boccardo E, Tapia JC, Aguayo F
Open biology7(11)(2017 Nov)

DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells.
Burke JM, Sullivan CS
RNA biology14(11)1457-1465(2017 Nov)

DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.
Burke JM, Kincaid RP, Nottingham RM, Lambowitz AM, Sullivan CS
Genes & development30(18)2076-2092(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DUSP11 converts the 5' triphosphate of miRNA precursors to a 5' monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5' monophosphate-dependent strand selection mechanism.
Title: DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.

the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution.
Title: Structure of human PIR1, an atypical dual-specificity phosphatase.

results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68
Title: Isolation and characterization of DUSP11, a novel p53 target gene.

The following DUSP11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DUSP11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu16437	NM_003584.2 Latest version!	Homo sapiens dual specificity phosphatase 11 (DUSP11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DUSP11 ( NM_003584.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003575.2 Homo sapiens dual specificity phosphatase 11 (DUSP11), mRNA.

Price & Availability↑

CloneID	OHu16437
Clone ID Related Accession (Same CDS sequence)	NM_003584.2
Accession Version	NM_003584.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	RNA/RNP complex-1-interacting phosphatase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP359552.1, BP349009.1, AF023917.1 and BC000346.2. On Sep 19, 2008 this sequence version replaced NM_003584.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000346.2, SRR1163655.469368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCAATA GCGAGACGCT GGAGCGCGGC GTAGGTGGCT GCCGAGTCTT TTCCTGTTTA 
GGGTCTTATC CTGGCATTGA GGGCGCCGGA CTGGCGCTTT TGGCCGACTT GGCATTGGGT 
GGGCGGCTTC TTGGGACCCA CATGAGCCAG TGGCATCATC CCCGCAGTGG CTGGGGCCGG 
AGACGCGACT TTTCAGGACG CTCCTCAGCC AAGAAGAAGG GCGGAAACCA CATCCCCGAA 
AGGTGGAAAG ACTATCTCCC AGTTGGACAG CGGATGCCTG GGACTCGTTT CATTGCTTTC 
AAAGTTCCTT TGCAAAAGAG TTTTGAAAAG AAACTTGCTC CAGAAGAATG CTTTTCCCCT 
TTGGATCTTT TTAACAAAAT CCGAGAACAA AATGAAGAAC TTGGACTGAT TATTGATTTA 
ACATATACTC AACGCTATTA TAAACCAGAG GATTTGCCAG AAACTGTTCC TTACTTAAAA 
ATTTTTACAG TTGGACATCA AGTGCCTGAT GATGAGACTA TTTTTAAATT CAAACACGCT 
GTTAATGGGT TTTTGAAAGA AAATAAAGAT AATGATAAAC TTATTGGTGT CCACTGTACC 
CATGGTTTAA ACAGGACTGG CTACCTCATT TGCAGATATT TGATTGATGT AGAAGGCGTG 
AGGCCAGATG ATGCAATTGA ATTATTCAAT AGGTGCCGGG GACATTGCTT AGAAAGACAA 
AACTACATTG AAGACCTTCA GAATGGTCCT ATCAGAAAGA ATTGGAATTC CAGTGTACCC 
AGGTCAAGTG ATTTTGAAGA CTCAGCACAT CTCATGCAAC CAGTCCACAA TAAGCCTGTT 
AAACAAGGAC CTAGGTATAA TCTACATCAG ATCCAGGGTC ACTCAGCTCC TCGACATTTC 
CACACCCAGA CCCAAAGTTT GCAACAATCA GTCAGAAAAT TTTCAGAGAA TCCACATGTT 
TACCAGAGAC ACCATCTCCC TCCTCCTGGT CCCCCTGGAG AGGACTATTC ACACAGGAGG 
TATTCTTGGA ATGTGAAGCC CAATGCCAGT CGGGCAGCCC AGGATAGAAG AAGGTGGTAT 
CCTTATAATT ACTCCAGACT CTCCTATCCA GCCTGTTGGG AATGGACCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003575.2
CDS	43..1176
Translation	MRNSETLERGVGGCRVFSCLGSYPGIEGAGLALLADLALGGRLLGTHMSQWHHPRSGWGRRRDFSGRSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKSFEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQNGPIRKNWNSSVPRSSDFEDSAHLMQPVHNKPVKQGPRYNLHQIQGHSAPRHFHTQTQSLQQSVRKFSENPHVYQRHHLPPPGPPGEDYSHRRYSWNVKPNASRAAQDRRRWYPYNYSRLSYPACWEWTQ

