TMPRSS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMPRSS3
Entrez Gene ID	64699
Full Name	transmembrane serine protease 3
Synonyms	DFNB10,DFNB8,ECHOS1,TADG12
General protein information	Preferred Names transmembrane serine protease 3 Names transmembrane protease serine 3 serine protease TADG-12 transmembrane protease, serine 3 tumor-associated differentially-expressed gene 12 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
Disorder MIM:	605511
Disorder Html:	Deafness, autosomal recessive 8/10, 601072 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_024022.2	NP_076927.1	transmembrane protease serine 3 isoform 1
NM_001256317.2	NP_001243246.1	transmembrane protease serine 3 isoform 4
NM_001256317.1	NP_001243246.1	transmembrane protease serine 3 isoform 4
NM_032405.1	NP_115781.1	transmembrane protease serine 3 isoform 3
NM_032404.2	NP_115780.1	transmembrane protease serine 3 isoform 2
NM_032405.2	NP_115781.1	transmembrane protease serine 3 isoform 3
NM_024022.3	NP_076927.1	transmembrane protease serine 3 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TMPRSS3	XP_425558.3
	TMPRSS3	XP_001105841.2
Canis lupus familiaris (dog)	TMPRSS3	XP_853682.3
Rattus norvegicus (Norway rat)	Tmprss3	NP_001101089.1
Drosophila melanogaster (fruit fly)	CG4613	NP_648707.2
Xenopus tropicalis (tropical clawed frog)	tmprss3	XP_002940514.2
Homo sapiens (human)	TMPRSS3	NP_001243246.1
Pan troglodytes (chimpanzee)	TMPRSS3	XP_001137100.3
Mus musculus (house mouse)	Tmprss3	NP_001157248.1
Danio rerio (zebrafish)	tmprss3a	XP_001340422.5
Drosophila melanogaster (fruit fly)	CG3355	NP_608848.1
Bos taurus (cattle)	TMPRSS3	NP_001179855.1

Gene Ontology
Bibliography

Related articles in PubMed

The Analysis of A Frequent TMPRSS3 Allele Containing P.V116M and P.V291L in A Cis Configuration among Deaf Koreans.
Kim AR, Chung J, Kim NKD, Lee C, Park WY, Oh DY, Choi BY
International journal of molecular sciences18(11)(2017 Oct)

Identification of
Gao X, Huang SS, Yuan YY, Xu JC, Gu P, Bai D, Kang DY, Han MY, Wang GJ, Zhang MG, Li J, Dai P
Neural plasticity20173192090(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In conclusion, TMPRSS3 and TNFRSF11B may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.
Title: Dysregulation of TMPRSS3 and TNFRSF11B correlates with tumorigenesis and poor prognosis in patients with breast cancer.

different combinations of TMPRSS3 mutations led to different hearing impairment phenotypes (DFNB8/DFNB10) in the Chinese family.
Title: Novel Mutations and Mutation Combinations of

TMPRSS3 mutations seem to be an important cause of autosomal recessive nonsyndromic hearing loss in Slovenia resulting in rather uniform phenotype with profound congenital hearing loss.
Title: TMPRSS3 mutations in autosomal recessive nonsyndromic hearing loss.

Study demonstrated that TMPRSS3 contributes to ovarian cancer cell proliferation, invasion and metastasis, probably via activation of the ERK1/2 signaling pathway.
Title: TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis.

TMPRSS3 expression is an independent prognostic factor for breast cancer patients. Bioinformatic analysis of potential TMPRSS3 binding proteins revealed that TMPRSS3 could be a key regulator of cancer pathways.
Title: TMPRSS3 is a novel poor prognostic factor for breast cancer.

The following TMPRSS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMPRSS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25754	NM_032405.2 Latest version!	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant D, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu26323	NM_024022.3 Latest version!	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu27004	NM_032404.2 Latest version!	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant C, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu27241	NM_001256317.2 Latest version!	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant F, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu27241	NM_001256317.1	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant F, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu25754	NM_032405.1	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant D, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu26323	NM_024022.2	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMPRSS3 ( NM_032405.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_115781.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant D, mRNA.

Price & Availability↑

CloneID	OHu25754
Clone ID Related Accession (Same CDS sequence)	NM_032405.1 , NM_032405.2
Accession Version	NM_032405.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-29
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038160.1. Transcript Variant: This variant (D) lacks several 3' exons, but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant A. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038160.1, AF267741.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT 
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT 
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115781.1
CDS	202..1236
Translation	MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLCGSAALPLFQEDLQLLIEAFL

Target ORF information:

RefSeq Version	NM_032405.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant D, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032405.1

ORF Insert Sequence:

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT 
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT 
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS3 ( NM_032405.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115781.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant D, mRNA.

