TOMM22 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TOMM22
Entrez Gene ID	56993
Full Name	translocase of outer mitochondrial membrane 22
Synonyms	1C9-2,MST065,MSTP065,TOM22
General protein information	Preferred Names translocase of outer mitochondrial membrane 22 Names mitochondrial import receptor subunit TOM22 homolog mitochondrial import receptor Tom22 translocase of outer membrane 22 kDa subunit homolog translocase of outer mitochondrial membrane 22 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008].
Disorder MIM:	607046

mRNA and Protein(s)

mRNA	Protein	Name
NM_020243.4	NP_064628.1	mitochondrial import receptor subunit TOM22 homolog
NM_020243.5	NP_064628.1	mitochondrial import receptor subunit TOM22 homolog

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tomm22	NP_766197.2
Pan troglodytes (chimpanzee)	TOMM22	XP_001163726.1
	TOMM22	XP_001094369.1
Drosophila melanogaster (fruit fly)	mge	NP_523910.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005376	XP_315384.3
Bos taurus (cattle)	TOMM22	NP_001093805.1
Rattus norvegicus (Norway rat)	Tomm22	NP_997679.1
Xenopus tropicalis (tropical clawed frog)	tomm22	NP_001039252.1
Homo sapiens (human)	TOMM22	NP_064628.1

Gene Ontology
Bibliography

Related articles in PubMed

The mitochondrial BK
Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, Toro L
Mitochondrion3384-101(2017 03)

An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.
Rajapaksha M, Kaur J, Prasad M, Pawlak KJ, Marshall B, Perry EW, Whittal RM, Bose HS
Molecular and cellular biology36(6)1032-47(2016 Jan)

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Kipper S, Hamad S, Caly L, Avrahami D, Bacharach E, Jans DA, Gerber D, Bajorek M
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Bertolin G, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K, Greene AW, Dauphin A, Waharte F, Bayot A, Salamero J, Lomb?s A, Bulteau AL, Fon EA, Brice A, Corti O
Autophagy9(11)1801-17(2013 Nov)

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast.
Renault TT, Grandier-Vazeille X, Arokium H, Velours G, Camougrand N, Priault M, Teijido O, Dejean LM, Manon S
FEBS letters586(2)116-21(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A directed proteomic approach discovered the novel interaction of BKCa with Tom22, a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (ANT).
Title: The mitochondrial BK

Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells.
Title: An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.

Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery.
Title: The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.

Studies indicate that PUMA and TOMM22 as potential targets for miRNA-BART viral transcripts.
Title: The role of miRNAs and EBV BARTs in NPC.

The interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane.
Title: The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast.

The following TOMM22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOMM22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30354	NM_020243.5 Latest version!	Homo sapiens translocase of outer mitochondrial membrane 22 (TOMM22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30354	NM_020243.4	Homo sapiens translocase of outer mitochondrial membrane 22 (TOMM22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TOMM22 ( NM_020243.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_064628.1 Homo sapiens translocase of outer mitochondrial membrane 22 (TOMM22), mRNA.

Price & Availability↑

CloneID	OHu30354
Clone ID Related Accession (Same CDS sequence)	NM_020243.4 , NM_020243.5
Accession Version	NM_020243.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	mitochondrial import receptor subunit TOM22 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB142641.1, AB041906.1, AA522979.1 and BQ961547.1. On Dec 22, 2004 this sequence version replaced NM_020243.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.109534.1, SRR1660805.301095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCG CCGTCGCTGC TGCCGGTGCA GGGGAACCCC AGTCCCCGGA CGAATTGCTC 
CCGAAAGGCG ACGCGGAGAA GCCTGAGGAG GAGCTGGAGG AGGACGACGA TGAGGAGCTA 
GATGAGACCC TGTCGGAGAG ACTATGGGGC CTGACGGAGA TGTTTCCGGA GAGGGTCCGG 
TCCGCGGCCG GAGCCACTTT TGATCTTTCC CTCTTTGTGG CTCAGAAAAT GTACAGGTTT 
TCCAGGGCAG CCTTGTGGAT TGGGACCACT TCCTTTATGA TCCTGGTTCT TCCCGTTGTC 
TTTGAGACGG AGAAGTTGCA AATGGAGCAA CAGCAGCAAC TGCAGCAGCG GCAGATACTT 
CTAGGACCTA ACACAGGGCT CTCAGGAGGA ATGCCAGGGG CTCTACCCTC ACTTCCTGGA 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064628.1
CDS	31..459
Translation	MAAAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPSLPGKI

Target ORF information:

RefSeq Version	NM_020243.4
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of outer mitochondrial membrane 22 (TOMM22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020243.4

ORF Insert Sequence:

ATGGCTGCCG CCGTCGCTGC TGCCGGTGCA GGGGAACCCC AGTCCCCGGA CGAATTGCTC 
CCGAAAGGCG ACGCGGAGAA GCCTGAGGAG GAGCTGGAGG AGGACGACGA TGAGGAGCTA 
GATGAGACCC TGTCGGAGAG ACTATGGGGC CTGACGGAGA TGTTTCCGGA GAGGGTCCGG 
TCCGCGGCCG GAGCCACTTT TGATCTTTCC CTCTTTGTGG CTCAGAAAAT GTACAGGTTT 
TCCAGGGCAG CCTTGTGGAT TGGGACCACT TCCTTTATGA TCCTGGTTCT TCCCGTTGTC 
TTTGAGACGG AGAAGTTGCA AATGGAGCAA CAGCAGCAAC TGCAGCAGCG GCAGATACTT 
CTAGGACCTA ACACAGGGCT CTCAGGAGGA ATGCCAGGGG CTCTACCCTC ACTTCCTGGA 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOMM22 ( NM_020243.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_064628.1 Homo sapiens translocase of outer mitochondrial membrane 22 (TOMM22), mRNA.

Price & Availability↑

CloneID	OHu30354
Clone ID Related Accession (Same CDS sequence)	NM_020243.4 , NM_020243.5
Accession Version	NM_020243.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	mitochondrial import receptor subunit TOM22 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB142641.1, AB041906.1, AA522979.1, BQ961547.1 and AL021707.2. On Nov 22, 2018 this sequence version replaced NM_020243.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.833620.1, SRR3476690.976671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000216034.6/ ENSP00000216034.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCCG CCGTCGCTGC TGCCGGTGCA GGGGAACCCC AGTCCCCGGA CGAATTGCTC 
CCGAAAGGCG ACGCGGAGAA GCCTGAGGAG GAGCTGGAGG AGGACGACGA TGAGGAGCTA 
GATGAGACCC TGTCGGAGAG ACTATGGGGC CTGACGGAGA TGTTTCCGGA GAGGGTCCGG 
TCCGCGGCCG GAGCCACTTT TGATCTTTCC CTCTTTGTGG CTCAGAAAAT GTACAGGTTT 
TCCAGGGCAG CCTTGTGGAT TGGGACCACT TCCTTTATGA TCCTGGTTCT TCCCGTTGTC 
TTTGAGACGG AGAAGTTGCA AATGGAGCAA CAGCAGCAAC TGCAGCAGCG GCAGATACTT 
CTAGGACCTA ACACAGGGCT CTCAGGAGGA ATGCCAGGGG CTCTACCCTC ACTTCCTGGA 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064628.1
CDS	23..451
Translation	MAAAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPSLPGKI

Target ORF information:

RefSeq Version	NM_020243.5
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of outer mitochondrial membrane 22 (TOMM22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020243.5

ORF Insert Sequence:

ATGGCTGCCG CCGTCGCTGC TGCCGGTGCA GGGGAACCCC AGTCCCCGGA CGAATTGCTC 
CCGAAAGGCG ACGCGGAGAA GCCTGAGGAG GAGCTGGAGG AGGACGACGA TGAGGAGCTA 
GATGAGACCC TGTCGGAGAG ACTATGGGGC CTGACGGAGA TGTTTCCGGA GAGGGTCCGG 
TCCGCGGCCG GAGCCACTTT TGATCTTTCC CTCTTTGTGG CTCAGAAAAT GTACAGGTTT 
TCCAGGGCAG CCTTGTGGAT TGGGACCACT TCCTTTATGA TCCTGGTTCT TCCCGTTGTC 
TTTGAGACGG AGAAGTTGCA AATGGAGCAA CAGCAGCAAC TGCAGCAGCG GCAGATACTT 
CTAGGACCTA ACACAGGGCT CTCAGGAGGA ATGCCAGGGG CTCTACCCTC ACTTCCTGGA 
AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mitochondrial BK
Mitochondrion3384-101(2017 03)
Zhang J,Li M,Zhang Z,Zhu R,Olcese R,Stefani E,Toro L

An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.
Molecular and cellular biology36(6)1032-47(2016 Jan)
Rajapaksha M,Kaur J,Prasad M,Pawlak KJ,Marshall B,Perry EW,Whittal RM,Bose HS

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)
Kipper S,Hamad S,Caly L,Avrahami D,Bacharach E,Jans DA,Gerber D,Bajorek M

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Autophagy9(11)1801-17(2013 Nov)
Bertolin G,Ferrando-Miguel R,Jacoupy M,Traver S,Grenier K,Greene AW,Dauphin A,Waharte F,Bayot A,Salamero J,Lomb?s A,Bulteau AL,Fon EA,Brice A,Corti O

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast.
FEBS letters586(2)116-21(2012 Jan)
Renault TT,Grandier-Vazeille X,Arokium H,Velours G,Camougrand N,Priault M,Teijido O,Dejean LM,Manon S

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TOMM22 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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