Tmprss3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tmprss3
Entrez Gene ID	140765
Full Name	transmembrane protease, serine 3
General protein information	Preferred Names transmembrane protease, serine 3 Names transmembrane protease serine 3 transmembrane proteinase serine 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_017317241.1	XP_017172730.1	transmembrane protease serine 3 isoform X1
NM_080727.2	NP_542765.2	transmembrane protease serine 3 isoform 2
NM_001163776.1	NP_001157248.1	transmembrane protease serine 3 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TMPRSS3	XP_425558.3
	TMPRSS3	XP_001105841.2
Canis lupus familiaris (dog)	TMPRSS3	XP_853682.3
Rattus norvegicus (Norway rat)	Tmprss3	NP_001101089.1
Drosophila melanogaster (fruit fly)	CG4613	NP_648707.2
Xenopus tropicalis (tropical clawed frog)	tmprss3	XP_002940514.2
Homo sapiens (human)	TMPRSS3	NP_001243246.1
Pan troglodytes (chimpanzee)	TMPRSS3	XP_001137100.3
Mus musculus (house mouse)	Tmprss3	NP_001157248.1
Danio rerio (zebrafish)	tmprss3a	XP_001340422.5
Drosophila melanogaster (fruit fly)	CG3355	NP_608848.1
Bos taurus (cattle)	TMPRSS3	NP_001179855.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-204 suppresses cochlear spiral ganglion neuron survival in?vitro by targeting TMPRSS3.
Li Y, Peng A, Ge S, Wang Q, Liu J
Hearing research31460-4(2014 Aug)

Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression.
Molina L, Fasquelle L, Nouvian R, Salvetat N, Scott HS, Guipponi M, Molina F, Puel JL, Delprat B
Human molecular genetics22(7)1289-99(2013 Apr)

[Expression of proteinase TMPRSS3 in mouse cochlea].
Ge S, Wang Q, Peng A, Wu W, Xie D
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences36(8)794-8(2011 Aug)

Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.
Fasquelle L, Scott HS, Lenoir M, Wang J, Rebillard G, Gaboyard S, Venteo S, Fran?ois F, Mausset-Bonnefont AL, Antonarakis SE, Neidhart E, Chabbert C, Puel JL, Guipponi M, Delprat B
The Journal of biological chemistry286(19)17383-97(2011 May)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-204 has a role in suppressing cochlear spiral ganglion neuron survival in vitro by targeting TMPRSS3
Title: miR-204 suppresses cochlear spiral ganglion neuron survival in?vitro by targeting TMPRSS3.

Lack of Tmprss3 leads to a decrease in Kcnma1 potassium channels expression in cochlear inner hair cells.
Title: Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression.

The distribution of TMPRSS3 was observed in many regions of the mouse cochlea, but mainly in the spiral ganglion neurons.
Title: [Expression of proteinase TMPRSS3 in mouse cochlea].

Tmprss3 acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival
Title: Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.

