CFHR5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CFHR5
Entrez Gene ID	81494
Full Name	complement factor H related 5
Synonyms	CFHL5,CFHR5D,FHR-5,FHR5
General protein information	Preferred Names complement factor H related 5 Names complement factor H-related protein 5 factor H-related protein 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.3
Summary	This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010].
Disorder MIM:	608593
Disorder Html:	Nephropathy due to CFHR5 deficiency, 614809 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_030787.4	NP_110414.1	complement factor H-related protein 5 precursor
NM_030787.3	NP_110414.1	complement factor H-related protein 5 precursor
XM_011510020.2	XP_011508322.1	complement factor H-related protein 5 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CFHR5	NP_110414.1
Pan troglodytes (chimpanzee)	CFHR5	XP_514078.3
Canis lupus familiaris (dog)	CFHR5	XP_547381.3

Gene Ontology
Bibliography

Related articles in PubMed

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.
Togarsimalemath SK, Sethi SK, Duggal R, Le Quintrec M, Jha P, Daniel R, Gonnet F, Bansal S, Roumenina LT, Fremeaux-Bacchi V, Kher V, Dragon-Durey MA
Kidney international92(4)876-887(2017 Oct)

Circulating complement factor H-related proteins 1?and 5 correlate with disease activity in IgA nephropathy.
Medjeral-Thomas NR, Lomax-Browne HJ, Beckwith H, Willicombe M, McLean AG, Brookes P, Pusey CD, Falchi M, Cook HT, Pickering MC
Kidney international92(4)942-952(2017 Oct)

Rare Variants in the Complement Factor H-Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy.
Zhai YL, Meng SJ, Zhu L, Shi SF, Wang SX, Liu LJ, Lv JC, Yu F, Zhao MH, Zhang H
Journal of the American Society of Nephrology : JASN27(9)2894-905(2016 Sep)

Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.
Hughes AE, Bridgett S, Meng W, Li M, Curcio CA, Stambolian D, Bradley DT
Investigative ophthalmology & visual science57(6)2763-9(2016 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgA Nephropathy, which suggests that CFHR5 is an IgA Nephropathy susceptibility gene
Title: Rare Variants in the Complement Factor H-Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy.

Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR5]
Title: Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.

Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.
Title: Factor H-related proteins determine complement-activating surfaces.

In this study, we identify pentraxin 3 (PTX3) as a novel ligand of CFHR5
Title: Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.

A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay.
Title: Complement factor H-related hybrid protein deregulates complement in dense deposit disease.

The following CFHR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CFHR5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22543	NM_030787.4 Latest version!	Homo sapiens complement factor H related 5 (CFHR5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu72899	XM_011510020.2 Latest version!	Homo sapiens complement factor H related 5 (CFHR5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu22543	NM_030787.3	Homo sapiens complement factor H related 5 (CFHR5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CFHR5 ( NM_030787.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_110414.1 Homo sapiens complement factor H related 5 (CFHR5), mRNA.

