DEFB106A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB106A
Entrez Gene ID	245909
Full Name	defensin beta 106A
Synonyms	BD-6,DEFB-6,DEFB106
General protein information	Preferred Names defensin beta 106A Names beta-defensin 106 beta-defensin 6 defensin, beta 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_152251.4	NP_689464.1	beta-defensin 106 precursor
NM_152251.3	NP_689464.1	beta-defensin 106 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFB106A	NP_689464.1
Homo sapiens (human)	DEFB106B	NP_001035794.1

Gene Ontology
Bibliography

Related articles in PubMed

Unique properties of human ?-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site.
De Paula VS, Pomin VH, Valente AP
The Journal of biological chemistry289(33)22969-79(2014 Aug)

Soluble fusion expression, characterization and localization of human ?-defensin 6.
Xin A, Zhao Y, Yu H, Shi H, Liu H, Diao H, Zhang Y
Molecular medicine reports9(1)149-55(2014 Jan)

Structural basis for the interaction of human ?-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles.
De Paula VS, Gomes NS, Lima LG, Miyamoto CA, Monteiro RQ, Almeida FC, Valente AP
Journal of molecular biology425(22)4479-95(2013 Nov)

Copy number variation of defensin genes and HIV infection in Brazilian children.
Milanese M, Segat L, Arraes LC, Garzino-Demo A, Crovella S
Journal of acquired immune deficiency syndromes (1999)50(3)331-3(2009 Mar)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Unique properties of human beta-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site.
Title: Unique properties of human ?-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site.

DEFB106 (also known as DEFB6) displays antimicrobial activity against E. coli, C. albicans and S. aureus.
Title: Soluble fusion expression, characterization and localization of human ?-defensin 6.

Observational study of gene-disease association. (HuGE Navigator)
Title: Copy number variation of defensin genes and HIV infection in Brazilian children.

A pilot study with cRNA probes for in situ hybridization and a synthetic propeptide for the functional characterization demonstrated the tissue-/cell-specific expression and the strong antimicrobial activity of DEFB106
Title: ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.

The epididymis-specific expression pattern of the beta-defensin isoform BD-6 has been characterized.
Title: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

The following DEFB106A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB106A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23268	NM_152251.4 Latest version!	Homo sapiens defensin beta 106A (DEFB106A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23268	NM_152251.3	Homo sapiens defensin beta 106A (DEFB106A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB106A ( NM_152251.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689464.1 Homo sapiens defensin beta 106A (DEFB106A), mRNA.

Price & Availability↑

CloneID	OHu23268
Clone ID Related Accession (Same CDS sequence)	NM_152251.4 , NM_152251.3
Accession Version	NM_152251.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	beta-defensin 106 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084121.13, AY122466.1 and BC111688.1. On May 17, 2019 this sequence version replaced NM_152251.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI910580.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000335186.3/ ENSP00000335307.2 Protein has antimicrobial activity :: PMID: 24189797 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGACTT TCCTCTTTCT CTTTGCCGTG CTCTTCTTTC TGACCCCAGC CAAGAATGCA 
TTTTTTGATG AGAAATGCAA CAAACTTAAA GGGACATGCA AGAACAATTG CGGGAAAAAT 
GAAGAACTTA TTGCTCTCTG CCAGAAGTCT CTGAAATGCT GTCGGACCAT CCAGCCATGT 
GGGAGCATTA TAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689464.1
CDS	39..236
Translation	MRTFLFLFAVLFFLTPAKNAFFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPCGSIID

Target ORF information:

RefSeq Version	NM_152251.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 106A (DEFB106A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152251.4

ORF Insert Sequence:

ATGAGGACTT TCCTCTTTCT CTTTGCCGTG CTCTTCTTTC TGACCCCAGC CAAGAATGCA 
TTTTTTGATG AGAAATGCAA CAAACTTAAA GGGACATGCA AGAACAATTG CGGGAAAAAT 
GAAGAACTTA TTGCTCTCTG CCAGAAGTCT CTGAAATGCT GTCGGACCAT CCAGCCATGT 
GGGAGCATTA TAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB106A ( NM_152251.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689464.1 Homo sapiens defensin beta 106A (DEFB106A), mRNA.

Price & Availability↑

CloneID	OHu23268
Clone ID Related Accession (Same CDS sequence)	NM_152251.4 , NM_152251.3
Accession Version	NM_152251.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	beta-defensin 106 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY122466.1 and BC111688.1. On or before May 31, 2006 this sequence version replaced XM_928779.1, NM_152251.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI910580.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 24189797 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGACTT TCCTCTTTCT CTTTGCCGTG CTCTTCTTTC TGACCCCAGC CAAGAATGCA 
TTTTTTGATG AGAAATGCAA CAAACTTAAA GGGACATGCA AGAACAATTG CGGGAAAAAT 
GAAGAACTTA TTGCTCTCTG CCAGAAGTCT CTGAAATGCT GTCGGACCAT CCAGCCATGT 
GGGAGCATTA TAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689464.1
CDS	6..203
Translation	MRTFLFLFAVLFFLTPAKNAFFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPCGSIID

Target ORF information:

RefSeq Version	NM_152251.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 106A (DEFB106A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152251.3

ORF Insert Sequence:

ATGAGGACTT TCCTCTTTCT CTTTGCCGTG CTCTTCTTTC TGACCCCAGC CAAGAATGCA 
TTTTTTGATG AGAAATGCAA CAAACTTAAA GGGACATGCA AGAACAATTG CGGGAAAAAT 
GAAGAACTTA TTGCTCTCTG CCAGAAGTCT CTGAAATGCT GTCGGACCAT CCAGCCATGT 
GGGAGCATTA TAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Unique properties of human ?-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site.
The Journal of biological chemistry289(33)22969-79(2014 Aug)
De Paula VS,Pomin VH,Valente AP

Soluble fusion expression, characterization and localization of human ?-defensin 6.
Molecular medicine reports9(1)149-55(2014 Jan)
Xin A,Zhao Y,Yu H,Shi H,Liu H,Diao H,Zhang Y

Structural basis for the interaction of human ?-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles.
Journal of molecular biology425(22)4479-95(2013 Nov)
De Paula VS,Gomes NS,Lima LG,Miyamoto CA,Monteiro RQ,Almeida FC,Valente AP

Copy number variation of defensin genes and HIV infection in Brazilian children.
Journal of acquired immune deficiency syndromes (1999)50(3)331-3(2009 Mar)
Milanese M,Segat L,Arraes LC,Garzino-Demo A,Crovella S

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

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DEFB106A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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