ME2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ME2
Entrez Gene ID	4200
Full Name	malic enzyme 2
Synonyms	ODS1
General protein information	Preferred Names malic enzyme 2 Names NAD-dependent malic enzyme, mitochondrial NAD-ME malate dehydrogenase (oxaloacetate-decarboxylating) malic enzyme 2, NAD(+)-dependent, mitochondrial pyruvic-malic carboxylase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.2
Summary	This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009].
Disorder MIM:	154270

mRNA and Protein(s)

mRNA	Protein	Name
NM_001168335.1	NP_001161807.1	NAD-dependent malic enzyme, mitochondrial isoform 2 precursor
NM_001168335.2	NP_001161807.1	NAD-dependent malic enzyme, mitochondrial isoform 2 precursor
NM_002396.4	NP_002387.1	NAD-dependent malic enzyme, mitochondrial isoform 1 precursor
NM_002396.5	NP_002387.1	NAD-dependent malic enzyme, mitochondrial isoform 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ME2	NP_001070282.1
Oryza sativa (rice)	Os01g0723400	NP_001044107.1
Homo sapiens (human)	ME2	NP_002387.1
Pan troglodytes (chimpanzee)	ME2	XP_001154897.1
	ME2	XP_001099883.2
Danio rerio (zebrafish)	LOC100537927	XP_003198629.1
Arabidopsis thaliana (thale cress)	NADP-ME3	NP_197960.1
Arabidopsis thaliana (thale cress)	NADP-ME2	NP_196728.1
Mus musculus (house mouse)	Me2	NP_663469.1
Rattus norvegicus (Norway rat)	Me2	NP_001100846.2
Danio rerio (zebrafish)	me2	NP_001003627.2
Canis lupus familiaris (dog)	ME2	XP_005615454.1
Xenopus tropicalis (tropical clawed frog)	me2	NP_001015690.1

Gene Ontology
Bibliography

Related articles in PubMed

Collateral Lethality in Pancreatic Cancer.

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA
Nature542(7639)119-123(2017 02)

Expression of Malic Enzymes in Sebaceous Lesions.
Su TF, Gao HW
The American Journal of dermatopathology38(8)580-5(2016 Aug)

The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
Cheng CP, Huang LC, Chang YL, Hsieh CH, Huang SM, Hueng DY
Oncotarget7(27)41460-41472(2016 Jul)

Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.
Chang YL, Gao HW, Chiang CP, Wang WM, Huang SM, Ku CF, Liu GY, Hung HC
The Journal of investigative dermatology135(3)807-815(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The chromosome 18q21 deletion in nearly one third of pancreatic adenocarcinomas eliminates not only the tumor suppressor SMAD4, but also neighboring genes with important cellular roles, such as ME2
Title: Collateral Lethality in Pancreatic Cancer.

deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Title: Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.

ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.
Title: Expression of Malic Enzymes in Sebaceous Lesions.

ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production.
Title: The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.

ME2 might be an important factor in melanoma progression and a novel biomarker of invasion.
Title: Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.

The following ME2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ME2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21107	NM_002396.5 Latest version!	Homo sapiens malic enzyme 2 (ME2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
OHu12192	NM_001168335.2 Latest version!	Homo sapiens malic enzyme 2 (ME2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu12192	NM_001168335.1	Homo sapiens malic enzyme 2 (ME2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu21107	NM_002396.4	Homo sapiens malic enzyme 2 (ME2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ME2 ( NM_002396.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002387.1 Homo sapiens malic enzyme 2 (ME2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21107
Clone ID Related Accession (Same CDS sequence)	NM_002396.4 , NM_002396.5
Accession Version	NM_002396.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1755bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	NAD-dependent malic enzyme, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA644731.1, BI559761.1, M55905.1, AK313391.1, AC087687.5 and CD370709.1. This sequence is a reference standard in the RefSeqGene project. On Dec 4, 2009 this sequence version replaced NM_002396.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.255124.1, SRR1660807.120905.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTG TGGCTTTAGC TGTTATTCTC 
TGTAACACCC GGCATATTAG TGACAGTGTT TTCCTAGAAG CTGCAAAGGC CCTGACAAGC 
CAATTGACAG ATGAAGAGCT AGCCCAAGGG AGACTTTACC CACCGCTTGC TAATATTCAG 
GAAGTTTCTA TTAACATTGC TATTAAAGTT ACAGAATACC TATATGCTAA TAAAATGGCT 
TTCCGATACC CAGAACCTGA AGACAAGGCC AAATATGTTA AAGAAAGAAC ATGGCGGAGT 
GAATATGATT CCCTGCTGCC AGATGTGTAT GAATGGCCAG AATCTGCATC AAGCCCTCCT 
GTGATAACAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002387.1
CDS	260..2014
Translation	MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE

Target ORF information:

RefSeq Version	NM_002396.4
Organism	Homo sapiens(human)
Definition	Homo sapiens malic enzyme 2 (ME2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002396.4

ORF Insert Sequence:

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTG TGGCTTTAGC TGTTATTCTC 
TGTAACACCC GGCATATTAG TGACAGTGTT TTCCTAGAAG CTGCAAAGGC CCTGACAAGC 
CAATTGACAG ATGAAGAGCT AGCCCAAGGG AGACTTTACC CACCGCTTGC TAATATTCAG 
GAAGTTTCTA TTAACATTGC TATTAAAGTT ACAGAATACC TATATGCTAA TAAAATGGCT 
TTCCGATACC CAGAACCTGA AGACAAGGCC AAATATGTTA AAGAAAGAAC ATGGCGGAGT 
GAATATGATT CCCTGCTGCC AGATGTGTAT GAATGGCCAG AATCTGCATC AAGCCCTCCT 
GTGATAACAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ME2 ( NM_002396.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002387.1 Homo sapiens malic enzyme 2 (ME2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21107
Clone ID Related Accession (Same CDS sequence)	NM_002396.4 , NM_002396.5
Accession Version	NM_002396.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1755bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	NAD-dependent malic enzyme, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI559761.1, M55905.1, AK313391.1, AC087687.5 and CD370709.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002396.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.6818.1, SRR1660807.255124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000321341.11/ ENSP00000321070.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTG TGGCTTTAGC TGTTATTCTC 
TGTAACACCC GGCATATTAG TGACAGTGTT TTCCTAGAAG CTGCAAAGGC CCTGACAAGC 
CAATTGACAG ATGAAGAGCT AGCCCAAGGG AGACTTTACC CACCGCTTGC TAATATTCAG 
GAAGTTTCTA TTAACATTGC TATTAAAGTT ACAGAATACC TATATGCTAA TAAAATGGCT 
TTCCGATACC CAGAACCTGA AGACAAGGCC AAATATGTTA AAGAAAGAAC ATGGCGGAGT 
GAATATGATT CCCTGCTGCC AGATGTGTAT GAATGGCCAG AATCTGCATC AAGCCCTCCT 
GTGATAACAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002387.1
CDS	204..1958
Translation	MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE

Target ORF information:

RefSeq Version	NM_002396.5
Organism	Homo sapiens(human)
Definition	Homo sapiens malic enzyme 2 (ME2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002396.5

ORF Insert Sequence:

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTG TGGCTTTAGC TGTTATTCTC 
TGTAACACCC GGCATATTAG TGACAGTGTT TTCCTAGAAG CTGCAAAGGC CCTGACAAGC 
CAATTGACAG ATGAAGAGCT AGCCCAAGGG AGACTTTACC CACCGCTTGC TAATATTCAG 
GAAGTTTCTA TTAACATTGC TATTAAAGTT ACAGAATACC TATATGCTAA TAAAATGGCT 
TTCCGATACC CAGAACCTGA AGACAAGGCC AAATATGTTA AAGAAAGAAC ATGGCGGAGT 
GAATATGATT CCCTGCTGCC AGATGTGTAT GAATGGCCAG AATCTGCATC AAGCCCTCCT 
GTGATAACAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ME2 ( NM_001168335.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161807.1 Homo sapiens malic enzyme 2 (ME2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12192
Clone ID Related Accession (Same CDS sequence)	NM_001168335.1 , NM_001168335.2
Accession Version	NM_001168335.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	NAD-dependent malic enzyme, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA644731.1, BI465083.1, BC000147.1, AC087687.5 and CD370709.1. Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000147.1, SRR1803617.98022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTT ACAGAATACC TATATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161807.1
CDS	260..1699
Translation	MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGYRIPIC

Target ORF information:

RefSeq Version	NM_001168335.1
Organism	Homo sapiens(human)
Definition	Homo sapiens malic enzyme 2 (ME2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168335.1

ORF Insert Sequence:

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTT ACAGAATACC TATATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ME2 ( NM_001168335.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161807.1 Homo sapiens malic enzyme 2 (ME2), transcript variant 2, mRNA.