Price & Availability↑

CloneID	OHu22543
Clone ID Related Accession (Same CDS sequence)	NM_030787.4 , NM_030787.3
Accession Version	NM_030787.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1710bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	complement factor H-related protein 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA638244.1, BC111773.1, BG568555.1, AF295327.1 and AL353809.20. On Aug 31, 2019 this sequence version replaced NM_030787.3. Sequence Note: An in-frame AUG is located 24 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF295327.1, BC111773.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGTTGCTCT TATTCAGTGT AATCCTAATC TCATGGGTAT CCACTGTTGG GGGAGAAGGA 
ACACTTTGTG ATTTTCCAAA AATACACCAT GGATTTCTGT ATGATGAAGA AGATTATAAC 
CCTTTTTCCC AAGTTCCTAC AGGGGAAGTT TTCTATTACT CCTGTGAATA TAATTTTGTG 
TCTCCTTCAA AATCCTTTTG GACTCGCATA ACATGCACAG AAGAAGGATG GTCACCAACA 
CCGAAGTGTC TCAGAATGTG TTCCTTTCCT TTTGTGAAAA ATGGTCATTC TGAATCTTCA 
GGACTAATAC ATCTGGAAGG TGATACTGTA CAAATTATTT GCAACACAGG ATACAGCCTT 
CAAAACAATG AGAAAAACAT TTCGTGTGTA GAACGGGGCT GGTCCACTCC TCCCATATGC 
AGCTTCACTA AAGGAGAATG TCATGTTCCA ATTTTAGAAG CCAATGTAGA TGCTCAGCCA 
AAAAAAGAAA GCTACAAAGT TGGAGACGTG TTGAAATTCT CCTGCAGAAA AAATCTTATA 
AGAGTTGGAT CAGACTCAGT TCAATGTTAC CAATTTGGGT GGTCACCTAA CTTTCCAACA 
TGCAAAGGAC AAGTACGATC ATGTGGTCCA CCTCCTCAAC TCTCCAATGG TGAAGTTAAG 
GAGATAAGAA AAGAGGAATA TGGACACAAT GAAGTAGTGG AATATGATTG CAATCCTAAT 
TTTATAATAA ACGGGCCTAA GAAAATACAA TGTGTGGATG GAGAATGGAC AACTTTACCC 
ACTTGTGTTG AACAAGTGAA AACATGTGGA TACATACCTG AACTCGAGTA CGGTTATGTT 
CAGCCGTCTG TCCCTCCCTA TCAACATGGA GTTTCAGTCG AGGTGAATTG CAGAAATGAA 
TATGCAATGA TTGGAAATAA CATGATTACC TGTATTAATG GAATATGGAC AGAGCTTCCT 
ATGTGTGTTG CAACACACCA ACTTAAGAGG TGCAAAATAG CAGGAGTTAA TATAAAAACA 
TTACTCAAGC TATCTGGGAA AGAATTTAAT CATAATTCTA GAATACGTTA CAGATGTTCA 
GACATCTTCA GATACAGGCA CTCAGTCTGT ATAAACGGGA AATGGAATCC TGAAGTAGAC 
TGCACAGAAA AAAGGGAACA ATTCTGCCCA CCGCCACCTC AGATACCTAA TGCTCAGAAT 
ATGACAACCA CAGTGAATTA TCAGGATGGA GAAAAAGTAG CTGTTCTCTG TAAAGAAAAC 
TATCTACTTC CAGAAGCAAA AGAAATTGTA TGTAAAGATG GACGATGGCA ATCATTACCA 
CGCTGTGTTG AGTCTACTGC ATATTGTGGG CCCCCTCCAT CTATTAACAA TGGAGATACC 
ACCTCATTCC CATTATCAGT ATATCCTCCA GGGTCAACAG TGACGTACCG TTGCCAGTCC 
TTCTATAAAC TCCAGGGCTC TGTAACTGTA ACATGCAGAA ATAAACAGTG GTCAGAACCA 
CCAAGATGCC TAGATCCATG TGTGGTATCT GAAGAAAACA TGAACAAAAA TAACATACAG 
TTAAAATGGA GAAACGATGG AAAACTCTAT GCAAAAACAG GGGATGCTGT TGAATTCCAG 
TGTAAATTCC CACATAAAGC GATGATATCA TCACCACCAT TTCGAGCAAT CTGTCAGGAA 
GGGAAATTTG AATATCCTAT ATGTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110414.1
CDS	110..1819
Translation	MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE

Target ORF information:

RefSeq Version	NM_030787.4
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor H related 5 (CFHR5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030787.4

ORF Insert Sequence:

