MMP21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP21
Entrez Gene ID	118856
Full Name	matrix metallopeptidase 21
Synonyms	HTX7,MMP-21
General protein information	Preferred Names matrix metallopeptidase 21 Names matrix metalloproteinase-21 matrix metalloproteinase 21
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.2
Summary	This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013].
Disorder MIM:	608416
Disorder Html:	Heterotaxy, visceral, 7, autosomal, 616749 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011539257.1	XP_011537559.1	matrix metalloproteinase-21 isoform X1
NM_147191.1	NP_671724.1	matrix metalloproteinase-21 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP21	XP_003312866.1
	MMP21	XP_001085506.1
Danio rerio (zebrafish)	LOC100003089	XP_001342721.4
Rattus norvegicus (Norway rat)	Mmp21	NP_001099778.1
Xenopus tropicalis (tropical clawed frog)	mmp21	XP_002932698.2
Homo sapiens (human)	MMP21	NP_671724.1
Mus musculus (house mouse)	Mmp21	NP_694423.1
Canis lupus familiaris (dog)	MMP21	XP_003640036.1

Gene Ontology
Bibliography

Related articles in PubMed

A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Perles Z, Moon S, Ta-Shma A, Yaacov B, Francescatto L, Edvardson S, Rein AJ, Elpeleg O, Katsanis N
Journal of medical genetics52(12)840-7(2015 Dec)

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Guimier A, Gabriel GC, Bajolle F, Tsang M, Liu H, Noll A, Schwartz M, El Malti R, Smith LD, Klena NT, Jimenez G, Miller NA, Oufadem M, Moreau de Bellaing A, Yagi H, Saunders CJ, Baker CN, Di Filippo S, Peterson KA, Thiffault I, Bole-Feysot C, Cooley LD, Farrow EG, Masson C, Schoen P, Deleuze JF, Nitschk? P, Lyonnet S, de Pontual L, Murray SA, Bonnet D, Kingsmore SF, Amiel J, Bouvagnet P, Lo CW, Gordon CT
Nature genetics47(11)1260-3(2015 Nov)

Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and prognosis.
Zhao Z, Yan L, Li S, Sun H, Zhou Y, Li X
Medical oncology (Northwood, London, England)31(8)91(2014 Aug)

High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis.
Pu Y, Wang L, Wu H, Feng Z, Wang Y, Guo C
Oncology reports31(6)2644-50(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling.
Title: A human laterality disorder caused by a homozygous deleterious mutation in MMP21.

Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance.
Title: MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.

Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis.
Title: Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and prognosis.

These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM
Title: High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis.

analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients
Title: Increased MMP-21 expression is associated with poor overall survival of patients with gastric cancer.

The following MMP21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu00568	NM_147191.1 Latest version!	Homo sapiens matrix metallopeptidase 21 (MMP21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu00568	XM_011539257.1 Latest version!	Homo sapiens matrix metallopeptidase 21 (MMP21), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP21 ( NM_147191.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_671724.1 Homo sapiens matrix metallopeptidase 21 (MMP21), mRNA.

