TAS2R3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R3
Entrez Gene ID	50831
Full Name	taste 2 receptor member 3
Synonyms	T2R3
General protein information	Preferred Names taste 2 receptor member 3 Names taste receptor type 2 member 3 candidate taste receptor T2R3 taste receptor, type 2, member 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008].
Disorder MIM:	604868

mRNA and Protein(s)

mRNA	Protein	Name
NM_016943.2	NP_058639.1	taste receptor type 2 member 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAS2R3	NP_001009105.1
Rattus norvegicus (Norway rat)	Tas2r137	NP_001020320.1
Homo sapiens (human)	TAS2R3	NP_058639.1
	TAS2R3	XP_001084659.1
Canis lupus familiaris (dog)	TAS2R3	NP_001138971.1
Bos taurus (cattle)	TAS2R3	NP_001040097.1
Mus musculus (house mouse)	Tas2r137	NP_001020556.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.
Nolden AA, McGeary JE, Hayes JE
Physiology & behavior156117-27(2016 Mar)

Genetic variants associated with disordered eating.
Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW, Martin NG
The International journal of eating disorders46(6)594-608(2013 Sep)

Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.
Hirai R, Takao K, Onoda K, Kokubun S, Ikeda M
The Annals of otology, rhinology, and laryngology121(2)113-8(2012 Feb)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

differences in the bitterness from chemicals associated with genetic polymorphisms in bitter taste receptor genes, specifically in TAS2R3, -4, -5 as well as TAS2R38.
Title: Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.

Our results show that the expression rate of some of the T2R taste receptor genes was increased significantly in patients with phantogeusia.
Title: Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.

Includes the study of a polymorphic upstream ORF in this gene, and shows that it functions to reduce protein levels by ~58%.
Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.

The following TAS2R3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu28670	NM_016943.2 Latest version!	Homo sapiens taste 2 receptor member 3 (TAS2R3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R3 ( NM_016943.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_058639.1 Homo sapiens taste 2 receptor member 3 (TAS2R3), mRNA.

Price & Availability↑

CloneID	OHu28670
Clone ID Related Accession (Same CDS sequence)	NM_016943.2
Accession Version	NM_016943.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095523.1 and AC004979.1. On Jun 17, 2005 this sequence version replaced NM_016943.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC095523.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 19372376 ##RefSeq-Attributes-END##

ATGATGGGAC TCACCGAGGG GGTGTTCCTG ATTCTGTCTG GCACTCAGTT CACACTGGGA 
ATTCTGGTCA ATTGTTTCAT TGAGTTGGTC AATGGTAGCA GCTGGTTCAA GACCAAGAGA 
ATGTCTTTGT CTGACTTCAT CATCACCACC CTGGCACTCT TGAGGATCAT TCTGCTGTGT 
ATTATCTTGA CTGATAGTTT TTTAATAGAA TTCTCTCCCA ACACACATGA TTCAGGGATA 
ATAATGCAAA TTATTGATGT TTCCTGGACA TTTACAAACC ATCTGAGCAT TTGGCTTGCC 
ACCTGTCTTG GTGTCCTCTA CTGCCTGAAA ATCGCCAGTT TCTCTCACCC CACATTCCTC 
TGGCTCAAGT GGAGAGTTTC TAGGGTGATG GTATGGATGC TGTTGGGTGC ACTGCTCTTA 
TCCTGTGGTA GTACCGCATC TCTGATCAAT GAGTTTAAGC TCTATTCTGT CTTTAGGGGA 
ATTGAGGCCA CCAGGAATGT GACTGAACAC TTCAGAAAGA AGAGGAGTGA GTATTATCTG 
ATCCATGTTC TTGGGACTCT GTGGTACCTG CCTCCCTTAA TTGTGTCCCT GGCCTCCTAC 
TCTTTGCTCA TCTTCTCCCT GGGGAGGCAC ACACGGCAGA TGCTGCAAAA TGGGACAAGC 
TCCAGAGATC CAACCACTGA GGCCCACAAG AGGGCCATCA GAATCATCCT TTCCTTCTTC 
TTTCTCTTCT TACTTTACTT TCTTGCTTTC TTAATTGCAT CATTTGGTAA TTTCCTACCA 
AAAACCAAGA TGGCTAAGAT GATTGGCGAA GTAATGACAA TGTTTTATCC TGCTGGCCAC 
TCATTTATTC TCATTCTGGG GAACAGTAAG CTGAAGCAGA CATTTGTAGT GATGCTCCGG 
TGTGAGTCTG GTCATCTGAA GCCTGGATCC AAGGGACCCA TTTTCTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058639.1
CDS	63..1013
Translation	MMGLTEGVFLILSGTQFTLGILVNCFIELVNGSSWFKTKRMSLSDFIITTLALLRIILLCIILTDSFLIEFSPNTHDSGIIMQIIDVSWTFTNHLSIWLATCLGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGALLLSCGSTASLINEFKLYSVFRGIEATRNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRHTRQMLQNGTSSRDPTTEAHKRAIRIILSFFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFYPAGHSFILILGNSKLKQTFVVMLRCESGHLKPGSKGPIFS

