SYP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SYP
Entrez Gene ID	6855
Full Name	synaptophysin
Synonyms	MRX96,MRXSYP
General protein information	Preferred Names synaptophysin Names synaptophysin major synaptic vesicle protein P38
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017].
Disorder MIM:	313475
Disorder Html:	Mental retardation, X-linked 96, 300802 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003179.2	NP_003170.1	synaptophysin

Pathways from BioSystems

Homologies

	SYP	XP_001106095.2
Homo sapiens (human)	SYP	NP_003170.1
Mus musculus (house mouse)	Syp	NP_033331.2
Xenopus tropicalis (tropical clawed frog)	syp	NP_001119974.1
Canis lupus familiaris (dog)	SYP	XP_005642145.1
Bos taurus (cattle)	SYP	NP_776388.1
Danio rerio (zebrafish)	sypa	NP_001137449.1
Rattus norvegicus (Norway rat)	Syp	NP_036796.1
Pan troglodytes (chimpanzee)	SYP	XP_521056.3

Gene Ontology
Bibliography

Related articles in PubMed

Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder.
Harper CB, Mancini GMS, van Slegtenhorst M, Cousin MA
Neurobiology of disease108298-306(2017 Dec)

Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide.
Pal SK, He M, Chen L, Yang L, Pillai R, Twardowski P, Hsu J, Kortylewski M, Jones JO
Urologic oncology(2017 Dec)

INSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic Cavity.
Rooper LM, Sharma R, Li QK, Illei PB, Westra WH
The American journal of surgical pathology41(11)1561-1569(2017 Nov)

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR
Nature genetics41(5)535-43(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Synaptophysin-positive epithelial proliferations suggest breast neoplasms.
Title: Effectiveness of computer-aided diagnosis (CADx) of breast pathology using immunohistochemistry results of core needle biopsy samples for synaptophysin, oestrogen receptor and CK14/p63 for classification of epithelial proliferative lesions of the breast.

Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56.
Title: INSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic Cavity.

High synaptophysin expression is associated with neuroendocrine differentiation in colorectal cancer.
Title: Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?

Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions.
Title: Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions.

Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
Title: [Development of the Human Olfactory Bulbs in the Prenatal Ontogenesis: an Immunochistochemical Study with Markers of Presynaptic Terminals (anti-SNAP-25, -Synapsin-I, -Synaptophysin)].

The following SYP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SYP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19314	NM_003179.2 Latest version!	Homo sapiens synaptophysin (SYP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SYP ( NM_003179.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003170.1 Homo sapiens synaptophysin (SYP), mRNA.

Price & Availability↑

CloneID	OHu19314
Clone ID Related Accession (Same CDS sequence)	NM_003179.2
Accession Version	NM_003179.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	synaptophysin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC064550.1, X06389.1 and BQ637168.1. This sequence is a reference standard in the RefSeqGene project. On Dec 17, 2004 this sequence version replaced NM_003179.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064550.1, SRR1660807.92345.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TGGCGGACAT GGACGTGGTG AATCAGCTGG TGGCTGGGGG TCAGTTCCGG 
GTGGTCAAGG AGCCCCTCGG CTTTGTGAAG GTGCTGCAAT GGGTCTTCGC CATCTTCGCC 
TTTGCCACAT GCGGCAGCTA CAGTGGGGAG CTCCAGCTGA GCGTGGATTG TGCCAACAAG 
ACCGAGAGTG ACCTCAGCAT CGAGGTCGAG TTCGAGTACC CCTTCAGGCT GCACCAAGTG 
TACTTTGATG CACCCACCTG CCGAGGGGGC ACCACCAAGG TCTTCTTAGT TGGGGACTAC 
TCCTCGTCAG CCGAATTCTT TGTCACCGTG GCCGTGTTTG CCTTCCTCTA CTCCATGGGG 
GCTCTGGCCA CCTACATCTT CCTGCAGAAC AAGTACCGAG AGAATAACAA AGGGCCCATG 
CTGGACTTTC TGGCCACGGC TGTGTTCGCC TTCATGTGGC TAGTTAGCTC ATCGGCATGG 
GCCAAGGGGC TGTCAGATGT GAAGATGGCC ACAGACCCAG AGAACATTAT CAAGGAGATG 
CCTGTCTGCC GCCAGACAGG GAACACATGC AAGGAGCTGA GAGACCCTGT GACCTCGGGA 
CTCAACACCT CGGTGGTGTT CGGCTTCCTG AACCTGGTGC TCTGGGTCGG CAACCTGTGG 
TTCGTGTTTA AGGAGACAGG CTGGGCCGCC CCGTTCCTGC GCGCGCCTCC CGGCGCCCCC 
GAGAAACAAC CGGCACCCGG GGACGCCTAC GGCGATGCAG GCTACGGGCA GGGCCCCGGC 
GGGTACGGGC CCCAGGATTC CTACGGGCCT CAGGGCGGCT ACCAGCCTGA CTATGGTCAA 
CCAGCCGGCA GCGGTGGCAG TGGCTACGGG CCTCAGGGCG ACTATGGGCA GCAAGGCTAC 
GGCCCGCAGG GTGCACCCAC CTCCTTCTCC AATCAGATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003170.1
CDS	17..958
Translation	MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGDYGQQGYGPQGAPTSFSNQM

Target ORF information:

RefSeq Version	NM_003179.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptophysin (SYP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003179.2

ORF Insert Sequence:

ATGCTGCTGC TGGCGGACAT GGACGTGGTG AATCAGCTGG TGGCTGGGGG TCAGTTCCGG 
GTGGTCAAGG AGCCCCTCGG CTTTGTGAAG GTGCTGCAAT GGGTCTTCGC CATCTTCGCC 
TTTGCCACAT GCGGCAGCTA CAGTGGGGAG CTCCAGCTGA GCGTGGATTG TGCCAACAAG 
ACCGAGAGTG ACCTCAGCAT CGAGGTCGAG TTCGAGTACC CCTTCAGGCT GCACCAAGTG 
TACTTTGATG CACCCACCTG CCGAGGGGGC ACCACCAAGG TCTTCTTAGT TGGGGACTAC 
TCCTCGTCAG CCGAATTCTT TGTCACCGTG GCCGTGTTTG CCTTCCTCTA CTCCATGGGG 
GCTCTGGCCA CCTACATCTT CCTGCAGAAC AAGTACCGAG AGAATAACAA AGGGCCCATG 
CTGGACTTTC TGGCCACGGC TGTGTTCGCC TTCATGTGGC TAGTTAGCTC ATCGGCATGG 
GCCAAGGGGC TGTCAGATGT GAAGATGGCC ACAGACCCAG AGAACATTAT CAAGGAGATG 
CCTGTCTGCC GCCAGACAGG GAACACATGC AAGGAGCTGA GAGACCCTGT GACCTCGGGA 
CTCAACACCT CGGTGGTGTT CGGCTTCCTG AACCTGGTGC TCTGGGTCGG CAACCTGTGG 
TTCGTGTTTA AGGAGACAGG CTGGGCCGCC CCGTTCCTGC GCGCGCCTCC CGGCGCCCCC 
GAGAAACAAC CGGCACCCGG GGACGCCTAC GGCGATGCAG GCTACGGGCA GGGCCCCGGC 
GGGTACGGGC CCCAGGATTC CTACGGGCCT CAGGGCGGCT ACCAGCCTGA CTATGGTCAA 
CCAGCCGGCA GCGGTGGCAG TGGCTACGGG CCTCAGGGCG ACTATGGGCA GCAAGGCTAC 
GGCCCGCAGG GTGCACCCAC CTCCTTCTCC AATCAGATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder.
Neurobiology of disease108298-306(2017 Dec)
Harper CB,Mancini GMS,van Slegtenhorst M,Cousin MA

Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide.
Urologic oncology(2017 Dec)
Pal SK,He M,Chen L,Yang L,Pillai R,Twardowski P,Hsu J,Kortylewski M,Jones JO

INSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic Cavity.
The American journal of surgical pathology41(11)1561-1569(2017 Nov)
Rooper LM,Sharma R,Li QK,Illei PB,Westra WH

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
Nature genetics41(5)535-43(2009 May)
Tarpey PS,Smith R,Pleasance E,Whibley A,Edkins S,Hardy C,O'Meara S,Latimer C,Dicks E,Menzies A,Stephens P,Blow M,Greenman C,Xue Y,Tyler-Smith C,Thompson D,Gray K,Andrews J,Barthorpe S,Buck G,Cole J,Dunmore R,Jones D,Maddison M,Mironenko T,Turner R,Turrell K,Varian J,West S,Widaa S,Wray P,Teague J,Butler A,Jenkinson A,Jia M,Richardson D,Shepherd R,Wooster R,Tejada MI,Martinez F,Carvill G,Goliath R,de Brouwer AP,van Bokhoven H,Van Esch H,Chelly J,Raynaud M,Ropers HH,Abidi FE,Srivastava AK,Cox J,Luo Y,Mallya U,Moon J,Parnau J,Mohammed S,Tolmie JL,Shoubridge C,Corbett M,Gardner A,Haan E,Rujirabanjerd S,Shaw M,Vandeleur L,Fullston T,Easton DF,Boyle J,Partington M,Hackett A,Field M,Skinner C,Stevenson RE,Bobrow M,Turner G,Schwartz CE,Gecz J,Raymond FL,Futreal PA,Stratton MR

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SYP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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