NLRP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NLRP5
Entrez Gene ID	126206
Full Name	NLR family pyrin domain containing 5
Synonyms	CLR19.8,MATER,NALP5,PAN11,PYPAF8
General protein information	Preferred Names NLR family pyrin domain containing 5 Names NACHT, LRR and PYD domains-containing protein 5 NACHT, leucine rich repeat and PYD containing 5 mater protein homolog maternal antigen that embryos require nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.43
Summary	The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	609658

mRNA and Protein(s)

mRNA	Protein	Name
NM_153447.4	NP_703148.4	NACHT, LRR and PYD domains-containing protein 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NLRP5	XP_001139299.2
	NLRP5	NP_001121103.1
Canis lupus familiaris (dog)	NLRP5	XP_005616898.1
Bos taurus (cattle)	NLRP5	NP_001007815.1
Rattus norvegicus (Norway rat)	Nlrp5	NP_001100944.1
Homo sapiens (human)	NLRP5	NP_703148.4
Mus musculus (house mouse)	Nlrp5	NP_035990.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic modifiers of multiple sclerosis progression, severity and onset.
Sadovnick AD, Traboulsee AL, Zhao Y, Bernales CQ, Encarnacion M, Ross JP, Yee IM, Criscuoli MG, Vilari?o-G?ell C
Clinical immunology (Orlando, Fla.)180100-105(2017 Jul)

NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging.
Maraldi T, Resca E, Nicoli A, Beretti F, Zavatti M, Capodanno F, Morini D, Palomba S, La Sala GB, De Pol A
Life sciences162108-14(2016 Oct)

Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Docherty LE, Rezwan FI, Poole RL, Turner CL, Kivuva E, Maher ER, Smithson SF, Hamilton-Shield JP, Patalan M, Gizewska M, Peregud-Pogorzelski J, Beygo J, Buiting K, Horsthemke B, Soellner L, Begemann M, Eggermann T, Baple E, Mansour S, Temple IK, Mackay DJ
Nature communications68086(2015 Sep)

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
Rovelet-Lecrux A, Legallic S, Wallon D, Flaman JM, Martinaud O, Bombois S, Rollin-Sillaire A, Michon A, Le Ber I, Pariente J, Puel M, Paquet C, Croisile B, Thomas-Ant?rion C, Vercelletto M, L?vy R, Fr?bourg T, Hannequin D, Campion D,
European journal of human genetics : EJHG20(6)613-7(2012 Jun)

The genetics of NOD-like receptors in Crohn's disease.
Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP
Tissue antigens76(1)48-56(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PSMG4 and NLRP5 appear of particular interest as they were found to be associated with more than one clinical phenotype and are implicated in biological processes considered relevant to the pathophysiology of MS. Also, PSMG4 p.W99R and NLRP5 p.R761L were found to correlate with an earlier age of MS clinical onset. Our data suggests PSMG4 and NLPR5 as potential targets for the development of modifying therapies for MS.
Title: Genetic modifiers of multiple sclerosis progression, severity and onset.

expression of MATER and NOX4 proteins are closely related to the follicular development and ovulation with particular regard for ovarian aging
Title: NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging.

NLRP5 mutation is associated with multilocus imprinting disorders and reproductive wastage.
Title: Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.

Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.

Observational study of gene-disease association. (HuGE Navigator)
Title: The genetics of NOD-like receptors in Crohn's disease.

The following NLRP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31436	NM_153447.4 Latest version!	Homo sapiens NLR family pyrin domain containing 5 (NLRP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NLRP5 ( NM_153447.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_703148.4 Homo sapiens NLR family pyrin domain containing 5 (NLRP5), mRNA.

