KCNK3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNK3
Entrez Gene ID	3777
Full Name	potassium two pore domain channel subfamily K member 3
Synonyms	K2p3.1,OAT1,PPH4,TASK,TASK-1,TBAK1
General protein information	Preferred Names potassium two pore domain channel subfamily K member 3 Names potassium channel subfamily K member 3 TWIK-related acid-sensitive K(+) channel 1 TWIK-related acid-sensitive K+ channel acid-sensitive potassium channel protein TASK acid-sensitive potassium channel protein TASK-1 cardiac potassium channel potassium channel, two pore domain subfamily K, member 3 potassium inwardly-rectifying channel, subfamily K, member 3 two P domain potassium channel two pore K(+) channel KT3.1 two pore potassium channel KT3.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p23.3
Summary	This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008].
Disorder MIM:	603220
Disorder Html:	Pulmonary hypertension, primary, 4, 615344 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005264293.2	XP_005264350.1	potassium channel subfamily K member 3 isoform X1
XM_005264293.1	XP_005264350.1	potassium channel subfamily K member 3 isoform X1
NM_002246.3	NP_002237.1	potassium channel subfamily K member 3
NM_002246.2	NP_002237.1	potassium channel subfamily K member 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnk3	NP_203694.1
Danio rerio (zebrafish)	kcnk3	NP_001025333.1
	KCNK3	XP_001087754.1
Canis lupus familiaris (dog)	KCNK3	XP_540117.3
Mus musculus (house mouse)	Kcnk3	NP_034738.1
Homo sapiens (human)	KCNK3	NP_002237.1
Gallus gallus (chicken)	KCNK9	XP_003641103.1
Bos taurus (cattle)	KCNK3	XP_002691504.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA?138 promotes proliferation and suppresses mitochondrial depolarization in human pulmonary artery smooth muscle cells through targeting TASK?1.
Liu JJ, Zhang H, Xing F, Tang B, Wu SL, Xuan L, Kang PF, Xu Q, Wang HJ, Zhang NR, Wang XJ
Molecular medicine reports17(2)3021-3027(2018 Feb)

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.
Olschewski A, Veale EL, Nagy BM, Nagaraj C, Kwapiszewska G, Antigny F, Lambert M, Humbert M, Czirj?k G, Enyedi P, Mathie A
The European respiratory journal50(5)(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our study indicates that TASK-1 is functionally regulated by caveolin-3, possibly via association with each other on the cell surface. These results point out a novel mechanism in the regulation of TASK-1.
Title: Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3.

A burden of rare variants in BMPR2 significantly contributed to the risk of pulmonary arterial hypertension. In the remaining one family, the patient carried a pathogenic variant in a member of potassium channels, KCNK3, which was the first replicative finding of channelopathy in an Asian population.
Title: A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension.

The present report supports the contribution of KCNK3 mutations to the genetic etiology of Pulmonary arterial hypertension and strongly suggests that mutations in KCNK3 follow incomplete dominance with worsening of the clinical features in homozygous patients.
Title: An homozygous mutation in KCNK3 is associated with an aggressive form of hereditary pulmonary arterial hypertension.

The results suggested that heterodimerization of TASK1 and TALK2 provides cells with the ability to make multiple responses to a variety of physiological and pharmacological stimuli.
Title: Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems.

In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 3 mutations found in KCNK3.
Title: Molecular Analysis of BMPR2, TBX4, and KCNK3 and Genotype-Phenotype Correlations in Spanish Patients and Families With Idiopathic and Hereditary Pulmonary Arterial Hypertension.

The following KCNK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18068	NM_002246.3 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
OHu35380	XM_005264293.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu35380	XM_005264293.1	Homo sapiens potassium channel, two pore domain subfamily K, member 3 (KCNK3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu18068	NM_002246.2	Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNK3 ( NM_002246.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002237.1 Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), mRNA.

