CELA2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CELA2B
Entrez Gene ID	51032
Full Name	chymotrypsin like elastase family member 2B
Synonyms	ELA2B
General protein information	Preferred Names chymotrypsin like elastase family member 2B Names chymotrypsin-like elastase family member 2B RP11-265F14.2 elastase 2B pancreatic elastase IIB (ELA2B)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.21
Summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008].
Disorder MIM:	609444

mRNA and Protein(s)

mRNA	Protein	Name
NM_015849.3	NP_056933.3	chymotrypsin-like elastase family member 2B preproprotein
NM_015849.2	NP_056933.2	chymotrypsin-like elastase family member 2B preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CELA2B	NP_056933.2
Pan troglodytes (chimpanzee)	CELA2B	XP_003307871.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occupational and environmental medicine66(12)848-53(2009 Dec)

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
Macaulay IC, Tijssen MR, Thijssen-Timmer DC, Gusnanto A, Steward M, Burns P, Langford CF, Ellis PD, Dudbridge F, Zwaginga JJ, Watkins NA, van der Schoot CE, Ouwehand WH
Blood109(8)3260-9(2007 Apr)

Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.
Szepessy E, Sahin-T?th M
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]6(1-2)117-22(2006)

Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
Fletcher TS, Shen WF, Largman C
Biochemistry26(23)7256-61(1987 Nov)

Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
Kawashima I, Tani T, Shimoda K, Takiguchi Y
DNA (Mary Ann Liebert, Inc.)6(2)163-72(1987 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

The following CELA2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CELA2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu15419	NM_015849.2 Latest version!	Homo sapiens chymotrypsin like elastase 2B (CELA2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu108590	NM_015849.3 Latest version!	Homo sapiens chymotrypsin like elastase 2B (CELA2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CELA2B ( NM_015849.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_056933.2 Homo sapiens chymotrypsin like elastase 2B (CELA2B), mRNA.

Price & Availability↑

CloneID	OHu15419
Clone ID Related Accession (Same CDS sequence)	NM_015849.2
Accession Version	NM_015849.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-10
Organism	Homo sapiens(human)
Product	chymotrypsin-like elastase family member 2B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069412.1, BC069455.1, M16653.1 and BU070386.1. On Jan 29, 2005 this sequence version replaced NM_015849.1. ##Evidence-Data-START## Transcript exon combination :: M16653.1, BC113540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATTAGGA CCCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGTCTCC 
ACTTACGCGC CTGATATGTC TAGGATGCTT GGAGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCCAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCGGGATC 
TACCGCGTGA TGCTGGGCCA GCATAACCTC TACGTTGCAG AGTCCGGCTC GCTGGCCGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCG ACCAGGTCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTCTCCCT GATGACCTGA AGCAGGGCCG GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGGC TGGTGGGGCA GCACCGTGAA GACGAATATG 
ATCTGTGCTG GGGGTGATGG CGTGATATGC ACCTGCAACG GAGACTCCGG TGGGCCGCTG 
AACTGTCAGG CATCTGACGG CCGGTGGGAG GTGCATGGCA TCGGCAGCCT CACGTCGGTC 
CTTGGTTGCA ACTACTACTA CAAGCCCTCC ATCTTCACGC GGGTCTCCAA CTACAACGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056933.2
CDS	26..835
Translation	MIRTLLLSTLVAGALSCGVSTYAPDMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIANSWVLTAAHCISSSGIYRVMLGQHNLYVAESGSLAVSVSKIVVHKDWNSDQVSKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGALPDDLKQGRLLVVDYATCSSSGWWGSTVKTNMICAGGDGVICTCNGDSGGPLNCQASDGRWEVHGIGSLTSVLGCNYYYKPSIFTRVSNYNDWINSVIANN

Target ORF information:

RefSeq Version	NM_015849.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chymotrypsin like elastase 2B (CELA2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015849.2

ORF Insert Sequence:

ATGATTAGGA CCCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGTCTCC 
ACTTACGCGC CTGATATGTC TAGGATGCTT GGAGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCCAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCGGGATC 
TACCGCGTGA TGCTGGGCCA GCATAACCTC TACGTTGCAG AGTCCGGCTC GCTGGCCGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCG ACCAGGTCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTCTCCCT GATGACCTGA AGCAGGGCCG GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGGC TGGTGGGGCA GCACCGTGAA GACGAATATG 
ATCTGTGCTG GGGGTGATGG CGTGATATGC ACCTGCAACG GAGACTCCGG TGGGCCGCTG 
AACTGTCAGG CATCTGACGG CCGGTGGGAG GTGCATGGCA TCGGCAGCCT CACGTCGGTC 
CTTGGTTGCA ACTACTACTA CAAGCCCTCC ATCTTCACGC GGGTCTCCAA CTACAACGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CELA2B ( NM_015849.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056933.3 Homo sapiens chymotrypsin like elastase 2B (CELA2B), mRNA.

