Kcnk3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk3
Entrez Gene ID	29553
Full Name	potassium two pore domain channel subfamily K member 3
Synonyms	Task-1,rTASK
General protein information	Preferred Names potassium two pore domain channel subfamily K member 3 Names potassium channel subfamily K member 3 TWIK-related acid-sensitive K(+) channel 1 TWIK-related acid-sensitive K+ channel acid-sensitive potassium channel protein TASK-1 potassium channel, subfamily K, member 3 potassium channel, two pore domain subfamily K, member 3 two pore K(+) channel KT3.1 two pore potassium channel KT3.1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q14
Summary	a TWIK-related acid-sensitive K+ channel; functions as an open rectifier baseline potassium channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_033376.1	NP_203694.1	potassium channel subfamily K member 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnk3	NP_203694.1
Danio rerio (zebrafish)	kcnk3	NP_001025333.1
	KCNK3	XP_001087754.1
Canis lupus familiaris (dog)	KCNK3	XP_540117.3
Mus musculus (house mouse)	Kcnk3	NP_034738.1
Homo sapiens (human)	KCNK3	NP_002237.1
Gallus gallus (chicken)	KCNK9	XP_003641103.1
Bos taurus (cattle)	KCNK3	XP_002691504.1

Gene Ontology
Bibliography

Related articles in PubMed

The Effect of Mechanical Ventilation on TASK-1 Expression in the Brain in a Rat Model.
Na B, Zhang H, Wang G, Dai L, Xia G
Canadian respiratory journal20178530352(2017)

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Antigny F, Hautefort A, Meloche J, Belacel-Ouari M, Manoury B, Rucker-Martin C, P?choux C, Potus F, Nadeau V, Tremblay E, Ruffenach G, Bourgeois A, Dorfm?ller P, Breuils-Bonnet S, Fadel E, Ranchoux B, Jourdon P, Girerd B, Montani D, Provencher S, Bonnet S, Simonneau G, Humbert M, Perros F
Circulation133(14)1371-85(2016 Apr)

Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.
Chuang CL, Huang HC, Chang CC, Lee FY, Wu JC, Lee JY, Hsieh HG, Lee SD
Journal of gastroenterology and hepatology30(1)199-207(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KCNK3 expression and function were reduced in pulmonary artery smooth muscle cells and endothelial cells in monocrotaline-induced pulmonary hypertension. Long-term KCNK3 inhibition induced distal neomuscularization and early hemodynamic signs of PH.
Title: Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.

Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A.
Title: Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.

Data indicate that Gja1, Cav3 and Kcnk3 were up-regulated and Hcn2 was down-regulated in hearts of exercise trained Goto-Kakizaki (GK) type 2 diabetic rat compared to sedentary GK controls.
Title: Effects of exercise training on excitation-contraction coupling and related mRNA expression in hearts of Goto-Kakizaki type 2 diabetic rats.

In the dorsal horn of the developing rat, TWIK-related acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were down-regulated during postnatal development
Title: Transcriptional expression of voltage-gated Na? and voltage-independent K? channels in the developing rat superficial dorsal horn.

TASK-1 in rat cardiomyocytes is controlled by endothelin-1 and suggest that the inhibition of TASK-1 via endothelin receptors is mediated by the activation of phospholipase C.
Title: The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C.

The following Kcnk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09119	NM_033376.1 Latest version!	Rattus norvegicus potassium two pore domain channel subfamily K member 3 (Kcnk3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk3 ( NM_033376.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_203694.1 Rattus norvegicus potassium two pore domain channel subfamily K member 3 (Kcnk3), mRNA.

Price & Availability↑

CloneID	ORa09119
Clone ID Related Accession (Same CDS sequence)	NM_033376.1
Accession Version	NM_033376.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel subfamily K member 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF031384.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF031384.1, CK602460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCGGC AGAATGTGCG CACGTTGGCT CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTGTTCGA CGCGCTGGAG TCGGAGCCGG AGATGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCTGGA GCTGCGGGCG CGCTACAACC TCAGCGAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACAA TCGGCTATGG TCATGCGGCT 
CCCAGCACGG ACGGAGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACACTAGTCA TGTTCCAGAG CCTGGGTGAA CGCATCAACA CCTTCGTGAG GTACCTGCTG 
CACCGTGCGA AGAGGGGGCT GGGCATGCGG CACGCCGAGG TGTCCATGGC CAACATGGTG 
CTCATCGGTT TCGTGTCGTG CATCAGCACG CTGTGTATCG GCGCCGCTGC CTTCTCCTAC 
TATGAGCGCT GGACTTTCTT CCAGGCCTAT TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTACGTGGC GCTGCAGAAG GACCAGGCGC TGCAAACGCA GCCTCAGTAC 
GTGGCCTTCA GCTTCGTATA CATCCTCACC GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGATTCAT GACCATGAAC GCCGAGGACG AGAAGCGTGA TGCAGAGCAC 
CGTGCGCTGC TCACGCACAA TGGCCAGGCT GGCGGCCTGG GTGGCCTGAG CTGCCTAAGC 
GGTAGCCTGG GCGATGGCGT GCGTCCCCGC GACCCAGTCA CTTGCGCAGC GGCTGCAGGC 
GGCATGGGCG TGGGCGTGGG CGTCGGTGGC AGCGGCTTCC GCAACGTCTA TGCTGAAATG 
CTGCACTTTC AGTCCATGTG CTCGTGCCTC TGGTACAAGA GCCGCGAGAA GCTGCAGTAC 
TCCATCCCCA TGATCATCCC GCGGGACCTC TCCACATCCG ACACGTGCGT GGAGCACAGC 
CACTCGTCGC CAGGAGGCGG CGGCCGCTAC AGCGACACGC CCTCACACCC TTGCCTGTGC 
AGCGGGACGC AACGCTCGGC CATCAGCTCC GTGTCCACGG GCCTGCACAG CCTGGCTACC 
TTCCGCGGCC TCATGAAGCG CAGGAGCTCA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203694.1
CDS	104..1339
Translation	MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGGSGFRNVYAEMLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLATFRGLMKRRSSV

Target ORF information:

RefSeq Version	NM_033376.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium two pore domain channel subfamily K member 3 (Kcnk3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033376.1

ORF Insert Sequence:

ATGAAGCGGC AGAATGTGCG CACGTTGGCT CTCATCGTGT GCACCTTCAC CTACCTGCTG 
GTGGGCGCCG CGGTGTTCGA CGCGCTGGAG TCGGAGCCGG AGATGATCGA GCGGCAGCGG 
CTGGAGCTGC GGCAGCTGGA GCTGCGGGCG CGCTACAACC TCAGCGAGGG CGGCTACGAG 
GAGCTGGAGC GCGTCGTGCT GCGCCTCAAG CCGCACAAGG CCGGCGTGCA GTGGCGCTTC 
GCCGGCTCCT TCTACTTCGC CATCACCGTC ATCACCACAA TCGGCTATGG TCATGCGGCT 
CCCAGCACGG ACGGAGGCAA GGTGTTCTGC ATGTTCTACG CGCTGCTGGG CATCCCGCTC 
ACACTAGTCA TGTTCCAGAG CCTGGGTGAA CGCATCAACA CCTTCGTGAG GTACCTGCTG 
CACCGTGCGA AGAGGGGGCT GGGCATGCGG CACGCCGAGG TGTCCATGGC CAACATGGTG 
CTCATCGGTT TCGTGTCGTG CATCAGCACG CTGTGTATCG GCGCCGCTGC CTTCTCCTAC 
TATGAGCGCT GGACTTTCTT CCAGGCCTAT TACTACTGCT TCATCACCCT CACCACCATC 
GGCTTCGGCG ACTACGTGGC GCTGCAGAAG GACCAGGCGC TGCAAACGCA GCCTCAGTAC 
GTGGCCTTCA GCTTCGTATA CATCCTCACC GGCCTCACGG TCATCGGCGC CTTCCTCAAC 
CTCGTGGTGC TGCGATTCAT GACCATGAAC GCCGAGGACG AGAAGCGTGA TGCAGAGCAC 
CGTGCGCTGC TCACGCACAA TGGCCAGGCT GGCGGCCTGG GTGGCCTGAG CTGCCTAAGC 
GGTAGCCTGG GCGATGGCGT GCGTCCCCGC GACCCAGTCA CTTGCGCAGC GGCTGCAGGC 
GGCATGGGCG TGGGCGTGGG CGTCGGTGGC AGCGGCTTCC GCAACGTCTA TGCTGAAATG 
CTGCACTTTC AGTCCATGTG CTCGTGCCTC TGGTACAAGA GCCGCGAGAA GCTGCAGTAC 
TCCATCCCCA TGATCATCCC GCGGGACCTC TCCACATCCG ACACGTGCGT GGAGCACAGC 
CACTCGTCGC CAGGAGGCGG CGGCCGCTAC AGCGACACGC CCTCACACCC TTGCCTGTGC 
AGCGGGACGC AACGCTCGGC CATCAGCTCC GTGTCCACGG GCCTGCACAG CCTGGCTACC 
TTCCGCGGCC TCATGAAGCG CAGGAGCTCA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Effect of Mechanical Ventilation on TASK-1 Expression in the Brain in a Rat Model.
Canadian respiratory journal20178530352(2017)
Na B,Zhang H,Wang G,Dai L,Xia G

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Circulation133(14)1371-85(2016 Apr)
Antigny F,Hautefort A,Meloche J,Belacel-Ouari M,Manoury B,Rucker-Martin C,P?choux C,Potus F,Nadeau V,Tremblay E,Ruffenach G,Bourgeois A,Dorfm?ller P,Breuils-Bonnet S,Fadel E,Ranchoux B,Jourdon P,Girerd B,Montani D,Provencher S,Bonnet S,Simonneau G,Humbert M,Perros F

Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.
Journal of gastroenterology and hepatology30(1)199-207(2015 Jan)
Chuang CL,Huang HC,Chang CC,Lee FY,Wu JC,Lee JY,Hsieh HG,Lee SD

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Kcnk3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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