Price & Availability↑

CloneID	OHu18068
Clone ID Related Accession (Same CDS sequence)	NM_002246.3 , NM_002246.2
Accession Version	NM_002246.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015977.9 and AF065163.1. On Nov 22, 2018 this sequence version replaced NM_002246.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF006823.1, AF065163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302909.4/ ENSP00000306275.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCGGC AGAACGTGCG CACGCTGGCG CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTCTTCGA CGCGCTGGAG TCGGAGCCCG AGCTGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCAGGA GCTGCGGGCG CGCTACAACC TCAGCCAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACCA TCGGCTACGG GCACGCGGCA 
CCCAGCACGG ATGGCGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG CGCATCAACA CCTTGGTGAG GTACCTGCTG 
CACCGCGCCA AGAAGGGGCT GGGCATGCGG CGCGCCGACG TGTCCATGGC CAACATGGTG 
CTCATCGGCT TCTTCTCGTG CATCAGCACG CTGTGCATCG GCGCCGCCGC CTTCTCCCAC 
TACGAGCACT GGACCTTCTT CCAGGCCTAC TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTACGTGGC GCTGCAGAAG GACCAGGCCC TGCAGACGCA GCCGCAGTAC 
GTGGCCTTCA GCTTCGTCTA CATCCTTACG GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGCTTCAT GACCATGAAC GCCGAGGACG AGAAGCGCGA CGCCGAGCAC 
CGCGCGCTGC TCACGCGCAA CGGGCAGGCG GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC 
ACTACGGACA CCGCCTCATC CACGGCGGCA GCGGGCGGCG GCGGCTTCCG CAACGTCTAC 
GCGGAGGTGC TGCACTTCCA GTCCATGTGC TCGTGCCTGT GGTACAAGAG CCGCGAGAAG 
CTGCAGTACT CCATCCCCAT GATCATCCCG CGGGACCTCT CCACGTCCGA CACGTGCGTG 
GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC GGCCGCTACA GCGACACGCC CTCGCGACGC 
TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC ATCAGCTCGG TGTCCACGGG TCTGCACAGC 
CTGTCCACCT TCCGCGGCCT CATGAAGCGC AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002237.1
CDS	155..1339
Translation	MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV

Target ORF information:

RefSeq Version	NM_002246.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002246.3

ORF Insert Sequence:

ATGAAGCGGC AGAACGTGCG CACGCTGGCG CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTCTTCGA CGCGCTGGAG TCGGAGCCCG AGCTGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCAGGA GCTGCGGGCG CGCTACAACC TCAGCCAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACCA TCGGCTACGG GCACGCGGCA 
CCCAGCACGG ATGGCGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG CGCATCAACA CCTTGGTGAG GTACCTGCTG 
CACCGCGCCA AGAAGGGGCT GGGCATGCGG CGCGCCGACG TGTCCATGGC CAACATGGTG 
CTCATCGGCT TCTTCTCGTG CATCAGCACG CTGTGCATCG GCGCCGCCGC CTTCTCCCAC 
TACGAGCACT GGACCTTCTT CCAGGCCTAC TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTACGTGGC GCTGCAGAAG GACCAGGCCC TGCAGACGCA GCCGCAGTAC 
GTGGCCTTCA GCTTCGTCTA CATCCTTACG GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGCTTCAT GACCATGAAC GCCGAGGACG AGAAGCGCGA CGCCGAGCAC 
CGCGCGCTGC TCACGCGCAA CGGGCAGGCG GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC 
ACTACGGACA CCGCCTCATC CACGGCGGCA GCGGGCGGCG GCGGCTTCCG CAACGTCTAC 
GCGGAGGTGC TGCACTTCCA GTCCATGTGC TCGTGCCTGT GGTACAAGAG CCGCGAGAAG 
CTGCAGTACT CCATCCCCAT GATCATCCCG CGGGACCTCT CCACGTCCGA CACGTGCGTG 
GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC GGCCGCTACA GCGACACGCC CTCGCGACGC 
TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC ATCAGCTCGG TGTCCACGGG TCTGCACAGC 
CTGTCCACCT TCCGCGGCCT CATGAAGCGC AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK3 ( NM_002246.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002237.1 Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), mRNA.