Price & Availability↑

CloneID	OHu25754
Clone ID Related Accession (Same CDS sequence)	NM_032405.1 , NM_032405.2
Accession Version	NM_032405.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038160.1. On Jun 2, 2019 this sequence version replaced NM_032405.1. Transcript Variant: This variant (D) lacks several 3' exons, but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant A. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF267741.1, AB038160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT 
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT 
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115781.1
CDS	163..1197
Translation	MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLCGSAALPLFQEDLQLLIEAFL

Target ORF information:

RefSeq Version	NM_032405.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant D, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032405.2

ORF Insert Sequence:

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT 
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT 
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS3 ( NM_024022.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076927.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu26323
Clone ID Related Accession (Same CDS sequence)	NM_024022.2 , NM_024022.3
Accession Version	NM_024022.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AK172842.1, AI251446.1 and AP001623.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_024022.2. Transcript Variant: This variant (A) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.169975.1, SRR1803614.222922.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG 
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC 
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC 
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC 
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC 
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076927.1
CDS	163..1527
Translation	MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT

Target ORF information:

RefSeq Version	NM_024022.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024022.3

ORF Insert Sequence:

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG 
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC 
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC 
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC 
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC 
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS3 ( NM_024022.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_076927.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant A, mRNA.

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CloneID	OHu26323
Clone ID Related Accession (Same CDS sequence)	NM_024022.2 , NM_024022.3
Accession Version	NM_024022.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AK172842.1 and AI251446.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2009 this sequence version replaced NM_024022.1. Transcript Variant: This variant (A) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038157.1, AY633572.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG 
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC 
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC 
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC 
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC 
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076927.1
CDS	202..1566
Translation	MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT

Target ORF information:

RefSeq Version	NM_024022.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024022.2

ORF Insert Sequence:

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG 
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC 
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC 
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC 
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC 
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS3 ( NM_032404.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115780.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant C, mRNA.

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CloneID	OHu27004
Clone ID Related Accession (Same CDS sequence)	NM_032404.2
Accession Version	NM_032404.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA643571.1, AB038159.1, AK172842.1 and AI251446.1. On or before Jan 19, 2012 this sequence version replaced NR_027348.1, NM_032404.1. Transcript Variant: This variant (C) lacks several 5' exons but contains an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant A. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038159.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCTCCG ATGACTGGAA GGGTCACTAC GCAAATGTTG CCTGTGCCCA ACTGGGTTTC 
CCAAGCTATG TGAGTTCAGA TAACCTCAGA GTGAGCTCGC TGGAGGGGCA GTTCCGGGAG 
GAGTTTGTGT CCATCGATCA CCTCTTGCCA GATGACAAGG TGACTGCATT ACACCACTCA 
GTATATGTGA GGGAGGGATG TGCCTCTGGC CACGTGGTTA CCTTGCAGTG CACAGCCTGT 
GGTCATAGAA GGGGCTACAG CTCACGCATC GTGGGTGGAA ACATGTCCTT GCTCTCGCAG 
TGGCCCTGGC AGGCCAGCCT TCAGTTCCAG GGCTACCACC TGTGCGGGGG CTCTGTCATC 
ACGCCCCTGT GGATCATCAC TGCTGCACAC TGTGTTTATG ACTTGTACCT CCCCAAGTCA 
TGGACCATCC AGGTGGGTCT AGTTTCCCTG TTGGACAATC CAGCCCCATC CCACTTGGTG 
GAGAAGATTG TCTACCACAG CAAGTACAAG CCAAAGAGGC TGGGCAATGA CATCGCCCTT 
ATGAAGCTGG CCGGGCCACT CACGTTCAAT GAAATGATCC AGCCTGTGTG CCTGCCCAAC 
TCTGAAGAGA ACTTCCCCGA TGGAAAAGTG TGCTGGACGT CAGGATGGGG GGCCACAGAG 
GATGGAGCAG GTGACGCCTC CCCTGTCCTG AACCACGCGG CCGTCCCTTT GATTTCCAAC 
AAGATCTGCA ACCACAGGGA CGTGTACGGT GGCATCATCT CCCCCTCCAT GCTCTGCGCG 
GGCTACCTGA CGGGTGGCGT GGACAGCTGC CAGGGGGACA GCGGGGGGCC CCTGGTGTGT 
CAAGAGAGGA GGCTGTGGAA GTTAGTGGGA GCGACCAGCT TTGGCATCGG CTGCGCAGAG 
GTGAACAAGC CTGGGGTGTA CACCCGTGTC ACCTCCTTCC TGGACTGGAT CCACGAGCAG 
ATGGAGAGAG ACCTAAAAAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115780.1
CDS	281..1264
Translation	MCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT

Target ORF information:

RefSeq Version	NM_032404.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant C, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032404.2