Target ORF information:

RefSeq Version	NM_016943.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 3 (TAS2R3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016943.2

ORF Insert Sequence:

ATGATGGGAC TCACCGAGGG GGTGTTCCTG ATTCTGTCTG GCACTCAGTT CACACTGGGA 
ATTCTGGTCA ATTGTTTCAT TGAGTTGGTC AATGGTAGCA GCTGGTTCAA GACCAAGAGA 
ATGTCTTTGT CTGACTTCAT CATCACCACC CTGGCACTCT TGAGGATCAT TCTGCTGTGT 
ATTATCTTGA CTGATAGTTT TTTAATAGAA TTCTCTCCCA ACACACATGA TTCAGGGATA 
ATAATGCAAA TTATTGATGT TTCCTGGACA TTTACAAACC ATCTGAGCAT TTGGCTTGCC 
ACCTGTCTTG GTGTCCTCTA CTGCCTGAAA ATCGCCAGTT TCTCTCACCC CACATTCCTC 
TGGCTCAAGT GGAGAGTTTC TAGGGTGATG GTATGGATGC TGTTGGGTGC ACTGCTCTTA 
TCCTGTGGTA GTACCGCATC TCTGATCAAT GAGTTTAAGC TCTATTCTGT CTTTAGGGGA 
ATTGAGGCCA CCAGGAATGT GACTGAACAC TTCAGAAAGA AGAGGAGTGA GTATTATCTG 
ATCCATGTTC TTGGGACTCT GTGGTACCTG CCTCCCTTAA TTGTGTCCCT GGCCTCCTAC 
TCTTTGCTCA TCTTCTCCCT GGGGAGGCAC ACACGGCAGA TGCTGCAAAA TGGGACAAGC 
TCCAGAGATC CAACCACTGA GGCCCACAAG AGGGCCATCA GAATCATCCT TTCCTTCTTC 
TTTCTCTTCT TACTTTACTT TCTTGCTTTC TTAATTGCAT CATTTGGTAA TTTCCTACCA 
AAAACCAAGA TGGCTAAGAT GATTGGCGAA GTAATGACAA TGTTTTATCC TGCTGGCCAC 
TCATTTATTC TCATTCTGGG GAACAGTAAG CTGAAGCAGA CATTTGTAGT GATGCTCCGG 
TGTGAGTCTG GTCATCTGAA GCCTGGATCC AAGGGACCCA TTTTCTCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.
Physiology & behavior156117-27(2016 Mar)
Nolden AA,McGeary JE,Hayes JE

Genetic variants associated with disordered eating.
The International journal of eating disorders46(6)594-608(2013 Sep)
Wade TD,Gordon S,Medland S,Bulik CM,Heath AC,Montgomery GW,Martin NG

Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.
The Annals of otology, rhinology, and laryngology121(2)113-8(2012 Feb)
Hirai R,Takao K,Onoda K,Kokubun S,Ikeda M

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

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TAS2R3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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