Price & Availability↑

CloneID	OHu18068
Clone ID Related Accession (Same CDS sequence)	NM_002246.3 , NM_002246.2
Accession Version	NM_002246.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015977.9 and AF065163.1. This sequence is a reference standard in the RefSeqGene project. On Aug 23, 2008 this sequence version replaced NM_002246.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB496944.1, AF006823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAGCGGC AGAACGTGCG CACGCTGGCG CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTCTTCGA CGCGCTGGAG TCGGAGCCCG AGCTGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCAGGA GCTGCGGGCG CGCTACAACC TCAGCCAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACCA TCGGCTACGG GCACGCGGCA 
CCCAGCACGG ATGGCGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG CGCATCAACA CCTTGGTGAG GTACCTGCTG 
CACCGCGCCA AGAAGGGGCT GGGCATGCGG CGCGCCGACG TGTCCATGGC CAACATGGTG 
CTCATCGGCT TCTTCTCGTG CATCAGCACG CTGTGCATCG GCGCCGCCGC CTTCTCCCAC 
TACGAGCACT GGACCTTCTT CCAGGCCTAC TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTACGTGGC GCTGCAGAAG GACCAGGCCC TGCAGACGCA GCCGCAGTAC 
GTGGCCTTCA GCTTCGTCTA CATCCTTACG GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGCTTCAT GACCATGAAC GCCGAGGACG AGAAGCGCGA CGCCGAGCAC 
CGCGCGCTGC TCACGCGCAA CGGGCAGGCG GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC 
ACTACGGACA CCGCCTCATC CACGGCGGCA GCGGGCGGCG GCGGCTTCCG CAACGTCTAC 
GCGGAGGTGC TGCACTTCCA GTCCATGTGC TCGTGCCTGT GGTACAAGAG CCGCGAGAAG 
CTGCAGTACT CCATCCCCAT GATCATCCCG CGGGACCTCT CCACGTCCGA CACGTGCGTG 
GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC GGCCGCTACA GCGACACGCC CTCGCGACGC 
TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC ATCAGCTCGG TGTCCACGGG TCTGCACAGC 
CTGTCCACCT TCCGCGGCCT CATGAAGCGC AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002237.1
CDS	164..1348
Translation	MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV

Target ORF information:

RefSeq Version	NM_002246.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002246.2

ORF Insert Sequence:

ATGAAGCGGC AGAACGTGCG CACGCTGGCG CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTCTTCGA CGCGCTGGAG TCGGAGCCCG AGCTGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCAGGA GCTGCGGGCG CGCTACAACC TCAGCCAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACCA TCGGCTACGG GCACGCGGCA 
CCCAGCACGG ATGGCGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG CGCATCAACA CCTTGGTGAG GTACCTGCTG 
CACCGCGCCA AGAAGGGGCT GGGCATGCGG CGCGCCGACG TGTCCATGGC CAACATGGTG 
CTCATCGGCT TCTTCTCGTG CATCAGCACG CTGTGCATCG GCGCCGCCGC CTTCTCCCAC 
TACGAGCACT GGACCTTCTT CCAGGCCTAC TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTACGTGGC GCTGCAGAAG GACCAGGCCC TGCAGACGCA GCCGCAGTAC 
GTGGCCTTCA GCTTCGTCTA CATCCTTACG GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGCTTCAT GACCATGAAC GCCGAGGACG AGAAGCGCGA CGCCGAGCAC 
CGCGCGCTGC TCACGCGCAA CGGGCAGGCG GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC 
ACTACGGACA CCGCCTCATC CACGGCGGCA GCGGGCGGCG GCGGCTTCCG CAACGTCTAC 
GCGGAGGTGC TGCACTTCCA GTCCATGTGC TCGTGCCTGT GGTACAAGAG CCGCGAGAAG 
CTGCAGTACT CCATCCCCAT GATCATCCCG CGGGACCTCT CCACGTCCGA CACGTGCGTG 
GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC GGCCGCTACA GCGACACGCC CTCGCGACGC 
TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC ATCAGCTCGG TGTCCACGGG TCTGCACAGC 
CTGTCCACCT TCCGCGGCCT CATGAAGCGC AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK3 ( XM_005264293.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264350.1 Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35380
Clone ID Related Accession (Same CDS sequence)	XM_005264293.2 , XM_005264293.1
Accession Version	XM_005264293.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005264293.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCTACG CGCTGCTGGG CATCCCGCTC ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG 
CGCATCAACA CCTTGGTGAG GTACCTGCTG CACCGCGCCA AGAAGGGGCT GGGCATGCGG 
CGCGCCGACG TGTCCATGGC CAACATGGTG CTCATCGGCT TCTTCTCGTG CATCAGCACG 
CTGTGCATCG GCGCCGCCGC CTTCTCCCAC TACGAGCACT GGACCTTCTT CCAGGCCTAC 
TACTACTGCT TCATCACCCT CACCACCATC GGCTTCGGCG ACTACGTGGC GCTGCAGAAG 
GACCAGGCCC TGCAGACGCA GCCGCAGTAC GTGGCCTTCA GCTTCGTCTA CATCCTTACG 
GGCCTCACGG TCATCGGCGC CTTCCTCAAC CTCGTGGTGC TGCGCTTCAT GACCATGAAC 
GCCGAGGACG AGAAGCGCGA CGCCGAGCAC CGCGCGCTGC TCACGCGCAA CGGGCAGGCG 
GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC ACTACGGACA CCGCCTCATC CACGGCGGCA 
GCGGGCGGCG GCGGCTTCCG CAACGTCTAC GCGGAGGTGC TGCACTTCCA GTCCATGTGC 
TCGTGCCTGT GGTACAAGAG CCGCGAGAAG CTGCAGTACT CCATCCCCAT GATCATCCCG 
CGGGACCTCT CCACGTCCGA CACGTGCGTG GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC 
GGCCGCTACA GCGACACGCC CTCGCGACGC TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC 
ATCAGCTCGG TGTCCACGGG TCTGCACAGC CTGTCCACCT TCCGCGGCCT CATGAAGCGC 
AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264350.1
CDS	122..976
Translation	MFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV

Target ORF information:

RefSeq Version	XM_005264293.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 3 (KCNK3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264293.2

ORF Insert Sequence:

ATGTTCTACG CGCTGCTGGG CATCCCGCTC ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG 
CGCATCAACA CCTTGGTGAG GTACCTGCTG CACCGCGCCA AGAAGGGGCT GGGCATGCGG 
CGCGCCGACG TGTCCATGGC CAACATGGTG CTCATCGGCT TCTTCTCGTG CATCAGCACG 
CTGTGCATCG GCGCCGCCGC CTTCTCCCAC TACGAGCACT GGACCTTCTT CCAGGCCTAC 
TACTACTGCT TCATCACCCT CACCACCATC GGCTTCGGCG ACTACGTGGC GCTGCAGAAG 
GACCAGGCCC TGCAGACGCA GCCGCAGTAC GTGGCCTTCA GCTTCGTCTA CATCCTTACG 
GGCCTCACGG TCATCGGCGC CTTCCTCAAC CTCGTGGTGC TGCGCTTCAT GACCATGAAC 
GCCGAGGACG AGAAGCGCGA CGCCGAGCAC CGCGCGCTGC TCACGCGCAA CGGGCAGGCG 
GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC ACTACGGACA CCGCCTCATC CACGGCGGCA 
GCGGGCGGCG GCGGCTTCCG CAACGTCTAC GCGGAGGTGC TGCACTTCCA GTCCATGTGC 
TCGTGCCTGT GGTACAAGAG CCGCGAGAAG CTGCAGTACT CCATCCCCAT GATCATCCCG 
CGGGACCTCT CCACGTCCGA CACGTGCGTG GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC 
GGCCGCTACA GCGACACGCC CTCGCGACGC TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC 
ATCAGCTCGG TGTCCACGGG TCTGCACAGC CTGTCCACCT TCCGCGGCCT CATGAAGCGC 
AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK3 ( XM_005264293.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005264350.1 Homo sapiens potassium channel, two pore domain subfamily K, member 3 (KCNK3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35380
Clone ID Related Accession (Same CDS sequence)	XM_005264293.2 , XM_005264293.1
Accession Version	XM_005264293.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	potassium channel subfamily K member 3 isoform X1
Comment