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CloneID	OHu12192
Clone ID Related Accession (Same CDS sequence)	NM_001168335.1 , NM_001168335.2
Accession Version	NM_001168335.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	NAD-dependent malic enzyme, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI465083.1, BC000147.1, AC087687.5 and CD370709.1. On May 31, 2019 this sequence version replaced NM_001168335.1. Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000147.1, SRR1803617.98022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTT ACAGAATACC TATATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161807.1
CDS	204..1643
Translation	MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGYRIPIC

Target ORF information:

RefSeq Version	NM_001168335.2
Organism	Homo sapiens(human)
Definition	Homo sapiens malic enzyme 2 (ME2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168335.2

ORF Insert Sequence:

ATGTTGTCCC GGTTAAGAGT AGTTTCCACC ACTTGTACTT TGGCATGTCG ACATTTGCAC 
ATAAAAGAAA AAGGCAAGCC ACTTATGCTG AACCCAAGAA CAAACAAGGG AATGGCATTT 
ACTTTACAAG AACGACAAAT GCTTGGTCTT CAAGGACTTC TACCTCCCAA AATAGAGACA 
CAAGATATTC AAGCCTTACG ATTTCATAGA AACTTGAAGA AAATGACTAG CCCTTTGGAA 
AAATATATCT ACATAATGGG AATACAAGAA AGAAATGAGA AATTGTTTTA TAGAATACTG 
CAAGATGACA TTGAGAGTTT AATGCCAATT GTATATACAC CGACGGTTGG TCTTGCCTGC 
TCCCAGTATG GACACATCTT TAGAAGACCT AAGGGATTAT TTATTTCGAT CTCAGACAGA 
GGTCATGTTA GATCAATTGT GGATAACTGG CCAGAAAATC ATGTTAAGGC TGTTGTAGTG 
ACTGATGGAG AGAGAATTCT GGGTCTTGGA GATCTGGGTG TCTATGGAAT GGGAATTCCA 
GTAGGAAAAC TTTGTTTGTA TACAGCTTGT GCAGGAATAC GGCCTGATAG ATGCCTGCCA 
GTGTGTATTG ATGTGGGAAC TGATAATATC GCACTCTTAA AAGACCCATT TTACATGGGC 
TTGTACCAGA AACGAGATCG CACACAACAG TATGATGACC TGATTGATGA GTTTATGAAA 
GCTATTACTG ACAGATATGG CCGGAACACA CTCATTCAGT TCGAAGACTT TGGAAATCAT 
AATGCATTCA GGTTCTTGAG AAAGTACCGA GAAAAATATT GTACTTTCAA TGATGATATT 
CAAGGGACAG CTGCAGTAGC TCTAGCAGGT CTTCTTGCAG CACAAAAAGT TATTAGTAAA 
CCAATCTCCG AACACAAAAT CTTATTCCTT GGAGCAGGAG AGGCTGCTCT TGGAATTGCA 
AATCTTATAG TTATGTCTAT GGTAGAAAAT GGCCTGTCAG AACAAGAGGC ACAAAAGAAA 
ATCTGGATGT TTGACAAGTA TGGTTTATTA GTTAAGGGAC GGAAAGCAAA AATAGATAGT 
TATCAGGAAC CATTTACTCA CTCAGCCCCA GAGAGCATAC CTGATACTTT TGAAGATGCA 
GTGAATATAC TGAAGCCTTC AACTATAATT GGAGTTGCAG GTGCTGGCCG TCTTTTCACT 
CCTGATGTAA TCAGAGCCAT GGCCTCTATC AATGAAAGGC CTGTAATATT TGCATTAAGT 
AATCCTACAG CACAGGCAGA GTGCACGGCT GAAGAAGCAT ATACACTTAC AGAGGGCAGG 
TGTTTGTTTG CCAGTGGCAG TCCATTTGGG CCAGTGAAAC TTACAGATGG GCGAGTCTTT 
ACACCAGGTC AAGGAAACAA TGTTTATATT TTTCCAGGTT ACAGAATACC TATATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Collateral Lethality in Pancreatic Cancer.
Cancer discovery7(4)342-343(2017 04)

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
Nature542(7639)119-123(2017 02)
Dey P,Baddour J,Muller F,Wu CC,Wang H,Liao WT,Lan Z,Chen A,Gutschner T,Kang Y,Fleming J,Satani N,Zhao D,Achreja A,Yang L,Lee J,Chang E,Genovese G,Viale A,Ying H,Draetta G,Maitra A,Wang YA,Nagrath D,DePinho RA

Expression of Malic Enzymes in Sebaceous Lesions.
The American Journal of dermatopathology38(8)580-5(2016 Aug)
Su TF,Gao HW

The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
Oncotarget7(27)41460-41472(2016 Jul)
Cheng CP,Huang LC,Chang YL,Hsieh CH,Huang SM,Hueng DY

Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.
The Journal of investigative dermatology135(3)807-815(2015 Mar)
Chang YL,Gao HW,Chiang CP,Wang WM,Huang SM,Ku CF,Liu GY,Hung HC

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ME2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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