NTS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NTS
Entrez Gene ID	4922
Full Name	neurotensin
Synonyms	NMN-125,NN,NT,NT/N,NTS1
General protein information	Preferred Names neurotensin Names neurotensin/neuromedin N pro-neurotensin/neuromedin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q21.31
Summary	This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014].
Disorder MIM:	162650

mRNA and Protein(s)

mRNA	Protein	Name
NM_006183.4	NP_006174.1	neurotensin/neuromedin N preproprotein
NM_006183.5	NP_006174.1	neurotensin/neuromedin N preproprotein

Pathways from BioSystems

Homologies

	NTS	XP_001090068.1
Mus musculus (house mouse)	Nts	NP_077755.1
Homo sapiens (human)	NTS	NP_006174.1
Pan troglodytes (chimpanzee)	NTS	XP_001165130.1
Canis lupus familiaris (dog)	NTS	XP_854478.1
Gallus gallus (chicken)	NTS	NP_001264289.1
Rattus norvegicus (Norway rat)	Nts	NP_001095851.1
Bos taurus (cattle)	NTS	NP_776370.2
Xenopus tropicalis (tropical clawed frog)	nts	XP_002937110.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of proneurotensin as marker of paediatric coeliac disease.
Mont?n C, Torinsson Naluai ?, Agardh D
Clinical and experimental immunology186(3)387-392(2016 Dec)

Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.
Sparks RP, Jenkins JL, Miner GE, Wang Y, Guida WC, Sparks CE, Fratti RA, Sparks JD
Biochemical and biophysical research communications479(3)551-556(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

children with untreated coeliac disease have elevated peripheral pro-NT levels compared with disease controls. Pro-NT levels also seem to reflect more severe forms of active coeliac disease, indicating a potential role of NT in small intestinal inflammation.
Title: Role of proneurotensin as marker of paediatric coeliac disease.

sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin binding site, and is a competitor of neurotensin
Title: Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.

Higher concentrations of proneurotensin are associated with a greater risk of incident cardiovascular events in the community. This association did not vary according to sex, baseline low-density lipoprotein, or sortilin receptor 1 genotype.
Title: Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study.

findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment
Title: An obligatory role for neurotensin in high-fat-diet-induced obesity.

Although no measures for pain threshold, thermal instability or gastric motility were performed in our study participants, higher plasma NT levels were found in PWS children
Title: High plasma neurotensin levels in children with Prader-Willi syndrome.

The following NTS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NTS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13918	NM_006183.5 Latest version!	Homo sapiens neurotensin (NTS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13918	NM_006183.4	Homo sapiens neurotensin (NTS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NTS ( NM_006183.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006174.1 Homo sapiens neurotensin (NTS), mRNA.

Price & Availability↑

CloneID	OHu13918
Clone ID Related Accession (Same CDS sequence)	NM_006183.4 , NM_006183.5
Accession Version	NM_006183.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	neurotensin/neuromedin N preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312066.1 and AF157682.1. This sequence is a reference standard in the RefSeqGene project. On Jan 6, 2011 this sequence version replaced NM_006183.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF157682.1, BC010918.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12074933 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGGCAG GAATGAAAAT CCAGCTTGTA TGCATGCTAC TCCTGGCTTT CAGCTCCTGG 
AGTCTGTGCT CAGATTCAGA AGAGGAAATG AAAGCATTAG AAGCAGATTT CTTGACCAAT 
ATGCATACAT CAAAGATTAG TAAAGCACAT GTTCCCTCTT GGAAGATGAC TCTGCTAAAT 
GTTTGCAGTC TTGTAAATAA TTTGAACAGC CCAGCTGAGG AAACAGGAGA AGTTCATGAA 
GAGGAGCTTG TTGCAAGAAG GAAACTTCCT ACTGCTTTAG ATGGCTTTAG CTTGGAAGCA 
ATGTTGACAA TATACCAGCT CCACAAAATC TGTCACAGCA GGGCTTTTCA ACACTGGGAG 
TTAATCCAGG AAGATATTCT TGATACTGGA AATGACAAAA ATGGAAAGGA AGAAGTCATA 
AAGAGAAAAA TTCCTTATAT TCTGAAACGG CAGCTGTATG AGAATAAACC CAGAAGACCC 
TACATACTCA AAAGAGATTC TTACTATTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006174.1
CDS	110..622
Translation	MMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY

Target ORF information:

RefSeq Version	NM_006183.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neurotensin (NTS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006183.4

ORF Insert Sequence:

ATGATGGCAG GAATGAAAAT CCAGCTTGTA TGCATGCTAC TCCTGGCTTT CAGCTCCTGG 
AGTCTGTGCT CAGATTCAGA AGAGGAAATG AAAGCATTAG AAGCAGATTT CTTGACCAAT 
ATGCATACAT CAAAGATTAG TAAAGCACAT GTTCCCTCTT GGAAGATGAC TCTGCTAAAT 
GTTTGCAGTC TTGTAAATAA TTTGAACAGC CCAGCTGAGG AAACAGGAGA AGTTCATGAA 
GAGGAGCTTG TTGCAAGAAG GAAACTTCCT ACTGCTTTAG ATGGCTTTAG CTTGGAAGCA 
ATGTTGACAA TATACCAGCT CCACAAAATC TGTCACAGCA GGGCTTTTCA ACACTGGGAG 
TTAATCCAGG AAGATATTCT TGATACTGGA AATGACAAAA ATGGAAAGGA AGAAGTCATA 
AAGAGAAAAA TTCCTTATAT TCTGAAACGG CAGCTGTATG AGAATAAACC CAGAAGACCC 
TACATACTCA AAAGAGATTC TTACTATTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NTS ( NM_006183.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006174.1 Homo sapiens neurotensin (NTS), mRNA.

Price & Availability↑

CloneID	OHu13918
Clone ID Related Accession (Same CDS sequence)	NM_006183.4 , NM_006183.5
Accession Version	NM_006183.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	neurotensin/neuromedin N preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312066.1 and AF157682.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006183.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF157682.1, SRR5189655.114135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256010.7/ ENSP00000256010.5 Protein has antimicrobial activity :: PMID: 12074933 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGCAG GAATGAAAAT CCAGCTTGTA TGCATGCTAC TCCTGGCTTT CAGCTCCTGG 
AGTCTGTGCT CAGATTCAGA AGAGGAAATG AAAGCATTAG AAGCAGATTT CTTGACCAAT 
ATGCATACAT CAAAGATTAG TAAAGCACAT GTTCCCTCTT GGAAGATGAC TCTGCTAAAT 
GTTTGCAGTC TTGTAAATAA TTTGAACAGC CCAGCTGAGG AAACAGGAGA AGTTCATGAA 
GAGGAGCTTG TTGCAAGAAG GAAACTTCCT ACTGCTTTAG ATGGCTTTAG CTTGGAAGCA 
ATGTTGACAA TATACCAGCT CCACAAAATC TGTCACAGCA GGGCTTTTCA ACACTGGGAG 
TTAATCCAGG AAGATATTCT TGATACTGGA AATGACAAAA ATGGAAAGGA AGAAGTCATA 
AAGAGAAAAA TTCCTTATAT TCTGAAACGG CAGCTGTATG AGAATAAACC CAGAAGACCC 
TACATACTCA AAAGAGATTC TTACTATTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006174.1
CDS	110..622
Translation	MMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY

Target ORF information:

RefSeq Version	NM_006183.5
Organism	Homo sapiens(human)
Definition	Homo sapiens neurotensin (NTS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006183.5

ORF Insert Sequence:

ATGATGGCAG GAATGAAAAT CCAGCTTGTA TGCATGCTAC TCCTGGCTTT CAGCTCCTGG 
AGTCTGTGCT CAGATTCAGA AGAGGAAATG AAAGCATTAG AAGCAGATTT CTTGACCAAT 
ATGCATACAT CAAAGATTAG TAAAGCACAT GTTCCCTCTT GGAAGATGAC TCTGCTAAAT 
GTTTGCAGTC TTGTAAATAA TTTGAACAGC CCAGCTGAGG AAACAGGAGA AGTTCATGAA 
GAGGAGCTTG TTGCAAGAAG GAAACTTCCT ACTGCTTTAG ATGGCTTTAG CTTGGAAGCA 
ATGTTGACAA TATACCAGCT CCACAAAATC TGTCACAGCA GGGCTTTTCA ACACTGGGAG 
TTAATCCAGG AAGATATTCT TGATACTGGA AATGACAAAA ATGGAAAGGA AGAAGTCATA 
AAGAGAAAAA TTCCTTATAT TCTGAAACGG CAGCTGTATG AGAATAAACC CAGAAGACCC 
TACATACTCA AAAGAGATTC TTACTATTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of proneurotensin as marker of paediatric coeliac disease.
Clinical and experimental immunology186(3)387-392(2016 Dec)
Mont?n C,Torinsson Naluai ?,Agardh D

Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.
Biochemical and biophysical research communications479(3)551-556(2016 Oct)
Sparks RP,Jenkins JL,Miner GE,Wang Y,Guida WC,Sparks CE,Fratti RA,Sparks JD

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NTS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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