The following Tmprss3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmprss3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09430	NM_001163776.1 Latest version!	Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00
OMu09742	NM_080727.2 Latest version!	Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu79458	XM_017317241.1 Latest version!	Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tmprss3 ( NM_001163776.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001157248.1 Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09430
Clone ID Related Accession (Same CDS sequence)	NM_001163776.1
Accession Version	NM_001163776.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158203.1 and AC167247.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK158203.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164135, SAMN01164143 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTT CAGAAATGGT GGAGGTGGAG CCGGAACCCA ACATCAGAGG CCCTGAGATA 
GTCACCATGG GGGAGAATGA CCCTCCGGCA GCCGAAGCTC CCTTCTCCTT CCGGTCTCTC 
TTCGGCTTGG ATGATTTGAA AATAAGTCCT GTGGCACCAG ATGGAGACGC AGTGGCTGCG 
CAGATCTTGT CCCTTCTGCC CTTGAAGTTT TTTCCGATCA TCGTCATTGG GATCATCGCC 
TTGATACTGG CGCTGGCCAT CGGTCTGGGC ATCCACTTCG ACTGCTCTGG GAAGTACAGG 
TGCCATTCAT CTTTCAAGTG TATTGAACTA ACAGCTCGAT GCGACGGGGT CTCCGACTGC 
AAGAACGCAG AGGATGAGTA CCGATGCGTG CGGGTGAGCG GCCAAAGAGC GGCGCTCCAA 
GTGTTCACAG CTGCTGCGTG GAGGACCATG TGCTCCGATG ACTGGAAAAG CCACTATGCC 
AAGATTGCCT GTGCCCAGCT GGGGTTTCCC AGCTATGTGA GCTCAGACCA CCTAAGAGTG 
GATGCGCTGG AGGAGCAGTT CCAGGGCGAC TTCGTGTCCA TCAATCACCT CTTGTCAGAT 
GACAAGGTGA CGGCGTTACA CCACTCTGTG TACATGAGGG AAGGCTGCAC CTCAGGCCAC 
GTGGTCACCT TGAAGTGCTC AGCCTGTGGC ACGAGAACGG GCTACAGTCC CCGAATTGTG 
GGTGGAAACA TGTCCTCGCT CACTCAGTGG CCCTGGCAGG TCAGCCTCCA GTTCCAGGGG 
TACCACCTAT GTGGGGGCTC CATCATCACC CCTCTGTGGA TCGTCACTGC GGCACACTGT 
GTTTATGACC TGTACCACCC CAAGTCCTGG ACTGTCCAGG TGGGTCTTGT GTCCCTGATG 
GACAGTCCTG TGCCCTCCCA TCTGGTGGAG AAAATCATCT ATCACAGCAA GTACAAGCCA 
AAGCGGCTGG GCAATGACAT AGCCCTCATG AAGCTGTCCG AGCCACTCAC CTTTGACGAG 
ACCATCCAGC CCATCTGTCT GCCCAACTCT GAAGAGAACT TTCCCGATGG GAAACTGTGC 
TGGACCTCAG GATGGGGAGC CACAGAGGAT GGAGGTGACG CCTCCCCTGT CCTGAACCAC 
GCGGCTGTCC CTTTAATTTC AAACAAGATC TGCAACCACA GGGACGTGTA TGGTGGTATC 
ATCTCTCCCT CCATGCTCTG TGCAGGCTAC CTGAAGGGCG GTGTGGACAG CTGCCAGGGA 
GACAGTGGAG GACCCCTGGT GTGCCAGGAG AGGAGACTGT GGAAGTTAGT GGGTGCAACA 
AGTTTTGGAA TCGGCTGTGC TGAAGTGAAC AAGCCTGGAG TCTATACGCG AATCACCTCC 
TTCCTGGACT GGATTCACGA ACAGTTGGAG AGAGATCTGA AGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157248.1
CDS	130..1557
Translation	MAASEMVEVEPEPNIRGPEIVTMGENDPPAAEAPFSFRSLFGLDDLKISPVAPDGDAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCHSSFKCIELTARCDGVSDCKNAEDEYRCVRVSGQRAALQVFTAAAWRTMCSDDWKSHYAKIACAQLGFPSYVSSDHLRVDALEEQFQGDFVSINHLLSDDKVTALHHSVYMREGCTSGHVVTLKCSACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHPKSWTVQVGLVSLMDSPVPSHLVEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETIQPICLPNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLKGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLERDLKT

Target ORF information:

RefSeq Version	NM_001163776.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163776.1

ORF Insert Sequence:

ATGGCCGCTT CAGAAATGGT GGAGGTGGAG CCGGAACCCA ACATCAGAGG CCCTGAGATA 
GTCACCATGG GGGAGAATGA CCCTCCGGCA GCCGAAGCTC CCTTCTCCTT CCGGTCTCTC 
TTCGGCTTGG ATGATTTGAA AATAAGTCCT GTGGCACCAG ATGGAGACGC AGTGGCTGCG 
CAGATCTTGT CCCTTCTGCC CTTGAAGTTT TTTCCGATCA TCGTCATTGG GATCATCGCC 
TTGATACTGG CGCTGGCCAT CGGTCTGGGC ATCCACTTCG ACTGCTCTGG GAAGTACAGG 
TGCCATTCAT CTTTCAAGTG TATTGAACTA ACAGCTCGAT GCGACGGGGT CTCCGACTGC 
AAGAACGCAG AGGATGAGTA CCGATGCGTG CGGGTGAGCG GCCAAAGAGC GGCGCTCCAA 
GTGTTCACAG CTGCTGCGTG GAGGACCATG TGCTCCGATG ACTGGAAAAG CCACTATGCC 
AAGATTGCCT GTGCCCAGCT GGGGTTTCCC AGCTATGTGA GCTCAGACCA CCTAAGAGTG 
GATGCGCTGG AGGAGCAGTT CCAGGGCGAC TTCGTGTCCA TCAATCACCT CTTGTCAGAT 
GACAAGGTGA CGGCGTTACA CCACTCTGTG TACATGAGGG AAGGCTGCAC CTCAGGCCAC 
GTGGTCACCT TGAAGTGCTC AGCCTGTGGC ACGAGAACGG GCTACAGTCC CCGAATTGTG 
GGTGGAAACA TGTCCTCGCT CACTCAGTGG CCCTGGCAGG TCAGCCTCCA GTTCCAGGGG 
TACCACCTAT GTGGGGGCTC CATCATCACC CCTCTGTGGA TCGTCACTGC GGCACACTGT 
GTTTATGACC TGTACCACCC CAAGTCCTGG ACTGTCCAGG TGGGTCTTGT GTCCCTGATG 
GACAGTCCTG TGCCCTCCCA TCTGGTGGAG AAAATCATCT ATCACAGCAA GTACAAGCCA 
AAGCGGCTGG GCAATGACAT AGCCCTCATG AAGCTGTCCG AGCCACTCAC CTTTGACGAG 
ACCATCCAGC CCATCTGTCT GCCCAACTCT GAAGAGAACT TTCCCGATGG GAAACTGTGC 
TGGACCTCAG GATGGGGAGC CACAGAGGAT GGAGGTGACG CCTCCCCTGT CCTGAACCAC 
GCGGCTGTCC CTTTAATTTC AAACAAGATC TGCAACCACA GGGACGTGTA TGGTGGTATC 
ATCTCTCCCT CCATGCTCTG TGCAGGCTAC CTGAAGGGCG GTGTGGACAG CTGCCAGGGA 
GACAGTGGAG GACCCCTGGT GTGCCAGGAG AGGAGACTGT GGAAGTTAGT GGGTGCAACA 
AGTTTTGGAA TCGGCTGTGC TGAAGTGAAC AAGCCTGGAG TCTATACGCG AATCACCTCC 
TTCCTGGACT GGATTCACGA ACAGTTGGAG AGAGATCTGA AGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss3 ( NM_080727.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_542765.2 Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu09742
Clone ID Related Accession (Same CDS sequence)	NM_080727.2
Accession Version	NM_080727.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167247.2 and AK158203.1. On Aug 1, 2009 this sequence version replaced NM_080727.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ300738.1, BC112375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAGA ATGACCCTCC GGCAGCCGAA GCTCCCTTCT CCTTCCGGTC TCTCTTCGGC 
