ZC3H12D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZC3H12D
Entrez Gene ID	340152
Full Name	zinc finger CCCH-type containing 12D
Synonyms	C6orf95,MCPIP4,TFL,dJ281H8.1,p34
General protein information	Preferred Names zinc finger CCCH-type containing 12D Names probable ribonuclease ZC3H12D Zinc finger CCCH domain-containing protein 12D transformed follicular lymphoma tumor suppressor TFL
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.1
Disorder MIM:	611106

mRNA and Protein(s)

mRNA	Protein	Name
NM_207360.2	NP_997243.2	probable ribonuclease ZC3H12D
NM_207360.3	NP_997243.2	probable ribonuclease ZC3H12D

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ZC3H12D	XP_541146.3
Rattus norvegicus (Norway rat)	Zc3h12d	NP_001100939.1
	ZC3H12D	XP_001087043.1
Homo sapiens (human)	ZC3H12D	NP_997243.2
Bos taurus (cattle)	ZC3H12D	XP_002690367.1
Pan troglodytes (chimpanzee)	ZC3H12D	XP_518794.2
Mus musculus (house mouse)	Zc3h12d	NP_766373.2

Gene Ontology
Bibliography

Related articles in PubMed

Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D.
Wawro M, Kochan J, Krzanik S, Jura J, Kasza A
Journal of cellular biochemistry118(3)487-498(2017 Mar)

ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes.
Zhang H, Wang WC, Chen JK, Zhou L, Wang M, Wang ZD, Yang B, Xia YM, Lei S, Fu EQ, Jiang T
Molecular immunology67(2 Pt B)206-12(2015 Oct)

Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation.
Huang S, Liu S, Fu JJ, Tony Wang T, Yao X, Kumar A, Liu G, Fu M
The Journal of biological chemistry290(34)20782-92(2015 Aug)

Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T
Journal of immunology (Baltimore, Md. : 1950)192(4)1512-24(2014 Feb)

The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages.
Huang S, Qi D, Liang J, Miao R, Minagawa K, Quinn T, Matsui T, Fan D, Liu J, Fu M
Cellular signalling24(2)569-76(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

overexpression of ZC3H12D increases the turnover rate of transcripts containing ZC3H12A 3'UTR.
Title: Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D.

The data indicated that ZC3H12D could suppress both the initial inflammation storm and chronic inflammation by targeting the mRNA of cytokines as well as NF-kappaB and c-fos.
Title: ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes.

MCPIP1 and MCPIP4 form a complex but they act independently in regulation of IL-6 mRNA degradation.
Title: Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation.

Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases.
Title: The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages.

MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.

The following ZC3H12D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZC3H12D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11845	NM_207360.3 Latest version!	Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu11845	NM_207360.2	Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZC3H12D ( NM_207360.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_997243.2 Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.

