Syp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Syp
Entrez Gene ID	24804
Full Name	synaptophysin
Synonyms	Syp1
General protein information	Preferred Names synaptophysin Names synaptophysin major synaptic vesicle protein p38
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq12
Summary	may play a role in synaptic vesicle organization and synaptic plasticity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012664.3	NP_036796.1	synaptophysin

Pathways from BioSystems

Homologies

	SYP	XP_001106095.2
Homo sapiens (human)	SYP	NP_003170.1
Mus musculus (house mouse)	Syp	NP_033331.2
Xenopus tropicalis (tropical clawed frog)	syp	NP_001119974.1
Canis lupus familiaris (dog)	SYP	XP_005642145.1
Bos taurus (cattle)	SYP	NP_776388.1
Danio rerio (zebrafish)	sypa	NP_001137449.1
Rattus norvegicus (Norway rat)	Syp	NP_036796.1
Pan troglodytes (chimpanzee)	SYP	XP_521056.3

Gene Ontology
Bibliography

Related articles in PubMed

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.
Ottestad-Hansen S, Hu QX, Follin-Arbelet VV, Bentea E, Sato H, Massie A, Zhou Y, Danbolt NC
Glia(2018 Jan)

A single high dose of dexamethasone increases GAP-43 and synaptophysin in the hippocampus of aged rats.
Tesic V, Perovic M, Zaletel I, Jovanovic M, Puskas N, Ruzdijic S, Kanazir S
Experimental gerontology9862-69(2017 Nov)

The effect of IL-1? on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy.
Xiao Z, Peng J, Wu L, Arafat A, Yin F
Neurological research39(7)640-648(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Synaptophysin cerebellar cortex expression was significantly reduced in newborn animals from diabetic mothers.
Title: Altered expression and localization of synaptophysin in developing cerebellar cortex of neonatal rats due to maternal diabetes mellitus.

Synaptophysin spinal cord levels were higher in balance and coordination trained animals compared with non-trained following sciatic nerve crush.
Title: Balance and coordination training, but not endurance training, enhances synaptophysin and neurotrophin-3 immunoreactivity in the lumbar spinal cord after sciatic nerve crush.

Increased GluN2A, synaptophysin, BDNF, but not MAP2, observed after neonatal prebiotic feeding may suggest alteration in neurotransmission rather than synaptic architecture
Title: Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus.

showed a significant down-regulation in mRNA expression of synaptophysin in the offspring born to diabetic animals
Title: The impacts of diabetes in pregnancy on hippocampal synaptogenesis in rat neonates.

Syp1 clears Syb2 from the presynaptic active zone to prevent short-term depression.
Title: Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.

The following Syp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa63235	NM_012664.3 Latest version!	Rattus norvegicus synaptophysin (Syp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Syp ( NM_012664.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036796.1 Rattus norvegicus synaptophysin (Syp), mRNA.

Price & Availability↑

CloneID	ORa63235
Clone ID Related Accession (Same CDS sequence)	NM_012664.3
Accession Version	NM_012664.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Rattus norvegicus(Norway rat)
Product	synaptophysin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC099798.1. On Apr 14, 2016 this sequence version replaced NM_012664.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099798.1, X06177.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGTGG TGAATCAGCT GGTGGCTGGG GGTCAGTTCC GGGTGGTCAA GGAGCCCCTT 
GGCTTCGTGA AGGTGCTGCA GTGGGTCTTT GCCATCTTCG CCTTTGCTAC GTGTGGCAGC 
TACACCGGGG AGCTTCGGCT GAGCGTGGAG TGTGCCAACA AGACGGAGAG TGCCCTCAAC 
ATCGAAGTTG AATTCGAGTA CCCCTTCAGG CTGCACCAAG TGTACTTTGA TGCACCCTCC 
TGCGTCAAAG GGGGCACTAC CAAGATCTTC CTGGTTGGGG ACTACTCCTC GTCGGCTGAA 
TTCTTTGTCA CCGTGGCTGT GTTTGCCTTC CTCTACTCCA TGGGGGCCCT GGCCACCTAC 
ATCTTCCTGC AGAACAAGTA CCGAGAGAAC AACAAAGGGC CTATGATGGA CTTTCTGGCT 
ACAGCCGTGT TCGCTTTCAT GTGGCTAGTT AGTTCATCAG CCTGGGCCAA AGGCCTGTCC 
GATGTGAAGA TGGCCACGGA CCCAGAGAAC ATTATCAAGG AGATGCCCAT GTGCCGCCAG 
ACAGGGAACA CATGCAAGGA ACTGAGGGAC CCTGTGACTT CAGGACTCAA CACCTCAGTG 
GTGTTTGGCT TCCTGAACCT GGTGCTCTGG GTTGGCAACT TATGGTTCGT GTTCAAGGAG 
ACAGGCTGGG CAGCCCCATT CATGCGCGCA CCTCCAGGCG CCCCGGAAAA GCAACCAGCA 
CCTGGCGATG CCTACGGCGA TGCGGGCTAC GGGCAGGGCC CCGGAGGCTA TGGGCCCCAG 
GACTCCTACG GGCCTCAGGG TGGTTATCAA CCCGATTACG GGCAGCCAGC CAGCGGTGGC 
GGTGGCTACG GGCCTCAGGG CGACTATGGG CAGCAAGGCT ATGGCCAACA GGGTGCGCCC 
ACCTCCTTCT CCAATCAGAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036796.1
CDS	16..939
Translation	MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGYGPQGDYGQQGYGQQGAPTSFSNQM

