NEUROG2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEUROG2
Entrez Gene ID	395577
Full Name	neurogenin 2
Synonyms	NGN2/ATH4A,neurogenin-2
General protein information	Preferred Names neurogenin 2 Names neurogenin-2 atonal-like protein 4a
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204796.1	NP_990127.1	neurogenin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NEUROG2	XP_001142826.1
	NEUROG2	XP_001093264.1
Homo sapiens (human)	NEUROG2	NP_076924.1
Bos taurus (cattle)	NEUROG2	NP_001137577.1
Mus musculus (house mouse)	Neurog2	NP_033848.1
Rattus norvegicus (Norway rat)	Neurog2	XP_227716.5
Canis lupus familiaris (dog)	NEUROG2	XP_005639341.1
Gallus gallus (chicken)	NEUROG2	NP_990127.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor ?1 (GFR?1) expression in the embryonic spinal cord.
Shimada T, Yaginuma H, Sato N, Homma S
Developmental biology370(2)250-63(2012 Oct)

NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.
Lacomme M, Liaubet L, Pituello F, Bel-Vialar S
Molecular and cellular biology32(13)2596-607(2012 Jul)

Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system.
Aaker JD, Patineau AL, Yang HJ, Ewart DT, Nakagawa Y, McLoon SC, Koyano-Nakagawa N
Neuroscience letters474(1)46-51(2010 Apr)

Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.
Aaker JD, Patineau AL, Yang HJ, Ewart DT, Gong W, Li T, Nakagawa Y, McLoon SC, Koyano-Nakagawa N
Molecular and cellular neurosciences42(4)267-77(2009 Dec)

The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord.
Bel-Vialar S, Medevielle F, Pituello F
Developmental biology305(2)659-73(2007 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ngn2 together with NeuroM serves as readout to regulate GFRalpha1 expression, which occurs in multiple subtypes of spinal neurons.
Title: Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor ?1 (GFR?1) expression in the embryonic spinal cord.

NEUROG2 activation leads to a rapid decrease of a subset of cell cycle regulators acting at G(1) and S phases, including CCND1, CCNE1/2, and CCNA2 but not CCND2.
Title: NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.

There is a functional relationship between specific MTG and bHLH proteins in developing chick spinal cord.
Title: Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system.

Data show that MTGR1 physically interacts with NEUROG2 and represses transcriptional activity of NEUROG2.
Title: Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.

Downregulation of Pax6 expression can be controlled by high levels of Ngn2.
Title: The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord.

The following NEUROG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEUROG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa01061	NM_204796.1 Latest version!	Gallus gallus neurogenin 2 (NEUROG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEUROG2 ( NM_204796.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990127.1 Gallus gallus neurogenin 2 (NEUROG2), mRNA.