Price & Availability↑

CloneID	OHu00568
Clone ID Related Accession (Same CDS sequence)	XM_011539257.1 , NM_147191.1
Accession Version	NM_147191.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1710bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	matrix metalloproteinase-21 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF520613.1 and AF331526.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF331526.1, AF520613.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2155628 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368808.3/ ENSP00000357798.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTCGCCG CCTCCATCTT CCGTCCGACA CTGCTGCTCT GCTGGCTGGC TGCTCCCTGG 
CCCACCCAGC CCGAGAGTCT CTTCCACAGC CGGGACCGCT CGGACCTGGA GCCGTCCCCA 
CTGCGCCAGG CCAAGCCCAT TGCCGACCTC CACGCTGCTC AGCGGTTCCT GTCCAGATAC 
GGCTGGTCAG GGGTGTGGGC GGCCTGGGGG CCCAGTCCCG AGGGGCCGCC GGAGACCCCC 
AAGGGCGCCG CCCTGGCCGA GGCGGTGCGC AGGTTCCAGC GGGCGAACGC GCTGCCGGCC 
AGCGGGGAGC TGGACGCGGC CACCCTAGCG GCCATGAACC GGCCGCGCTG CGGGGTCCCG 
GACATGCGCC CACCGCCCCC CTCCGCCCCG CCTTCGCCCC CGGGCCCGCC CCCCAGAGCC 
CGCTCCAGGC GCTCCCCGCG GGCGCCGCTG TCCTTGTCCC GGCGGGGTTG GCAGCCCCGG 
GGCTACCCCG ACGGCGGAGC TGCCCAGGCC TTCTCCAAGA GGACGCTGAG CTGGCGGCTG 
CTGGGCGAGG CCCTGAGCAG CCAACTGTCC GTGGCCGACC AGCGGCGCAT TGTGGCGCTG 
GCCTTCAGGA TGTGGAGCGA GGTGACGCCG CTGGACTTCC GCGAGGACCT GGCCGCCCCC 
GGGGCCGCGG TCGACATCAA GCTGGGCTTT GGGAGAGGCC GGCACCTGGG CTGTCCGCGG 
GCCTTCGATG GGAGCGGGCA GGAGTTTGCA CACGCCTGGC GCCTAGGTGA CATTCACTTT 
GACGACGACG AGCACTTCAC ACCTCCCACC AGTGACACGG GCATCAGCCT TCTCAAGGTG 
GCCGTCCATG AAATTGGCCA TGTCCTGGGC TTGCCTCACA CCTACAGGAC GGGATCCATA 
ATGCAACCAA ATTACATTCC CCAGGAGCCT GCCTTTGAGT TGGACTGGTC AGACAGGAAA 
GCAATTCAAA AGCTGTATGG CTCCTGTGAG GGATCATTTG ATACTGCGTT TGACTGGATT 
CGCAAAGAGA GAAACCAATA TGGAGAGGTG ATGGTGAGAT TTAGCACATA TTTCTTCCGT 
AACAGCTGGT ACTGGCTTTA TGAAAATCGA AACAATAGGA CACGCTATGG GGACCCTATC 
CAAATCCTCA CTGGCTGGCC TGGAATCCCA ACACACAACA TAGATGCCTT TGTTCACATC 
TGGACATGGA AAAGAGATGA ACGTTATTTT TTTCAAGGAA ATCAATACTG GAGATATGAC 
AGTGACAAGG ATCAGGCCCT CACAGAAGAT GAACAAGGAA AAAGCTATCC CAAATTGATT 
TCAGAAGGAT TTCCTGGCAT CCCAAGTCCC CTAGACACGG CGTTTTATGA CCGAAGACAG 
AAGTTAATTT ACTTCTTCAA GGAGTCCCTT GTATTTGCAT TTGATGTCAA CAGAAATCGA 
GTACTTAATT CTTATCCAAA GAGGATTACT GAAGTTTTTC CAGCAGTAAT ACCACAAAAT 
CATCCTTTCA GAAATATAGA TTCCGCTTAT TACTCCTATG CATACAACTC CATTTTCTTT 
TTCAAAGGCA ATGCATACTG GAAGGTAGTT AATGACAAGG ACAAACAACA GAATTCCTGG 
CTTCCTGCTA ATGGCTTATT TCCAAAAAAG TTTATTTCAG AGAAGTGGTT TGATGTTTGT 
GACGTCCATA TCTCCACACT GAACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671724.1
CDS	1..1710
Translation	MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM

Target ORF information:

RefSeq Version	NM_147191.1
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 21 (MMP21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147191.1

ORF Insert Sequence:

ATGCTCGCCG CCTCCATCTT CCGTCCGACA CTGCTGCTCT GCTGGCTGGC TGCTCCCTGG 
CCCACCCAGC CCGAGAGTCT CTTCCACAGC CGGGACCGCT CGGACCTGGA GCCGTCCCCA 
CTGCGCCAGG CCAAGCCCAT TGCCGACCTC CACGCTGCTC AGCGGTTCCT GTCCAGATAC 
GGCTGGTCAG GGGTGTGGGC GGCCTGGGGG CCCAGTCCCG AGGGGCCGCC GGAGACCCCC 
AAGGGCGCCG CCCTGGCCGA GGCGGTGCGC AGGTTCCAGC GGGCGAACGC GCTGCCGGCC 
AGCGGGGAGC TGGACGCGGC CACCCTAGCG GCCATGAACC GGCCGCGCTG CGGGGTCCCG 
GACATGCGCC CACCGCCCCC CTCCGCCCCG CCTTCGCCCC CGGGCCCGCC CCCCAGAGCC 
CGCTCCAGGC GCTCCCCGCG GGCGCCGCTG TCCTTGTCCC GGCGGGGTTG GCAGCCCCGG 
GGCTACCCCG ACGGCGGAGC TGCCCAGGCC TTCTCCAAGA GGACGCTGAG CTGGCGGCTG 
CTGGGCGAGG CCCTGAGCAG CCAACTGTCC GTGGCCGACC AGCGGCGCAT TGTGGCGCTG 
GCCTTCAGGA TGTGGAGCGA GGTGACGCCG CTGGACTTCC GCGAGGACCT GGCCGCCCCC 
GGGGCCGCGG TCGACATCAA GCTGGGCTTT GGGAGAGGCC GGCACCTGGG CTGTCCGCGG 
GCCTTCGATG GGAGCGGGCA GGAGTTTGCA CACGCCTGGC GCCTAGGTGA CATTCACTTT 
GACGACGACG AGCACTTCAC ACCTCCCACC AGTGACACGG GCATCAGCCT TCTCAAGGTG 
GCCGTCCATG AAATTGGCCA TGTCCTGGGC TTGCCTCACA CCTACAGGAC GGGATCCATA 
ATGCAACCAA ATTACATTCC CCAGGAGCCT GCCTTTGAGT TGGACTGGTC AGACAGGAAA 
GCAATTCAAA AGCTGTATGG CTCCTGTGAG GGATCATTTG ATACTGCGTT TGACTGGATT 
CGCAAAGAGA GAAACCAATA TGGAGAGGTG ATGGTGAGAT TTAGCACATA TTTCTTCCGT 
AACAGCTGGT ACTGGCTTTA TGAAAATCGA AACAATAGGA CACGCTATGG GGACCCTATC 
CAAATCCTCA CTGGCTGGCC TGGAATCCCA ACACACAACA TAGATGCCTT TGTTCACATC 
TGGACATGGA AAAGAGATGA ACGTTATTTT TTTCAAGGAA ATCAATACTG GAGATATGAC 
AGTGACAAGG ATCAGGCCCT CACAGAAGAT GAACAAGGAA AAAGCTATCC CAAATTGATT 
TCAGAAGGAT TTCCTGGCAT CCCAAGTCCC CTAGACACGG CGTTTTATGA CCGAAGACAG 
AAGTTAATTT ACTTCTTCAA GGAGTCCCTT GTATTTGCAT TTGATGTCAA CAGAAATCGA 
GTACTTAATT CTTATCCAAA GAGGATTACT GAAGTTTTTC CAGCAGTAAT ACCACAAAAT 
CATCCTTTCA GAAATATAGA TTCCGCTTAT TACTCCTATG CATACAACTC CATTTTCTTT 
TTCAAAGGCA ATGCATACTG GAAGGTAGTT AATGACAAGG ACAAACAACA GAATTCCTGG 
CTTCCTGCTA ATGGCTTATT TCCAAAAAAG TTTATTTCAG AGAAGTGGTT TGATGTTTGT 
GACGTCCATA TCTCCACACT GAACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMP21 ( XM_011539257.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011537559.1 Homo sapiens matrix metallopeptidase 21 (MMP21), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu00568
Clone ID Related Accession (Same CDS sequence)	XM_011539257.1 , NM_147191.1
Accession Version	XM_011539257.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1710bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	matrix metalloproteinase-21 isoform X1
Comment

