CALML3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CALML3
Entrez Gene ID	810
Full Name	calmodulin like 3
Synonyms	CLP
General protein information	Preferred Names calmodulin like 3 Names calmodulin-like protein 3 caM-like protein calmodulin-related protein NB-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p15.1
Disorder MIM:	114184

mRNA and Protein(s)

mRNA	Protein	Name
NM_005185.3	NP_005176.1	calmodulin-like protein 3
NM_005185.4	NP_005176.1	calmodulin-like protein 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CALML3	XP_003951634.1
Arabidopsis thaliana (thale cress)	CAM1	NP_198594.1
Oryza sativa (rice)	Os05g0491100	NP_001055907.1
Homo sapiens (human)	CALML3	NP_005176.1
Gallus gallus (chicken)	CALML3	NP_001075166.1
Mus musculus (house mouse)	Calml3	NP_081692.1
Rattus norvegicus (Norway rat)	Calml3	NP_001012054.1
Arabidopsis thaliana (thale cress)	CAM4	NP_176814.1

Gene Ontology
Bibliography

Related articles in PubMed

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.
Qin S, Ingle JN, Liu M, Yu J, Wickerham DL, Kubo M, Weinshilboum RM, Wang L
Breast cancer research : BCR19(1)95(2017 Aug)

Immunolocalization of the tumor-sensitive calmodulin-like protein CALML3 in normal human skin and hyperproliferative skin disorders.
Bennett RD, Pittelkow MR, Strehler EE
PloS one8(4)e62347(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased CALML3 expression in suprabasal layers is characteristic for differentiating keratinocytes in normal epidermis, and nuclear expression of CALML3 inversely correlates with expression of the proliferation marker Ki-67.
Title: Immunolocalization of the tumor-sensitive calmodulin-like protein CALML3 in normal human skin and hyperproliferative skin disorders.

increased CLP expression and CLP-mediated Myo10 function are important for skin differentiation and wound reepithelialization
Title: Calmodulin-like protein upregulates myosin-10 in human keratinocytes and is regulated during epidermal wound healing in vivo.

expression was readily detected in areas of normal oral mucosa, while a notable downregulation of expression occurred in areas of malignant transformation
Title: Human calmodulin-like protein (CLP) expression in oral squamous mucosa and in malignant transformation.

CLP may be required during terminal differentiation to increase myosin-10 function as cells migrate toward the upper layers and establish new adhesive contacts.
Title: Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The following CALML3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALML3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24670	NM_005185.4 Latest version!	Homo sapiens calmodulin like 3 (CALML3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24670	NM_005185.3	Homo sapiens calmodulin like 3 (CALML3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CALML3 ( NM_005185.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005176.1 Homo sapiens calmodulin like 3 (CALML3), mRNA.

Price & Availability↑

CloneID	OHu24670
Clone ID Related Accession (Same CDS sequence)	NM_005185.3 , NM_005185.4
Accession Version	NM_005185.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-29
Organism	Homo sapiens(human)
Product	calmodulin-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY060230.1, BC031889.1, CU454493.1 and DR421766.1. On May 17, 2014 this sequence version replaced NM_005185.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCCGACC AGCTGACTGA GGAGCAGGTC ACAGAATTCA AGGAGGCCTT CTCCCTGTTT 
GACAAGGATG GGGACGGCTG CATCACCACC CGCGAGCTGG GCACGGTCAT GCGGTCCCTG 
GGCCAGAACC CCACGGAGGC CGAGCTGCGG GACATGATGA GTGAGATCGA CCGGGACGGC 
AACGGCACCG TGGACTTCCC CGAGTTCCTG GGCATGATGG CCAGGAAGAT GAAGGACACG 
GACAACGAGG AGGAGATCCG CGAGGCCTTC CGCGTGTTCG ACAAGGACGG CAACGGCTTC 
GTCAGCGCCG CCGAGCTGCG ACACGTCATG ACCCGGCTGG GGGAGAAGCT GAGTGACGAG 
GAGGTGGACG AGATGATCCG GGCCGCGGAC ACGGACGGAG ACGGACAGGT GAACTACGAG 
GAGTTTGTCC GTGTGCTGGT GTCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005176.1
CDS	198..647
Translation	MADQLTEEQVTEFKEAFSLFDKDGDGCITTRELGTVMRSLGQNPTEAELRDMMSEIDRDGNGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGEKLSDEEVDEMIRAADTDGDGQVNYEEFVRVLVSK

Target ORF information:

RefSeq Version	NM_005185.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin like 3 (CALML3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005185.3

