RAB33B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB33B
Entrez Gene ID	83452
Full Name	RAB33B, member RAS oncogene family
Synonyms	SMC2
General protein information	Preferred Names RAB33B, member RAS oncogene family Names ras-related protein Rab-33B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q31.1
Summary	This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016].
Disorder MIM:	605950
Disorder Html:	Smith-McCort dysplasia 2, 615222 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_031296.1	NP_112586.1	ras-related protein Rab-33B
XM_011532299.1	XP_011530601.1	ras-related protein Rab-33B isoform X1
NM_031296.2	NP_112586.1	ras-related protein Rab-33B
NM_031296.3	NP_112586.1	ras-related protein Rab-33B

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rab33b	NP_001102414.1
	RAB33B	XP_001088193.1
Canis lupus familiaris (dog)	RAB33B	XP_003639751.1
Homo sapiens (human)	RAB33B	NP_112586.1
Bos taurus (cattle)	RAB33B	NP_001076909.1
Mus musculus (house mouse)	Rab33b	NP_058554.1
Gallus gallus (chicken)	RAB33B	NP_001008466.1
Caenorhabditis elegans (roundworm)	rab-33	NP_499314.1
Pan troglodytes (chimpanzee)	RAB33B	XP_517445.2
Danio rerio (zebrafish)	LOC572060	NP_001155979.1
Xenopus tropicalis (tropical clawed frog)	rab33b	NP_001008109.1

Gene Ontology
Bibliography

Related articles in PubMed

Rab33B Controls Hepatitis B Virus Assembly by Regulating Core Membrane Association and Nucleocapsid Processing.
Bartusch C, D?ring T, Prange R
Viruses9(6)(2017 Jun)

Additional three patients with Smith-McCort dysplasia due to novel RAB33B mutations.
Salian S, Cho TJ, Phadke SR, Gowrishankar K, Bhavani GS, Shukla A, Jagadeesh S, Kim OH, Nishimura G, Girisha KM
American journal of medical genetics. Part A173(3)588-595(2017 Mar)

A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells.
Panarella A, Bexiga MG, Galea G, O' Neill ED, Salvati A, Dawson KA, Simpson JC
Scientific reports628865(2016 Jul)

Deciphering the role of Atg5 in nucleotide dependent interaction of Rab33B with the dimeric complex, Atg5-Atg16L1.
Chandra M, Saran R, Datta S
Biochemical and biophysical research communications473(1)8-16(2016 Apr)

Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve--Melchior--Clausen locus.
Alshammari MJ, Al-Otaibi L, Alkuraya FS
Journal of medical genetics49(7)455-61(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here we present three SMC patients with four novel pathogenic variants in RAB33B, including homozygosity for c.211C>T (p.R71*), homozygosity for c.365T>C (p.F122S), and compound heterozygosity for c.48delCGGGGCAG (p.G17Vfs*58) and c.490C>T (p.Q164*).
Title: Additional three patients with Smith-McCort dysplasia due to novel RAB33B mutations.

Arg-24 of Atg16L1 is crucial for its interaction with Atg5 which has implications in the binding of the dimeric complex to Rab33B
Title: Deciphering the role of Atg5 in nucleotide dependent interaction of Rab33B with the dimeric complex, Atg5-Atg16L1.

Analysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability.
Title: Rab33B and its autophagic Atg5/12/16L1 effector assist in hepatitis B virus naked capsid formation and release.

Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.
Title: Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.

A second autosomal recessive locus for Dyggve-Melchior-Clausen syndrome exists on 4q31.1 and that Rab protein-encoding gene, RAB33B, is the likely disease gene in that locus.
Title: Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve--Melchior--Clausen locus.

The following RAB33B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB33B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29415	NM_031296.3 Latest version!	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu73060	XM_011532299.1 Latest version!	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu29415	NM_031296.1	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29415	NM_031296.2	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB33B ( NM_031296.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_112586.1 Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.