Target ORF information:

RefSeq Version	NM_003584.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 11 (DUSP11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003584.2

ORF Insert Sequence:

ATGCGCAATA GCGAGACGCT GGAGCGCGGC GTAGGTGGCT GCCGAGTCTT TTCCTGTTTA 
GGGTCTTATC CTGGCATTGA GGGCGCCGGA CTGGCGCTTT TGGCCGACTT GGCATTGGGT 
GGGCGGCTTC TTGGGACCCA CATGAGCCAG TGGCATCATC CCCGCAGTGG CTGGGGCCGG 
AGACGCGACT TTTCAGGACG CTCCTCAGCC AAGAAGAAGG GCGGAAACCA CATCCCCGAA 
AGGTGGAAAG ACTATCTCCC AGTTGGACAG CGGATGCCTG GGACTCGTTT CATTGCTTTC 
AAAGTTCCTT TGCAAAAGAG TTTTGAAAAG AAACTTGCTC CAGAAGAATG CTTTTCCCCT 
TTGGATCTTT TTAACAAAAT CCGAGAACAA AATGAAGAAC TTGGACTGAT TATTGATTTA 
ACATATACTC AACGCTATTA TAAACCAGAG GATTTGCCAG AAACTGTTCC TTACTTAAAA 
ATTTTTACAG TTGGACATCA AGTGCCTGAT GATGAGACTA TTTTTAAATT CAAACACGCT 
GTTAATGGGT TTTTGAAAGA AAATAAAGAT AATGATAAAC TTATTGGTGT CCACTGTACC 
CATGGTTTAA ACAGGACTGG CTACCTCATT TGCAGATATT TGATTGATGT AGAAGGCGTG 
AGGCCAGATG ATGCAATTGA ATTATTCAAT AGGTGCCGGG GACATTGCTT AGAAAGACAA 
AACTACATTG AAGACCTTCA GAATGGTCCT ATCAGAAAGA ATTGGAATTC CAGTGTACCC 
AGGTCAAGTG ATTTTGAAGA CTCAGCACAT CTCATGCAAC CAGTCCACAA TAAGCCTGTT 
AAACAAGGAC CTAGGTATAA TCTACATCAG ATCCAGGGTC ACTCAGCTCC TCGACATTTC 
CACACCCAGA CCCAAAGTTT GCAACAATCA GTCAGAAAAT TTTCAGAGAA TCCACATGTT 
TACCAGAGAC ACCATCTCCC TCCTCCTGGT CCCCCTGGAG AGGACTATTC ACACAGGAGG 
TATTCTTGGA ATGTGAAGCC CAATGCCAGT CGGGCAGCCC AGGATAGAAG AAGGTGGTAT 
CCTTATAATT ACTCCAGACT CTCCTATCCA GCCTGTTGGG AATGGACCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells.
Open biology7(11)(2017 Nov)
Carrillo D,Mu?oz JP,Huerta H,Leal G,Corval?n A,Le?n O,Calaf GM,Urz?a U,Boccardo E,Tapia JC,Aguayo F

DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells.
RNA biology14(11)1457-1465(2017 Nov)
Burke JM,Sullivan CS

DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.
Genes & development30(18)2076-2092(2016 Sep)
Burke JM,Kincaid RP,Nottingham RM,Lambowitz AM,Sullivan CS

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DUSP11 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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