TTGGATGATT TGAAAATAAG TCCTGTGGCA CCAGATGGAG ACGCAGTGGC TGCGCAGATC 
TTGTCCCTTC TGCCCTTGAA GTTTTTTCCG ATCATCGTCA TTGGGATCAT CGCCTTGATA 
CTGGCGCTGG CCATCGGTCT GGGCATCCAC TTCGACTGCT CTGGGAAGTA CAGGTGCCAT 
TCATCTTTCA AGTGTATTGA ACTAACAGCT CGATGCGACG GGGTCTCCGA CTGCAAGAAC 
GCAGAGGATG AGTACCGATG CGTGCGGGTG AGCGGCCAAA GAGCGGCGCT CCAAGTGTTC 
ACAGCTGCTG CGTGGAGGAC CATGTGCTCC GATGACTGGA AAAGCCACTA TGCCAAGATT 
GCCTGTGCCC AGCTGGGGTT TCCCAGCTAT GTGAGCTCAG ACCACCTAAG AGTGGATGCG 
CTGGAGGAGC AGTTCCAGGG CGACTTCGTG TCCATCAATC ACCTCTTGTC AGATGACAAG 
GTGACGGCGT TACACCACTC TGTGTACATG AGGGAAGGCT GCACCTCAGG CCACGTGGTC 
ACCTTGAAGT GCTCAGCCTG TGGCACGAGA ACGGGCTACA GTCCCCGAAT TGTGGGTGGA 
AACATGTCCT CGCTCACTCA GTGGCCCTGG CAGGTCAGCC TCCAGTTCCA GGGGTACCAC 
CTATGTGGGG GCTCCATCAT CACCCCTCTG TGGATCGTCA CTGCGGCACA CTGTGTTTAT 
GACCTGTACC ACCCCAAGTC CTGGACTGTC CAGGTGGGTC TTGTGTCCCT GATGGACAGT 
CCTGTGCCCT CCCATCTGGT GGAGAAAATC ATCTATCACA GCAAGTACAA GCCAAAGCGG 
CTGGGCAATG ACATAGCCCT CATGAAGCTG TCCGAGCCAC TCACCTTTGA CGAGACCATC 
CAGCCCATCT GTCTGCCCAA CTCTGAAGAG AACTTTCCCG ATGGGAAACT GTGCTGGACC 
TCAGGATGGG GAGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCT 
GTCCCTTTAA TTTCAAACAA GATCTGCAAC CACAGGGACG TGTATGGTGG TATCATCTCT 
CCCTCCATGC TCTGTGCAGG CTACCTGAAG GGCGGTGTGG ACAGCTGCCA GGGAGACAGT 
GGAGGACCCC TGGTGTGCCA GGAGAGGAGA CTGTGGAAGT TAGTGGGTGC AACAAGTTTT 
GGAATCGGCT GTGCTGAAGT GAACAAGCCT GGAGTCTATA CGCGAATCAC CTCCTTCCTG 
GACTGGATTC ACGAACAGTT GGAGAGAGAT CTGAAGACTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542765.2
CDS	56..1417
Translation	MGENDPPAAEAPFSFRSLFGLDDLKISPVAPDGDAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCHSSFKCIELTARCDGVSDCKNAEDEYRCVRVSGQRAALQVFTAAAWRTMCSDDWKSHYAKIACAQLGFPSYVSSDHLRVDALEEQFQGDFVSINHLLSDDKVTALHHSVYMREGCTSGHVVTLKCSACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHPKSWTVQVGLVSLMDSPVPSHLVEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETIQPICLPNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLKGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLERDLKT

Target ORF information:

RefSeq Version	NM_080727.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080727.2

ORF Insert Sequence:

ATGGGGGAGA ATGACCCTCC GGCAGCCGAA GCTCCCTTCT CCTTCCGGTC TCTCTTCGGC 
TTGGATGATT TGAAAATAAG TCCTGTGGCA CCAGATGGAG ACGCAGTGGC TGCGCAGATC 
TTGTCCCTTC TGCCCTTGAA GTTTTTTCCG ATCATCGTCA TTGGGATCAT CGCCTTGATA 
CTGGCGCTGG CCATCGGTCT GGGCATCCAC TTCGACTGCT CTGGGAAGTA CAGGTGCCAT 
TCATCTTTCA AGTGTATTGA ACTAACAGCT CGATGCGACG GGGTCTCCGA CTGCAAGAAC 
GCAGAGGATG AGTACCGATG CGTGCGGGTG AGCGGCCAAA GAGCGGCGCT CCAAGTGTTC 
ACAGCTGCTG CGTGGAGGAC CATGTGCTCC GATGACTGGA AAAGCCACTA TGCCAAGATT 
GCCTGTGCCC AGCTGGGGTT TCCCAGCTAT GTGAGCTCAG ACCACCTAAG AGTGGATGCG 
CTGGAGGAGC AGTTCCAGGG CGACTTCGTG TCCATCAATC ACCTCTTGTC AGATGACAAG 
GTGACGGCGT TACACCACTC TGTGTACATG AGGGAAGGCT GCACCTCAGG CCACGTGGTC 
ACCTTGAAGT GCTCAGCCTG TGGCACGAGA ACGGGCTACA GTCCCCGAAT TGTGGGTGGA 
AACATGTCCT CGCTCACTCA GTGGCCCTGG CAGGTCAGCC TCCAGTTCCA GGGGTACCAC 
CTATGTGGGG GCTCCATCAT CACCCCTCTG TGGATCGTCA CTGCGGCACA CTGTGTTTAT 
GACCTGTACC ACCCCAAGTC CTGGACTGTC CAGGTGGGTC TTGTGTCCCT GATGGACAGT 
CCTGTGCCCT CCCATCTGGT GGAGAAAATC ATCTATCACA GCAAGTACAA GCCAAAGCGG 
CTGGGCAATG ACATAGCCCT CATGAAGCTG TCCGAGCCAC TCACCTTTGA CGAGACCATC 
CAGCCCATCT GTCTGCCCAA CTCTGAAGAG AACTTTCCCG ATGGGAAACT GTGCTGGACC 
TCAGGATGGG GAGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCT 
GTCCCTTTAA TTTCAAACAA GATCTGCAAC CACAGGGACG TGTATGGTGG TATCATCTCT 
CCCTCCATGC TCTGTGCAGG CTACCTGAAG GGCGGTGTGG ACAGCTGCCA GGGAGACAGT 
GGAGGACCCC TGGTGTGCCA GGAGAGGAGA CTGTGGAAGT TAGTGGGTGC AACAAGTTTT 
GGAATCGGCT GTGCTGAAGT GAACAAGCCT GGAGTCTATA CGCGAATCAC CTCCTTCCTG 
GACTGGATTC ACGAACAGTT GGAGAGAGAT CTGAAGACTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss3 ( XM_017317241.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017172730.1 Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu79458
Clone ID Related Accession (Same CDS sequence)	XM_017317241.1
Accession Version	XM_017317241.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	transmembrane protease serine 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAGA ATGACCCTCC GGCAGCCGAA GCTCCCTTCT CCTTCCGGTC TCTCTTCGGC 
TTGGATGATT TGAAAATAAG TCCTGTGGCA CCAGATGGAG ACGCAGTGGC TGCGCAGATC 
TTGTCCCTTC TGCCCTTGAA GTTTTTTCCG ATCATCGTCA TTGGGATCAT CGCCTTGATA 
CTGGCGCTGG CCATCGGTCT GGGCATCCAC TTCGACTGCT CTGGGAAGTA CAGGTGCCAT 
TCATCTTTCA AGTGTATTGA ACTAACAGCT CGATGCGACG GGGTCTCCGA CTGCAAGAAC 
GCAGAGGATG AGTACCGATG CGTGCGGGTG AGCGGCCAAA GAGCGGCGCT CCAAGTGTTC 
ACAGCTGCTG CGTGGAGGAC CATGTGCTCC GATGACTGGA AAAGCCACTA TGCCAAGATT 
GCCTGTGCCC AGCTGGGGTT TCCCAGCTAT GTGAGCTCAG ACCACCTAAG AGTGGATGCG 
CTGGAGGAGC AGTTCCAGGG CGACTTCGTG TCCATCAATC ACCTCTTGTC AGATGACAAG 
GTGACGGCGT TACACCACTC TGTGTACATG AGGGAAGGCT GCACCTCAGG CCACGTGGTC 
ACCTTGAAGT GCTCAGCCTG TGGCACGAGA ACGGGCTACA GTCCCCGAAT TGTGGGTGGA 
AACATGTCCT CGCTCACTCA GTGGCCCTGG CAGCCTGTAC CACCCCAAGT CCTGGACTGT 
CCAGGTGGGT CTTGTGTCCC TGATGGACAG TCCTGTGCCC TCCCATCTGG TGGAGAAAAT 
CATCTATCAC AGCAAGTACA AGCCAAAGCG GCTGGGCAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017172730.1
CDS	2811..3632
Translation	MGENDPPAAEAPFSFRSLFGLDDLKISPVAPDGDAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCHSSFKCIELTARCDGVSDCKNAEDEYRCVRVSGQRAALQVFTAAAWRTMCSDDWKSHYAKIACAQLGFPSYVSSDHLRVDALEEQFQGDFVSINHLLSDDKVTALHHSVYMREGCTSGHVVTLKCSACGTRTGYSPRIVGGNMSSLTQWPWQPVPPQVLDCPGGSCVPDGQSCALPSGGENHLSQQVQAKAAGQ

