BTG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BTG1
Entrez Gene ID	694
Full Name	BTG anti-proliferation factor 1
Synonyms	APRO2
General protein information	Preferred Names BTG anti-proliferation factor 1 Names protein BTG1 B-cell translocation gene 1 protein B-cell translocation gene 1, anti-proliferative
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q21.33
Summary	This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008].
Disorder MIM:	109580

mRNA and Protein(s)

mRNA	Protein	Name
NM_001731.2	NP_001722.1	protein BTG1
NM_001731.3	NP_001722.1	protein BTG1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BTG1	NP_776424.1
Rattus norvegicus (Norway rat)	Btg1	NP_058954.1
Homo sapiens (human)	BTG1	NP_001722.1
Pan troglodytes (chimpanzee)	BTG1	XP_509262.1
Mus musculus (house mouse)	Btg1	NP_031595.1
Xenopus tropicalis (tropical clawed frog)	btg1	NP_988926.1
	BTG1	XP_001104420.1
Gallus gallus (chicken)	BTG1	NP_990681.1
Danio rerio (zebrafish)	btg1	NP_956314.1

Gene Ontology
Bibliography

Related articles in PubMed

BTG1 low expression in pancreatic ductal adenocarcinoma is associated with a poorer prognosis.
Huang Y, Zheng J, Tan T, Song L, Huang S, Zhang Y, Lin L, Liu J, Zheng P, Chen X, Chen X, Ouyang X
The International journal of biological markers0(2017 Oct)

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.
Russell LJ, Jones L, Enshaei A, Tonin S, Ryan SL, Eswaran J, Nakjang S, Papaemmanuil E, Tubio JM, Fielding AK, Vora A, Campbell PJ, Moorman AV, Harrison CJ
Genes, chromosomes & cancer56(5)363-372(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BTG1 gene deletion is associated with acute lymphoblastic leukemia.
Title: Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.

our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.
Title: Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.

BTG1 interacts with ATF4 and positively modulates its activity by recruiting the protein arginine methyl transferase PRMT1 to methylate ATF4 on arginine residue 239.
Title: Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress.

our data suggest that BTG1 overexpression combined with radiation therapy increases the therapeutic efficacy of breast cancer treatment via regulation of the cell cycle and apoptosis-related signaling pathways.
Title: Upregulation of BTG1 enhances the radiation sensitivity of human breast cancer in vitro and in vivo.

Suggest that down-regulated BTG1 expression might promote gastric carcinogenesis partially due to its promoter methylation. BTG1 overexpression might reverse the aggressive phenotypes.
Title: BTG1 expression correlates with pathogenesis, aggressive behaviors and prognosis of gastric cancer: a potential target for gene therapy.

The following BTG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BTG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17579	NM_001731.3 Latest version!	Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17579	NM_001731.2	Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BTG1 ( NM_001731.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001722.1 Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.

Price & Availability↑

CloneID	OHu17579
Clone ID Related Accession (Same CDS sequence)	NM_001731.2 , NM_001731.3
Accession Version	NM_001731.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein BTG1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB042281.1, AK313309.1, BC064953.1, X61123.1, BC009050.1 and AC025164.37. On Oct 15, 2008 this sequence version replaced NM_001731.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AU133562.1, SRR1803614.241137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATCCCT TCTACACCCG GGCCGCCACC ATGATAGGCG AGATCGCCGC CGCCGTGTCC 
TTCATCTCCA AGTTTCTCCG CACCAAGGGG CTCACGAGCG AGCGACAGCT GCAGACCTTC 
AGCCAGAGCC TGCAGGAGCT GCTGGCAGAA CATTATAAAC ATCACTGGTT CCCAGAAAAG 
CCATGCAAGG GATCGGGTTA CCGTTGTATT CGCATCAACC ATAAAATGGA TCCTCTGATT 
GGACAGGCAG CACAGCGGAT TGGACTGAGC AGTCAGGAGC TGTTCAGGCT TCTCCCAAGT 
GAACTCACAC TCTGGGTTGA CCCCTATGAA GTGTCCTACA GAATTGGAGA GGATGGCTCC 
ATCTGTGTGC TGTATGAAGC CTCACCAGCA GGAGGTAGCA CTCAAAACAG CACCAACGTG 
CAAATGGTAG ACAGCCGAAT CAGCTGTAAG GAGGAACTTC TCTTGGGCAG AACGAGCCCT 
TCCAAAAACT ACAATATGAT GACTGTATCA GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001722.1
CDS	363..878
Translation	MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG

Target ORF information:

RefSeq Version	NM_001731.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001731.2

ORF Insert Sequence:

ATGCATCCCT TCTACACCCG GGCCGCCACC ATGATAGGCG AGATCGCCGC CGCCGTGTCC 
TTCATCTCCA AGTTTCTCCG CACCAAGGGG CTCACGAGCG AGCGACAGCT GCAGACCTTC 
AGCCAGAGCC TGCAGGAGCT GCTGGCAGAA CATTATAAAC ATCACTGGTT CCCAGAAAAG 
CCATGCAAGG GATCGGGTTA CCGTTGTATT CGCATCAACC ATAAAATGGA TCCTCTGATT 
GGACAGGCAG CACAGCGGAT TGGACTGAGC AGTCAGGAGC TGTTCAGGCT TCTCCCAAGT 
GAACTCACAC TCTGGGTTGA CCCCTATGAA GTGTCCTACA GAATTGGAGA GGATGGCTCC 
ATCTGTGTGC TGTATGAAGC CTCACCAGCA GGAGGTAGCA CTCAAAACAG CACCAACGTG 
CAAATGGTAG ACAGCCGAAT CAGCTGTAAG GAGGAACTTC TCTTGGGCAG AACGAGCCCT 
TCCAAAAACT ACAATATGAT GACTGTATCA GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BTG1 ( NM_001731.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001722.1 Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.

Price & Availability↑

CloneID	OHu17579
Clone ID Related Accession (Same CDS sequence)	NM_001731.2 , NM_001731.3
Accession Version	NM_001731.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein BTG1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313309.1, BC064953.1, X61123.1, BC009050.1 and AC025164.37. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001731.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA700239.1, SRR1803614.241137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256015.5/ ENSP00000256015.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCATCCCT TCTACACCCG GGCCGCCACC ATGATAGGCG AGATCGCCGC CGCCGTGTCC 
TTCATCTCCA AGTTTCTCCG CACCAAGGGG CTCACGAGCG AGCGACAGCT GCAGACCTTC 
AGCCAGAGCC TGCAGGAGCT GCTGGCAGAA CATTATAAAC ATCACTGGTT CCCAGAAAAG 
CCATGCAAGG GATCGGGTTA CCGTTGTATT CGCATCAACC ATAAAATGGA TCCTCTGATT 
GGACAGGCAG CACAGCGGAT TGGACTGAGC AGTCAGGAGC TGTTCAGGCT TCTCCCAAGT 
GAACTCACAC TCTGGGTTGA CCCCTATGAA GTGTCCTACA GAATTGGAGA GGATGGCTCC 
ATCTGTGTGC TGTATGAAGC CTCACCAGCA GGAGGTAGCA CTCAAAACAG CACCAACGTG 
CAAATGGTAG ACAGCCGAAT CAGCTGTAAG GAGGAACTTC TCTTGGGCAG AACGAGCCCT 
TCCAAAAACT ACAATATGAT GACTGTATCA GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001722.1
CDS	312..827
Translation	MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG

Target ORF information:

RefSeq Version	NM_001731.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001731.3

ORF Insert Sequence:

ATGCATCCCT TCTACACCCG GGCCGCCACC ATGATAGGCG AGATCGCCGC CGCCGTGTCC 
TTCATCTCCA AGTTTCTCCG CACCAAGGGG CTCACGAGCG AGCGACAGCT GCAGACCTTC 
AGCCAGAGCC TGCAGGAGCT GCTGGCAGAA CATTATAAAC ATCACTGGTT CCCAGAAAAG 
CCATGCAAGG GATCGGGTTA CCGTTGTATT CGCATCAACC ATAAAATGGA TCCTCTGATT 
GGACAGGCAG CACAGCGGAT TGGACTGAGC AGTCAGGAGC TGTTCAGGCT TCTCCCAAGT 
GAACTCACAC TCTGGGTTGA CCCCTATGAA GTGTCCTACA GAATTGGAGA GGATGGCTCC 
ATCTGTGTGC TGTATGAAGC CTCACCAGCA GGAGGTAGCA CTCAAAACAG CACCAACGTG 
CAAATGGTAG ACAGCCGAAT CAGCTGTAAG GAGGAACTTC TCTTGGGCAG AACGAGCCCT 
TCCAAAAACT ACAATATGAT GACTGTATCA GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BTG1 low expression in pancreatic ductal adenocarcinoma is associated with a poorer prognosis.
The International journal of biological markers0(2017 Oct)
Huang Y,Zheng J,Tan T,Song L,Huang S,Zhang Y,Lin L,Liu J,Zheng P,Chen X,Chen X,Ouyang X

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.
Genes, chromosomes & cancer56(5)363-372(2017 May)
Russell LJ,Jones L,Enshaei A,Tonin S,Ryan SL,Eswaran J,Nakjang S,Papaemmanuil E,Tubio JM,Fielding AK,Vora A,Campbell PJ,Moorman AV,Harrison CJ

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BTG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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