Tomm22 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tomm22
Entrez Gene ID	223696
Full Name	translocase of outer mitochondrial membrane 22 homolog (yeast)
Synonyms	2310047D01,Tom22
General protein information	Preferred Names translocase of outer mitochondrial membrane 22 homolog (yeast) Names mitochondrial import receptor subunit TOM22 homolog translocase of outer membrane 22 kDa subunit homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_172609.3	NP_766197.2	mitochondrial import receptor subunit TOM22 homolog

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tomm22	NP_766197.2
Pan troglodytes (chimpanzee)	TOMM22	XP_001163726.1
	TOMM22	XP_001094369.1
Drosophila melanogaster (fruit fly)	mge	NP_523910.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005376	XP_315384.3
Bos taurus (cattle)	TOMM22	NP_001093805.1
Rattus norvegicus (Norway rat)	Tomm22	NP_997679.1
Xenopus tropicalis (tropical clawed frog)	tomm22	NP_001039252.1
Homo sapiens (human)	TOMM22	NP_064628.1

Gene Ontology
Bibliography

Related articles in PubMed

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Kravic B, Harbauer AB, Romanello V, Simeone L, V?gtle FN, Kaiser T, Straubinger M, Huraskin D, B?ttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S
Autophagy1-65(2017 Nov)

An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.
Rajapaksha M, Kaur J, Prasad M, Pawlak KJ, Marshall B, Perry EW, Whittal RM, Bose HS
Molecular and cellular biology36(6)1032-47(2016 Jan)

Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.
Safdar A, Little JP, Stokl AJ, Hettinga BP, Akhtar M, Tarnopolsky MA
The Journal of biological chemistry286(12)10605-17(2011 Mar)

Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.
Tummala H, Li X, Homayouni R
The European journal of neuroscience31(11)1926-34(2010 Jun)

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K
Nature cell biology11(8)958-66(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells.
Title: An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.

The following Tomm22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tomm22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18668	NM_172609.3 Latest version!	Mus musculus translocase of outer mitochondrial membrane 22 (Tomm22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tomm22 ( NM_172609.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766197.2 Mus musculus translocase of outer mitochondrial membrane 22 (Tomm22), mRNA.

Price & Availability↑

CloneID	OMu18668
Clone ID Related Accession (Same CDS sequence)	NM_172609.3
Accession Version	NM_172609.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Mus musculus(house mouse)
Product	mitochondrial import receptor subunit TOM22 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK009868.1. On Apr 6, 2007 this sequence version replaced NM_172609.2. ##Evidence-Data-START## Transcript exon combination :: AK009868.1, AK150787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCGCCG CCGTCGCTGC AGCCGGCGCT GGGGAGCCTC TGTCCCCCGA GGAATTACTC 
CCGAAAGCCG AGGCAGAGAA AGCCGAGGAG GAGCTGGAAG AAGACGACGA CGACGAGCTA 
GACGAGACCC TGTCGGAGAG ACTCTGGGGT CTGACGGAGA TGTTTCCCGA GAGGGTCCGG 
TCAGCCGCCG GAGCCACCTT TGACCTCTCG CTCTTCGTGG CTCAGAAGAT GTACAGATTT 
TCCAGGGCAG CTTTGTGGAT TGGGACCACT TCCTTCATGA TCCTGGTTCT TCCCGTTGTC 
TTTGAGACAG AAAAGTTGCA GATGGAGCAA CAGCAGCAAC TGCAGCAACG GCAGATACTT 
TTAGGGCCTA ACACAGGGCT GTCAGGAGGA ATGCCAGGGG CTCTACCTCC ACTTCCTGGA 
AAGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766197.2
CDS	25..453
Translation	MAAAVAAAGAGEPLSPEELLPKAEAEKAEEELEEDDDDELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPPLPGKM

Target ORF information:

RefSeq Version	NM_172609.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus translocase of outer mitochondrial membrane 22 (Tomm22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172609.3

ORF Insert Sequence:

ATGGCCGCCG CCGTCGCTGC AGCCGGCGCT GGGGAGCCTC TGTCCCCCGA GGAATTACTC 
CCGAAAGCCG AGGCAGAGAA AGCCGAGGAG GAGCTGGAAG AAGACGACGA CGACGAGCTA 
GACGAGACCC TGTCGGAGAG ACTCTGGGGT CTGACGGAGA TGTTTCCCGA GAGGGTCCGG 
TCAGCCGCCG GAGCCACCTT TGACCTCTCG CTCTTCGTGG CTCAGAAGAT GTACAGATTT 
TCCAGGGCAG CTTTGTGGAT TGGGACCACT TCCTTCATGA TCCTGGTTCT TCCCGTTGTC 
TTTGAGACAG AAAAGTTGCA GATGGAGCAA CAGCAGCAAC TGCAGCAACG GCAGATACTT 
TTAGGGCCTA ACACAGGGCT GTCAGGAGGA ATGCCAGGGG CTCTACCTCC ACTTCCTGGA 
AAGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Autophagy1-65(2017 Nov)
Kravic B,Harbauer AB,Romanello V,Simeone L,V?gtle FN,Kaiser T,Straubinger M,Huraskin D,B?ttcher M,Cerqua C,Martin ED,Poveda-Huertes D,Buttgereit A,Rabalski AJ,Heuss D,Rudolf R,Friedrich O,Litchfield D,Marber M,Salviati L,Mougiakakos D,Neuhuber W,Sandri M,Meisinger C,Hashemolhosseini S

An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.
Molecular and cellular biology36(6)1032-47(2016 Jan)
Rajapaksha M,Kaur J,Prasad M,Pawlak KJ,Marshall B,Perry EW,Whittal RM,Bose HS

Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.
The Journal of biological chemistry286(12)10605-17(2011 Mar)
Safdar A,Little JP,Stokl AJ,Hettinga BP,Akhtar M,Tarnopolsky MA

Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.
The European journal of neuroscience31(11)1926-34(2010 Jun)
Tummala H,Li X,Homayouni R

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.
Nature cell biology11(8)958-66(2009 Aug)
Ishihara N,Nomura M,Jofuku A,Kato H,Suzuki SO,Masuda K,Otera H,Nakanishi Y,Nonaka I,Goto Y,Taguchi N,Morinaga H,Maeda M,Takayanagi R,Yokota S,Mihara K

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Tomm22 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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