Price & Availability↑

CloneID	OHu11845
Clone ID Related Accession (Same CDS sequence)	NM_207360.2 , NM_207360.3
Accession Version	NM_207360.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	probable ribonuclease ZC3H12D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL031133.1. On Dec 30, 2009 this sequence version replaced NM_207360.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC157832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCACC CCAGCAAGAT GGAATTCTTC CAGAAGCTGG GCTATGACCG GGAGGATGTG 
CTCCGGGTGT TGGGCAAGCT GGGCGAGGGC GCCCTGGTCA ACGACGTGCT GCAGGAGCTT 
ATCCGCACGG GCAGCCGCCC GGGTGCCCTG GAGCACCCGG CTGCACCCAG GCTAGTGCCT 
CGGGGCTCCT GTGGGGTCCC GGACTCTGCC CAGCGTGGCC CGGGGACAGC CCTGGAAGAG 
GACTTCAGAA CCCTGGCCAG TTCTCTGCGA CCCATAGTGA TTGATGGCAG CAACGTGGCG 
ATGAGCCATG GAAATAAAGA AACCTTCTCT TGCCGGGGAA TCAAGCTGGC TGTTGACTGG 
TTCAGGGACA GAGGACACAC CTACATCAAA GTTTTTGTTC CATCCTGGAG GAAGGACCCA 
CCAAGAGCTG ACACCCCTAT CAGAGAGCAG CACGTGCTGG CGGAGCTGGA GCGGCAGGCG 
GTGCTGGTGT ACACGCCGTC CCGCAAGGTG CACGGCAAGC GCCTGGTCTG CTACGACGAC 
CGCTACATCG TGAAGGTGGC CTACGAGCAG GACGGCGTCA TCGTCTCCAA CGACAACTAC 
CGGGACCTGC AGAGCGAGAA CCCCGAGTGG AAGTGGTTCA TCGAGCAGAG GCTGCTCATG 
TTCTCCTTCG TCAACGACCG GTTCATGCCG CCTGATGACC CCCTGGGCCG CCATGGACCC 
TCCCTGAGCA ACTTCCTGAG CAGGAAGCCG AAGCCCCCAG AGCCATCCTG GCAGCATTGT 
CCTTATGGCA AGAAATGCAC CTATGGCATC AAGTGCAAGT TCTACCACCC GGAGAGGCCG 
CACCACGCGC AACTGGCGGT GGCCGACGAG CTCCGCGCCA AGACAGGGGC CCGGCCTGGC 
GCGGGCGCCG AGGAGCAGCG GCCACCGAGA GCCCCGGGCG GCTCCGCAGG AGCCCGGGCG 
GCCCCCCGGG AACCATTTGC GCACAGCCTC CCGCCGGCGC GGGGGTCCCC GGACCTGGCC 
GCCCTGCGAG GGAGCTTCTC TCGGCTGGCC TTCAGCGACG ACCTGGGGCC CCTGGGGCCG 
CCTCTCCCGG TCCCCGCCTG CAGCCTCACG CCCCGACTGG GCGGGCCCGA CTGGGTGTCC 
GCGGGCGGCC GGGTGCCAGG CCCGCTCAGC CTCCCTAGCC CGGAGAGCCA GTTCTCCCCG 
GGCGACCTCC CGCCTCCGCC CGGCCTGCAG CTCCAGCCGC GGGGCGAACA CCGCCCTAGG 
GACCTGCACG GCGACTTGCT TTCCCCGCGC AGGCCACCCG ACGACCCGTG GGCCCGTCCA 
CCCCGCTCCG ACCGCTTCCC TGGGCGCTCC GTCTGGGCGG AGCCGGCCTG GGGCGACGGC 
GCCACTGGGG GACTTTCAGT GTACGCGACC GAGGACGACG AGGGGGACGC GCGCGCCCGG 
GCTCGCATCG CGCTCTACAG CGTCTTCCCG CGTGACCAGG TGGACCGCGT GATGGCCGCG 
TTCCCGGAGC TCTCAGACCT CGCCAGGCTC ATCCTCCTGG TACAGAGATG CCAGAGCGCG 
GGGGCGCCCC TGGGCAAGCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997243.2
CDS	271..1854
Translation	MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP

Target ORF information:

RefSeq Version	NM_207360.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207360.2

ORF Insert Sequence:

ATGGAGCACC CCAGCAAGAT GGAATTCTTC CAGAAGCTGG GCTATGACCG GGAGGATGTG 
CTCCGGGTGT TGGGCAAGCT GGGCGAGGGC GCCCTGGTCA ACGACGTGCT GCAGGAGCTT 
ATCCGCACGG GCAGCCGCCC GGGTGCCCTG GAGCACCCGG CTGCACCCAG GCTAGTGCCT 
CGGGGCTCCT GTGGGGTCCC GGACTCTGCC CAGCGTGGCC CGGGGACAGC CCTGGAAGAG 
GACTTCAGAA CCCTGGCCAG TTCTCTGCGA CCCATAGTGA TTGATGGCAG CAACGTGGCG 
ATGAGCCATG GAAATAAAGA AACCTTCTCT TGCCGGGGAA TCAAGCTGGC TGTTGACTGG 
TTCAGGGACA GAGGACACAC CTACATCAAA GTTTTTGTTC CATCCTGGAG GAAGGACCCA 
CCAAGAGCTG ACACCCCTAT CAGAGAGCAG CACGTGCTGG CGGAGCTGGA GCGGCAGGCG 
GTGCTGGTGT ACACGCCGTC CCGCAAGGTG CACGGCAAGC GCCTGGTCTG CTACGACGAC 
CGCTACATCG TGAAGGTGGC CTACGAGCAG GACGGCGTCA TCGTCTCCAA CGACAACTAC 
CGGGACCTGC AGAGCGAGAA CCCCGAGTGG AAGTGGTTCA TCGAGCAGAG GCTGCTCATG 
TTCTCCTTCG TCAACGACCG GTTCATGCCG CCTGATGACC CCCTGGGCCG CCATGGACCC 
TCCCTGAGCA ACTTCCTGAG CAGGAAGCCG AAGCCCCCAG AGCCATCCTG GCAGCATTGT 
CCTTATGGCA AGAAATGCAC CTATGGCATC AAGTGCAAGT TCTACCACCC GGAGAGGCCG 
CACCACGCGC AACTGGCGGT GGCCGACGAG CTCCGCGCCA AGACAGGGGC CCGGCCTGGC 
GCGGGCGCCG AGGAGCAGCG GCCACCGAGA GCCCCGGGCG GCTCCGCAGG AGCCCGGGCG 
GCCCCCCGGG AACCATTTGC GCACAGCCTC CCGCCGGCGC GGGGGTCCCC GGACCTGGCC 
GCCCTGCGAG GGAGCTTCTC TCGGCTGGCC TTCAGCGACG ACCTGGGGCC CCTGGGGCCG 
CCTCTCCCGG TCCCCGCCTG CAGCCTCACG CCCCGACTGG GCGGGCCCGA CTGGGTGTCC 
GCGGGCGGCC GGGTGCCAGG CCCGCTCAGC CTCCCTAGCC CGGAGAGCCA GTTCTCCCCG 
GGCGACCTCC CGCCTCCGCC CGGCCTGCAG CTCCAGCCGC GGGGCGAACA CCGCCCTAGG 
GACCTGCACG GCGACTTGCT TTCCCCGCGC AGGCCACCCG ACGACCCGTG GGCCCGTCCA 
CCCCGCTCCG ACCGCTTCCC TGGGCGCTCC GTCTGGGCGG AGCCGGCCTG GGGCGACGGC 
GCCACTGGGG GACTTTCAGT GTACGCGACC GAGGACGACG AGGGGGACGC GCGCGCCCGG 
GCTCGCATCG CGCTCTACAG CGTCTTCCCG CGTGACCAGG TGGACCGCGT GATGGCCGCG 
TTCCCGGAGC TCTCAGACCT CGCCAGGCTC ATCCTCCTGG TACAGAGATG CCAGAGCGCG 
GGGGCGCCCC TGGGCAAGCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZC3H12D ( NM_207360.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997243.2 Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.