ATGTTGCTCT TATTCAGTGT AATCCTAATC TCATGGGTAT CCACTGTTGG GGGAGAAGGA 
ACACTTTGTG ATTTTCCAAA AATACACCAT GGATTTCTGT ATGATGAAGA AGATTATAAC 
CCTTTTTCCC AAGTTCCTAC AGGGGAAGTT TTCTATTACT CCTGTGAATA TAATTTTGTG 
TCTCCTTCAA AATCCTTTTG GACTCGCATA ACATGCACAG AAGAAGGATG GTCACCAACA 
CCGAAGTGTC TCAGAATGTG TTCCTTTCCT TTTGTGAAAA ATGGTCATTC TGAATCTTCA 
GGACTAATAC ATCTGGAAGG TGATACTGTA CAAATTATTT GCAACACAGG ATACAGCCTT 
CAAAACAATG AGAAAAACAT TTCGTGTGTA GAACGGGGCT GGTCCACTCC TCCCATATGC 
AGCTTCACTA AAGGAGAATG TCATGTTCCA ATTTTAGAAG CCAATGTAGA TGCTCAGCCA 
AAAAAAGAAA GCTACAAAGT TGGAGACGTG TTGAAATTCT CCTGCAGAAA AAATCTTATA 
AGAGTTGGAT CAGACTCAGT TCAATGTTAC CAATTTGGGT GGTCACCTAA CTTTCCAACA 
TGCAAAGGAC AAGTACGATC ATGTGGTCCA CCTCCTCAAC TCTCCAATGG TGAAGTTAAG 
GAGATAAGAA AAGAGGAATA TGGACACAAT GAAGTAGTGG AATATGATTG CAATCCTAAT 
TTTATAATAA ACGGGCCTAA GAAAATACAA TGTGTGGATG GAGAATGGAC AACTTTACCC 
ACTTGTGTTG AACAAGTGAA AACATGTGGA TACATACCTG AACTCGAGTA CGGTTATGTT 
CAGCCGTCTG TCCCTCCCTA TCAACATGGA GTTTCAGTCG AGGTGAATTG CAGAAATGAA 
TATGCAATGA TTGGAAATAA CATGATTACC TGTATTAATG GAATATGGAC AGAGCTTCCT 
ATGTGTGTTG CAACACACCA ACTTAAGAGG TGCAAAATAG CAGGAGTTAA TATAAAAACA 
TTACTCAAGC TATCTGGGAA AGAATTTAAT CATAATTCTA GAATACGTTA CAGATGTTCA 
GACATCTTCA GATACAGGCA CTCAGTCTGT ATAAACGGGA AATGGAATCC TGAAGTAGAC 
TGCACAGAAA AAAGGGAACA ATTCTGCCCA CCGCCACCTC AGATACCTAA TGCTCAGAAT 
ATGACAACCA CAGTGAATTA TCAGGATGGA GAAAAAGTAG CTGTTCTCTG TAAAGAAAAC 
TATCTACTTC CAGAAGCAAA AGAAATTGTA TGTAAAGATG GACGATGGCA ATCATTACCA 
CGCTGTGTTG AGTCTACTGC ATATTGTGGG CCCCCTCCAT CTATTAACAA TGGAGATACC 
ACCTCATTCC CATTATCAGT ATATCCTCCA GGGTCAACAG TGACGTACCG TTGCCAGTCC 
TTCTATAAAC TCCAGGGCTC TGTAACTGTA ACATGCAGAA ATAAACAGTG GTCAGAACCA 
CCAAGATGCC TAGATCCATG TGTGGTATCT GAAGAAAACA TGAACAAAAA TAACATACAG 
TTAAAATGGA GAAACGATGG AAAACTCTAT GCAAAAACAG GGGATGCTGT TGAATTCCAG 
TGTAAATTCC CACATAAAGC GATGATATCA TCACCACCAT TTCGAGCAAT CTGTCAGGAA 
GGGAAATTTG AATATCCTAT ATGTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFHR5 ( NM_030787.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_110414.1 Homo sapiens complement factor H related 5 (CFHR5), mRNA.