ATGTTCTACG CGCTGCTGGG CATCCCGCTC ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG 
CGCATCAACA CCTTGGTGAG GTACCTGCTG CACCGCGCCA AGAAGGGGCT GGGCATGCGG 
CGCGCCGACG TGTCCATGGC CAACATGGTG CTCATCGGCT TCTTCTCGTG CATCAGCACG 
CTGTGCATCG GCGCCGCCGC CTTCTCCCAC TACGAGCACT GGACCTTCTT CCAGGCCTAC 
TACTACTGCT TCATCACCCT CACCACCATC GGCTTCGGCG ACTACGTGGC GCTGCAGAAG 
GACCAGGCCC TGCAGACGCA GCCGCAGTAC GTGGCCTTCA GCTTCGTCTA CATCCTTACG 
GGCCTCACGG TCATCGGCGC CTTCCTCAAC CTCGTGGTGC TGCGCTTCAT GACCATGAAC 
GCCGAGGACG AGAAGCGCGA CGCCGAGCAC CGCGCGCTGC TCACGCGCAA CGGGCAGGCG 
GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC ACTACGGACA CCGCCTCATC CACGGCGGCA 
GCGGGCGGCG GCGGCTTCCG CAACGTCTAC GCGGAGGTGC TGCACTTCCA GTCCATGTGC 
TCGTGCCTGT GGTACAAGAG CCGCGAGAAG CTGCAGTACT CCATCCCCAT GATCATCCCG 
CGGGACCTCT CCACGTCCGA CACGTGCGTG GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC 
GGCCGCTACA GCGACACGCC CTCGCGACGC TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC 
ATCAGCTCGG TGTCCACGGG TCTGCACAGC CTGTCCACCT TCCGCGGCCT CATGAAGCGC 
AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005264350.1
Translation	MFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV

Target ORF information:

RefSeq Version	XM_005264293.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens potassium channel, two pore domain subfamily K, member 3 (KCNK3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005264293.1

ORF Insert Sequence:

ATGTTCTACG CGCTGCTGGG CATCCCGCTC ACGCTCGTCA TGTTCCAGAG CCTGGGCGAG 
CGCATCAACA CCTTGGTGAG GTACCTGCTG CACCGCGCCA AGAAGGGGCT GGGCATGCGG 
CGCGCCGACG TGTCCATGGC CAACATGGTG CTCATCGGCT TCTTCTCGTG CATCAGCACG 
CTGTGCATCG GCGCCGCCGC CTTCTCCCAC TACGAGCACT GGACCTTCTT CCAGGCCTAC 
TACTACTGCT TCATCACCCT CACCACCATC GGCTTCGGCG ACTACGTGGC GCTGCAGAAG 
GACCAGGCCC TGCAGACGCA GCCGCAGTAC GTGGCCTTCA GCTTCGTCTA CATCCTTACG 
GGCCTCACGG TCATCGGCGC CTTCCTCAAC CTCGTGGTGC TGCGCTTCAT GACCATGAAC 
GCCGAGGACG AGAAGCGCGA CGCCGAGCAC CGCGCGCTGC TCACGCGCAA CGGGCAGGCG 
GGCGGCGGCG GAGGGGGTGG CAGCGCGCAC ACTACGGACA CCGCCTCATC CACGGCGGCA 
GCGGGCGGCG GCGGCTTCCG CAACGTCTAC GCGGAGGTGC TGCACTTCCA GTCCATGTGC 
TCGTGCCTGT GGTACAAGAG CCGCGAGAAG CTGCAGTACT CCATCCCCAT GATCATCCCG 
CGGGACCTCT CCACGTCCGA CACGTGCGTG GAGCAGAGCC ACTCGTCGCC GGGAGGGGGC 
GGCCGCTACA GCGACACGCC CTCGCGACGC TGCCTGTGCA GCGGGGCGCC ACGCTCCGCC 
ATCAGCTCGG TGTCCACGGG TCTGCACAGC CTGTCCACCT TCCGCGGCCT CATGAAGCGC 
AGGAGCTCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA?138 promotes proliferation and suppresses mitochondrial depolarization in human pulmonary artery smooth muscle cells through targeting TASK?1.
Molecular medicine reports17(2)3021-3027(2018 Feb)
Liu JJ,Zhang H,Xing F,Tang B,Wu SL,Xuan L,Kang PF,Xu Q,Wang HJ,Zhang NR,Wang XJ

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.
The European respiratory journal50(5)(2017 Nov)
Olschewski A,Veale EL,Nagy BM,Nagaraj C,Kwapiszewska G,Antigny F,Lambert M,Humbert M,Czirj?k G,Enyedi P,Mathie A

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KCNK3 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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