ATGCTCGCCG CCTCCATCTT CCGTCCGACA CTGCTGCTCT GCTGGCTGGC TGCTCCCTGG 
CCCACCCAGC CCGAGAGTCT CTTCCACAGC CGGGACCGCT CGGACCTGGA GCCGTCCCCA 
CTGCGCCAGG CCAAGCCCAT TGCCGACCTC CACGCTGCTC AGCGGTTCCT GTCCAGATAC 
GGCTGGTCAG GGGTGTGGGC GGCCTGGGGG CCCAGTCCCG AGGGGCCGCC GGAGACCCCC 
AAGGGCGCCG CCCTGGCCGA GGCGGTGCGC AGGTTCCAGC GGGCGAACGC GCTGCCGGCC 
AGCGGGGAGC TGGACGCGGC CACCCTAGCG GCCATGAACC GGCCGCGCTG CGGGGTCCCG 
GACATGCGCC CACCGCCCCC CTCCGCCCCG CCTTCGCCCC CGGGCCCGCC CCCCAGAGCC 
CGCTCCAGGC GCTCCCCGCG GGCGCCGCTG TCCTTGTCCC GGCGGGGTTG GCAGCCCCGG 
GGCTACCCCG ACGGCGGAGC TGCCCAGGCC TTCTCCAAGA GGACGCTGAG CTGGCGGCTG 
CTGGGCGAGG CCCTGAGCAG CCAACTGTCC GTGGCCGACC AGCGGCGCAT TGTGGCGCTG 
GCCTTCAGGA TGTGGAGCGA GGTGACGCCG CTGGACTTCC GCGAGGACCT GGCCGCCCCC 
GGGGCCGCGG TCGACATCAA GCTGGGCTTT GGGAGAGGCC GGCACCTGGG CTGTCCGCGG 
GCCTTCGATG GGAGCGGGCA GGAGTTTGCA CACGCCTGGC GCCTAGGTGA CATTCACTTT 
GACGACGACG AGCACTTCAC ACCTCCCACC AGTGACACGG GCATCAGCCT TCTCAAGGTG 
GCCGTCCATG AAATTGGCCA TGTCCTGGGC TTGCCTCACA CCTACAGGAC GGGATCCATA 
ATGCAACCAA ATTACATTCC CCAGGAGCCT GCCTTTGAGT TGGACTGGTC AGACAGGAAA 
GCAATTCAAA AGCTGTATGG CTCCTGTGAG GGATCATTTG ATACTGCGTT TGACTGGATT 
CGCAAAGAGA GAAACCAATA TGGAGAGGTG ATGGTGAGAT TTAGCACATA TTTCTTCCGT 
AACAGCTGGT ACTGGCTTTA TGAAAATCGA AACAATAGGA CACGCTATGG GGACCCTATC 
CAAATCCTCA CTGGCTGGCC TGGAATCCCA ACACACAACA TAGATGCCTT TGTTCACATC 
TGGACATGGA AAAGAGATGA ACGTTATTTT TTTCAAGGAA ATCAATACTG GAGATATGAC 
AGTGACAAGG ATCAGGCCCT CACAGAAGAT GAACAAGGAA AAAGCTATCC CAAATTGATT 
TCAGAAGGAT TTCCTGGCAT CCCAAGTCCC CTAGACACGG CGTTTTATGA CCGAAGACAG 
AAGTTAATTT ACTTCTTCAA GGAGTCCCTT GTATTTGCAT TTGATGTCAA CAGAAATCGA 
GTACTTAATT CTTATCCAAA GAGGATTACT GAAGTTTTTC CAGCAGTAAT ACCACAAAAT 
CATCCTTTCA GAAATATAGA TTCCGCTTAT TACTCCTATG CATACAACTC CATTTTCTTT 
TTCAAAGGCA ATGCATACTG GAAGGTAGTT AATGACAAGG ACAAACAACA GAATTCCTGG 
CTTCCTGCTA ATGGCTTATT TCCAAAAAAG TTTATTTCAG AGAAGTGGTT TGATGTTTGT 
GACGTCCATA TCTCCACACT GAACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011537559.1

Translation

MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM

Target ORF information:

RefSeq Version	XM_011539257.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens matrix metallopeptidase 21 (MMP21), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539257.1

ORF Insert Sequence:

ATGCTCGCCG CCTCCATCTT CCGTCCGACA CTGCTGCTCT GCTGGCTGGC TGCTCCCTGG 
CCCACCCAGC CCGAGAGTCT CTTCCACAGC CGGGACCGCT CGGACCTGGA GCCGTCCCCA 
CTGCGCCAGG CCAAGCCCAT TGCCGACCTC CACGCTGCTC AGCGGTTCCT GTCCAGATAC 
GGCTGGTCAG GGGTGTGGGC GGCCTGGGGG CCCAGTCCCG AGGGGCCGCC GGAGACCCCC 
AAGGGCGCCG CCCTGGCCGA GGCGGTGCGC AGGTTCCAGC GGGCGAACGC GCTGCCGGCC 
AGCGGGGAGC TGGACGCGGC CACCCTAGCG GCCATGAACC GGCCGCGCTG CGGGGTCCCG 
GACATGCGCC CACCGCCCCC CTCCGCCCCG CCTTCGCCCC CGGGCCCGCC CCCCAGAGCC 
CGCTCCAGGC GCTCCCCGCG GGCGCCGCTG TCCTTGTCCC GGCGGGGTTG GCAGCCCCGG 
GGCTACCCCG ACGGCGGAGC TGCCCAGGCC TTCTCCAAGA GGACGCTGAG CTGGCGGCTG 
CTGGGCGAGG CCCTGAGCAG CCAACTGTCC GTGGCCGACC AGCGGCGCAT TGTGGCGCTG 
GCCTTCAGGA TGTGGAGCGA GGTGACGCCG CTGGACTTCC GCGAGGACCT GGCCGCCCCC 
GGGGCCGCGG TCGACATCAA GCTGGGCTTT GGGAGAGGCC GGCACCTGGG CTGTCCGCGG 
GCCTTCGATG GGAGCGGGCA GGAGTTTGCA CACGCCTGGC GCCTAGGTGA CATTCACTTT 
GACGACGACG AGCACTTCAC ACCTCCCACC AGTGACACGG GCATCAGCCT TCTCAAGGTG 
GCCGTCCATG AAATTGGCCA TGTCCTGGGC TTGCCTCACA CCTACAGGAC GGGATCCATA 
ATGCAACCAA ATTACATTCC CCAGGAGCCT GCCTTTGAGT TGGACTGGTC AGACAGGAAA 
GCAATTCAAA AGCTGTATGG CTCCTGTGAG GGATCATTTG ATACTGCGTT TGACTGGATT 
CGCAAAGAGA GAAACCAATA TGGAGAGGTG ATGGTGAGAT TTAGCACATA TTTCTTCCGT 
AACAGCTGGT ACTGGCTTTA TGAAAATCGA AACAATAGGA CACGCTATGG GGACCCTATC 
CAAATCCTCA CTGGCTGGCC TGGAATCCCA ACACACAACA TAGATGCCTT TGTTCACATC 
TGGACATGGA AAAGAGATGA ACGTTATTTT TTTCAAGGAA ATCAATACTG GAGATATGAC 
AGTGACAAGG ATCAGGCCCT CACAGAAGAT GAACAAGGAA AAAGCTATCC CAAATTGATT 
TCAGAAGGAT TTCCTGGCAT CCCAAGTCCC CTAGACACGG CGTTTTATGA CCGAAGACAG 
AAGTTAATTT ACTTCTTCAA GGAGTCCCTT GTATTTGCAT TTGATGTCAA CAGAAATCGA 
GTACTTAATT CTTATCCAAA GAGGATTACT GAAGTTTTTC CAGCAGTAAT ACCACAAAAT 
CATCCTTTCA GAAATATAGA TTCCGCTTAT TACTCCTATG CATACAACTC CATTTTCTTT 
TTCAAAGGCA ATGCATACTG GAAGGTAGTT AATGACAAGG ACAAACAACA GAATTCCTGG 
CTTCCTGCTA ATGGCTTATT TCCAAAAAAG TTTATTTCAG AGAAGTGGTT TGATGTTTGT 
GACGTCCATA TCTCCACACT GAACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Journal of medical genetics52(12)840-7(2015 Dec)
Perles Z,Moon S,Ta-Shma A,Yaacov B,Francescatto L,Edvardson S,Rein AJ,Elpeleg O,Katsanis N

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Nature genetics47(11)1260-3(2015 Nov)
Guimier A,Gabriel GC,Bajolle F,Tsang M,Liu H,Noll A,Schwartz M,El Malti R,Smith LD,Klena NT,Jimenez G,Miller NA,Oufadem M,Moreau de Bellaing A,Yagi H,Saunders CJ,Baker CN,Di Filippo S,Peterson KA,Thiffault I,Bole-Feysot C,Cooley LD,Farrow EG,Masson C,Schoen P,Deleuze JF,Nitschk? P,Lyonnet S,de Pontual L,Murray SA,Bonnet D,Kingsmore SF,Amiel J,Bouvagnet P,Lo CW,Gordon CT

Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and prognosis.
Medical oncology (Northwood, London, England)31(8)91(2014 Aug)
Zhao Z,Yan L,Li S,Sun H,Zhou Y,Li X

High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis.
Oncology reports31(6)2644-50(2014 Jun)
Pu Y,Wang L,Wu H,Feng Z,Wang Y,Guo C

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MMP21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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