Target ORF information:

RefSeq Version	NM_012664.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptophysin (Syp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012664.3

ORF Insert Sequence:

ATGGACGTGG TGAATCAGCT GGTGGCTGGG GGTCAGTTCC GGGTGGTCAA GGAGCCCCTT 
GGCTTCGTGA AGGTGCTGCA GTGGGTCTTT GCCATCTTCG CCTTTGCTAC GTGTGGCAGC 
TACACCGGGG AGCTTCGGCT GAGCGTGGAG TGTGCCAACA AGACGGAGAG TGCCCTCAAC 
ATCGAAGTTG AATTCGAGTA CCCCTTCAGG CTGCACCAAG TGTACTTTGA TGCACCCTCC 
TGCGTCAAAG GGGGCACTAC CAAGATCTTC CTGGTTGGGG ACTACTCCTC GTCGGCTGAA 
TTCTTTGTCA CCGTGGCTGT GTTTGCCTTC CTCTACTCCA TGGGGGCCCT GGCCACCTAC 
ATCTTCCTGC AGAACAAGTA CCGAGAGAAC AACAAAGGGC CTATGATGGA CTTTCTGGCT 
ACAGCCGTGT TCGCTTTCAT GTGGCTAGTT AGTTCATCAG CCTGGGCCAA AGGCCTGTCC 
GATGTGAAGA TGGCCACGGA CCCAGAGAAC ATTATCAAGG AGATGCCCAT GTGCCGCCAG 
ACAGGGAACA CATGCAAGGA ACTGAGGGAC CCTGTGACTT CAGGACTCAA CACCTCAGTG 
GTGTTTGGCT TCCTGAACCT GGTGCTCTGG GTTGGCAACT TATGGTTCGT GTTCAAGGAG 
ACAGGCTGGG CAGCCCCATT CATGCGCGCA CCTCCAGGCG CCCCGGAAAA GCAACCAGCA 
CCTGGCGATG CCTACGGCGA TGCGGGCTAC GGGCAGGGCC CCGGAGGCTA TGGGCCCCAG 
GACTCCTACG GGCCTCAGGG TGGTTATCAA CCCGATTACG GGCAGCCAGC CAGCGGTGGC 
GGTGGCTACG GGCCTCAGGG CGACTATGGG CAGCAAGGCT ATGGCCAACA GGGTGCGCCC 
ACCTCCTTCT CCAATCAGAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.
Glia(2018 Jan)
Ottestad-Hansen S,Hu QX,Follin-Arbelet VV,Bentea E,Sato H,Massie A,Zhou Y,Danbolt NC

A single high dose of dexamethasone increases GAP-43 and synaptophysin in the hippocampus of aged rats.
Experimental gerontology9862-69(2017 Nov)
Tesic V,Perovic M,Zaletel I,Jovanovic M,Puskas N,Ruzdijic S,Kanazir S

The effect of IL-1? on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy.
Neurological research39(7)640-648(2017 Jul)
Xiao Z,Peng J,Wu L,Arafat A,Yin F

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Syp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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