Price & Availability↑

CloneID	OHu29415
Clone ID Related Accession (Same CDS sequence)	NM_031296.1 , NM_031296.2 , NM_031296.3
Accession Version	NM_031296.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ras-related protein Rab-33B
Comment

ATGGCTGAGG AGATGGAGTC GTCGCTCGAG GCAAGCTTTT CGTCCAGCGG GGCAGTGTCA 
GGGGCCTCAG GGTTTTTGCC TCCTGCCCGC TCCCGCATCT TCAAGATAAT CGTGATCGGC 
GACTCCAATG TGGGCAAGAC ATGCCTGACC TACCGCTTCT GCGCTGGCCG CTTCCCCGAC 
CGCACCGAGG CCACGATAGG GGTGGATTTC CGAGAACGAG CGGTGGAGAT TGATGGGGAG 
CGCATCAAGA TCCAGCTATG GGACACAGCA GGACAAGAAC GATTCAGAAA GAGCATGGTT 
CAGCACTACT ACAGAAATGT ACATGCTGTT GTCTTCGTGT ATGATATGAC CAACATGGCT 
AGTTTTCATA GCCTACCATC TTGGATAGAA GAATGCAAAC AACATTTGCT AGCCAATGAT 
ATACCACGGA TTCTTGTTGG AAATAAATGT GACTTGAGAA GTGCCATACA GGTACCCACA 
GACTTGGCAC AAAAATTTGC TGACACACAC AGTATGCCTT TGTTTGAAAC GTCTGCTAAA 
AACCCCAATG ATAATGACCA TGTGGAAGCT ATATTTATGA CCTTGGCTCA TAAGCTTAAG 
AGCCACAAAC CATTAATGCT TAGTCAGCCC CCTGATAATG GAATTATCCT GAAGCCTGAA 
CCAAAGCCTG CAATGACGTG CTGGTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112586.1
Translation	MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC

Target ORF information:

RefSeq Version	NM_031296.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031296.1

ORF Insert Sequence:

ATGGCTGAGG AGATGGAGTC GTCGCTCGAG GCAAGCTTTT CGTCCAGCGG GGCAGTGTCA 
GGGGCCTCAG GGTTTTTGCC TCCTGCCCGC TCCCGCATCT TCAAGATAAT CGTGATCGGC 
GACTCCAATG TGGGCAAGAC ATGCCTGACC TACCGCTTCT GCGCTGGCCG CTTCCCCGAC 
CGCACCGAGG CCACGATAGG GGTGGATTTC CGAGAACGAG CGGTGGAGAT TGATGGGGAG 
CGCATCAAGA TCCAGCTATG GGACACAGCA GGACAAGAAC GATTCAGAAA GAGCATGGTT 
CAGCACTACT ACAGAAATGT ACATGCTGTT GTCTTCGTGT ATGATATGAC CAACATGGCT 
AGTTTTCATA GCCTACCATC TTGGATAGAA GAATGCAAAC AACATTTGCT AGCCAATGAT 
ATACCACGGA TTCTTGTTGG AAATAAATGT GACTTGAGAA GTGCCATACA GGTACCCACA 
GACTTGGCAC AAAAATTTGC TGACACACAC AGTATGCCTT TGTTTGAAAC GTCTGCTAAA 
AACCCCAATG ATAATGACCA TGTGGAAGCT ATATTTATGA CCTTGGCTCA TAAGCTTAAG 
AGCCACAAAC CATTAATGCT TAGTCAGCCC CCTGATAATG GAATTATCCT GAAGCCTGAA 
CCAAAGCCTG CAATGACGTG CTGGTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB33B ( NM_031296.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_112586.1 Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.

