CCL28 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL28
Entrez Gene ID	56477
Full Name	C-C motif chemokine ligand 28
Synonyms	CCK1,MEC,SCYA28
General protein information	Preferred Names C-C motif chemokine ligand 28 Names C-C motif chemokine 28 CC chemokine CCL28 chemokine (C-C motif) ligand 28 splice variant chi mucosae-associated epithelial chemokine small inducible cytokine A28 small inducible cytokine subfamily A (Cys-Cys), member 28
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p12
Summary	This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Disorder MIM:	605240

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301874.1	NP_001288803.1	C-C motif chemokine 28 isoform a precursor
NM_001301873.1	NP_001288802.1	C-C motif chemokine 28 isoform a precursor
NM_001301874.2	NP_001288803.1	C-C motif chemokine 28 isoform a precursor
NM_148672.3	NP_683513.1	C-C motif chemokine 28 isoform a precursor
NM_001301875.1	NP_001288804.1	C-C motif chemokine 28 isoform b
NM_001301875.2	NP_001288804.1	C-C motif chemokine 28 isoform b
NM_001301873.2	NP_001288802.1	C-C motif chemokine 28 isoform a precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCL28	XP_001135733.1
	CCL28	NP_001028049.1
Rattus norvegicus (Norway rat)	Ccl28	NP_446152.1
Homo sapiens (human)	CCL28	NP_683513.1
Canis lupus familiaris (dog)	CCL28	NP_001005257.1
Bos taurus (cattle)	CCL28	NP_001094633.1
Mus musculus (house mouse)	Ccl28	NP_064675.1

Gene Ontology
Bibliography

Related articles in PubMed

CCL28 chemokine: An anchoring point bridging innate and adaptive immunity.
Mohan T, Deng L, Wang BZ
International immunopharmacology51165-170(2017 Oct)

CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis.
Yang XL, Liu KY, Lin FJ, Shi HM, Ou ZL
Oncology reports38(3)1393-1401(2017 Sep)

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, D?ring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C
Science translational medicine9(384)(2017 Apr)

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer.
Ren L, Yu Y, Wang L, Zhu Z, Lu R, Yao Z
Oncotarget7(46)75763-75773(2016 Nov)

CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.
Hieshima K, Ohtani H, Shibano M, Izawa D, Nakayama T, Kawasaki Y, Shiba F, Shiota M, Katou F, Saito T, Yoshie O
Journal of immunology (Baltimore, Md. : 1950)170(3)1452-61(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCL28 was absent in saliva of primary Sjogren's syndrome patients. This finding did not correlate with salivary IgA levels.
Title: Absence of salivary CCL28 in primary Sj?gren's syndrome.

High CCL28 gene methylation is associated with gastric tumor aggressiveness.
Title: Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome.

disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE
Title: CCL28 Cannot Replace IgE for Severity by Objective SCORAD Index in Atopic Dermatitis in Children.

CCL28-CCR3 interactions are involved in the homeostatic trafficking of CD4(+) T cells to the upper airways.
Title: A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa.

CCL28 is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells.
Title: Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells.

The following CCL28 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL28 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24917	NM_001301873.2 Latest version!	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24917	NM_001301874.2 Latest version!	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24917	NM_148672.3 Latest version!	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu70052	NM_001301875.2 Latest version!	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu24917	NM_001301874.1	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu70052	NM_001301875.1	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu24917	NM_001301873.1	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL28 ( NM_001301874.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288803.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu24917
Clone ID Related Accession (Same CDS sequence)	NM_001301874.1 , NM_001301873.1 , NM_001301874.2 , NM_148672.3 , NM_001301873.2
Accession Version	NM_001301874.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX486632.1 and AF266504.1. On Sep 24, 2014 this sequence version replaced XR_241708.1. Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF266504.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 10975800 Protein has antimicrobial activity :: PMID: 12538707 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288803.1
CDS	76..459
Translation	MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_001301874.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301874.1

ORF Insert Sequence:

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL28 ( NM_001301873.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288802.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24917
Clone ID Related Accession (Same CDS sequence)	NM_001301874.1 , NM_001301873.1 , NM_001301874.2 , NM_148672.3 , NM_001301873.2
Accession Version	NM_001301873.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX486632.1, AF110384.1 and AC025457.5. On Sep 24, 2014 this sequence version replaced XR_241707.1. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF110384.1, BC069532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation Protein has antimicrobial activity :: PMID: 12538707 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288802.1
CDS	76..459
Translation	MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_001301873.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301873.1

ORF Insert Sequence:

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL28 ( NM_001301874.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288803.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu24917
Clone ID Related Accession (Same CDS sequence)	NM_001301874.1 , NM_001301873.1 , NM_001301874.2 , NM_148672.3 , NM_001301873.2
Accession Version	NM_001301874.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX486632.1 and AF266504.1. On May 31, 2019 this sequence version replaced NM_001301874.1. Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF266504.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 10975800 Protein has antimicrobial activity :: PMID: 12538707 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288803.1
CDS	76..459
Translation	MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_001301874.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301874.2

ORF Insert Sequence:

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL28 ( NM_148672.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_683513.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24917
Clone ID Related Accession (Same CDS sequence)	NM_001301874.1 , NM_001301873.1 , NM_001301874.2 , NM_148672.3 , NM_001301873.2
Accession Version	NM_148672.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX486632.1 and AC025457.5. On Sep 24, 2014 this sequence version replaced NM_148672.2. Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062668.1, BX486632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361115.4/ ENSP00000354416.4 Protein has antimicrobial activity :: PMID: 12538707 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_683513.1
CDS	76..459
Translation	MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_148672.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_148672.3

ORF Insert Sequence:

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL28 ( NM_001301873.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288802.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24917
Clone ID Related Accession (Same CDS sequence)	NM_001301874.1 , NM_001301873.1 , NM_001301874.2 , NM_148672.3 , NM_001301873.2
Accession Version	NM_001301873.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX486632.1, AF110384.1 and AC025457.5. On Jun 1, 2019 this sequence version replaced NM_001301873.1. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF110384.1, BC069532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation Protein has antimicrobial activity :: PMID: 12538707 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288802.1
CDS	76..459
Translation	MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_001301873.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301873.2

ORF Insert Sequence:

ATGCAGCAGA GAGGACTCGC CATCGTGGCC TTGGCTGTCT GTGCGGCCCT ACATGCCTCA 
GAAGCCATAC TTCCCATTGC CTCCAGCTGT TGCACGGAGG TTTCACATCA TATTTCCAGA 
AGGCTCCTGG AAAGAGTGAA TATGTGTCGC ATCCAGAGAG CTGATGGGGA TTGTGACTTG 
GCTGCTGTCA TCCTTCATGT CAAGCGCAGA AGAATCTGTG TCAGCCCGCA CAACCATACT 
GTTAAGCAGT GGATGAAAGT GCAAGCTGCC AAGAAAAATG GTAAAGGAAA TGTTTGCCAC 
AGGAAGAAAC ACCATGGCAA GAGGAACAGT AACAGGGCAC ATCAGGGGAA ACACGAAACA 
TACGGCCATA AAACTCCTTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL28 ( NM_001301875.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288804.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu70052
Clone ID Related Accession (Same CDS sequence)	NM_001301875.1 , NM_001301875.2
Accession Version	NM_001301875.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-20
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD671712.1 and AC025457.5. Transcript Variant: This variant (4) uses an alternate promoter, as evidenced by epigenomic data, and has an alternate 5' terminal exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD671712.1, AK307307.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149178 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTCGCA TCCAGAGAGC TGATGGGGAT TGTGACTTGG CTGCTGTCAT CCTTCATGTC 
AAGCGCAGAA GAATCTGTGT CAGCCCGCAC AACCATACTG TTAAGCAGTG GATGAAAGTG 
CAAGCTGCCA AGAAAAATGG TAAAGGAAAT GTTTGCCACA GGAAGAAACA CCATGGCAAG 
AGGAACAGTA ACAGGGCACA TCAGGGGAAA CACGAAACAT ACGGCCATAA AACTCCTTAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288804.1
CDS	308..550
Translation	MCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_001301875.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301875.1

