PTGIS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTGIS
Entrez Gene ID	5740
Full Name	prostaglandin I2 synthase
Synonyms	CYP8,CYP8A1,PGIS,PTGI
General protein information	Preferred Names prostaglandin I2 synthase Names prostacyclin synthase cytochrome P450, family 8, subfamily A, polypeptide 1 prostaglandin I2 (prostacyclin) synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.13
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	601699
Disorder Html:	Hypertension, essential, 145500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000961.4	NP_000952.1	prostacyclin synthase precursor
NM_000961.3	NP_000952.1	prostacyclin synthase precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PTGIS	XP_005635412.1
Mus musculus (house mouse)	Ptgis	NP_032994.1
Pan troglodytes (chimpanzee)	PTGIS	XP_514713.3
Rattus norvegicus (Norway rat)	Ptgis	NP_113745.1
Xenopus tropicalis (tropical clawed frog)	ptgis	XP_002933228.2
Homo sapiens (human)	PTGIS	NP_000952.1
	PTGIS	XP_001098575.1
Bos taurus (cattle)	PTGIS	NP_776869.1
Danio rerio (zebrafish)	ptgis	NP_001104630.1

Gene Ontology
Bibliography

Related articles in PubMed

Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage.
Velez Edwards DR, Edwards TL, Bray MJ, Torstenson E, Jones S, Shrubsole MJ, Muff HJ, Hartmann KE
Scientific reports7(1)9874(2017 Aug)

Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer.
Singh AK, Chandra N, Bapat SA
Clinical cancer research : an official journal of the American Association for Cancer Research21(22)5151-63(2015 Nov)

Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.
Cho SA, Rohn-Glowacki KJ, Jarrar YB, Yi M, Kim WY, Shin JG, Lee SJ
Archives of biochemistry and biophysics56910-8(2015 Mar)

Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy.
Camacho M, Pi?eiro Z, Alcolea S, Garc?a J, Balart J, Terra X, Avil?s-Jurado FX, Soler M, Quer M, Le?n X, Vila L
The Journal of pathology235(1)125-35(2015 Jan)

Biological insights from 108 schizophrenia-associated genetic loci.

Nature511(7510)421-7(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA, 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression
Title: Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer.

Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.
Title: Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.

results indicate that PGIS expression was associated with radiotherapy efficiency
Title: Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy.

In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.
Title: Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

Type-2 diabetes is associated with higher COX-2 expression, but lower eNOS and PGIS expression in subcutaneous arteries.
Title: Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients.

The following PTGIS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTGIS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17838	NM_000961.4 Latest version!	Homo sapiens prostaglandin I2 synthase (PTGIS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu17838	NM_000961.3	Homo sapiens prostaglandin I2 synthase (PTGIS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTGIS ( NM_000961.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000952.1 Homo sapiens prostaglandin I2 synthase (PTGIS), mRNA.