Price & Availability↑

CloneID	OHu29415
Clone ID Related Accession (Same CDS sequence)	NM_031296.1 , NM_031296.2 , NM_031296.3
Accession Version	NM_031296.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	ras-related protein Rab-33B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136904.1 and AF350420.1. This sequence is a reference standard in the RefSeqGene project. On Dec 9, 2015 this sequence version replaced NM_031296.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL136904.1, AF350420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGG AGATGGAGTC GTCGCTCGAG GCAAGCTTTT CGTCCAGCGG GGCAGTGTCA 
GGGGCCTCAG GGTTTTTGCC TCCTGCCCGC TCCCGCATCT TCAAGATAAT CGTGATCGGC 
GACTCCAATG TGGGCAAGAC ATGCCTGACC TACCGCTTCT GCGCTGGCCG CTTCCCCGAC 
CGCACCGAGG CCACGATAGG GGTGGATTTC CGAGAACGAG CGGTGGAGAT TGATGGGGAG 
CGCATCAAGA TCCAGCTATG GGACACAGCA GGACAAGAAC GATTCAGAAA GAGCATGGTT 
CAGCACTACT ACAGAAATGT ACATGCTGTT GTCTTCGTGT ATGATATGAC CAACATGGCT 
AGTTTTCATA GCCTACCATC TTGGATAGAA GAATGCAAAC AACATTTGCT AGCCAATGAT 
ATACCACGGA TTCTTGTTGG AAATAAATGT GACTTGAGAA GTGCCATACA GGTACCCACA 
GACTTGGCAC AAAAATTTGC TGACACACAC AGTATGCCTT TGTTTGAAAC GTCTGCTAAA 
AACCCCAATG ATAATGACCA TGTGGAAGCT ATATTTATGA CCTTGGCTCA TAAGCTTAAG 
AGCCACAAAC CATTAATGCT TAGTCAGCCC CCTGATAATG GAATTATCCT GAAGCCTGAA 
CCAAAGCCTG CAATGACGTG CTGGTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112586.1
CDS	390..1079
Translation	MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC

Target ORF information:

RefSeq Version	NM_031296.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031296.2

ORF Insert Sequence:

ATGGCTGAGG AGATGGAGTC GTCGCTCGAG GCAAGCTTTT CGTCCAGCGG GGCAGTGTCA 
GGGGCCTCAG GGTTTTTGCC TCCTGCCCGC TCCCGCATCT TCAAGATAAT CGTGATCGGC 
GACTCCAATG TGGGCAAGAC ATGCCTGACC TACCGCTTCT GCGCTGGCCG CTTCCCCGAC 
CGCACCGAGG CCACGATAGG GGTGGATTTC CGAGAACGAG CGGTGGAGAT TGATGGGGAG 
CGCATCAAGA TCCAGCTATG GGACACAGCA GGACAAGAAC GATTCAGAAA GAGCATGGTT 
CAGCACTACT ACAGAAATGT ACATGCTGTT GTCTTCGTGT ATGATATGAC CAACATGGCT 
AGTTTTCATA GCCTACCATC TTGGATAGAA GAATGCAAAC AACATTTGCT AGCCAATGAT 
ATACCACGGA TTCTTGTTGG AAATAAATGT GACTTGAGAA GTGCCATACA GGTACCCACA 
GACTTGGCAC AAAAATTTGC TGACACACAC AGTATGCCTT TGTTTGAAAC GTCTGCTAAA 
AACCCCAATG ATAATGACCA TGTGGAAGCT ATATTTATGA CCTTGGCTCA TAAGCTTAAG 
AGCCACAAAC CATTAATGCT TAGTCAGCCC CCTGATAATG GAATTATCCT GAAGCCTGAA 
CCAAAGCCTG CAATGACGTG CTGGTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB33B ( NM_031296.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112586.1 Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.

Price & Availability↑

CloneID	OHu29415
Clone ID Related Accession (Same CDS sequence)	NM_031296.1 , NM_031296.2 , NM_031296.3
Accession Version	NM_031296.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	ras-related protein Rab-33B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136904.1, AF350420.1 and AC114743.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_031296.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.249893.1, SRR1803614.60934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305626.6/ ENSP00000306496.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGG AGATGGAGTC GTCGCTCGAG GCAAGCTTTT CGTCCAGCGG GGCAGTGTCA 
GGGGCCTCAG GGTTTTTGCC TCCTGCCCGC TCCCGCATCT TCAAGATAAT CGTGATCGGC 
GACTCCAATG TGGGCAAGAC ATGCCTGACC TACCGCTTCT GCGCTGGCCG CTTCCCCGAC 
CGCACCGAGG CCACGATAGG GGTGGATTTC CGAGAACGAG CGGTGGAGAT TGATGGGGAG 
CGCATCAAGA TCCAGCTATG GGACACAGCA GGACAAGAAC GATTCAGAAA GAGCATGGTT 
CAGCACTACT ACAGAAATGT ACATGCTGTT GTCTTCGTGT ATGATATGAC CAACATGGCT 
AGTTTTCATA GCCTACCATC TTGGATAGAA GAATGCAAAC AACATTTGCT AGCCAATGAT 
ATACCACGGA TTCTTGTTGG AAATAAATGT GACTTGAGAA GTGCCATACA GGTACCCACA 
GACTTGGCAC AAAAATTTGC TGACACACAC AGTATGCCTT TGTTTGAAAC GTCTGCTAAA 
AACCCCAATG ATAATGACCA TGTGGAAGCT ATATTTATGA CCTTGGCTCA TAAGCTTAAG 
AGCCACAAAC CATTAATGCT TAGTCAGCCC CCTGATAATG GAATTATCCT GAAGCCTGAA 
CCAAAGCCTG CAATGACGTG CTGGTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112586.1
CDS	76..765
Translation	MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC

Target ORF information:

RefSeq Version	NM_031296.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031296.3

ORF Insert Sequence:

ATGGCTGAGG AGATGGAGTC GTCGCTCGAG GCAAGCTTTT CGTCCAGCGG GGCAGTGTCA 
GGGGCCTCAG GGTTTTTGCC TCCTGCCCGC TCCCGCATCT TCAAGATAAT CGTGATCGGC 
GACTCCAATG TGGGCAAGAC ATGCCTGACC TACCGCTTCT GCGCTGGCCG CTTCCCCGAC 
CGCACCGAGG CCACGATAGG GGTGGATTTC CGAGAACGAG CGGTGGAGAT TGATGGGGAG 
CGCATCAAGA TCCAGCTATG GGACACAGCA GGACAAGAAC GATTCAGAAA GAGCATGGTT 
CAGCACTACT ACAGAAATGT ACATGCTGTT GTCTTCGTGT ATGATATGAC CAACATGGCT 
AGTTTTCATA GCCTACCATC TTGGATAGAA GAATGCAAAC AACATTTGCT AGCCAATGAT 
ATACCACGGA TTCTTGTTGG AAATAAATGT GACTTGAGAA GTGCCATACA GGTACCCACA 
GACTTGGCAC AAAAATTTGC TGACACACAC AGTATGCCTT TGTTTGAAAC GTCTGCTAAA 
AACCCCAATG ATAATGACCA TGTGGAAGCT ATATTTATGA CCTTGGCTCA TAAGCTTAAG 
AGCCACAAAC CATTAATGCT TAGTCAGCCC CCTGATAATG GAATTATCCT GAAGCCTGAA 
CCAAAGCCTG CAATGACGTG CTGGTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB33B ( XM_011532299.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530601.1 Homo sapiens RAB33B, member RAS oncogene family (RAB33B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu73060
Clone ID Related Accession (Same CDS sequence)	XM_011532299.1
Accession Version	XM_011532299.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ras-related protein Rab-33B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCACATC CTCAGCGGCA AGCTGAAGAA ACCTGTCTCC TCTCTGGGGC GACCAAACGA 
TACGTCGATG CCGGAACCGA CCCGACGCCG GAGCCGTCGG CTCCGTCCTT ACCGTTGCTC 
TCCAGTTTGG GGCGGGTCGG GGGAATGGCT GAGGAGATGG AGTCGTCGCT CGAGGCAAGC 
TTTTCGTCCA GCGGGGCAGT GTCAGGGGCC TCAGGGTTTT TGCCTCCTGC CCGCTCCCGC 
ATCTTCAAGA TAATCGTGAT CGGCGACTCC AATGTGGGCA AGACATGCCT GACCTACCGC 
TTCTGCGCTG GCCGCTTCCC CGACCGCACC GAGGCCACGA TAGGGGTGGA TTTCCGAGAA 
CGAGCGGTGG AGATTGATGG GGAGCGCATC AAGATCCAGC TATGGGACAC AGCAGGACAA 
GAACGATTCA GAAAGAGCAT GGTTCAGCAC TACTACAGAA ATGTACATGC TGTTGTCTTC 
GTGTATGATA TGACCAACAT GGCTAGTTTT CATAGCCTAC CATCTTGGAT AGAAGAATGC 
AAACAACATT TGCTAGCCAA TGATATACCA CGGATTCTTG TTGGAAATAA ATGTGACTTG 
AGAAGTGCCA TACAGGTACC CACAGACTTG GCACAAAAAT TTGCTGACAC ACACAGTATG 
CCTTTGTTTG AAACGTCTGC TAAAAACCCC AATGATAATG ACCATGTGGA AGCTATATTT 
ATGACCTTGG CTCATAAGCT TAAGAGCCAC AAACCATTAA TGCTTAGTCA GCCCCCTGAT 
AATGGAATTA TCCTGAAGCC TGAACCAAAG CCTGCAATGA CGTGCTGGTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530601.1
CDS	342..1175
Translation	MPHPQRQAEETCLLSGATKRYVDAGTDPTPEPSAPSLPLLSSLGRVGGMAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC

Target ORF information:

RefSeq Version	XM_011532299.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB33B, member RAS oncogene family (RAB33B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532299.1

ORF Insert Sequence:

ATGCCACATC CTCAGCGGCA AGCTGAAGAA ACCTGTCTCC TCTCTGGGGC GACCAAACGA 
TACGTCGATG CCGGAACCGA CCCGACGCCG GAGCCGTCGG CTCCGTCCTT ACCGTTGCTC 
TCCAGTTTGG GGCGGGTCGG GGGAATGGCT GAGGAGATGG AGTCGTCGCT CGAGGCAAGC 
TTTTCGTCCA GCGGGGCAGT GTCAGGGGCC TCAGGGTTTT TGCCTCCTGC CCGCTCCCGC 
ATCTTCAAGA TAATCGTGAT CGGCGACTCC AATGTGGGCA AGACATGCCT GACCTACCGC 
TTCTGCGCTG GCCGCTTCCC CGACCGCACC GAGGCCACGA TAGGGGTGGA TTTCCGAGAA 
CGAGCGGTGG AGATTGATGG GGAGCGCATC AAGATCCAGC TATGGGACAC AGCAGGACAA 
GAACGATTCA GAAAGAGCAT GGTTCAGCAC TACTACAGAA ATGTACATGC TGTTGTCTTC 
GTGTATGATA TGACCAACAT GGCTAGTTTT CATAGCCTAC CATCTTGGAT AGAAGAATGC 
AAACAACATT TGCTAGCCAA TGATATACCA CGGATTCTTG TTGGAAATAA ATGTGACTTG 
AGAAGTGCCA TACAGGTACC CACAGACTTG GCACAAAAAT TTGCTGACAC ACACAGTATG 
CCTTTGTTTG AAACGTCTGC TAAAAACCCC AATGATAATG ACCATGTGGA AGCTATATTT 
ATGACCTTGG CTCATAAGCT TAAGAGCCAC AAACCATTAA TGCTTAGTCA GCCCCCTGAT 
AATGGAATTA TCCTGAAGCC TGAACCAAAG CCTGCAATGA CGTGCTGGTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab33B Controls Hepatitis B Virus Assembly by Regulating Core Membrane Association and Nucleocapsid Processing.
Viruses9(6)(2017 Jun)
Bartusch C,D?ring T,Prange R

Additional three patients with Smith-McCort dysplasia due to novel RAB33B mutations.
American journal of medical genetics. Part A173(3)588-595(2017 Mar)
Salian S,Cho TJ,Phadke SR,Gowrishankar K,Bhavani GS,Shukla A,Jagadeesh S,Kim OH,Nishimura G,Girisha KM

A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells.
Scientific reports628865(2016 Jul)
Panarella A,Bexiga MG,Galea G,O' Neill ED,Salvati A,Dawson KA,Simpson JC

Deciphering the role of Atg5 in nucleotide dependent interaction of Rab33B with the dimeric complex, Atg5-Atg16L1.
Biochemical and biophysical research communications473(1)8-16(2016 Apr)
Chandra M,Saran R,Datta S

Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve--Melchior--Clausen locus.
Journal of medical genetics49(7)455-61(2012 Jul)
Alshammari MJ,Al-Otaibi L,Alkuraya FS

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RAB33B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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