Target ORF information:

RefSeq Version	XM_017317241.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protease, serine 3 (Tmprss3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017317241.1

ORF Insert Sequence:

ATGGGGGAGA ATGACCCTCC GGCAGCCGAA GCTCCCTTCT CCTTCCGGTC TCTCTTCGGC 
TTGGATGATT TGAAAATAAG TCCTGTGGCA CCAGATGGAG ACGCAGTGGC TGCGCAGATC 
TTGTCCCTTC TGCCCTTGAA GTTTTTTCCG ATCATCGTCA TTGGGATCAT CGCCTTGATA 
CTGGCGCTGG CCATCGGTCT GGGCATCCAC TTCGACTGCT CTGGGAAGTA CAGGTGCCAT 
TCATCTTTCA AGTGTATTGA ACTAACAGCT CGATGCGACG GGGTCTCCGA CTGCAAGAAC 
GCAGAGGATG AGTACCGATG CGTGCGGGTG AGCGGCCAAA GAGCGGCGCT CCAAGTGTTC 
ACAGCTGCTG CGTGGAGGAC CATGTGCTCC GATGACTGGA AAAGCCACTA TGCCAAGATT 
GCCTGTGCCC AGCTGGGGTT TCCCAGCTAT GTGAGCTCAG ACCACCTAAG AGTGGATGCG 
CTGGAGGAGC AGTTCCAGGG CGACTTCGTG TCCATCAATC ACCTCTTGTC AGATGACAAG 
GTGACGGCGT TACACCACTC TGTGTACATG AGGGAAGGCT GCACCTCAGG CCACGTGGTC 
ACCTTGAAGT GCTCAGCCTG TGGCACGAGA ACGGGCTACA GTCCCCGAAT TGTGGGTGGA 
AACATGTCCT CGCTCACTCA GTGGCCCTGG CAGCCTGTAC CACCCCAAGT CCTGGACTGT 
CCAGGTGGGT CTTGTGTCCC TGATGGACAG TCCTGTGCCC TCCCATCTGG TGGAGAAAAT 
CATCTATCAC AGCAAGTACA AGCCAAAGCG GCTGGGCAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-204 suppresses cochlear spiral ganglion neuron survival in?vitro by targeting TMPRSS3.
Hearing research31460-4(2014 Aug)
Li Y,Peng A,Ge S,Wang Q,Liu J

Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression.
Human molecular genetics22(7)1289-99(2013 Apr)
Molina L,Fasquelle L,Nouvian R,Salvetat N,Scott HS,Guipponi M,Molina F,Puel JL,Delprat B

[Expression of proteinase TMPRSS3 in mouse cochlea].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences36(8)794-8(2011 Aug)
Ge S,Wang Q,Peng A,Wu W,Xie D

Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.
The Journal of biological chemistry286(19)17383-97(2011 May)
Fasquelle L,Scott HS,Lenoir M,Wang J,Rebillard G,Gaboyard S,Venteo S,Fran?ois F,Mausset-Bonnefont AL,Antonarakis SE,Neidhart E,Chabbert C,Puel JL,Guipponi M,Delprat B

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Tmprss3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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