ORF Insert Sequence:

ATGGCCGACC AGCTGACTGA GGAGCAGGTC ACAGAATTCA AGGAGGCCTT CTCCCTGTTT 
GACAAGGATG GGGACGGCTG CATCACCACC CGCGAGCTGG GCACGGTCAT GCGGTCCCTG 
GGCCAGAACC CCACGGAGGC CGAGCTGCGG GACATGATGA GTGAGATCGA CCGGGACGGC 
AACGGCACCG TGGACTTCCC CGAGTTCCTG GGCATGATGG CCAGGAAGAT GAAGGACACG 
GACAACGAGG AGGAGATCCG CGAGGCCTTC CGCGTGTTCG ACAAGGACGG CAACGGCTTC 
GTCAGCGCCG CCGAGCTGCG ACACGTCATG ACCCGGCTGG GGGAGAAGCT GAGTGACGAG 
GAGGTGGACG AGATGATCCG GGCCGCGGAC ACGGACGGAG ACGGACAGGT GAACTACGAG 
GAGTTTGTCC GTGTGCTGGT GTCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALML3 ( NM_005185.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005176.1 Homo sapiens calmodulin like 3 (CALML3), mRNA.

Price & Availability↑

CloneID	OHu24670
Clone ID Related Accession (Same CDS sequence)	NM_005185.3 , NM_005185.4
Accession Version	NM_005185.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	calmodulin-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY060230.1, BC031889.1, CU454493.1, DR421766.1 and AL732437.12. On May 17, 2019 this sequence version replaced NM_005185.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: M36707.1, M58026.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000315238.3/ ENSP00000315299.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGACC AGCTGACTGA GGAGCAGGTC ACAGAATTCA AGGAGGCCTT CTCCCTGTTT 
GACAAGGATG GGGACGGCTG CATCACCACC CGCGAGCTGG GCACGGTCAT GCGGTCCCTG 
GGCCAGAACC CCACGGAGGC CGAGCTGCGG GACATGATGA GTGAGATCGA CCGGGACGGC 
AACGGCACCG TGGACTTCCC CGAGTTCCTG GGCATGATGG CCAGGAAGAT GAAGGACACG 
GACAACGAGG AGGAGATCCG CGAGGCCTTC CGCGTGTTCG ACAAGGACGG CAACGGCTTC 
GTCAGCGCCG CCGAGCTGCG ACACGTCATG ACCCGGCTGG GGGAGAAGCT GAGTGACGAG 
GAGGTGGACG AGATGATCCG GGCCGCGGAC ACGGACGGAG ACGGACAGGT GAACTACGAG 
GAGTTTGTCC GTGTGCTGGT GTCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005176.1
CDS	126..575
Translation	MADQLTEEQVTEFKEAFSLFDKDGDGCITTRELGTVMRSLGQNPTEAELRDMMSEIDRDGNGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGEKLSDEEVDEMIRAADTDGDGQVNYEEFVRVLVSK

Target ORF information:

RefSeq Version	NM_005185.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin like 3 (CALML3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005185.4

ORF Insert Sequence:

ATGGCCGACC AGCTGACTGA GGAGCAGGTC ACAGAATTCA AGGAGGCCTT CTCCCTGTTT 
GACAAGGATG GGGACGGCTG CATCACCACC CGCGAGCTGG GCACGGTCAT GCGGTCCCTG 
GGCCAGAACC CCACGGAGGC CGAGCTGCGG GACATGATGA GTGAGATCGA CCGGGACGGC 
AACGGCACCG TGGACTTCCC CGAGTTCCTG GGCATGATGG CCAGGAAGAT GAAGGACACG 
GACAACGAGG AGGAGATCCG CGAGGCCTTC CGCGTGTTCG ACAAGGACGG CAACGGCTTC 
GTCAGCGCCG CCGAGCTGCG ACACGTCATG ACCCGGCTGG GGGAGAAGCT GAGTGACGAG 
GAGGTGGACG AGATGATCCG GGCCGCGGAC ACGGACGGAG ACGGACAGGT GAACTACGAG 
GAGTTTGTCC GTGTGCTGGT GTCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.
Breast cancer research : BCR19(1)95(2017 Aug)
Qin S,Ingle JN,Liu M,Yu J,Wickerham DL,Kubo M,Weinshilboum RM,Wang L

Immunolocalization of the tumor-sensitive calmodulin-like protein CALML3 in normal human skin and hyperproliferative skin disorders.
PloS one8(4)e62347(2013)
Bennett RD,Pittelkow MR,Strehler EE

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CALML3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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