Price & Availability↑

CloneID	OHu22543
Clone ID Related Accession (Same CDS sequence)	NM_030787.4 , NM_030787.3
Accession Version	NM_030787.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1710bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	complement factor H-related protein 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA638244.1, BC111773.1, BG568555.1 and AF295327.1. This sequence is a reference standard in the RefSeqGene project. On Jan 11, 2008 this sequence version replaced NM_030787.2. Sequence Note: An in-frame AUG is located 24 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF295327.1, BC111773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGTTGCTCT TATTCAGTGT AATCCTAATC TCATGGGTAT CCACTGTTGG GGGAGAAGGA 
ACACTTTGTG ATTTTCCAAA AATACACCAT GGATTTCTGT ATGATGAAGA AGATTATAAC 
CCTTTTTCCC AAGTTCCTAC AGGGGAAGTT TTCTATTACT CCTGTGAATA TAATTTTGTG 
TCTCCTTCAA AATCCTTTTG GACTCGCATA ACATGCACAG AAGAAGGATG GTCACCAACA 
CCGAAGTGTC TCAGAATGTG TTCCTTTCCT TTTGTGAAAA ATGGTCATTC TGAATCTTCA 
GGACTAATAC ATCTGGAAGG TGATACTGTA CAAATTATTT GCAACACAGG ATACAGCCTT 
CAAAACAATG AGAAAAACAT TTCGTGTGTA GAACGGGGCT GGTCCACTCC TCCCATATGC 
AGCTTCACTA AAGGAGAATG TCATGTTCCA ATTTTAGAAG CCAATGTAGA TGCTCAGCCA 
AAAAAAGAAA GCTACAAAGT TGGAGACGTG TTGAAATTCT CCTGCAGAAA AAATCTTATA 
AGAGTTGGAT CAGACTCAGT TCAATGTTAC CAATTTGGGT GGTCACCTAA CTTTCCAACA 
TGCAAAGGAC AAGTACGATC ATGTGGTCCA CCTCCTCAAC TCTCCAATGG TGAAGTTAAG 
GAGATAAGAA AAGAGGAATA TGGACACAAT GAAGTAGTGG AATATGATTG CAATCCTAAT 
TTTATAATAA ACGGGCCTAA GAAAATACAA TGTGTGGATG GAGAATGGAC AACTTTACCC 
ACTTGTGTTG AACAAGTGAA AACATGTGGA TACATACCTG AACTCGAGTA CGGTTATGTT 
CAGCCGTCTG TCCCTCCCTA TCAACATGGA GTTTCAGTCG AGGTGAATTG CAGAAATGAA 
TATGCAATGA TTGGAAATAA CATGATTACC TGTATTAATG GAATATGGAC AGAGCTTCCT 
ATGTGTGTTG CAACACACCA ACTTAAGAGG TGCAAAATAG CAGGAGTTAA TATAAAAACA 
TTACTCAAGC TATCTGGGAA AGAATTTAAT CATAATTCTA GAATACGTTA CAGATGTTCA 
GACATCTTCA GATACAGGCA CTCAGTCTGT ATAAACGGGA AATGGAATCC TGAAGTAGAC 
TGCACAGAAA AAAGGGAACA ATTCTGCCCA CCGCCACCTC AGATACCTAA TGCTCAGAAT 
ATGACAACCA CAGTGAATTA TCAGGATGGA GAAAAAGTAG CTGTTCTCTG TAAAGAAAAC 
TATCTACTTC CAGAAGCAAA AGAAATTGTA TGTAAAGATG GACGATGGCA ATCATTACCA 
CGCTGTGTTG AGTCTACTGC ATATTGTGGG CCCCCTCCAT CTATTAACAA TGGAGATACC 
ACCTCATTCC CATTATCAGT ATATCCTCCA GGGTCAACAG TGACGTACCG TTGCCAGTCC 
TTCTATAAAC TCCAGGGCTC TGTAACTGTA ACATGCAGAA ATAAACAGTG GTCAGAACCA 
CCAAGATGCC TAGATCCATG TGTGGTATCT GAAGAAAACA TGAACAAAAA TAACATACAG 
TTAAAATGGA GAAACGATGG AAAACTCTAT GCAAAAACAG GGGATGCTGT TGAATTCCAG 
TGTAAATTCC CACATAAAGC GATGATATCA TCACCACCAT TTCGAGCAAT CTGTCAGGAA 
GGGAAATTTG AATATCCTAT ATGTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110414.1
CDS	129..1838
Translation	MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE

Target ORF information:

RefSeq Version	NM_030787.3
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor H related 5 (CFHR5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030787.3

ORF Insert Sequence:

ATGTTGCTCT TATTCAGTGT AATCCTAATC TCATGGGTAT CCACTGTTGG GGGAGAAGGA 
ACACTTTGTG ATTTTCCAAA AATACACCAT GGATTTCTGT ATGATGAAGA AGATTATAAC 
CCTTTTTCCC AAGTTCCTAC AGGGGAAGTT TTCTATTACT CCTGTGAATA TAATTTTGTG 
TCTCCTTCAA AATCCTTTTG GACTCGCATA ACATGCACAG AAGAAGGATG GTCACCAACA 
CCGAAGTGTC TCAGAATGTG TTCCTTTCCT TTTGTGAAAA ATGGTCATTC TGAATCTTCA 
GGACTAATAC ATCTGGAAGG TGATACTGTA CAAATTATTT GCAACACAGG ATACAGCCTT 
CAAAACAATG AGAAAAACAT TTCGTGTGTA GAACGGGGCT GGTCCACTCC TCCCATATGC 
AGCTTCACTA AAGGAGAATG TCATGTTCCA ATTTTAGAAG CCAATGTAGA TGCTCAGCCA 
AAAAAAGAAA GCTACAAAGT TGGAGACGTG TTGAAATTCT CCTGCAGAAA AAATCTTATA 
AGAGTTGGAT CAGACTCAGT TCAATGTTAC CAATTTGGGT GGTCACCTAA CTTTCCAACA 
TGCAAAGGAC AAGTACGATC ATGTGGTCCA CCTCCTCAAC TCTCCAATGG TGAAGTTAAG 
GAGATAAGAA AAGAGGAATA TGGACACAAT GAAGTAGTGG AATATGATTG CAATCCTAAT 
TTTATAATAA ACGGGCCTAA GAAAATACAA TGTGTGGATG GAGAATGGAC AACTTTACCC 
ACTTGTGTTG AACAAGTGAA AACATGTGGA TACATACCTG AACTCGAGTA CGGTTATGTT 
CAGCCGTCTG TCCCTCCCTA TCAACATGGA GTTTCAGTCG AGGTGAATTG CAGAAATGAA 
TATGCAATGA TTGGAAATAA CATGATTACC TGTATTAATG GAATATGGAC AGAGCTTCCT 
ATGTGTGTTG CAACACACCA ACTTAAGAGG TGCAAAATAG CAGGAGTTAA TATAAAAACA 
TTACTCAAGC TATCTGGGAA AGAATTTAAT CATAATTCTA GAATACGTTA CAGATGTTCA 
GACATCTTCA GATACAGGCA CTCAGTCTGT ATAAACGGGA AATGGAATCC TGAAGTAGAC 
TGCACAGAAA AAAGGGAACA ATTCTGCCCA CCGCCACCTC AGATACCTAA TGCTCAGAAT 
ATGACAACCA CAGTGAATTA TCAGGATGGA GAAAAAGTAG CTGTTCTCTG TAAAGAAAAC 
TATCTACTTC CAGAAGCAAA AGAAATTGTA TGTAAAGATG GACGATGGCA ATCATTACCA 
CGCTGTGTTG AGTCTACTGC ATATTGTGGG CCCCCTCCAT CTATTAACAA TGGAGATACC 
ACCTCATTCC CATTATCAGT ATATCCTCCA GGGTCAACAG TGACGTACCG TTGCCAGTCC 
TTCTATAAAC TCCAGGGCTC TGTAACTGTA ACATGCAGAA ATAAACAGTG GTCAGAACCA 
CCAAGATGCC TAGATCCATG TGTGGTATCT GAAGAAAACA TGAACAAAAA TAACATACAG 
TTAAAATGGA GAAACGATGG AAAACTCTAT GCAAAAACAG GGGATGCTGT TGAATTCCAG 
TGTAAATTCC CACATAAAGC GATGATATCA TCACCACCAT TTCGAGCAAT CTGTCAGGAA 
GGGAAATTTG AATATCCTAT ATGTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFHR5 ( XM_011510020.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508322.1 Homo sapiens complement factor H related 5 (CFHR5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu72899
Clone ID Related Accession (Same CDS sequence)	XM_011510020.2