Price & Availability↑

CloneID	OHu31436
Clone ID Related Accession (Same CDS sequence)	NM_153447.4
Accession Version	NM_153447.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY154460.1 and AC024580.6. This sequence is a reference standard in the RefSeqGene project. On Oct 16, 2007 this sequence version replaced NM_153447.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY054986.1, AY154460.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000390649.8/ ENSP00000375063.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGGTTG CAGGAGGACT TGAACTTGGA GCTGCTGCTC TGCTCTCAGC ATCACCACGT 
GCTCTTGTCA CTCTTTCCAC AGGTCCTACT TGCTCTATAT TACCAAAGAA TCCACTTTTC 
CCCCAAAACC TGAGCTCTCA GCCTTGTATC AAGATGGAAG GAGACAAATC GCTCACCTTT 
TCCAGCTACG GGCTGCAATG GTGTCTCTAT GAGCTAGACA AGGAAGAATT TCAGACATTC 
AAGGAATTAC TAAAGAAGAA ATCTTCAGAA TCGACCACAT GCTCTATTCC ACAGTTTGAA 
ATCGAGAATG CCAACGTGGA ATGTCTGGCA CTCCTCTTGC ATGAGTATTA TGGAGCATCG 
CTGGCCTGGG CTACGTCCAT TAGCATCTTT GAAAACATGA ACCTGCGAAC CCTCTCGGAG 
AAGGCACGGG ATGACATGAA AAGACATTCA CCAGAAGATC CTGAAGCAAC GATGACTGAC 
CAAGGACCAA GCAAGGAAAA AGTGCCAGGA ATTTCACAAG CTGTGCAACA AGATAGTGCC 
ACAGCTGCAG AGACAAAAGA ACAAGAAATT TCACAAGCTA TGGAACAAGA AGGTGCCACA 
GCAGCAGAGA CAGAAGAACA AGAAATTTCA CAAGCTATGG AACAAGAAGG TGCCACAGCA 
GCAGAGACAG AAGAACAAGG ACATGGAGGT GACACATGGG ACTACAAGAG TCACGTGATG 
ACCAAATTCG CTGAGGAGGA GGATGTACGT CGTAGTTTTG AAAACACTGC TGCTGACTGG 
CCGGAAATGC AAACGTTGGC TGGTGCTTTT GATTCAGACC GGTGGGGCTT CCGGCCTCGC 
ACGGTGGTTC TGCACGGAAA GTCAGGAATT GGGAAATCGG CTCTAGCCAG AAGGATCGTG 
CTGTGCTGGG CGCAAGGTGG ACTCTACCAG GGAATGTTCT CCTACGTCTT CTTCCTCCCC 
GTTAGAGAGA TGCAGCGGAA GAAGGAGAGC AGTGTCACAG AGTTCATCTC CAGGGAGTGG 
CCAGACTCCC AGGCTCCGGT GACGGAGATC ATGTCCCGAC CAGAAAGGCT GTTGTTCATC 
ATTGACGGTT TCGATGACCT GGGCTCTGTC CTCAACAATG ACACAAAGCT CTGCAAAGAC 
TGGGCTGAGA AGCAGCCTCC GTTCACCCTC ATACGCAGTC TGCTGAGGAA GGTCCTGCTC 
CCTGAGTCCT TCCTGATCGT CACCGTCAGA GACGTGGGCA CAGAGAAGCT CAAGTCAGAG 
GTCGTGTCTC CCCGTTACCT GTTAGTTAGA GGAATCTCCG GGGAACAAAG AATCCACTTG 
CTCCTTGAGC GCGGGATTGG TGAGCATCAG AAGACACAAG GGTTGCGTGC GATCATGAAC 
AACCGTGAGC TGCTCGACCA GTGCCAGGTG CCCGCCGTGG GCTCTCTCAT CTGCGTGGCC 
CTGCAGCTGC AGGACGTGGT GGGGGAGAGC GTCGCCCCCT TCAACCAAAC GCTCACAGGC 
CTGCACGCCG CTTTTGTGTT TCATCAGCTC ACCCCTCGAG GCGTGGTCCG GCGCTGTCTC 
AATCTGGAGG AAAGAGTTGT CCTGAAGCGC TTCTGCCGTA TGGCTGTGGA GGGAGTGTGG 
