NEUROG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEUROG2
Entrez Gene ID	63973
Full Name	neurogenin 2
Synonyms	Atoh4,Math4A,NGN2,bHLHa8,ngn-2
General protein information	Preferred Names neurogenin 2 Names neurogenin-2 class A basic helix-loop-helix protein 8 protein atonal homolog 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q25
Summary	This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012].
Disorder MIM:	606624

mRNA and Protein(s)

mRNA	Protein	Name
NM_024019.3	NP_076924.1	neurogenin-2
NM_024019.4	NP_076924.1	neurogenin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NEUROG2	XP_001142826.1
	NEUROG2	XP_001093264.1
Homo sapiens (human)	NEUROG2	NP_076924.1
Bos taurus (cattle)	NEUROG2	NP_001137577.1
Mus musculus (house mouse)	Neurog2	NP_033848.1
Rattus norvegicus (Norway rat)	Neurog2	XP_227716.5
Canis lupus familiaris (dog)	NEUROG2	XP_005639341.1
Gallus gallus (chicken)	NEUROG2	NP_990127.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurogenin 2 enhances the generation of patient-specific induced neuronal cells.
Zhao P, Zhu T, Lu X, Zhu J, Li L
Brain research161551-60(2015 Jul)

Rapid neurogenesis through transcriptional activation in human stem cells.
Busskamp V, Lewis NE, Guye P, Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J, Li Y, Li S, Stadler M, Weiss R, Church GM
Molecular systems biology10760(2014 Nov)

Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury.
Perrin FE, Boniface G, Serguera C, Lonjon N, Serre A, Prieto M, Mallet J, Privat A
PloS one5(12)e15914(2010 Dec)

A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP
Human molecular genetics19(12)2497-506(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows neurogenin 2 enhances the generation of patient-specific induced neuronal cells.
Title: Neurogenin 2 enhances the generation of patient-specific induced neuronal cells.

Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media.
Title: Rapid neurogenesis through transcriptional activation in human stem cells.

human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury
Title: Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury.

Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.

The following NEUROG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEUROG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11871	NM_024019.4 Latest version!	Homo sapiens neurogenin 2 (NEUROG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu11871	NM_024019.3	Homo sapiens neurogenin 2 (NEUROG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEUROG2 ( NM_024019.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076924.1 Homo sapiens neurogenin 2 (NEUROG2), mRNA.

Price & Availability↑

CloneID	OHu11871
Clone ID Related Accession (Same CDS sequence)	NM_024019.3 , NM_024019.4
Accession Version	NM_024019.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	neurogenin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036847.1 and AC023886.7. On Apr 19, 2012 this sequence version replaced NM_024019.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036847.1, AL540071.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END##

ATGTTCGTCA AATCCGAGAC CTTGGAGTTG AAGGAGGAAG AGGACGTGTT AGTGCTGCTC 
GGATCGGCCT CCCCCGCCTT GGCGGCCCTG ACCCCGCTGT CATCCAGCGC CGACGAAGAA 
GAGGAGGAGG AGCCGGGCGC GTCAGGCGGG GCGCGTCGGC AGCGCGGGGC TGAGGCCGGG 
CAGGGGGCGC GGGGCGGCGT GGCTGCGGGT GCGGAGGGCT GCCGGCCCGC ACGGCTGCTG 
GGTCTGGTAC ACGATTGCAA ACGGCGCCCT TCCCGGGCGC GGGCCGTCTC CCGAGGCGCC 
AAGACGGCCG AGACGGTGCA GCGCATCAAG AAGACCCGTA GACTGAAGGC CAACAACCGC 
GAGCGAAACC GCATGCACAA CCTCAACGCG GCACTGGACG CGCTGCGCGA GGTGCTCCCC 
ACGTTCCCCG AGGACGCCAA GCTCACCAAG ATCGAGACCC TGCGCTTCGC CCACAACTAC 
ATCTGGGCAC TCACCGAGAC CCTGCGCCTG GCGGATCACT GCGGGGGCGG CGGCGGGGGC 
CTGCCGGGGG CGCTCTTCTC CGAGGCAGTG TTGCTGAGCC CGGGAGGAGC CAGCGCCGCC 
CTGAGCAGCA GCGGAGACAG CCCCTCGCCC GCCTCCACGT GGAGTTGCAC CAACAGCCCC 
GCGCCGTCCT CCTCCGTGTC CTCCAATTCC ACCTCCCCCT ACAGCTGCAC TTTATCGCCC 
GCCAGCCCGG CCGGGTCAGA CATGGACTAT TGGCAGCCCC CACCTCCCGA CAAGCACCGC 
TATGCACCTC ACCTCCCCAT AGCCAGGGAT TGTATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076924.1
CDS	328..1146
Translation	MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI

Target ORF information:

RefSeq Version	NM_024019.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neurogenin 2 (NEUROG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024019.3

ORF Insert Sequence:

ATGTTCGTCA AATCCGAGAC CTTGGAGTTG AAGGAGGAAG AGGACGTGTT AGTGCTGCTC 
GGATCGGCCT CCCCCGCCTT GGCGGCCCTG ACCCCGCTGT CATCCAGCGC CGACGAAGAA 
GAGGAGGAGG AGCCGGGCGC GTCAGGCGGG GCGCGTCGGC AGCGCGGGGC TGAGGCCGGG 
CAGGGGGCGC GGGGCGGCGT GGCTGCGGGT GCGGAGGGCT GCCGGCCCGC ACGGCTGCTG 
GGTCTGGTAC ACGATTGCAA ACGGCGCCCT TCCCGGGCGC GGGCCGTCTC CCGAGGCGCC 
AAGACGGCCG AGACGGTGCA GCGCATCAAG AAGACCCGTA GACTGAAGGC CAACAACCGC 
GAGCGAAACC GCATGCACAA CCTCAACGCG GCACTGGACG CGCTGCGCGA GGTGCTCCCC 
ACGTTCCCCG AGGACGCCAA GCTCACCAAG ATCGAGACCC TGCGCTTCGC CCACAACTAC 
ATCTGGGCAC TCACCGAGAC CCTGCGCCTG GCGGATCACT GCGGGGGCGG CGGCGGGGGC 
CTGCCGGGGG CGCTCTTCTC CGAGGCAGTG TTGCTGAGCC CGGGAGGAGC CAGCGCCGCC 
CTGAGCAGCA GCGGAGACAG CCCCTCGCCC GCCTCCACGT GGAGTTGCAC CAACAGCCCC 
GCGCCGTCCT CCTCCGTGTC CTCCAATTCC ACCTCCCCCT ACAGCTGCAC TTTATCGCCC 
GCCAGCCCGG CCGGGTCAGA CATGGACTAT TGGCAGCCCC CACCTCCCGA CAAGCACCGC 
TATGCACCTC ACCTCCCCAT AGCCAGGGAT TGTATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEUROG2 ( NM_024019.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_076924.1 Homo sapiens neurogenin 2 (NEUROG2), mRNA.

Price & Availability↑

CloneID	OHu11871
Clone ID Related Accession (Same CDS sequence)	NM_024019.3 , NM_024019.4
Accession Version	NM_024019.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	neurogenin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023886.7 and BC036847.1. On Nov 22, 2018 this sequence version replaced NM_024019.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036847.1, AL540071.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313341.4/ ENSP00000317333.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCGTCA AATCCGAGAC CTTGGAGTTG AAGGAGGAAG AGGACGTGTT AGTGCTGCTC 
GGATCGGCCT CCCCCGCCTT GGCGGCCCTG ACCCCGCTGT CATCCAGCGC CGACGAAGAA 
GAGGAGGAGG AGCCGGGCGC GTCAGGCGGG GCGCGTCGGC AGCGCGGGGC TGAGGCCGGG 
CAGGGGGCGC GGGGCGGCGT GGCTGCGGGT GCGGAGGGCT GCCGGCCCGC ACGGCTGCTG 
GGTCTGGTAC ACGATTGCAA ACGGCGCCCT TCCCGGGCGC GGGCCGTCTC CCGAGGCGCC 
AAGACGGCCG AGACGGTGCA GCGCATCAAG AAGACCCGTA GACTGAAGGC CAACAACCGC 
GAGCGAAACC GCATGCACAA CCTCAACGCG GCACTGGACG CGCTGCGCGA GGTGCTCCCC 
ACGTTCCCCG AGGACGCCAA GCTCACCAAG ATCGAGACCC TGCGCTTCGC CCACAACTAC 
ATCTGGGCAC TCACCGAGAC CCTGCGCCTG GCGGATCACT GCGGGGGCGG CGGCGGGGGC 
CTGCCGGGGG CGCTCTTCTC CGAGGCAGTG TTGCTGAGCC CGGGAGGAGC CAGCGCCGCC 
CTGAGCAGCA GCGGAGACAG CCCCTCGCCC GCCTCCACGT GGAGTTGCAC CAACAGCCCC 
GCGCCGTCCT CCTCCGTGTC CTCCAATTCC ACCTCCCCCT ACAGCTGCAC TTTATCGCCC 
GCCAGCCCGG CCGGGTCAGA CATGGACTAT TGGCAGCCCC CACCTCCCGA CAAGCACCGC 
TATGCACCTC ACCTCCCCAT AGCCAGGGAT TGTATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076924.1
CDS	336..1154
Translation	MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI

Target ORF information:

RefSeq Version	NM_024019.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neurogenin 2 (NEUROG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024019.4

ORF Insert Sequence:

ATGTTCGTCA AATCCGAGAC CTTGGAGTTG AAGGAGGAAG AGGACGTGTT AGTGCTGCTC 
GGATCGGCCT CCCCCGCCTT GGCGGCCCTG ACCCCGCTGT CATCCAGCGC CGACGAAGAA 
GAGGAGGAGG AGCCGGGCGC GTCAGGCGGG GCGCGTCGGC AGCGCGGGGC TGAGGCCGGG 
CAGGGGGCGC GGGGCGGCGT GGCTGCGGGT GCGGAGGGCT GCCGGCCCGC ACGGCTGCTG 
GGTCTGGTAC ACGATTGCAA ACGGCGCCCT TCCCGGGCGC GGGCCGTCTC CCGAGGCGCC 
AAGACGGCCG AGACGGTGCA GCGCATCAAG AAGACCCGTA GACTGAAGGC CAACAACCGC 
GAGCGAAACC GCATGCACAA CCTCAACGCG GCACTGGACG CGCTGCGCGA GGTGCTCCCC 
ACGTTCCCCG AGGACGCCAA GCTCACCAAG ATCGAGACCC TGCGCTTCGC CCACAACTAC 
ATCTGGGCAC TCACCGAGAC CCTGCGCCTG GCGGATCACT GCGGGGGCGG CGGCGGGGGC 
CTGCCGGGGG CGCTCTTCTC CGAGGCAGTG TTGCTGAGCC CGGGAGGAGC CAGCGCCGCC 
CTGAGCAGCA GCGGAGACAG CCCCTCGCCC GCCTCCACGT GGAGTTGCAC CAACAGCCCC 
GCGCCGTCCT CCTCCGTGTC CTCCAATTCC ACCTCCCCCT ACAGCTGCAC TTTATCGCCC 
GCCAGCCCGG CCGGGTCAGA CATGGACTAT TGGCAGCCCC CACCTCCCGA CAAGCACCGC 
TATGCACCTC ACCTCCCCAT AGCCAGGGAT TGTATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurogenin 2 enhances the generation of patient-specific induced neuronal cells.
Brain research161551-60(2015 Jul)
Zhao P,Zhu T,Lu X,Zhu J,Li L

Rapid neurogenesis through transcriptional activation in human stem cells.
Molecular systems biology10760(2014 Nov)
Busskamp V,Lewis NE,Guye P,Ng AH,Shipman SL,Byrne SM,Sanjana NE,Murn J,Li Y,Li S,Stadler M,Weiss R,Church GM

Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury.
PloS one5(12)e15914(2010 Dec)
Perrin FE,Boniface G,Serguera C,Lonjon N,Serre A,Prieto M,Mallet J,Privat A

A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Human molecular genetics19(12)2497-506(2010 Jun)
Kalsi G,Kuo PH,Aliev F,Alexander J,McMichael O,Patterson DG,Walsh D,Zhao Z,Schuckit M,Nurnberger J Jr,Edenberg H,Kramer J,Hesselbrock V,Tischfield JA,Vladimirov V,Prescott CA,Dick DM,Kendler KS,Riley BP

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NEUROG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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