Price & Availability↑

CloneID	OGa01061
Clone ID Related Accession (Same CDS sequence)	NM_204796.1
Accession Version	NM_204796.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2013-04-17
Organism	Gallus gallus(chicken)
Product	neurogenin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF109014.1. On Aug 30, 2004 this sequence version replaced XM_429251.1. ##Evidence-Data-START## Transcript exon combination :: AF109014.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCGGTGA AGGCGGAGAG CCCGGCGCCC GCGGCGGAGG ACGAACTGCT GCTGCTGCGC 
CTCGCCTCGC CCGCCCCCTC GGCCTCGCTG CCGTCCAGCG CCGGCGAGGA GGACGAGGAC 
GAGGAGGACG GGCGGCCGAG GCGGCTGCAG GAGGGCGCTC GGCGGGCGGG GCGGCAGCGA 
GGGCCCCCGC GGGCGGCGCG CACGGCGGAA ACGGCGCAGC GCATCAAGCG GAGCCGGCGG 
CTGAAAGCCA ACAACCGCGA GCGCAACCGC ATGCACAACC TGAACGCGGC GCTGGACGCG 
CTGCGCGACT GCGTGCCCAC CTTCCCCGAG GACGCCAAGC TCACCAAGAT CGAGACGCTG 
CGCTTCGCCC ACAACTACAT CTGGGCGCTC ACCGAGACGC TGCGCCTGGC CGGGGCCGCC 
CGCCTGGGGG GCGCCGCCGA CGCCGCGCCC GGGGCGGCCG CCGAGGGCAG CCCCTCGCCC 
GCCTCGTCGT GGAGCGGCGG CGCCAGCCCC GCGCCCTCCG CCTCGCCCTA CGCCTGCACT 
TTATCGCCCG GCAGCCCCGC CGGCTCCGCC TCGGACGCCG AGCACTGGCC GCCCCCGCGG 
GGCCGCTTCG CCCCGCCGCC GCCGCCCCAC CGCTGCCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990127.1
CDS	101..742
Translation	MPVKAESPAPAAEDELLLLRLASPAPSASLPSSAGEEDEDEEDGRPRRLQEGARRAGRQRGPPRAARTAETAQRIKRSRRLKANNRERNRMHNLNAALDALRDCVPTFPEDAKLTKIETLRFAHNYIWALTETLRLAGAARLGGAADAAPGAAAEGSPSPASSWSGGASPAPSASPYACTLSPGSPAGSASDAEHWPPPRGRFAPPPPPHRCL

Target ORF information:

RefSeq Version	NM_204796.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus neurogenin 2 (NEUROG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204796.1

ORF Insert Sequence:

ATGCCGGTGA AGGCGGAGAG CCCGGCGCCC GCGGCGGAGG ACGAACTGCT GCTGCTGCGC 
CTCGCCTCGC CCGCCCCCTC GGCCTCGCTG CCGTCCAGCG CCGGCGAGGA GGACGAGGAC 
GAGGAGGACG GGCGGCCGAG GCGGCTGCAG GAGGGCGCTC GGCGGGCGGG GCGGCAGCGA 
GGGCCCCCGC GGGCGGCGCG CACGGCGGAA ACGGCGCAGC GCATCAAGCG GAGCCGGCGG 
CTGAAAGCCA ACAACCGCGA GCGCAACCGC ATGCACAACC TGAACGCGGC GCTGGACGCG 
CTGCGCGACT GCGTGCCCAC CTTCCCCGAG GACGCCAAGC TCACCAAGAT CGAGACGCTG 
CGCTTCGCCC ACAACTACAT CTGGGCGCTC ACCGAGACGC TGCGCCTGGC CGGGGCCGCC 
CGCCTGGGGG GCGCCGCCGA CGCCGCGCCC GGGGCGGCCG CCGAGGGCAG CCCCTCGCCC 
GCCTCGTCGT GGAGCGGCGG CGCCAGCCCC GCGCCCTCCG CCTCGCCCTA CGCCTGCACT 
TTATCGCCCG GCAGCCCCGC CGGCTCCGCC TCGGACGCCG AGCACTGGCC GCCCCCGCGG 
GGCCGCTTCG CCCCGCCGCC GCCGCCCCAC CGCTGCCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor ?1 (GFR?1) expression in the embryonic spinal cord.
Developmental biology370(2)250-63(2012 Oct)
Shimada T,Yaginuma H,Sato N,Homma S

NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.
Molecular and cellular biology32(13)2596-607(2012 Jul)
Lacomme M,Liaubet L,Pituello F,Bel-Vialar S

Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system.
Neuroscience letters474(1)46-51(2010 Apr)
Aaker JD,Patineau AL,Yang HJ,Ewart DT,Nakagawa Y,McLoon SC,Koyano-Nakagawa N

Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.
Molecular and cellular neurosciences42(4)267-77(2009 Dec)
Aaker JD,Patineau AL,Yang HJ,Ewart DT,Gong W,Li T,Nakagawa Y,McLoon SC,Koyano-Nakagawa N

The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord.
Developmental biology305(2)659-73(2007 May)
Bel-Vialar S,Medevielle F,Pituello F

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NEUROG2 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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