AATAGGAAGT CAGTGTTTGA CGGTGACGAC CTCATGGTTC AAGGACTCGG GGAGTCTGAG 
CTCCGTGCTC TGTTTCACAT GAACATCCTT CTCCCAGACA GCCACTGTGA GGAGTACTAC 
ACCTTCTTCC ACCTCAGTCT CCAGGACTTC TGTGCCGCCT TGTACTACGT GTTAGAGGGC 
CTGGAAATCG AGCCAGCTCT CTGCCCTCTG TACGTTGAGA AGACAAAGAG GTCCATGGAG 
CTTAAACAGG CAGGCTTCCA TATCCACTCG CTTTGGATGA AGCGTTTCTT GTTTGGCCTC 
GTGAGCGAAG ACGTAAGGAG GCCACTGGAG GTCCTGCTGG GCTGTCCCGT TCCCCTGGGG 
GTGAAGCAGA AGCTTCTGCA CTGGGTCTCT CTGTTGGGTC AGCAGCCTAA TGCCACCACC 
CCAGGAGACA CCCTGGACGC CTTCCACTGT CTTTTCGAGA CTCAAGACAA AGAGTTTGTT 
CGCTTGGCAT TAAACAGCTT CCAAGAAGTG TGGCTTCCGA TTAACCAGAA CCTGGACTTG 
ATAGCATCTT CCTTCTGCCT CCAGCACTGT CCGTATTTGC GGAAAATTCG GGTGGATGTC 
AAAGGGATCT TCCCAAGAGA TGAGTCCGCT GAGGCATGTC CTGTGGTCCC TCTATGGATG 
CGGGATAAGA CCCTCATTGA GGAGCAGTGG GAAGATTTCT GCTCCATGCT TGGCACCCAC 
CCACACCTGC GGCAGCTGGA CCTGGGCAGC AGCATCCTGA CAGAGCGGGC CATGAAGACC 
CTGTGTGCCA AGCTGAGGCA TCCCACCTGC AAGATACAGA CCCTGATGTT TAGAAATGCA 
CAGATTACCC CTGGTGTGCA GCACCTCTGG AGAATCGTCA TGGCCAACCG TAACCTAAGA 
TCCCTCAACT TGGGAGGCAC CCACCTGAAG GAAGAGGATG TAAGGATGGC GTGTGAAGCC 
TTAAAACACC CAAAATGTTT GTTGGAGTCT TTGAGGCTGG ATTGCTGTGG ATTGACCCAT 
GCCTGTTACC TGAAGATCTC CCAAATCCTT ACGACCTCCC CCAGCCTGAA ATCTCTGAGC 
CTGGCAGGAA ACAAGGTGAC AGACCAGGGA GTAATGCCTC TCAGTGATGC CTTGAGAGTC 
TCCCAGTGCG CCCTGCAGAA GCTGATACTG GAGGACTGTG GCATCACAGC CACGGGTTGC 
CAGAGTCTGG CCTCAGCCCT CGTCAGCAAC CGGAGCTTGA CACACCTGTG CCTATCCAAC 
AACAGCCTGG GGAACGAAGG TGTAAATCTA CTGTGTCGAT CCATGAGGCT TCCCCACTGT 
AGTCTGCAGA GGCTGATGCT GAATCAGTGC CACCTGGACA CGGCTGGCTG TGGTTTTCTT 
GCACTTGCGC TTATGGGTAA CTCATGGCTG ACGCACCTGA GCCTTAGCAT GAACCCTGTG 
GAAGACAATG GCGTGAAGCT TCTGTGCGAG GTCATGAGAG AACCATCTTG TCATCTCCAG 
GACCTGGAGT TGGTAAAGTG TCATCTCACC GCCGCGTGCT GTGAGAGTCT GTCCTGTGTG 
ATCTCGAGGA GCAGACACCT GAAGAGCCTG GATCTCACGG ACAATGCCCT GGGTGACGGT 
GGGGTTGCTG CGCTGTGCGA GGGACTGAAG CAAAAGAACA GTGTTCTGGC GAGACTCGGG 
TTGAAGGCAT GTGGACTGAC TTCTGATTGC TGTGAGGCAC TCTCCTTGGC CCTTTCCTGC 
AACCGGCATC TGACCAGTCT AAACCTGGTG CAGAATAACT TCAGTCCCAA AGGAATGATG 
AAGCTGTGTT CGGCCTTTGC CTGTCCCACG TCTAACTTAC AGATAATTGG GCTGTGGAAA 
TGGCAGTACC CTGTGCAAAT AAGGAAGCTG CTGGAGGAAG TGCAGCTACT CAAGCCCCGA 
GTCGTAATTG ACGGTAGTTG GCATTCTTTT GATGAAGATG ACCGGTACTG GTGGAAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_703148.4
CDS	1..3603
Translation	MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN

Target ORF information:

RefSeq Version	NM_153447.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 5 (NLRP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153447.4

ORF Insert Sequence:

ATGAAGGTTG CAGGAGGACT TGAACTTGGA GCTGCTGCTC TGCTCTCAGC ATCACCACGT 
GCTCTTGTCA CTCTTTCCAC AGGTCCTACT TGCTCTATAT TACCAAAGAA TCCACTTTTC 
CCCCAAAACC TGAGCTCTCA GCCTTGTATC AAGATGGAAG GAGACAAATC GCTCACCTTT 
TCCAGCTACG GGCTGCAATG GTGTCTCTAT GAGCTAGACA AGGAAGAATT TCAGACATTC 
AAGGAATTAC TAAAGAAGAA ATCTTCAGAA TCGACCACAT GCTCTATTCC ACAGTTTGAA 
ATCGAGAATG CCAACGTGGA ATGTCTGGCA CTCCTCTTGC ATGAGTATTA TGGAGCATCG 
CTGGCCTGGG CTACGTCCAT TAGCATCTTT GAAAACATGA ACCTGCGAAC CCTCTCGGAG 
AAGGCACGGG ATGACATGAA AAGACATTCA CCAGAAGATC CTGAAGCAAC GATGACTGAC 
CAAGGACCAA GCAAGGAAAA AGTGCCAGGA ATTTCACAAG CTGTGCAACA AGATAGTGCC 
ACAGCTGCAG AGACAAAAGA ACAAGAAATT TCACAAGCTA TGGAACAAGA AGGTGCCACA 
GCAGCAGAGA CAGAAGAACA AGAAATTTCA CAAGCTATGG AACAAGAAGG TGCCACAGCA 
GCAGAGACAG AAGAACAAGG ACATGGAGGT GACACATGGG ACTACAAGAG TCACGTGATG 
ACCAAATTCG CTGAGGAGGA GGATGTACGT CGTAGTTTTG AAAACACTGC TGCTGACTGG 
CCGGAAATGC AAACGTTGGC TGGTGCTTTT GATTCAGACC GGTGGGGCTT CCGGCCTCGC 
ACGGTGGTTC TGCACGGAAA GTCAGGAATT GGGAAATCGG CTCTAGCCAG AAGGATCGTG 
CTGTGCTGGG CGCAAGGTGG ACTCTACCAG GGAATGTTCT CCTACGTCTT CTTCCTCCCC 
GTTAGAGAGA TGCAGCGGAA GAAGGAGAGC AGTGTCACAG AGTTCATCTC CAGGGAGTGG 
CCAGACTCCC AGGCTCCGGT GACGGAGATC ATGTCCCGAC CAGAAAGGCT GTTGTTCATC 
ATTGACGGTT TCGATGACCT GGGCTCTGTC CTCAACAATG ACACAAAGCT CTGCAAAGAC 
TGGGCTGAGA AGCAGCCTCC GTTCACCCTC ATACGCAGTC TGCTGAGGAA GGTCCTGCTC 
CCTGAGTCCT TCCTGATCGT CACCGTCAGA GACGTGGGCA CAGAGAAGCT CAAGTCAGAG 
GTCGTGTCTC CCCGTTACCT GTTAGTTAGA GGAATCTCCG GGGAACAAAG AATCCACTTG 
CTCCTTGAGC GCGGGATTGG TGAGCATCAG AAGACACAAG GGTTGCGTGC GATCATGAAC 
AACCGTGAGC TGCTCGACCA GTGCCAGGTG CCCGCCGTGG GCTCTCTCAT CTGCGTGGCC 
CTGCAGCTGC AGGACGTGGT GGGGGAGAGC GTCGCCCCCT TCAACCAAAC GCTCACAGGC 
CTGCACGCCG CTTTTGTGTT TCATCAGCTC ACCCCTCGAG GCGTGGTCCG GCGCTGTCTC 
AATCTGGAGG AAAGAGTTGT CCTGAAGCGC TTCTGCCGTA TGGCTGTGGA GGGAGTGTGG 
AATAGGAAGT CAGTGTTTGA CGGTGACGAC CTCATGGTTC AAGGACTCGG GGAGTCTGAG 
CTCCGTGCTC TGTTTCACAT GAACATCCTT CTCCCAGACA GCCACTGTGA GGAGTACTAC 
ACCTTCTTCC ACCTCAGTCT CCAGGACTTC TGTGCCGCCT TGTACTACGT GTTAGAGGGC 
CTGGAAATCG AGCCAGCTCT CTGCCCTCTG TACGTTGAGA AGACAAAGAG GTCCATGGAG 