Price & Availability↑

CloneID	OHu108590
Clone ID Related Accession (Same CDS sequence)	NM_015849.3
Accession Version	NM_015849.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	chymotrypsin-like elastase family member 2B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL512883.5. On May 17, 2019 this sequence version replaced NM_015849.2. ##Evidence-Data-START## Transcript exon combination :: DRR138526.135323.1, DRR138526.54578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375910.8/ ENSP00000365075.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATTAGGA CCCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGTCTCC 
ACTTACGCGC CTGATATGTC TAGGATGCTT GGAGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCCAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCGGGATC 
TACCGCGTGA TGCTGGGCCA GCATAACCTC TACGTTGCAG AGTCCGGCTC GCTGGCCGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCG ACCAGGTCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTCTCCCT GATGACCTGA AGCAGGGCCA GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGGC TGGTGGGGCA GCACCGTGAA GACGAATATG 
ATCTGTGCTG GGGGTGATGG CGTGATATGC ACCTGCAACG GAGACTCCGG TGGGCCGCTG 
AACTGTCAGG CATCTGACGG CCGGTGGGAG GTGCATGGCA TCGGCAGCCT CACGTCGGTC 
CTTGGTTGCA ACTACTACTA CAAGCCCTCC ATCTTCACGC GGGTCTCCAA CTACAACGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056933.3
CDS	23..832
Translation	MIRTLLLSTLVAGALSCGVSTYAPDMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIANSWVLTAAHCISSSGIYRVMLGQHNLYVAESGSLAVSVSKIVVHKDWNSDQVSKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGALPDDLKQGQLLVVDYATCSSSGWWGSTVKTNMICAGGDGVICTCNGDSGGPLNCQASDGRWEVHGIGSLTSVLGCNYYYKPSIFTRVSNYNDWINSVIANN

Target ORF information:

RefSeq Version	NM_015849.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chymotrypsin like elastase 2B (CELA2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015849.3

ORF Insert Sequence:

ATGATTAGGA CCCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGTCTCC 
ACTTACGCGC CTGATATGTC TAGGATGCTT GGAGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCCAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCGGGATC 
TACCGCGTGA TGCTGGGCCA GCATAACCTC TACGTTGCAG AGTCCGGCTC GCTGGCCGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCG ACCAGGTCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTCTCCCT GATGACCTGA AGCAGGGCCA GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGGC TGGTGGGGCA GCACCGTGAA GACGAATATG 
ATCTGTGCTG GGGGTGATGG CGTGATATGC ACCTGCAACG GAGACTCCGG TGGGCCGCTG 
AACTGTCAGG CATCTGACGG CCGGTGGGAG GTGCATGGCA TCGGCAGCCT CACGTCGGTC 
CTTGGTTGCA ACTACTACTA CAAGCCCTCC ATCTTCACGC GGGTCTCCAA CTACAACGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Occupational and environmental medicine66(12)848-53(2009 Dec)
Hosgood HD 3rd,Zhang L,Shen M,Berndt SI,Vermeulen R,Li G,Yin S,Yeager M,Yuenger J,Rothman N,Chanock S,Smith M,Lan Q

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
Blood109(8)3260-9(2007 Apr)
Macaulay IC,Tijssen MR,Thijssen-Timmer DC,Gusnanto A,Steward M,Burns P,Langford CF,Ellis PD,Dudbridge F,Zwaginga JJ,Watkins NA,van der Schoot CE,Ouwehand WH

Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]6(1-2)117-22(2006)
Szepessy E,Sahin-T?th M

Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
Biochemistry26(23)7256-61(1987 Nov)
Fletcher TS,Shen WF,Largman C

Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
DNA (Mary Ann Liebert, Inc.)6(2)163-72(1987 Apr)
Kawashima I,Tani T,Shimoda K,Takiguchi Y

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CELA2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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