Accession Version	XM_011510020.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1719bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	complement factor H-related protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510020.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAAGC CTTTGAGACA GAAGAGAAAC CAGGAGAATG TGGTGTTCCA TAGACCATGT 
GAAGCAGGAA CACTTTGTGA TTTTCCAAAA ATACACCATG GATTTCTGTA TGATGAAGAA 
GATTATAACC CTTTTTCCCA AGTTCCTACA GGGGAAGTTT TCTATTACTC CTGTGAATAT 
AATTTTGTGT CTCCTTCAAA ATCCTTTTGG ACTCGCATAA CATGCACAGA AGAAGGATGG 
TCACCAACAC CGAAGTGTCT CAGAATGTGT TCCTTTCCTT TTGTGAAAAA TGGTCATTCT 
GAATCTTCAG GACTAATACA TCTGGAAGGT GATACTGTAC AAATTATTTG CAACACAGGA 
TACAGCCTTC AAAACAATGA GAAAAACATT TCGTGTGTAG AACGGGGCTG GTCCACTCCT 
CCCATATGCA GCTTCACTAA AGGAGAATGT CATGTTCCAA TTTTAGAAGC CAATGTAGAT 
GCTCAGCCAA AAAAAGAAAG CTACAAAGTT GGAGACGTGT TGAAATTCTC CTGCAGAAAA 
AATCTTATAA GAGTTGGATC AGACTCAGTT CAATGTTACC AATTTGGGTG GTCACCTAAC 
TTTCCAACAT GCAAAGGACA AGTACGATCA TGTGGTCCAC CTCCTCAACT CTCCAATGGT 
GAAGTTAAGG AGATAAGAAA AGAGGAATAT GGACACAATG AAGTAGTGGA ATATGATTGC 
AATCCTAATT TTATAATAAA CGGGCCTAAG AAAATACAAT GTGTGGATGG AGAATGGACA 
ACTTTACCCA CTTGTGTTGA ACAAGTGAAA ACATGTGGAT ACATACCTGA ACTCGAGTAC 
GGTTATGTTC AGCCGTCTGT CCCTCCCTAT CAACATGGAG TTTCAGTCGA GGTGAATTGC 
AGAAATGAAT ATGCAATGAT TGGAAATAAC ATGATTACCT GTATTAATGG AATATGGACA 
GAGCTTCCTA TGTGTGTTGC AACACACCAA CTTAAGAGGT GCAAAATAGC AGGAGTTAAT 
ATAAAAACAT TACTCAAGCT ATCTGGGAAA GAATTTAATC ATAATTCTAG AATACGTTAC 
AGATGTTCAG ACATCTTCAG ATACAGGCAC TCAGTCTGTA TAAACGGGAA ATGGAATCCT 
GAAGTAGACT GCACAGAAAA AAGGGAACAA TTCTGCCCAC CGCCACCTCA GATACCTAAT 
GCTCAGAATA TGACAACCAC AGTGAATTAT CAGGATGGAG AAAAAGTAGC TGTTCTCTGT 
AAAGAAAACT ATCTACTTCC AGAAGCAAAA GAAATTGTAT GTAAAGATGG ACGATGGCAA 
TCATTACCAC GCTGTGTTGA GTCTACTGCA TATTGTGGGC CCCCTCCATC TATTAACAAT 
GGAGATACCA CCTCATTCCC ATTATCAGTA TATCCTCCAG GGTCAACAGT GACGTACCGT 
TGCCAGTCCT TCTATAAACT CCAGGGCTCT GTAACTGTAA CATGCAGAAA TAAACAGTGG 
TCAGAACCAC CAAGATGCCT AGATCCATGT GTGGTATCTG AAGAAAACAT GAACAAAAAT 
AACATACAGT TAAAATGGAG AAACGATGGA AAACTCTATG CAAAAACAGG GGATGCTGTT 
GAATTCCAGT GTAAATTCCC ACATAAAGCG ATGATATCAT CACCACCATT TCGAGCAATC 
TGTCAGGAAG GGAAATTTGA ATATCCTATA TGTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508322.1
CDS	27..1745
Translation	MVKPLRQKRNQENVVFHRPCEAGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE

Target ORF information:

RefSeq Version	XM_011510020.2
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor H related 5 (CFHR5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510020.2

ORF Insert Sequence:

ATGGTGAAGC CTTTGAGACA GAAGAGAAAC CAGGAGAATG TGGTGTTCCA TAGACCATGT 
GAAGCAGGAA CACTTTGTGA TTTTCCAAAA ATACACCATG GATTTCTGTA TGATGAAGAA 
GATTATAACC CTTTTTCCCA AGTTCCTACA GGGGAAGTTT TCTATTACTC CTGTGAATAT 
AATTTTGTGT CTCCTTCAAA ATCCTTTTGG ACTCGCATAA CATGCACAGA AGAAGGATGG 
TCACCAACAC CGAAGTGTCT CAGAATGTGT TCCTTTCCTT TTGTGAAAAA TGGTCATTCT 
GAATCTTCAG GACTAATACA TCTGGAAGGT GATACTGTAC AAATTATTTG CAACACAGGA 
TACAGCCTTC AAAACAATGA GAAAAACATT TCGTGTGTAG AACGGGGCTG GTCCACTCCT 
CCCATATGCA GCTTCACTAA AGGAGAATGT CATGTTCCAA TTTTAGAAGC CAATGTAGAT 
GCTCAGCCAA AAAAAGAAAG CTACAAAGTT GGAGACGTGT TGAAATTCTC CTGCAGAAAA 
AATCTTATAA GAGTTGGATC AGACTCAGTT CAATGTTACC AATTTGGGTG GTCACCTAAC 
TTTCCAACAT GCAAAGGACA AGTACGATCA TGTGGTCCAC CTCCTCAACT CTCCAATGGT 
GAAGTTAAGG AGATAAGAAA AGAGGAATAT GGACACAATG AAGTAGTGGA ATATGATTGC 
AATCCTAATT TTATAATAAA CGGGCCTAAG AAAATACAAT GTGTGGATGG AGAATGGACA 
ACTTTACCCA CTTGTGTTGA ACAAGTGAAA ACATGTGGAT ACATACCTGA ACTCGAGTAC 
GGTTATGTTC AGCCGTCTGT CCCTCCCTAT CAACATGGAG TTTCAGTCGA GGTGAATTGC 
AGAAATGAAT ATGCAATGAT TGGAAATAAC ATGATTACCT GTATTAATGG AATATGGACA 
GAGCTTCCTA TGTGTGTTGC AACACACCAA CTTAAGAGGT GCAAAATAGC AGGAGTTAAT 
ATAAAAACAT TACTCAAGCT ATCTGGGAAA GAATTTAATC ATAATTCTAG AATACGTTAC 
AGATGTTCAG ACATCTTCAG ATACAGGCAC TCAGTCTGTA TAAACGGGAA ATGGAATCCT 
GAAGTAGACT GCACAGAAAA AAGGGAACAA TTCTGCCCAC CGCCACCTCA GATACCTAAT 
GCTCAGAATA TGACAACCAC AGTGAATTAT CAGGATGGAG AAAAAGTAGC TGTTCTCTGT 
AAAGAAAACT ATCTACTTCC AGAAGCAAAA GAAATTGTAT GTAAAGATGG ACGATGGCAA 
TCATTACCAC GCTGTGTTGA GTCTACTGCA TATTGTGGGC CCCCTCCATC TATTAACAAT 
GGAGATACCA CCTCATTCCC ATTATCAGTA TATCCTCCAG GGTCAACAGT GACGTACCGT 
TGCCAGTCCT TCTATAAACT CCAGGGCTCT GTAACTGTAA CATGCAGAAA TAAACAGTGG 
TCAGAACCAC CAAGATGCCT AGATCCATGT GTGGTATCTG AAGAAAACAT GAACAAAAAT 
AACATACAGT TAAAATGGAG AAACGATGGA AAACTCTATG CAAAAACAGG GGATGCTGTT 
GAATTCCAGT GTAAATTCCC ACATAAAGCG ATGATATCAT CACCACCATT TCGAGCAATC 
TGTCAGGAAG GGAAATTTGA ATATCCTATA TGTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.
Kidney international92(4)876-887(2017 Oct)
Togarsimalemath SK,Sethi SK,Duggal R,Le Quintrec M,Jha P,Daniel R,Gonnet F,Bansal S,Roumenina LT,Fremeaux-Bacchi V,Kher V,Dragon-Durey MA

Circulating complement factor H-related proteins 1?and 5 correlate with disease activity in IgA nephropathy.
Kidney international92(4)942-952(2017 Oct)
Medjeral-Thomas NR,Lomax-Browne HJ,Beckwith H,Willicombe M,McLean AG,Brookes P,Pusey CD,Falchi M,Cook HT,Pickering MC

Rare Variants in the Complement Factor H-Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy.
Journal of the American Society of Nephrology : JASN27(9)2894-905(2016 Sep)
Zhai YL,Meng SJ,Zhu L,Shi SF,Wang SX,Liu LJ,Lv JC,Yu F,Zhao MH,Zhang H

Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.
Investigative ophthalmology & visual science57(6)2763-9(2016 05)
Hughes AE,Bridgett S,Meng W,Li M,Curcio CA,Stambolian D,Bradley DT

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CFHR5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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