CTTAAACAGG CAGGCTTCCA TATCCACTCG CTTTGGATGA AGCGTTTCTT GTTTGGCCTC 
GTGAGCGAAG ACGTAAGGAG GCCACTGGAG GTCCTGCTGG GCTGTCCCGT TCCCCTGGGG 
GTGAAGCAGA AGCTTCTGCA CTGGGTCTCT CTGTTGGGTC AGCAGCCTAA TGCCACCACC 
CCAGGAGACA CCCTGGACGC CTTCCACTGT CTTTTCGAGA CTCAAGACAA AGAGTTTGTT 
CGCTTGGCAT TAAACAGCTT CCAAGAAGTG TGGCTTCCGA TTAACCAGAA CCTGGACTTG 
ATAGCATCTT CCTTCTGCCT CCAGCACTGT CCGTATTTGC GGAAAATTCG GGTGGATGTC 
AAAGGGATCT TCCCAAGAGA TGAGTCCGCT GAGGCATGTC CTGTGGTCCC TCTATGGATG 
CGGGATAAGA CCCTCATTGA GGAGCAGTGG GAAGATTTCT GCTCCATGCT TGGCACCCAC 
CCACACCTGC GGCAGCTGGA CCTGGGCAGC AGCATCCTGA CAGAGCGGGC CATGAAGACC 
CTGTGTGCCA AGCTGAGGCA TCCCACCTGC AAGATACAGA CCCTGATGTT TAGAAATGCA 
CAGATTACCC CTGGTGTGCA GCACCTCTGG AGAATCGTCA TGGCCAACCG TAACCTAAGA 
TCCCTCAACT TGGGAGGCAC CCACCTGAAG GAAGAGGATG TAAGGATGGC GTGTGAAGCC 
TTAAAACACC CAAAATGTTT GTTGGAGTCT TTGAGGCTGG ATTGCTGTGG ATTGACCCAT 
GCCTGTTACC TGAAGATCTC CCAAATCCTT ACGACCTCCC CCAGCCTGAA ATCTCTGAGC 
CTGGCAGGAA ACAAGGTGAC AGACCAGGGA GTAATGCCTC TCAGTGATGC CTTGAGAGTC 
TCCCAGTGCG CCCTGCAGAA GCTGATACTG GAGGACTGTG GCATCACAGC CACGGGTTGC 
CAGAGTCTGG CCTCAGCCCT CGTCAGCAAC CGGAGCTTGA CACACCTGTG CCTATCCAAC 
AACAGCCTGG GGAACGAAGG TGTAAATCTA CTGTGTCGAT CCATGAGGCT TCCCCACTGT 
AGTCTGCAGA GGCTGATGCT GAATCAGTGC CACCTGGACA CGGCTGGCTG TGGTTTTCTT 
GCACTTGCGC TTATGGGTAA CTCATGGCTG ACGCACCTGA GCCTTAGCAT GAACCCTGTG 
GAAGACAATG GCGTGAAGCT TCTGTGCGAG GTCATGAGAG AACCATCTTG TCATCTCCAG 
GACCTGGAGT TGGTAAAGTG TCATCTCACC GCCGCGTGCT GTGAGAGTCT GTCCTGTGTG 
ATCTCGAGGA GCAGACACCT GAAGAGCCTG GATCTCACGG ACAATGCCCT GGGTGACGGT 
GGGGTTGCTG CGCTGTGCGA GGGACTGAAG CAAAAGAACA GTGTTCTGGC GAGACTCGGG 
TTGAAGGCAT GTGGACTGAC TTCTGATTGC TGTGAGGCAC TCTCCTTGGC CCTTTCCTGC 
AACCGGCATC TGACCAGTCT AAACCTGGTG CAGAATAACT TCAGTCCCAA AGGAATGATG 
AAGCTGTGTT CGGCCTTTGC CTGTCCCACG TCTAACTTAC AGATAATTGG GCTGTGGAAA 
TGGCAGTACC CTGTGCAAAT AAGGAAGCTG CTGGAGGAAG TGCAGCTACT CAAGCCCCGA 
GTCGTAATTG ACGGTAGTTG GCATTCTTTT GATGAAGATG ACCGGTACTG GTGGAAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic modifiers of multiple sclerosis progression, severity and onset.
Clinical immunology (Orlando, Fla.)180100-105(2017 Jul)
Sadovnick AD,Traboulsee AL,Zhao Y,Bernales CQ,Encarnacion M,Ross JP,Yee IM,Criscuoli MG,Vilari?o-G?ell C

NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging.
Life sciences162108-14(2016 Oct)
Maraldi T,Resca E,Nicoli A,Beretti F,Zavatti M,Capodanno F,Morini D,Palomba S,La Sala GB,De Pol A

Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Nature communications68086(2015 Sep)
Docherty LE,Rezwan FI,Poole RL,Turner CL,Kivuva E,Maher ER,Smithson SF,Hamilton-Shield JP,Patalan M,Gizewska M,Peregud-Pogorzelski J,Beygo J,Buiting K,Horsthemke B,Soellner L,Begemann M,Eggermann T,Baple E,Mansour S,Temple IK,Mackay DJ

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
European journal of human genetics : EJHG20(6)613-7(2012 Jun)
Rovelet-Lecrux A,Legallic S,Wallon D,Flaman JM,Martinaud O,Bombois S,Rollin-Sillaire A,Michon A,Le Ber I,Pariente J,Puel M,Paquet C,Croisile B,Thomas-Ant?rion C,Vercelletto M,L?vy R,Fr?bourg T,Hannequin D,Campion D,

The genetics of NOD-like receptors in Crohn's disease.
Tissue antigens76(1)48-56(2010 Jul)
Cummings JR,Cooney RM,Clarke G,Beckly J,Geremia A,Pathan S,Hancock L,Guo C,Cardon LR,Jewell DP

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NLRP5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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