Btg1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Btg1
Entrez Gene ID	12226
Full Name	B cell translocation gene 1, anti-proliferative
Synonyms	AI426953,AW546738
General protein information	Preferred Names B cell translocation gene 1, anti-proliferative Names protein BTG1 B-cell translocation gene 1 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_007569.2	NP_031595.1	protein BTG1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BTG1	NP_776424.1
Rattus norvegicus (Norway rat)	Btg1	NP_058954.1
Homo sapiens (human)	BTG1	NP_001722.1
Pan troglodytes (chimpanzee)	BTG1	XP_509262.1
Mus musculus (house mouse)	Btg1	NP_031595.1
Xenopus tropicalis (tropical clawed frog)	btg1	NP_988926.1
	BTG1	XP_001104420.1
Gallus gallus (chicken)	BTG1	NP_990681.1
Danio rerio (zebrafish)	btg1	NP_956314.1

Gene Ontology
Bibliography

Related articles in PubMed

Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice.
Mastrorilli V, Scopa C, Saraulli D, Costanzi M, Scardigli R, Rouault JP, Farioli-Vecchioli S, Tirone F
Brain structure & function222(6)2855-2876(2017 Aug)

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Scheijen B, Boer JM, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer LT, Pieters R, Escherich G, Horstmann MA, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper RP, Hoogerbrugge PM, den Boer ML, van Leeuwen FN
Haematologica102(3)541-551(2017 03)

Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development.
Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Havinga J, Rouault JP, Hoogerbrugge PM, van Leeuwen FN, Scheijen B
Haematologica101(7)e272-6(2016 07)

BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism.
Xiao F, Deng J, Guo Y, Niu Y, Yuan F, Yu J, Chen S, Guo F
Science signaling9(428)ra50(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.
Title: Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.

Btg1 gain- and loss-of-function experiments were consistent with the pattern of expression of this gene in the developing digits. We detected a negative influence of BTG1 in the progress of cartilage maturation and a positive influence in the formation of fibrogenic tissue.
Title: The tumor suppressor BTG1 is expressed in the developing digits and regulates skeletogenic differentiation of limb mesodermal progenitors in high density cultures.

BTG1 has a role in regulating hepatic lipid metabolism and in preventing ATF4 and SCD1 from inducing liver steatosis
Title: BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism.

BTG1 overexpression or knockdown improved or impaired insulin signaling respectively.
Title: A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun.

Btg1 regulates the proliferation of cerebellar granule precursors selectively through cyclin D1.
Title: Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1.

The following Btg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Btg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00393	NM_007569.2 Latest version!	Mus musculus BTG anti-proliferation factor 1 (Btg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Btg1 ( NM_007569.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031595.1 Mus musculus BTG anti-proliferation factor 1 (Btg1), mRNA.

Price & Availability↑

CloneID	OMu00393
Clone ID Related Accession (Same CDS sequence)	NM_007569.2
Accession Version	NM_007569.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	protein BTG1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155936.7. On Oct 15, 2008 this sequence version replaced NM_007569.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149547.1, AK162764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCATCCCT TCTACACCCG GGCCGCCACC ATGATAGGCG AGATCGCCGC CGCGGTGTCC 
TTCATCTCCA AGTTCCTCCG CACCAAGGGG CTCACGAGCG AGCGACAGCT GCAGACTTTC 
AGCCAGAGCC TGCAGGAGCT GCTGGCAGAA CATTACAAAC ATCACTGGTT CCCAGAAAAG 
CCGTGCAAGG GATCAGGTTA CCGTTGTATT CGCATCAACC ATAAGATGGA TCCTCTGATT 
GGACAGGCAG CCCAGCGGAT TGGACTGAGC AGTCAGGAGT TGTTCAGGCT TCTCCCAAGT 
GAACTCACAC TCTGGGTTGA CCCCTACGAA GTGTCCTACC GGATTGGAGA GGATGGCTCC 
ATCTGCGTGC TGTACGAAGC CTCACCAGCA GGAGGTAGCA CTCAAAACAG CACCAACGTG 
CAAATGGTAG ACAGCAGAAT CAGCTGTAAG GAGGAACTTC TCTTGGGCAG AACAAGCCCT 
TCCAAAAACT ACAATATGAT GACTGTATCA GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031595.1
CDS	325..840
Translation	MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG

Target ORF information:

RefSeq Version	NM_007569.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus BTG anti-proliferation factor 1 (Btg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007569.2

ORF Insert Sequence:

ATGCATCCCT TCTACACCCG GGCCGCCACC ATGATAGGCG AGATCGCCGC CGCGGTGTCC 
TTCATCTCCA AGTTCCTCCG CACCAAGGGG CTCACGAGCG AGCGACAGCT GCAGACTTTC 
AGCCAGAGCC TGCAGGAGCT GCTGGCAGAA CATTACAAAC ATCACTGGTT CCCAGAAAAG 
CCGTGCAAGG GATCAGGTTA CCGTTGTATT CGCATCAACC ATAAGATGGA TCCTCTGATT 
GGACAGGCAG CCCAGCGGAT TGGACTGAGC AGTCAGGAGT TGTTCAGGCT TCTCCCAAGT 
GAACTCACAC TCTGGGTTGA CCCCTACGAA GTGTCCTACC GGATTGGAGA GGATGGCTCC 
ATCTGCGTGC TGTACGAAGC CTCACCAGCA GGAGGTAGCA CTCAAAACAG CACCAACGTG 
CAAATGGTAG ACAGCAGAAT CAGCTGTAAG GAGGAACTTC TCTTGGGCAG AACAAGCCCT 
TCCAAAAACT ACAATATGAT GACTGTATCA GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice.
Brain structure & function222(6)2855-2876(2017 Aug)
Mastrorilli V,Scopa C,Saraulli D,Costanzi M,Scardigli R,Rouault JP,Farioli-Vecchioli S,Tirone F

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Haematologica102(3)541-551(2017 03)
Scheijen B,Boer JM,Marke R,Tijchon E,van Ingen Schenau D,Waanders E,van Emst L,van der Meer LT,Pieters R,Escherich G,Horstmann MA,Sonneveld E,Venn N,Sutton R,Dalla-Pozza L,Kuiper RP,Hoogerbrugge PM,den Boer ML,van Leeuwen FN

Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development.
Haematologica101(7)e272-6(2016 07)
Tijchon E,van Emst L,Yuniati L,van Ingen Schenau D,Havinga J,Rouault JP,Hoogerbrugge PM,van Leeuwen FN,Scheijen B

BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism.
Science signaling9(428)ra50(2016 May)
Xiao F,Deng J,Guo Y,Niu Y,Yuan F,Yu J,Chen S,Guo F