NMS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NMS
Entrez Gene ID	129521
Full Name	neuromedin S
General protein information	Preferred Names neuromedin S Names neuromedin-S neuromedin S precursor-related peptide/neuromedin S preproprotein prepro-NMS
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q11.2
Summary	This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011717.1	NP_001011717.1	neuromedin-S preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nms	NP_001011684.3
	LOC710021	XP_001105196.1
Bos taurus (cattle)	NMS	NP_001070990.1
Rattus norvegicus (Norway rat)	NMS	NP_001012233.1
Canis lupus familiaris (dog)	NMS	XP_005626065.1
Homo sapiens (human)	NMS	NP_001011717.1
Pan troglodytes (chimpanzee)	NMS	XP_001161586.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.
Mori K, Ida T, Fudetani M, Mori M, Kaiya H, Hino J, Nakahara K, Murakami N, Miyazato M, Kangawa K
Scientific reports7(1)10468(2017 Sep)

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.
Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M
Neuron85(5)1086-102(2015 Mar)

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)

Association study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(5)1070-80(2010 Jul)

Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
Mitchell JD, Maguire JJ, Davenport AP
British journal of pharmacology158(1)87-103(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neuromedin s neurons define a subpopulation of pacemakers that control suprachiasmatic nucleus network synchrony.
Title: Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.

In man, NMS elicits vasoconstriction in isolated saphenous vein with comparable potency with NMU, but significantly reduces maximum contractile response.
Title: Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.

both NMU receptor and peptide are expressed in human cardiovascular tissues and have shown that NMU-25 and NMS act as potent vasoconstrictors in human vascular beds
Title: Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system.

NMS is implicated in the regulation of circadian rhythm and feeding behavior
Title: Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.

The following NMS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NMS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30965	NM_001011717.1 Latest version!	Homo sapiens neuromedin S (NMS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NMS ( NM_001011717.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001011717.1 Homo sapiens neuromedin S (NMS), mRNA.

Price & Availability↑

CloneID	OHu30965
Clone ID Related Accession (Same CDS sequence)	NM_001011717.1
Accession Version	NM_001011717.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	neuromedin-S preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB164464.1. On Feb 9, 2005 this sequence version replaced XM_065278.3. ##Evidence-Data-START## Transcript exon combination :: AB164464.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376865.1/ ENSP00000366061.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAACATC TTCGTCCCCA GTTCCCTCTC ATCTTGGCCA TCTACTGCTT CTGCATGCTA 
CAGATTCCCT CCTCAGGATT TCCTCAACCT TTAGCTGATC CTTCAGATGG CTTGGATATT 
GTGCAGCTTG AGCAGCTGGC ATATTGTCTG AGTCAGTGGG CACCTCTTTC TCGCCAACCT 
AAGGATAATC AAGACATATA CAAAAGGTTT TTGTTTCACT ACTCCAGAAC TCAGGAGGCA 
ACACATCCAG TTAAAACTGG GTTTCCTCCA GTGCATCCTC TAATGCACCT GGCTGCCAAG 
CTCGCCAACA GGCGGATGAA GAGAATTCTG CAGCGAGGCT CGGGGACTGC TGCAGTGGAC 
TTCACCAAGA AGGATCACAC TGCGACCTGG GGACGACCCT TTTTCCTTTT CAGGCCCAGG 
AATGGAAGAA ACATTGAAGA TGAGGCCCAG ATTCAGTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011717.1
CDS	8..469
Translation	MKHLRPQFPLILAIYCFCMLQIPSSGFPQPLADPSDGLDIVQLEQLAYCLSQWAPLSRQPKDNQDIYKRFLFHYSRTQEATHPVKTGFPPVHPLMHLAAKLANRRMKRILQRGSGTAAVDFTKKDHTATWGRPFFLFRPRNGRNIEDEAQIQW

Target ORF information:

RefSeq Version	NM_001011717.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuromedin S (NMS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011717.1

ORF Insert Sequence:

ATGAAACATC TTCGTCCCCA GTTCCCTCTC ATCTTGGCCA TCTACTGCTT CTGCATGCTA 
CAGATTCCCT CCTCAGGATT TCCTCAACCT TTAGCTGATC CTTCAGATGG CTTGGATATT 
GTGCAGCTTG AGCAGCTGGC ATATTGTCTG AGTCAGTGGG CACCTCTTTC TCGCCAACCT 
AAGGATAATC AAGACATATA CAAAAGGTTT TTGTTTCACT ACTCCAGAAC TCAGGAGGCA 
ACACATCCAG TTAAAACTGG GTTTCCTCCA GTGCATCCTC TAATGCACCT GGCTGCCAAG 
CTCGCCAACA GGCGGATGAA GAGAATTCTG CAGCGAGGCT CGGGGACTGC TGCAGTGGAC 
TTCACCAAGA AGGATCACAC TGCGACCTGG GGACGACCCT TTTTCCTTTT CAGGCCCAGG 
AATGGAAGAA ACATTGAAGA TGAGGCCCAG ATTCAGTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.
Scientific reports7(1)10468(2017 Sep)
Mori K,Ida T,Fudetani M,Mori M,Kaiya H,Hino J,Nakahara K,Murakami N,Miyazato M,Kangawa K

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.
Neuron85(5)1086-102(2015 Mar)
Lee IT,Chang AS,Manandhar M,Shan Y,Fan J,Izumo M,Ikeda Y,Motoike T,Dixon S,Seinfeld JE,Takahashi JS,Yanagisawa M

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)
Rietveld CA,Esko T,Davies G,Pers TH,Turley P,Benyamin B,Chabris CF,Emilsson V,Johnson AD,Lee JJ,de Leeuw C,Marioni RE,Medland SE,Miller MB,Rostapshova O,van der Lee SJ,Vinkhuyzen AA,Amin N,Conley D,Derringer J,van Duijn CM,Fehrmann R,Franke L,Glaeser EL,Hansell NK,Hayward C,Iacono WG,Ibrahim-Verbaas C,Jaddoe V,Karjalainen J,Laibson D,Lichtenstein P,Liewald DC,Magnusson PK,Martin NG,McGue M,McMahon G,Pedersen NL,Pinker S,Porteous DJ,Posthuma D,Rivadeneira F,Smith BH,Starr JM,Tiemeier H,Timpson NJ,Trzaskowski M,Uitterlinden AG,Verhulst FC,Ward ME,Wright MJ,Davey Smith G,Deary IJ,Johannesson M,Plomin R,Visscher PM,Benjamin DJ,Cesarini D,Koellinger PD

Association study of 182 candidate genes in anorexia nervosa.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(5)1070-80(2010 Jul)
Pinheiro AP,Bulik CM,Thornton LM,Sullivan PF,Root TL,Bloss CS,Berrettini WH,Schork NJ,Kaye WH,Bergen AW,Magistretti P,Brandt H,Crawford S,Crow S,Fichter MM,Goldman D,Halmi KA,Johnson C,Kaplan AS,Keel PK,Klump KL,La Via M,Mitchell JE,Strober M,Rotondo A,Treasure J,Woodside DB

Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
British journal of pharmacology158(1)87-103(2009 Sep)
Mitchell JD,Maguire JJ,Davenport AP

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NMS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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