CCL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL2
Entrez Gene ID	6347
Full Name	C-C motif chemokine ligand 2
Synonyms	GDCF-2,HC11,HSMCR30,MCAF,MCP-1,MCP1,SCYA2,SMC-CF
General protein information	Preferred Names C-C motif chemokine ligand 2 Names C-C motif chemokine 2 chemokine (C-C motif) ligand 2 monocyte chemoattractant protein-1 monocyte chemotactic and activating factor monocyte chemotactic protein 1 monocyte secretory protein JE small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) small inducible cytokine subfamily A (Cys-Cys), member 2 small-inducible cytokine A2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013].
Disorder MIM:	158105
Disorder Html:	{HIV-1, resistance to}, 609423 (3); {Spina bifida, susceptibility to}, 182940 (3); {Coronary artery disease, modifier of} (3); {Mycobacterium tuberculosis, susceptibility to}, 607948 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002982.4	NP_002973.1	C-C motif chemokine 2 precursor
NM_002982.3	NP_002973.1	C-C motif chemokine 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCL2	XP_001174551.1
Bos taurus (cattle)	CCL2	NP_776431.1
Canis lupus familiaris (dog)	CCL2	NP_001003297.1
Homo sapiens (human)	CCL2	NP_002973.1
	CCL2	NP_001027993.1
Mus musculus (house mouse)	Ccl12	NP_035461.2
Rattus norvegicus (Norway rat)	Ccl12	NP_001099292.1

Gene Ontology

The following CCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18411	NM_002982.4 Latest version!	Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18411	NM_002982.3	Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL2 ( NM_002982.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002973.1 Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA.

Price & Availability↑

CloneID	OHu18411
Clone ID Related Accession (Same CDS sequence)	NM_002982.4 , NM_002982.3
Accession Version	NM_002982.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	C-C motif chemokine 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG530064.1 and BC009716.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002982.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.15518.1, SRR5189652.174085.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225831.4/ ENSP00000225831.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGTCT CTGCCGCCCT TCTGTGCCTG CTGCTCATAG CAGCCACCTT CATTCCCCAA 
GGGCTCGCTC AGCCAGATGC AATCAATGCC CCAGTCACCT GCTGTTATAA CTTCACCAAT 
AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG CAAGTGTCCC 
AAAGAAGCTG TGATCTTCAA GACCATTGTG GCCAAGGAGA TCTGTGCTGA CCCCAAGCAG 
AAGTGGGTTC AGGATTCCAT GGACCACCTG GACAAGCAAA CCCAAACTCC GAAGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002973.1
CDS	66..365
Translation	MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

Target ORF information:

RefSeq Version	NM_002982.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002982.4

ORF Insert Sequence:

ATGAAAGTCT CTGCCGCCCT TCTGTGCCTG CTGCTCATAG CAGCCACCTT CATTCCCCAA 
GGGCTCGCTC AGCCAGATGC AATCAATGCC CCAGTCACCT GCTGTTATAA CTTCACCAAT 
AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG CAAGTGTCCC 
AAAGAAGCTG TGATCTTCAA GACCATTGTG GCCAAGGAGA TCTGTGCTGA CCCCAAGCAG 
AAGTGGGTTC AGGATTCCAT GGACCACCTG GACAAGCAAA CCCAAACTCC GAAGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL2 ( NM_002982.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002973.1 Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA.

Price & Availability↑

CloneID	OHu18411
Clone ID Related Accession (Same CDS sequence)	NM_002982.4 , NM_002982.3
Accession Version	NM_002982.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	C-C motif chemokine 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG530064.1 and BC009716.1. This sequence is a reference standard in the RefSeqGene project. On Nov 29, 2004 this sequence version replaced NM_002982.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA449867.1, CD522574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGTCT CTGCCGCCCT TCTGTGCCTG CTGCTCATAG CAGCCACCTT CATTCCCCAA 
GGGCTCGCTC AGCCAGATGC AATCAATGCC CCAGTCACCT GCTGTTATAA CTTCACCAAT 
AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG CAAGTGTCCC 
AAAGAAGCTG TGATCTTCAA GACCATTGTG GCCAAGGAGA TCTGTGCTGA CCCCAAGCAG 
AAGTGGGTTC AGGATTCCAT GGACCACCTG GACAAGCAAA CCCAAACTCC GAAGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002973.1
CDS	74..373
Translation	MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

Target ORF information:

RefSeq Version	NM_002982.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002982.3

ORF Insert Sequence:

ATGAAAGTCT CTGCCGCCCT TCTGTGCCTG CTGCTCATAG CAGCCACCTT CATTCCCCAA 
GGGCTCGCTC AGCCAGATGC AATCAATGCC CCAGTCACCT GCTGTTATAA CTTCACCAAT 
AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG CAAGTGTCCC 
AAAGAAGCTG TGATCTTCAA GACCATTGTG GCCAAGGAGA TCTGTGCTGA CCCCAAGCAG 
AAGTGGGTTC AGGATTCCAT GGACCACCTG GACAAGCAAA CCCAAACTCC GAAGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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CCL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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