DEFB106B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB106B
Entrez Gene ID	503841
Full Name	defensin beta 106B
Synonyms	BD-6,DEFB-6
General protein information	Preferred Names defensin beta 106B Names beta-defensin 106 beta-defensin 6 defensin, beta 106
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106B, represents the more telomeric copy. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040704.1	NP_001035794.1	beta-defensin 106 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFB106A	NP_689464.1
Homo sapiens (human)	DEFB106B	NP_001035794.1

Gene Ontology
Bibliography

Related articles in PubMed

Soluble fusion expression, characterization and localization of human ?-defensin 6.
Xin A, Zhao Y, Yu H, Shi H, Liu H, Diao H, Zhang Y
Molecular medicine reports9(1)149-55(2014 Jan)

Structural basis for the interaction of human ?-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles.
De Paula VS, Gomes NS, Lima LG, Miyamoto CA, Monteiro RQ, Almeida FC, Valente AP
Journal of molecular biology425(22)4479-95(2013 Nov)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.
Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M, Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF, Shimizu N, Siddiqui R, Platzer M
BMC genomics5(1)92(2004 Dec)

Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.
Boniotto M, Ventura M, Eskdale J, Crovella S, Gallagher G
Genetic testing8(3)325-7(2004)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DEFB106 (also known as DEFB6) displays antimicrobial activity against E. coli, C. albicans and S. aureus.
Title: Soluble fusion expression, characterization and localization of human ?-defensin 6.

The following DEFB106B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB106B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23268	NM_001040704.1 Latest version!	Homo sapiens defensin beta 106B (DEFB106B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB106B ( NM_001040704.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035794.1 Homo sapiens defensin beta 106B (DEFB106B), mRNA.

Price & Availability↑

CloneID	OHu23268
Clone ID Related Accession (Same CDS sequence)	NM_001040704.1
Accession Version	NM_001040704.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	beta-defensin 106 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC134684.5 and AC130360.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BX104316.1, AW103145.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 24189797 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGACTT TCCTCTTTCT CTTTGCCGTG CTCTTCTTTC TGACCCCAGC CAAGAATGCA 
TTTTTTGATG AGAAATGCAA CAAACTTAAA GGGACATGCA AGAACAATTG CGGGAAAAAT 
GAAGAACTTA TTGCTCTCTG CCAGAAGTCT CTGAAATGCT GTCGGACCAT CCAGCCATGT 
GGGAGCATTA TAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035794.1
CDS	6..203
Translation	MRTFLFLFAVLFFLTPAKNAFFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPCGSIID

Target ORF information:

RefSeq Version	NM_001040704.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 106B (DEFB106B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040704.1

ORF Insert Sequence:

ATGAGGACTT TCCTCTTTCT CTTTGCCGTG CTCTTCTTTC TGACCCCAGC CAAGAATGCA 
TTTTTTGATG AGAAATGCAA CAAACTTAAA GGGACATGCA AGAACAATTG CGGGAAAAAT 
GAAGAACTTA TTGCTCTCTG CCAGAAGTCT CTGAAATGCT GTCGGACCAT CCAGCCATGT 
GGGAGCATTA TAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Soluble fusion expression, characterization and localization of human ?-defensin 6.
Molecular medicine reports9(1)149-55(2014 Jan)
Xin A,Zhao Y,Yu H,Shi H,Liu H,Diao H,Zhang Y

Structural basis for the interaction of human ?-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles.
Journal of molecular biology425(22)4479-95(2013 Nov)
De Paula VS,Gomes NS,Lima LG,Miyamoto CA,Monteiro RQ,Almeida FC,Valente AP

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.
BMC genomics5(1)92(2004 Dec)
Taudien S,Galgoczy P,Huse K,Reichwald K,Schilhabel M,Szafranski K,Shimizu A,Asakawa S,Frankish A,Loncarevic IF,Shimizu N,Siddiqui R,Platzer M

Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.
Genetic testing8(3)325-7(2004)
Boniotto M,Ventura M,Eskdale J,Crovella S,Gallagher G

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

DEFB106B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報