ORF Insert Sequence:

ATGTGCTCCG ATGACTGGAA GGGTCACTAC GCAAATGTTG CCTGTGCCCA ACTGGGTTTC 
CCAAGCTATG TGAGTTCAGA TAACCTCAGA GTGAGCTCGC TGGAGGGGCA GTTCCGGGAG 
GAGTTTGTGT CCATCGATCA CCTCTTGCCA GATGACAAGG TGACTGCATT ACACCACTCA 
GTATATGTGA GGGAGGGATG TGCCTCTGGC CACGTGGTTA CCTTGCAGTG CACAGCCTGT 
GGTCATAGAA GGGGCTACAG CTCACGCATC GTGGGTGGAA ACATGTCCTT GCTCTCGCAG 
TGGCCCTGGC AGGCCAGCCT TCAGTTCCAG GGCTACCACC TGTGCGGGGG CTCTGTCATC 
ACGCCCCTGT GGATCATCAC TGCTGCACAC TGTGTTTATG ACTTGTACCT CCCCAAGTCA 
TGGACCATCC AGGTGGGTCT AGTTTCCCTG TTGGACAATC CAGCCCCATC CCACTTGGTG 
GAGAAGATTG TCTACCACAG CAAGTACAAG CCAAAGAGGC TGGGCAATGA CATCGCCCTT 
ATGAAGCTGG CCGGGCCACT CACGTTCAAT GAAATGATCC AGCCTGTGTG CCTGCCCAAC 
TCTGAAGAGA ACTTCCCCGA TGGAAAAGTG TGCTGGACGT CAGGATGGGG GGCCACAGAG 
GATGGAGCAG GTGACGCCTC CCCTGTCCTG AACCACGCGG CCGTCCCTTT GATTTCCAAC 
AAGATCTGCA ACCACAGGGA CGTGTACGGT GGCATCATCT CCCCCTCCAT GCTCTGCGCG 
GGCTACCTGA CGGGTGGCGT GGACAGCTGC CAGGGGGACA GCGGGGGGCC CCTGGTGTGT 
CAAGAGAGGA GGCTGTGGAA GTTAGTGGGA GCGACCAGCT TTGGCATCGG CTGCGCAGAG 
GTGAACAAGC CTGGGGTGTA CACCCGTGTC ACCTCCTTCC TGGACTGGAT CCACGAGCAG 
ATGGAGAGAG ACCTAAAAAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS3 ( NM_001256317.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243246.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant F, mRNA.

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CloneID	OHu27241
Clone ID Related Accession (Same CDS sequence)	NM_001256317.2 , NM_001256317.1
Accession Version	NM_001256317.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AY358458.1, AK172842.1, AB038159.1, AI251446.1 and AP001623.1. On Jun 2, 2019 this sequence version replaced NM_001256317.1. Transcript Variant: This variant (F) uses an alternate in-frame splice site in the central coding region, compared to variant A, resulting in an isoform (4) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358458.1, SRR1803612.116058.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC 
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC 
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC 
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT 
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG 
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243246.1
CDS	163..1524
Translation	MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT

Target ORF information:

RefSeq Version	NM_001256317.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant F, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256317.2

ORF Insert Sequence:

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC 
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC 
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC 
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT 
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG 
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS3 ( NM_001256317.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243246.1 Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant F, mRNA.

Price & Availability↑

CloneID	OHu27241
Clone ID Related Accession (Same CDS sequence)	NM_001256317.2 , NM_001256317.1
Accession Version	NM_001256317.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	transmembrane protease serine 3 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AY358458.1, AK172842.1, AB038159.1 and AI251446.1. Transcript Variant: This variant (F) uses an alternate in-frame splice site in the central coding region, compared to variant A, resulting in an isoform (4) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172842.1, AF201380.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC 
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC 
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC 
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT 
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG 
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243246.1
CDS	202..1563
Translation	MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT

Target ORF information:

RefSeq Version	NM_001256317.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 3 (TMPRSS3), transcript variant F, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256317.1

ORF Insert Sequence:

ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC 
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA 
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC 
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC 
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC 
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT 
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG 
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG 
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT 
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA 
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC 
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT 
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT 
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG 
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC 
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG 
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC 
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC 
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC 
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT 
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG 
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Analysis of A Frequent TMPRSS3 Allele Containing P.V116M and P.V291L in A Cis Configuration among Deaf Koreans.
International journal of molecular sciences18(11)(2017 Oct)
Kim AR,Chung J,Kim NKD,Lee C,Park WY,Oh DY,Choi BY

Identification of
Neural plasticity20173192090(2017)
Gao X,Huang SS,Yuan YY,Xu JC,Gu P,Bai D,Kang DY,Han MY,Wang GJ,Zhang MG,Li J,Dai P

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TMPRSS3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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