CCL2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL2
Entrez Gene ID	403981
Full Name	chemokine (C-C motif) ligand 2
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003297.1	NP_001003297.1	C-C motif chemokine 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCL2	XP_001174551.1
Bos taurus (cattle)	CCL2	NP_776431.1
Canis lupus familiaris (dog)	CCL2	NP_001003297.1
Homo sapiens (human)	CCL2	NP_002973.1
	CCL2	NP_001027993.1
Mus musculus (house mouse)	Ccl12	NP_035461.2
Rattus norvegicus (Norway rat)	Ccl12	NP_001099292.1

Gene Ontology
Bibliography

Related articles in PubMed

MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis.
Gal?n A, Mayer I, Rafaj RB, Bendelja K, Su?i? V, Cer?n JJ, Mrljak V
PloS one13(1)e0190474(2018)

CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis.
Murakami K, Maeda S, Yonezawa T, Matsuki N
Veterinary immunology and immunopathology18252-58(2016 Dec)

Assessment of CCL2 and CXCL8 chemokines in serum, bronchoalveolar lavage fluid and lung tissue samples from dogs affected with canine idiopathic pulmonary fibrosis.
Roels E, Krafft E, Farnir F, Holopainen S, Laurila HP, Rajam?ki MM, Day MJ, Antoine N, Pirottin D, Clercx C
Veterinary journal (London, England : 1997)206(1)75-82(2015 Oct)

Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis.
Roels E, Krafft E, Antoine N, Farnir F, Laurila HP, Holopainen S, Rajam?ki MM, Clercx C
Research in veterinary science10157-62(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that CCL2 acts as a PMNs chemotactic factor as well as CXCL8, and both CCL2 and CXCL8 facilitate the infiltration of PMNs into the joints of idiopathic polyarthritis
Title: CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis.

The study findings suggest that both CCL2 and CXCL8 are involved in the pathogenesis of canine idiopathic pulmonary fibrosis.
Title: Assessment of CCL2 and CXCL8 chemokines in serum, bronchoalveolar lavage fluid and lung tissue samples from dogs affected with canine idiopathic pulmonary fibrosis.

CCL2 concentrations might be related to the breed predisposition of the West Highland white terrier for canine idiopathic pulmonary fibrosis.
Title: Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis.

MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs.
Title: Monocyte chemoattractant protein-1 in dogs affected with neoplasia or inflammation.

Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10.
Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.

The following CCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00302	NM_001003297.1 Latest version!	Canis lupus familiaris C-C motif chemokine ligand 2 (CCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL2 ( NM_001003297.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003297.1 Canis lupus familiaris C-C motif chemokine ligand 2 (CCL2), mRNA.

Price & Availability↑

CloneID	OCe00302
Clone ID Related Accession (Same CDS sequence)	NM_001003297.1
Accession Version	NM_001003297.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Canis lupus familiaris(dog)
Product	C-C motif chemokine 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U29653.1. ##Evidence-Data-START## Transcript exon combination :: U29653.1, CX013922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN07419803 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCT CCGCAGCGCT CCTCTGCCTG CTGCTCATAG CCGCCGCCCT CACCACCCAG 
GTGCTCACCC AGCCAGATGC AATTATTTCT CCAGTCACCT GCTGCTATAC ACTCACCAAT 
AAGAAGATCT CAATTCAGAG GCTGGCCAGC TATAAAAGAG TCACCAGCAG CAAGTGTCCC 
AAAGAAGCTG TGATCTTCAA GACCGTCCTA AACAAGGAGA TCTGTGCTGA CCCCAAACAG 
AAGTGGGTCC AGGATTCCAT GGCACACCTA GACAAGAAAA GCCAAACCCA AACTGCAAAG 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003297.1
CDS	2..307
Translation	MKVSAALLCLLLIAAALTTQVLTQPDAIISPVTCCYTLTNKKISIQRLASYKRVTSSKCPKEAVIFKTVLNKEICADPKQKWVQDSMAHLDKKSQTQTAKP

Target ORF information:

RefSeq Version	NM_001003297.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris C-C motif chemokine ligand 2 (CCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003297.1

ORF Insert Sequence:

ATGAAGGTCT CCGCAGCGCT CCTCTGCCTG CTGCTCATAG CCGCCGCCCT CACCACCCAG 
GTGCTCACCC AGCCAGATGC AATTATTTCT CCAGTCACCT GCTGCTATAC ACTCACCAAT 
AAGAAGATCT CAATTCAGAG GCTGGCCAGC TATAAAAGAG TCACCAGCAG CAAGTGTCCC 
AAAGAAGCTG TGATCTTCAA GACCGTCCTA AACAAGGAGA TCTGTGCTGA CCCCAAACAG 
AAGTGGGTCC AGGATTCCAT GGCACACCTA GACAAGAAAA GCCAAACCCA AACTGCAAAG 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis.
PloS one13(1)e0190474(2018)
Gal?n A,Mayer I,Rafaj RB,Bendelja K,Su?i? V,Cer?n JJ,Mrljak V

CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis.
Veterinary immunology and immunopathology18252-58(2016 Dec)
Murakami K,Maeda S,Yonezawa T,Matsuki N

Assessment of CCL2 and CXCL8 chemokines in serum, bronchoalveolar lavage fluid and lung tissue samples from dogs affected with canine idiopathic pulmonary fibrosis.
Veterinary journal (London, England : 1997)206(1)75-82(2015 Oct)
Roels E,Krafft E,Farnir F,Holopainen S,Laurila HP,Rajam?ki MM,Day MJ,Antoine N,Pirottin D,Clercx C

Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis.
Research in veterinary science10157-62(2015 Aug)
Roels E,Krafft E,Antoine N,Farnir F,Laurila HP,Holopainen S,Rajam?ki MM,Clercx C

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CCL2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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