Price & Availability↑

CloneID	OHu17838
Clone ID Related Accession (Same CDS sequence)	NM_000961.4 , NM_000961.3
Accession Version	NM_000961.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	prostacyclin synthase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D83402.2, AF297048.1, D38145.1 and AL118525.17. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000961.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.168310.1, D38145.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244043.5/ ENSP00000244043.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTGGG CCGCGCTCCT CGGCCTCCTG GCCGCACTGT TGCTGCTGCT GCTACTGAGC 
CGCCGCCGCA CGCGGCGACC TGGTGAGCCT CCCCTGGACC TGGGCAGCAT CCCCTGGTTG 
GGGTATGCCT TGGACTTTGG AAAAGATGCT GCCAGCTTCC TCACGAGGAT GAAGGAGAAG 
CACGGTGACA TCTTTACTAT ACTGGTTGGG GGCAGGTATG TCACCGTTCT CCTGGACCCA 
CACTCCTACG ACGCGGTGGT GTGGGAGCCT CGCACCAGGC TCGACTTCCA TGCCTATGCC 
ATCTTCCTCA TGGAGAGGAT TTTTGATGTG CAGCTTCCAC ATTACAGCCC CAGTGATGAA 
AAGGCCAGGA TGAAACTGAC TCTTCTCCAC AGAGAGCTCC AGGCACTCAC AGAAGCCATG 
TATACCAACC TCCATGCAGT GCTGTTGGGC GATGCTACAG AAGCAGGCAG TGGCTGGCAC 
GAGATGGGTC TCCTCGACTT CTCCTACAGC TTCCTGCTCA GAGCCGGCTA CCTGACTCTT 
TACGGAATTG AGGCGCTGCC ACGCACCCAT GAAAGCCAGG CCCAGGACCG CGTCCACTCA 
GCTGATGTCT TCCACACCTT TCGCCAGCTC GACCGGCTGC TCCCCAAACT GGCCCGTGGC 
TCCCTGTCAG TGGGGGACAA GGACCACATG TGCAGTGTCA AAAGTCGCCT GTGGAAGCTG 
CTATCCCCAG CCAGGCTGGC CAGGCGGGCC CACCGGAGCA AATGGCTGGA GAGTTACCTG 
CTGCACCTGG AGGAGATGGG TGTGTCAGAG GAGATGCAGG CACGGGCCCT GGTGCTGCAG 
CTGTGGGCCA CACAGGGGAA TATGGGTCCC GCTGCCTTCT GGCTCCTGCT CTTCCTTCTC 
AAGAATCCTG AAGCCCTGGC TGCTGTCCGC GGAGAGCTCG AGAGTATCCT TTGGCAAGCG 
GAGCAGCCTG TCTCGCAGAC GACCACTCTC CCACAGAAGG TTCTAGACAG CACACCTGTG 
CTTGATAGCG TGCTGAGTGA GAGCCTCAGG CTTACAGCTG CCCCCTTCAT CACCCGCGAG 
GTTGTGGTGG ACCTGGCCAT GCCCATGGCA GACGGGCGAG AATTCAACCT GCGACGTGGT 
GACCGCCTCC TCCTCTTCCC CTTCCTGAGC CCCCAGAGAG ACCCAGAAAT CTACACAGAC 
CCAGAGGTAT TTAAATACAA CCGATTCCTG AACCCTGACG GATCAGAGAA GAAAGACTTT 
TACAAGGATG GGAAACGGCT GAAGAATTAC AACATGCCCT GGGGGGCGGG GCACAATCAC 
TGCCTGGGGA GGAGTTATGC GGTCAACAGC ATCAAACAAT TTGTGTTCCT TGTGCTGGTG 
CACTTGGACT TGGAGCTGAT CAACGCAGAT GTGGAGATCC CTGAGTTTGA CCTCAGCAGG 
TACGGCTTCG GTCTGATGCA GCCGGAACAC GACGTGCCCG TCCGCTACCG CATCCGCCCA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000952.1
CDS	22..1524
Translation	MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

Target ORF information:

RefSeq Version	NM_000961.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prostaglandin I2 synthase (PTGIS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000961.4

ORF Insert Sequence:

ATGGCTTGGG CCGCGCTCCT CGGCCTCCTG GCCGCACTGT TGCTGCTGCT GCTACTGAGC 
CGCCGCCGCA CGCGGCGACC TGGTGAGCCT CCCCTGGACC TGGGCAGCAT CCCCTGGTTG 
GGGTATGCCT TGGACTTTGG AAAAGATGCT GCCAGCTTCC TCACGAGGAT GAAGGAGAAG 
CACGGTGACA TCTTTACTAT ACTGGTTGGG GGCAGGTATG TCACCGTTCT CCTGGACCCA 
CACTCCTACG ACGCGGTGGT GTGGGAGCCT CGCACCAGGC TCGACTTCCA TGCCTATGCC 
ATCTTCCTCA TGGAGAGGAT TTTTGATGTG CAGCTTCCAC ATTACAGCCC CAGTGATGAA 
AAGGCCAGGA TGAAACTGAC TCTTCTCCAC AGAGAGCTCC AGGCACTCAC AGAAGCCATG 
TATACCAACC TCCATGCAGT GCTGTTGGGC GATGCTACAG AAGCAGGCAG TGGCTGGCAC 
GAGATGGGTC TCCTCGACTT CTCCTACAGC TTCCTGCTCA GAGCCGGCTA CCTGACTCTT 
TACGGAATTG AGGCGCTGCC ACGCACCCAT GAAAGCCAGG CCCAGGACCG CGTCCACTCA 
GCTGATGTCT TCCACACCTT TCGCCAGCTC GACCGGCTGC TCCCCAAACT GGCCCGTGGC 
TCCCTGTCAG TGGGGGACAA GGACCACATG TGCAGTGTCA AAAGTCGCCT GTGGAAGCTG 
CTATCCCCAG CCAGGCTGGC CAGGCGGGCC CACCGGAGCA AATGGCTGGA GAGTTACCTG 
CTGCACCTGG AGGAGATGGG TGTGTCAGAG GAGATGCAGG CACGGGCCCT GGTGCTGCAG 
CTGTGGGCCA CACAGGGGAA TATGGGTCCC GCTGCCTTCT GGCTCCTGCT CTTCCTTCTC 
AAGAATCCTG AAGCCCTGGC TGCTGTCCGC GGAGAGCTCG AGAGTATCCT TTGGCAAGCG 
GAGCAGCCTG TCTCGCAGAC GACCACTCTC CCACAGAAGG TTCTAGACAG CACACCTGTG 
CTTGATAGCG TGCTGAGTGA GAGCCTCAGG CTTACAGCTG CCCCCTTCAT CACCCGCGAG 
GTTGTGGTGG ACCTGGCCAT GCCCATGGCA GACGGGCGAG AATTCAACCT GCGACGTGGT 
GACCGCCTCC TCCTCTTCCC CTTCCTGAGC CCCCAGAGAG ACCCAGAAAT CTACACAGAC 
CCAGAGGTAT TTAAATACAA CCGATTCCTG AACCCTGACG GATCAGAGAA GAAAGACTTT 
TACAAGGATG GGAAACGGCT GAAGAATTAC AACATGCCCT GGGGGGCGGG GCACAATCAC 
TGCCTGGGGA GGAGTTATGC GGTCAACAGC ATCAAACAAT TTGTGTTCCT TGTGCTGGTG 
CACTTGGACT TGGAGCTGAT CAACGCAGAT GTGGAGATCC CTGAGTTTGA CCTCAGCAGG 
TACGGCTTCG GTCTGATGCA GCCGGAACAC GACGTGCCCG TCCGCTACCG CATCCGCCCA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTGIS ( NM_000961.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000952.1 Homo sapiens prostaglandin I2 synthase (PTGIS), mRNA.

