BPY2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BPY2B
Entrez Gene ID	442867
Full Name	basic charge, Y-linked, 2B
Synonyms	VCY2B
General protein information	Preferred Names basic charge, Y-linked, 2B Names testis-specific basic protein Y 2 basic charge, Y-linked 2 basic protein on Y chromosome 2 variable charge, Y-linked, 2 variably charged protein Y 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.23
Summary	This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the more centromeric copy within the palindrome. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002760.1	NP_001002760.1	testis-specific basic protein Y 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region.
Repping S, van Daalen SK, Korver CM, Brown LG, Marszalek JD, Gianotten J, Oates RD, Silber S, van der Veen F, Page DC, Rozen S
Genomics83(6)1046-52(2004 Jun)

Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.
Wong EY, Tse JY, Yao KM, Lui VC, Tam PC, Yeung WS
Biology of reproduction70(3)775-84(2004 Mar)

Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.
Tse JY, Wong EY, Cheung AN, O WS, Tam PC, Yeung WS
Biology of reproduction69(3)746-51(2003 Sep)

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC
Nature423(6942)825-37(2003 Jun)

VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.
Wong EY, Tse JY, Yao KM, Tam PC, Yeung WS
Biochemical and biophysical research communications296(5)1104-11(2002 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

VCY2 was weakly expressed at the spermatogonia and immunonegative in spermatocytes and round spermatids in testicular biopsy specimens with maturation arrest or hypospermatogenesis.
Title: Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.

VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A
Title: VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.

The following BPY2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BPY2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19235	NM_001002760.1 Latest version!	Homo sapiens basic charge Y-linked 2B (BPY2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BPY2B ( NM_001002760.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002760.1 Homo sapiens basic charge Y-linked 2B (BPY2B), mRNA.

Price & Availability↑

CloneID	OHu19235
Clone ID Related Accession (Same CDS sequence)	NM_001002760.1
Accession Version	NM_001002760.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	testis-specific basic protein Y 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010153.3. CCDS Note: This CCDS ID represents the protein described in PMIDs: 12724276 and 12207887. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 12724276. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the more centromeric copy within the palindrome. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382392.5/ ENSP00000371829.1 NMD candidate :: translation inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGACGC TTGTCCCCAG AGCCAGGACA CGTGCAGGAC AGGATCATTA CTCTCATCCC 
TGCCCCAGAT TTTCACAGGT GCTGCTTACA GAGGGCATCA TGACATATTG CTTGACAAAG 
AACCTAAGTG ATGTTAATAT TCTGCATAGG TTGCTAAAAA ATGGGAATGT GAGAAATACC 
TTGCTTCAGT CCAAAGTGGG CTTGCTGACA TATTATGTGA AACTGTACCC GGGTGAAGTG 
ACTCTTCTGA CTAGGCCCAG CATACAAATG AGATTATGCT GTATCACTGG CTCAGTGTCG 
AGGCCCAGAT CACAGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002760.1
CDS	333..653
Translation	MMTLVPRARTRAGQDHYSHPCPRFSQVLLTEGIMTYCLTKNLSDVNILHRLLKNGNVRNTLLQSKVGLLTYYVKLYPGEVTLLTRPSIQMRLCCITGSVSRPRSQK

Target ORF information:

RefSeq Version	NM_001002760.1
Organism	Homo sapiens(human)
Definition	Homo sapiens basic charge Y-linked 2B (BPY2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002760.1

ORF Insert Sequence:

ATGATGACGC TTGTCCCCAG AGCCAGGACA CGTGCAGGAC AGGATCATTA CTCTCATCCC 
TGCCCCAGAT TTTCACAGGT GCTGCTTACA GAGGGCATCA TGACATATTG CTTGACAAAG 
AACCTAAGTG ATGTTAATAT TCTGCATAGG TTGCTAAAAA ATGGGAATGT GAGAAATACC 
TTGCTTCAGT CCAAAGTGGG CTTGCTGACA TATTATGTGA AACTGTACCC GGGTGAAGTG 
ACTCTTCTGA CTAGGCCCAG CATACAAATG AGATTATGCT GTATCACTGG CTCAGTGTCG 
AGGCCCAGAT CACAGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region.
Genomics83(6)1046-52(2004 Jun)
Repping S,van Daalen SK,Korver CM,Brown LG,Marszalek JD,Gianotten J,Oates RD,Silber S,van der Veen F,Page DC,Rozen S

Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.
Biology of reproduction70(3)775-84(2004 Mar)
Wong EY,Tse JY,Yao KM,Lui VC,Tam PC,Yeung WS

Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility.
Biology of reproduction69(3)746-51(2003 Sep)
Tse JY,Wong EY,Cheung AN,O WS,Tam PC,Yeung WS

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Nature423(6942)825-37(2003 Jun)
Skaletsky H,Kuroda-Kawaguchi T,Minx PJ,Cordum HS,Hillier L,Brown LG,Repping S,Pyntikova T,Ali J,Bieri T,Chinwalla A,Delehaunty A,Delehaunty K,Du H,Fewell G,Fulton L,Fulton R,Graves T,Hou SF,Latrielle P,Leonard S,Mardis E,Maupin R,McPherson J,Miner T,Nash W,Nguyen C,Ozersky P,Pepin K,Rock S,Rohlfing T,Scott K,Schultz B,Strong C,Tin-Wollam A,Yang SP,Waterston RH,Wilson RK,Rozen S,Page DC

VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A.
Biochemical and biophysical research communications296(5)1104-11(2002 Sep)
Wong EY,Tse JY,Yao KM,Tam PC,Yeung WS

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BPY2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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