SLX1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLX1B
Entrez Gene ID	79008
Full Name	SLX1 homolog B, structure-specific endonuclease subunit
Synonyms	GIYD2
General protein information	Preferred Names SLX1 homolog B, structure-specific endonuclease subunit Names structure-specific endonuclease subunit SLX1 GIY-YIG domain-containing protein 1 SLX1 structure-specific endonuclease subunit homolog B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010].
Disorder MIM:	615823

mRNA and Protein(s)

mRNA	Protein	Name
NM_024044.3	NP_076949.1	structure-specific endonuclease subunit SLX1 isoform 1
NM_024044.4	NP_076949.1	structure-specific endonuclease subunit SLX1 isoform 1
NM_178044.2	NP_835145.1	structure-specific endonuclease subunit SLX1 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLX1A	NP_001014999.1
Homo sapiens (human)	SLX1B	NP_076949.1
Rattus norvegicus (Norway rat)	Slx1b	NP_001009292.1
Caenorhabditis elegans (roundworm)	slx-1	NP_491541.1
Schizosaccharomyces pombe (fission yeast)	slx1	NP_593420.1
	SLX1B	XP_001109511.1
Mus musculus (house mouse)	Slx1b	NP_083696.2
Danio rerio (zebrafish)	LOC100001845	XP_001337124.1
Xenopus tropicalis (tropical clawed frog)	slx1a	XP_002943477.2
Bos taurus (cattle)	SLX1A	NP_001032533.1
Drosophila melanogaster (fruit fly)	slx1	NP_649484.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002259	XP_565552.4
Canis lupus familiaris (dog)	SLX1A	XP_849594.1

Gene Ontology
Bibliography

Related articles in PubMed

SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.
Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M
Cell reports4(5)861-9(2013 Sep)

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW
Cell138(1)63-77(2009 Jul)

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Fekairi S, Scaglione S, Chahwan C, Taylor ER, Tissier A, Coulon S, Dong MQ, Ruse C, Yates JR 3rd, Russell P, Fuchs RP, McGowan CH, Gaillard PH
Cell138(1)78-89(2009 Jul)

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
Mu?oz IM, Hain K, D?clais AC, Gardiner M, Toh GW, Sanchez-Pulido L, Heuckmann JM, Toth R, Macartney T, Eppink B, Kanaar R, Ponting CP, Lilley DM, Rouse J
Molecular cell35(1)116-27(2009 Jul)

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.
Andersen SL, Bergstralh DT, Kohl KP, LaRocque JR, Moore CB, Sekelsky J
Molecular cell35(1)128-35(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLX1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLX1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27744	NM_178044.2 Latest version!	Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27746	NM_024044.4 Latest version!	Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu27746	NM_024044.3	Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLX1B ( NM_178044.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_835145.1 Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27744
Clone ID Related Accession (Same CDS sequence)	NM_178044.2
Accession Version	NM_178044.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	structure-specific endonuclease subunit SLX1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC133555.3 and BC069007.1. On Dec 1, 2010 this sequence version replaced NM_178044.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC069007.1, SRR1163657.328305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCCG CGGGGGTCGC GGCGAGGCCA GGGCGCTTTT TCGGCGTCTA CCTGCTCTAC 
TGCCTGAACC CCCGGTACCG GGGCCGCGTC TACGTGGGGT TCACTGTCAA CACTGCTCGT 
CGGGTCCAGC AGCACAATGG GGGCCGCAAA AAAGGCGGGG CCTGGCGGAC CAGCGGGCGA 
GGGCCCTGGG AGATGGTGCT CGTCGTGCAC GGCTTCCCGT CCTCCGTGGC CGCCCTTCGG 
GATGAAGAGG GGCCCTTGTG TTGCCCCCAC CCTGGCTGCC TGCTAAGGGC CCATGTGATC 
TGCCTGGCAG AGGAGTTTCT TCAGGAAGAA CCAGGGCAGC TTCTGCCCCT AGAGGGCCAA 
TGCCCTTGCT GTGAGAAGTC ACTGCTTTGG GGAGACCTGA TCTGGCTGTG CCAGATGGAC 
ACTGAGAAAG AAGTAGAAGA CTCAGAATTA GAAGAGGCAC ACTGGACAGA CCTGCTGGAG 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835145.1
CDS	243..728
Translation	MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGRGPWEMVLVVHGFPSSVAALRDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEKSLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET

Target ORF information:

RefSeq Version	NM_178044.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178044.2

ORF Insert Sequence:

ATGGGTCCCG CGGGGGTCGC GGCGAGGCCA GGGCGCTTTT TCGGCGTCTA CCTGCTCTAC 
TGCCTGAACC CCCGGTACCG GGGCCGCGTC TACGTGGGGT TCACTGTCAA CACTGCTCGT 
CGGGTCCAGC AGCACAATGG GGGCCGCAAA AAAGGCGGGG CCTGGCGGAC CAGCGGGCGA 
GGGCCCTGGG AGATGGTGCT CGTCGTGCAC GGCTTCCCGT CCTCCGTGGC CGCCCTTCGG 
GATGAAGAGG GGCCCTTGTG TTGCCCCCAC CCTGGCTGCC TGCTAAGGGC CCATGTGATC 
TGCCTGGCAG AGGAGTTTCT TCAGGAAGAA CCAGGGCAGC TTCTGCCCCT AGAGGGCCAA 
TGCCCTTGCT GTGAGAAGTC ACTGCTTTGG GGAGACCTGA TCTGGCTGTG CCAGATGGAC 
ACTGAGAAAG AAGTAGAAGA CTCAGAATTA GAAGAGGCAC ACTGGACAGA CCTGCTGGAG 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLX1B ( NM_024044.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076949.1 Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27746
Clone ID Related Accession (Same CDS sequence)	NM_024044.3 , NM_024044.4
Accession Version	NM_024044.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	structure-specific endonuclease subunit SLX1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC133555.3 and BC000754.2. On Dec 1, 2010 this sequence version replaced NM_024044.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC015990.2, SRR1163658.405028.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCCG CGGGGGTCGC GGCGAGGCCA GGGCGCTTTT TCGGCGTCTA CCTGCTCTAC 
TGCCTGAACC CCCGGTACCG GGGCCGCGTC TACGTGGGGT TCACTGTCAA CACTGCTCGT 
CGGGTCCAGC AGCACAATGG GGGCCGCAAA AAAGGCGGGG CCTGGCGGAC CAGCGGGCGA 
GGGCCCTGGG AGATGGTGCT CGTCGTGCAC GGCTTCCCGT CCTCCGTGGC CGCCCTTCGG 
TTTGAGTGGG CTTGGCAGCA CCCGCACGCC TCGCGCCGCC TGGCGCACGT GGGGCCTCGC 
CTGCGAGGAG AGACAGCCTT CGCTTTCCAC CTGCGCGTGC TGGCGCACAT GCTGCGCGCA 
CCGCCCTGGG CTCGCCTCCC GCTCACGCTG CGCTGGGTGC GCCCAGACCT CCGCCAGGAC 
CTCTGCCTCC CGCCGCCGCC GCACGTGCCT CTGGCCTTCG GGCCTCCACC GCCCCAGGCC 
CCGGCCCCAA GGCGCCGCGC AGGTCCCTTT GATGACGCGG AGCCTGAGCC AGACCAGGGG 
GATCCAGGGG CCTGCTGCTC CCTGTGCGCC CAGACCATCC AGGATGAAGA GGGGCCCTTG 
TGTTGCCCCC ACCCTGGCTG CCTGCTAAGG GCCCATGTGA TCTGCCTGGC AGAGGAGTTT 
CTTCAGGAAG AACCAGGGCA GCTTCTGCCC CTAGAGGGCC AATGCCCTTG CTGTGAGAAG 
TCACTGCTTT GGGGAGACCT GATCTGGCTG TGCCAGATGG ACACTGAGAA AGAAGTAGAA 
GACTCAGAAT TAGAAGAGGC ACACTGGACA GACCTGCTGG AGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076949.1
CDS	243..1070
Translation	MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGRGPWEMVLVVHGFPSSVAALRFEWAWQHPHASRRLAHVGPRLRGETAFAFHLRVLAHMLRAPPWARLPLTLRWVRPDLRQDLCLPPPPHVPLAFGPPPPQAPAPRRRAGPFDDAEPEPDQGDPGACCSLCAQTIQDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEKSLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET

Target ORF information:

RefSeq Version	NM_024044.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024044.3

ORF Insert Sequence:

ATGGGTCCCG CGGGGGTCGC GGCGAGGCCA GGGCGCTTTT TCGGCGTCTA CCTGCTCTAC 
TGCCTGAACC CCCGGTACCG GGGCCGCGTC TACGTGGGGT TCACTGTCAA CACTGCTCGT 
CGGGTCCAGC AGCACAATGG GGGCCGCAAA AAAGGCGGGG CCTGGCGGAC CAGCGGGCGA 
GGGCCCTGGG AGATGGTGCT CGTCGTGCAC GGCTTCCCGT CCTCCGTGGC CGCCCTTCGG 
TTTGAGTGGG CTTGGCAGCA CCCGCACGCC TCGCGCCGCC TGGCGCACGT GGGGCCTCGC 
CTGCGAGGAG AGACAGCCTT CGCTTTCCAC CTGCGCGTGC TGGCGCACAT GCTGCGCGCA 
CCGCCCTGGG CTCGCCTCCC GCTCACGCTG CGCTGGGTGC GCCCAGACCT CCGCCAGGAC 
CTCTGCCTCC CGCCGCCGCC GCACGTGCCT CTGGCCTTCG GGCCTCCACC GCCCCAGGCC 
CCGGCCCCAA GGCGCCGCGC AGGTCCCTTT GATGACGCGG AGCCTGAGCC AGACCAGGGG 
GATCCAGGGG CCTGCTGCTC CCTGTGCGCC CAGACCATCC AGGATGAAGA GGGGCCCTTG 
TGTTGCCCCC ACCCTGGCTG CCTGCTAAGG GCCCATGTGA TCTGCCTGGC AGAGGAGTTT 
CTTCAGGAAG AACCAGGGCA GCTTCTGCCC CTAGAGGGCC AATGCCCTTG CTGTGAGAAG 
TCACTGCTTT GGGGAGACCT GATCTGGCTG TGCCAGATGG ACACTGAGAA AGAAGTAGAA 
GACTCAGAAT TAGAAGAGGC ACACTGGACA GACCTGCTGG AGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLX1B ( NM_024044.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_076949.1 Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27746
Clone ID Related Accession (Same CDS sequence)	NM_024044.3 , NM_024044.4
Accession Version	NM_024044.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	structure-specific endonuclease subunit SLX1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC133555.3 and BC000754.2. On May 17, 2019 this sequence version replaced NM_024044.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC015990.2, SRR7410570.600781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000330181.9/ ENSP00000328940.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCCG CGGGGGTCGC GGCGAGGCCA GGGCGCTTTT TCGGCGTCTA CCTGCTCTAC 
TGCCTGAACC CCCGGTACCG GGGCCGCGTC TACGTGGGGT TCACTGTCAA CACTGCTCGT 
CGGGTCCAGC AGCACAATGG GGGCCGCAAA AAAGGCGGGG CCTGGCGGAC CAGCGGGCGA 
GGGCCCTGGG AGATGGTGCT CGTCGTGCAC GGCTTCCCGT CCTCCGTGGC CGCCCTTCGG 
TTTGAGTGGG CTTGGCAGCA CCCGCACGCC TCGCGCCGCC TGGCGCACGT GGGGCCTCGC 
CTGCGAGGAG AGACAGCCTT CGCTTTCCAC CTGCGCGTGC TGGCGCACAT GCTGCGCGCA 
CCGCCCTGGG CTCGCCTCCC GCTCACGCTG CGCTGGGTGC GCCCAGACCT CCGCCAGGAC 
CTCTGCCTCC CGCCGCCGCC GCACGTGCCT CTGGCCTTCG GGCCTCCACC GCCCCAGGCC 
CCGGCCCCAA GGCGCCGCGC AGGTCCCTTT GATGACGCGG AGCCTGAGCC AGACCAGGGG 
GATCCAGGGG CCTGCTGCTC CCTGTGCGCC CAGACCATCC AGGATGAAGA GGGGCCCTTG 
TGTTGCCCCC ACCCTGGCTG CCTGCTAAGG GCCCATGTGA TCTGCCTGGC AGAGGAGTTT 
CTTCAGGAAG AACCAGGGCA GCTTCTGCCC CTAGAGGGCC AATGCCCTTG CTGTGAGAAG 
TCACTGCTTT GGGGAGACCT GATCTGGCTG TGCCAGATGG ACACTGAGAA AGAAGTAGAA 
GACTCAGAAT TAGAAGAGGC ACACTGGACA GACCTGCTGG AGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076949.1
CDS	243..1070
Translation	MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGRGPWEMVLVVHGFPSSVAALRFEWAWQHPHASRRLAHVGPRLRGETAFAFHLRVLAHMLRAPPWARLPLTLRWVRPDLRQDLCLPPPPHVPLAFGPPPPQAPAPRRRAGPFDDAEPEPDQGDPGACCSLCAQTIQDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEKSLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET

Target ORF information:

RefSeq Version	NM_024044.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SLX1 homolog B, structure-specific endonuclease subunit (SLX1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024044.4

ORF Insert Sequence:

ATGGGTCCCG CGGGGGTCGC GGCGAGGCCA GGGCGCTTTT TCGGCGTCTA CCTGCTCTAC 
TGCCTGAACC CCCGGTACCG GGGCCGCGTC TACGTGGGGT TCACTGTCAA CACTGCTCGT 
CGGGTCCAGC AGCACAATGG GGGCCGCAAA AAAGGCGGGG CCTGGCGGAC CAGCGGGCGA 
GGGCCCTGGG AGATGGTGCT CGTCGTGCAC GGCTTCCCGT CCTCCGTGGC CGCCCTTCGG 
TTTGAGTGGG CTTGGCAGCA CCCGCACGCC TCGCGCCGCC TGGCGCACGT GGGGCCTCGC 
CTGCGAGGAG AGACAGCCTT CGCTTTCCAC CTGCGCGTGC TGGCGCACAT GCTGCGCGCA 
CCGCCCTGGG CTCGCCTCCC GCTCACGCTG CGCTGGGTGC GCCCAGACCT CCGCCAGGAC 
CTCTGCCTCC CGCCGCCGCC GCACGTGCCT CTGGCCTTCG GGCCTCCACC GCCCCAGGCC 
CCGGCCCCAA GGCGCCGCGC AGGTCCCTTT GATGACGCGG AGCCTGAGCC AGACCAGGGG 
GATCCAGGGG CCTGCTGCTC CCTGTGCGCC CAGACCATCC AGGATGAAGA GGGGCCCTTG 
TGTTGCCCCC ACCCTGGCTG CCTGCTAAGG GCCCATGTGA TCTGCCTGGC AGAGGAGTTT 
CTTCAGGAAG AACCAGGGCA GCTTCTGCCC CTAGAGGGCC AATGCCCTTG CTGTGAGAAG 
TCACTGCTTT GGGGAGACCT GATCTGGCTG TGCCAGATGG ACACTGAGAA AGAAGTAGAA 
GACTCAGAAT TAGAAGAGGC ACACTGGACA GACCTGCTGG AGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.
Cell reports4(5)861-9(2013 Sep)
Wan B,Yin J,Horvath K,Sarkar J,Chen Y,Wu J,Wan K,Lu J,Gu P,Yu EY,Lue NF,Chang S,Liu Y,Lei M

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Cell138(1)63-77(2009 Jul)
Svendsen JM,Smogorzewska A,Sowa ME,O'Connell BC,Gygi SP,Elledge SJ,Harper JW

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Cell138(1)78-89(2009 Jul)
Fekairi S,Scaglione S,Chahwan C,Taylor ER,Tissier A,Coulon S,Dong MQ,Ruse C,Yates JR 3rd,Russell P,Fuchs RP,McGowan CH,Gaillard PH

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
Molecular cell35(1)116-27(2009 Jul)
Mu?oz IM,Hain K,D?clais AC,Gardiner M,Toh GW,Sanchez-Pulido L,Heuckmann JM,Toth R,Macartney T,Eppink B,Kanaar R,Ponting CP,Lilley DM,Rouse J

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.
Molecular cell35(1)128-35(2009 Jul)
Andersen SL,Bergstralh DT,Kohl KP,LaRocque JR,Moore CB,Sekelsky J

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SLX1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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