Price & Availability↑

CloneID	OHu17838
Clone ID Related Accession (Same CDS sequence)	NM_000961.4 , NM_000961.3
Accession Version	NM_000961.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	prostacyclin synthase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D83402.2, AF297048.1, D38145.1 and AL118525.17. This sequence is a reference standard in the RefSeqGene project. On Mar 22, 2005 this sequence version replaced NM_000961.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.168310.1, D38145.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTTGGG CCGCGCTCCT CGGCCTCCTG GCCGCACTGT TGCTGCTGCT GCTACTGAGC 
CGCCGCCGCA CGCGGCGACC TGGTGAGCCT CCCCTGGACC TGGGCAGCAT CCCCTGGTTG 
GGGTATGCCT TGGACTTTGG AAAAGATGCT GCCAGCTTCC TCACGAGGAT GAAGGAGAAG 
CACGGTGACA TCTTTACTAT ACTGGTTGGG GGCAGGTATG TCACCGTTCT CCTGGACCCA 
CACTCCTACG ACGCGGTGGT GTGGGAGCCT CGCACCAGGC TCGACTTCCA TGCCTATGCC 
ATCTTCCTCA TGGAGAGGAT TTTTGATGTG CAGCTTCCAC ATTACAGCCC CAGTGATGAA 
AAGGCCAGGA TGAAACTGAC TCTTCTCCAC AGAGAGCTCC AGGCACTCAC AGAAGCCATG 
TATACCAACC TCCATGCAGT GCTGTTGGGC GATGCTACAG AAGCAGGCAG TGGCTGGCAC 
GAGATGGGTC TCCTCGACTT CTCCTACAGC TTCCTGCTCA GAGCCGGCTA CCTGACTCTT 
TACGGAATTG AGGCGCTGCC ACGCACCCAT GAAAGCCAGG CCCAGGACCG CGTCCACTCA 
GCTGATGTCT TCCACACCTT TCGCCAGCTC GACCGGCTGC TCCCCAAACT GGCCCGTGGC 
TCCCTGTCAG TGGGGGACAA GGACCACATG TGCAGTGTCA AAAGTCGCCT GTGGAAGCTG 
CTATCCCCAG CCAGGCTGGC CAGGCGGGCC CACCGGAGCA AATGGCTGGA GAGTTACCTG 
CTGCACCTGG AGGAGATGGG TGTGTCAGAG GAGATGCAGG CACGGGCCCT GGTGCTGCAG 
CTGTGGGCCA CACAGGGGAA TATGGGTCCC GCTGCCTTCT GGCTCCTGCT CTTCCTTCTC 
AAGAATCCTG AAGCCCTGGC TGCTGTCCGC GGAGAGCTCG AGAGTATCCT TTGGCAAGCG 
GAGCAGCCTG TCTCGCAGAC GACCACTCTC CCACAGAAGG TTCTAGACAG CACACCTGTG 
CTTGATAGCG TGCTGAGTGA GAGCCTCAGG CTTACAGCTG CCCCCTTCAT CACCCGCGAG 
GTTGTGGTGG ACCTGGCCAT GCCCATGGCA GACGGGCGAG AATTCAACCT GCGACGTGGT 
GACCGCCTCC TCCTCTTCCC CTTCCTGAGC CCCCAGAGAG ACCCAGAAAT CTACACAGAC 
CCAGAGGTAT TTAAATACAA CCGATTCCTG AACCCTGACG GATCAGAGAA GAAAGACTTT 
TACAAGGATG GGAAACGGCT GAAGAATTAC AACATGCCCT GGGGGGCGGG GCACAATCAC 
TGCCTGGGGA GGAGTTATGC GGTCAACAGC ATCAAACAAT TTGTGTTCCT TGTGCTGGTG 
CACTTGGACT TGGAGCTGAT CAACGCAGAT GTGGAGATCC CTGAGTTTGA CCTCAGCAGG 
TACGGCTTCG GTCTGATGCA GCCGGAACAC GACGTGCCCG TCCGCTACCG CATCCGCCCA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000952.1
CDS	55..1557
Translation	MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

Target ORF information:

RefSeq Version	NM_000961.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prostaglandin I2 synthase (PTGIS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000961.3

ORF Insert Sequence:

ATGGCTTGGG CCGCGCTCCT CGGCCTCCTG GCCGCACTGT TGCTGCTGCT GCTACTGAGC 
CGCCGCCGCA CGCGGCGACC TGGTGAGCCT CCCCTGGACC TGGGCAGCAT CCCCTGGTTG 
GGGTATGCCT TGGACTTTGG AAAAGATGCT GCCAGCTTCC TCACGAGGAT GAAGGAGAAG 
CACGGTGACA TCTTTACTAT ACTGGTTGGG GGCAGGTATG TCACCGTTCT CCTGGACCCA 
CACTCCTACG ACGCGGTGGT GTGGGAGCCT CGCACCAGGC TCGACTTCCA TGCCTATGCC 
ATCTTCCTCA TGGAGAGGAT TTTTGATGTG CAGCTTCCAC ATTACAGCCC CAGTGATGAA 
AAGGCCAGGA TGAAACTGAC TCTTCTCCAC AGAGAGCTCC AGGCACTCAC AGAAGCCATG 
TATACCAACC TCCATGCAGT GCTGTTGGGC GATGCTACAG AAGCAGGCAG TGGCTGGCAC 
GAGATGGGTC TCCTCGACTT CTCCTACAGC TTCCTGCTCA GAGCCGGCTA CCTGACTCTT 
TACGGAATTG AGGCGCTGCC ACGCACCCAT GAAAGCCAGG CCCAGGACCG CGTCCACTCA 
GCTGATGTCT TCCACACCTT TCGCCAGCTC GACCGGCTGC TCCCCAAACT GGCCCGTGGC 
TCCCTGTCAG TGGGGGACAA GGACCACATG TGCAGTGTCA AAAGTCGCCT GTGGAAGCTG 
CTATCCCCAG CCAGGCTGGC CAGGCGGGCC CACCGGAGCA AATGGCTGGA GAGTTACCTG 
CTGCACCTGG AGGAGATGGG TGTGTCAGAG GAGATGCAGG CACGGGCCCT GGTGCTGCAG 
CTGTGGGCCA CACAGGGGAA TATGGGTCCC GCTGCCTTCT GGCTCCTGCT CTTCCTTCTC 
AAGAATCCTG AAGCCCTGGC TGCTGTCCGC GGAGAGCTCG AGAGTATCCT TTGGCAAGCG 
GAGCAGCCTG TCTCGCAGAC GACCACTCTC CCACAGAAGG TTCTAGACAG CACACCTGTG 
CTTGATAGCG TGCTGAGTGA GAGCCTCAGG CTTACAGCTG CCCCCTTCAT CACCCGCGAG 
GTTGTGGTGG ACCTGGCCAT GCCCATGGCA GACGGGCGAG AATTCAACCT GCGACGTGGT 
GACCGCCTCC TCCTCTTCCC CTTCCTGAGC CCCCAGAGAG ACCCAGAAAT CTACACAGAC 
CCAGAGGTAT TTAAATACAA CCGATTCCTG AACCCTGACG GATCAGAGAA GAAAGACTTT 
TACAAGGATG GGAAACGGCT GAAGAATTAC AACATGCCCT GGGGGGCGGG GCACAATCAC 
TGCCTGGGGA GGAGTTATGC GGTCAACAGC ATCAAACAAT TTGTGTTCCT TGTGCTGGTG 
CACTTGGACT TGGAGCTGAT CAACGCAGAT GTGGAGATCC CTGAGTTTGA CCTCAGCAGG 
TACGGCTTCG GTCTGATGCA GCCGGAACAC GACGTGCCCG TCCGCTACCG CATCCGCCCA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage.
Scientific reports7(1)9874(2017 Aug)
Velez Edwards DR,Edwards TL,Bray MJ,Torstenson E,Jones S,Shrubsole MJ,Muff HJ,Hartmann KE

Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research21(22)5151-63(2015 Nov)
Singh AK,Chandra N,Bapat SA

Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.
Archives of biochemistry and biophysics56910-8(2015 Mar)
Cho SA,Rohn-Glowacki KJ,Jarrar YB,Yi M,Kim WY,Shin JG,Lee SJ

Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy.
The Journal of pathology235(1)125-35(2015 Jan)
Camacho M,Pi?eiro Z,Alcolea S,Garc?a J,Balart J,Terra X,Avil?s-Jurado FX,Soler M,Quer M,Le?n X,Vila L

Biological insights from 108 schizophrenia-associated genetic loci.
Nature511(7510)421-7(2014 Jul)

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PTGIS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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