ORF Insert Sequence:

ATGTGTCGCA TCCAGAGAGC TGATGGGGAT TGTGACTTGG CTGCTGTCAT CCTTCATGTC 
AAGCGCAGAA GAATCTGTGT CAGCCCGCAC AACCATACTG TTAAGCAGTG GATGAAAGTG 
CAAGCTGCCA AGAAAAATGG TAAAGGAAAT GTTTGCCACA GGAAGAAACA CCATGGCAAG 
AGGAACAGTA ACAGGGCACA TCAGGGGAAA CACGAAACAT ACGGCCATAA AACTCCTTAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL28 ( NM_001301875.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288804.1 Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu70052
Clone ID Related Accession (Same CDS sequence)	NM_001301875.1 , NM_001301875.2
Accession Version	NM_001301875.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	C-C motif chemokine 28 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD671712.1 and AC025457.5. On May 31, 2019 this sequence version replaced NM_001301875.1. Transcript Variant: This variant (4) uses an alternate promoter, as evidenced by epigenomic data, and has an alternate 5' terminal exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138512.644403.1, DRR138512.218814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149178 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTCGCA TCCAGAGAGC TGATGGGGAT TGTGACTTGG CTGCTGTCAT CCTTCATGTC 
AAGCGCAGAA GAATCTGTGT CAGCCCGCAC AACCATACTG TTAAGCAGTG GATGAAAGTG 
CAAGCTGCCA AGAAAAATGG TAAAGGAAAT GTTTGCCACA GGAAGAAACA CCATGGCAAG 
AGGAACAGTA ACAGGGCACA TCAGGGGAAA CACGAAACAT ACGGCCATAA AACTCCTTAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288804.1
CDS	181..423
Translation	MCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

Target ORF information:

RefSeq Version	NM_001301875.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301875.2

ORF Insert Sequence:

ATGTGTCGCA TCCAGAGAGC TGATGGGGAT TGTGACTTGG CTGCTGTCAT CCTTCATGTC 
AAGCGCAGAA GAATCTGTGT CAGCCCGCAC AACCATACTG TTAAGCAGTG GATGAAAGTG 
CAAGCTGCCA AGAAAAATGG TAAAGGAAAT GTTTGCCACA GGAAGAAACA CCATGGCAAG 
AGGAACAGTA ACAGGGCACA TCAGGGGAAA CACGAAACAT ACGGCCATAA AACTCCTTAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCL28 chemokine: An anchoring point bridging innate and adaptive immunity.
International immunopharmacology51165-170(2017 Oct)
Mohan T,Deng L,Wang BZ

CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis.
Oncology reports38(3)1393-1401(2017 Sep)
Yang XL,Liu KY,Lin FJ,Shi HM,Ou ZL

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Science translational medicine9(384)(2017 Apr)
von Hundelshausen P,Agten SM,Eckardt V,Blanchet X,Schmitt MM,Ippel H,Neideck C,Bidzhekov K,Leberzammer J,Wichapong K,Faussner A,Drechsler M,Grommes J,van Geffen JP,Li H,Ortega-Gomez A,Megens RT,Naumann R,Dijkgraaf I,Nicolaes GA,D?ring Y,Soehnlein O,Lutgens E,Heemskerk JW,Koenen RR,Mayo KH,Hackeng TM,Weber C

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer.
Oncotarget7(46)75763-75773(2016 Nov)
Ren L,Yu Y,Wang L,Zhu Z,Lu R,Yao Z

CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.
Journal of immunology (Baltimore, Md. : 1950)170(3)1452-61(2003 Feb)
Hieshima K,Ohtani H,Shibano M,Izawa D,Nakayama T,Kawasaki Y,Shiba F,Shiota M,Katou F,Saito T,Yoshie O

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CCL28 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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