Price & Availability↑

CloneID	OHu11845
Clone ID Related Accession (Same CDS sequence)	NM_207360.2 , NM_207360.3
Accession Version	NM_207360.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	probable ribonuclease ZC3H12D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL031133.1. On May 17, 2019 this sequence version replaced NM_207360.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC157832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000409806.8/ ENSP00000386616.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCACC CCAGCAAGAT GGAATTCTTC CAGAAGCTGG GCTATGACCG GGAGGATGTG 
CTCCGGGTGT TGGGCAAGCT GGGCGAGGGC GCCCTGGTCA ACGACGTGCT GCAGGAGCTT 
ATCCGCACGG GCAGCCGCCC GGGTGCCCTG GAGCACCCGG CTGCACCCAG GCTAGTGCCT 
CGGGGCTCCT GTGGGGTCCC GGACTCTGCC CAGCGTGGCC CGGGGACAGC CCTGGAAGAG 
GACTTCAGAA CCCTGGCCAG TTCTCTGCGA CCCATAGTGA TTGATGGCAG CAACGTGGCG 
ATGAGCCATG GAAATAAAGA AACCTTCTCT TGCCGGGGAA TCAAGCTGGC TGTTGACTGG 
TTCAGGGACA GAGGACACAC CTACATCAAA GTTTTTGTTC CATCCTGGAG GAAGGACCCA 
CCAAGAGCTG ACACCCCTAT CAGAGAGCAG CACGTGCTGG CGGAGCTGGA GCGGCAGGCG 
GTGCTGGTGT ACACGCCGTC CCGCAAGGTG CACGGCAAGC GCCTGGTCTG CTACGACGAC 
CGCTACATCG TGAAGGTGGC CTACGAGCAG GACGGCGTCA TCGTCTCCAA CGACAACTAC 
CGGGACCTGC AGAGCGAGAA CCCCGAGTGG AAGTGGTTCA TCGAGCAGAG GCTGCTCATG 
TTCTCCTTCG TCAACGACCG GTTCATGCCG CCTGATGACC CCCTGGGCCG CCATGGACCC 
TCCCTGAGCA ACTTCCTGAG CAGGAAGCCG AAGCCCCCAG AGCCATCCTG GCAGCATTGT 
CCTTATGGCA AGAAATGCAC CTATGGCATC AAGTGCAAGT TCTACCACCC GGAGAGGCCG 
CACCACGCGC AACTGGCGGT GGCCGACGAG CTCCGCGCCA AGACAGGGGC CCGGCCTGGC 
GCGGGCGCCG AGGAGCAGCG GCCACCGAGA GCCCCGGGCG GCTCCGCAGG AGCCCGGGCG 
GCCCCCCGGG AACCATTTGC GCACAGCCTC CCGCCGGCGC GGGGGTCCCC GGACCTGGCC 
GCCCTGCGAG GGAGCTTCTC TCGGCTGGCC TTCAGCGACG ACCTGGGGCC CCTGGGGCCG 
CCTCTCCCGG TCCCCGCCTG CAGCCTCACG CCCCGACTGG GCGGGCCCGA CTGGGTGTCC 
GCGGGCGGCC GGGTGCCAGG CCCGCTCAGC CTCCCTAGCC CGGAGAGCCA GTTCTCCCCG 
GGCGACCTCC CGCCTCCGCC CGGCCTGCAG CTCCAGCCGC GGGGCGAACA CCGCCCTAGG 
GACCTGCACG GCGACTTGCT TTCCCCGCGC AGGCCACCCG ACGACCCGTG GGCCCGTCCA 
CCCCGCTCCG ACCGCTTCCC TGGGCGCTCC GTCTGGGCGG AGCCGGCCTG GGGCGACGGC 
GCCACTGGGG GACTTTCAGT GTACGCGACC GAGGACGACG AGGGGGACGC GCGCGCCCGG 
GCTCGCATCG CGCTCTACAG CGTCTTCCCG CGTGACCAGG TGGACCGCGT GATGGCCGCG 
TTCCCGGAGC TCTCAGACCT CGCCAGGCTC ATCCTCCTGG TACAGAGATG CCAGAGCGCG 
GGGGCGCCCC TGGGCAAGCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997243.2
CDS	273..1856
Translation	MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP

Target ORF information:

RefSeq Version	NM_207360.3
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207360.3

ORF Insert Sequence:

ATGGAGCACC CCAGCAAGAT GGAATTCTTC CAGAAGCTGG GCTATGACCG GGAGGATGTG 
CTCCGGGTGT TGGGCAAGCT GGGCGAGGGC GCCCTGGTCA ACGACGTGCT GCAGGAGCTT 
ATCCGCACGG GCAGCCGCCC GGGTGCCCTG GAGCACCCGG CTGCACCCAG GCTAGTGCCT 
CGGGGCTCCT GTGGGGTCCC GGACTCTGCC CAGCGTGGCC CGGGGACAGC CCTGGAAGAG 
GACTTCAGAA CCCTGGCCAG TTCTCTGCGA CCCATAGTGA TTGATGGCAG CAACGTGGCG 
ATGAGCCATG GAAATAAAGA AACCTTCTCT TGCCGGGGAA TCAAGCTGGC TGTTGACTGG 
TTCAGGGACA GAGGACACAC CTACATCAAA GTTTTTGTTC CATCCTGGAG GAAGGACCCA 
CCAAGAGCTG ACACCCCTAT CAGAGAGCAG CACGTGCTGG CGGAGCTGGA GCGGCAGGCG 
GTGCTGGTGT ACACGCCGTC CCGCAAGGTG CACGGCAAGC GCCTGGTCTG CTACGACGAC 
CGCTACATCG TGAAGGTGGC CTACGAGCAG GACGGCGTCA TCGTCTCCAA CGACAACTAC 
CGGGACCTGC AGAGCGAGAA CCCCGAGTGG AAGTGGTTCA TCGAGCAGAG GCTGCTCATG 
TTCTCCTTCG TCAACGACCG GTTCATGCCG CCTGATGACC CCCTGGGCCG CCATGGACCC 
TCCCTGAGCA ACTTCCTGAG CAGGAAGCCG AAGCCCCCAG AGCCATCCTG GCAGCATTGT 
CCTTATGGCA AGAAATGCAC CTATGGCATC AAGTGCAAGT TCTACCACCC GGAGAGGCCG 
CACCACGCGC AACTGGCGGT GGCCGACGAG CTCCGCGCCA AGACAGGGGC CCGGCCTGGC 
GCGGGCGCCG AGGAGCAGCG GCCACCGAGA GCCCCGGGCG GCTCCGCAGG AGCCCGGGCG 
GCCCCCCGGG AACCATTTGC GCACAGCCTC CCGCCGGCGC GGGGGTCCCC GGACCTGGCC 
GCCCTGCGAG GGAGCTTCTC TCGGCTGGCC TTCAGCGACG ACCTGGGGCC CCTGGGGCCG 
CCTCTCCCGG TCCCCGCCTG CAGCCTCACG CCCCGACTGG GCGGGCCCGA CTGGGTGTCC 
GCGGGCGGCC GGGTGCCAGG CCCGCTCAGC CTCCCTAGCC CGGAGAGCCA GTTCTCCCCG 
GGCGACCTCC CGCCTCCGCC CGGCCTGCAG CTCCAGCCGC GGGGCGAACA CCGCCCTAGG 
GACCTGCACG GCGACTTGCT TTCCCCGCGC AGGCCACCCG ACGACCCGTG GGCCCGTCCA 
CCCCGCTCCG ACCGCTTCCC TGGGCGCTCC GTCTGGGCGG AGCCGGCCTG GGGCGACGGC 
GCCACTGGGG GACTTTCAGT GTACGCGACC GAGGACGACG AGGGGGACGC GCGCGCCCGG 
GCTCGCATCG CGCTCTACAG CGTCTTCCCG CGTGACCAGG TGGACCGCGT GATGGCCGCG 
TTCCCGGAGC TCTCAGACCT CGCCAGGCTC ATCCTCCTGG TACAGAGATG CCAGAGCGCG 
GGGGCGCCCC TGGGCAAGCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D.
Journal of cellular biochemistry118(3)487-498(2017 Mar)
Wawro M,Kochan J,Krzanik S,Jura J,Kasza A

ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes.
Molecular immunology67(2 Pt B)206-12(2015 Oct)
Zhang H,Wang WC,Chen JK,Zhou L,Wang M,Wang ZD,Yang B,Xia YM,Lei S,Fu EQ,Jiang T

Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation.
The Journal of biological chemistry290(34)20782-92(2015 Aug)
Huang S,Liu S,Fu JJ,Tony Wang T,Yao X,Kumar A,Liu G,Fu M

Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
Journal of immunology (Baltimore, Md. : 1950)192(4)1512-24(2014 Feb)
Minagawa K,Wakahashi K,Kawano H,Nishikawa S,Fukui C,Kawano Y,Asada N,Sato M,Sada A,Katayama Y,Matsui T

The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages.
Cellular signalling24(2)569-76(2012 Feb)
Huang S,Qi D,Liang J,Miao R,Minagawa K,Quinn T,Matsui T,Fan D,Liu J,Fu M

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ZC3H12D cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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