Mmp21 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp21
Entrez Gene ID	214766
Full Name	matrix metallopeptidase 21
Synonyms	b2b2458Clo,b2b873Clo
General protein information	Preferred Names matrix metallopeptidase 21 Names matrix metalloproteinase-21
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F3
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. Mice harboring certain mutations in this gene exhibit congenital heart defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001320216.1	NP_001307145.1	matrix metalloproteinase-21 isoform 2 precursor
NM_152944.1	NP_694423.1	matrix metalloproteinase-21 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP21	XP_003312866.1
	MMP21	XP_001085506.1
Danio rerio (zebrafish)	LOC100003089	XP_001342721.4
Rattus norvegicus (Norway rat)	Mmp21	NP_001099778.1
Xenopus tropicalis (tropical clawed frog)	mmp21	XP_002932698.2
Homo sapiens (human)	MMP21	NP_671724.1
Mus musculus (house mouse)	Mmp21	NP_694423.1
Canis lupus familiaris (dog)	MMP21	XP_003640036.1

Gene Ontology
Bibliography

Related articles in PubMed

A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Perles Z, Moon S, Ta-Shma A, Yaacov B, Francescatto L, Edvardson S, Rein AJ, Elpeleg O, Katsanis N
Journal of medical genetics52(12)840-7(2015 Dec)

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.
Akawi N, McRae J, Ansari M, Balasubramanian M, Blyth M, Brady AF, Clayton S, Cole T, Deshpande C, Fitzgerald TW, Foulds N, Francis R, Gabriel G, Gerety SS, Goodship J, Hobson E, Jones WD, Joss S, King D, Klena N, Kumar A, Lees M, Lelliott C, Lord J, McMullan D, O'Regan M, Osio D, Piombo V, Prigmore E, Rajan D, Rosser E, Sifrim A, Smith A, Swaminathan GJ, Turnpenny P, Whitworth J, Wright CF, Firth HV, Barrett JC, Lo CW, FitzPatrick DR, Hurles ME,
Nature genetics47(11)1363-9(2015 Nov)

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Guimier A, Gabriel GC, Bajolle F, Tsang M, Liu H, Noll A, Schwartz M, El Malti R, Smith LD, Klena NT, Jimenez G, Miller NA, Oufadem M, Moreau de Bellaing A, Yagi H, Saunders CJ, Baker CN, Di Filippo S, Peterson KA, Thiffault I, Bole-Feysot C, Cooley LD, Farrow EG, Masson C, Schoen P, Deleuze JF, Nitschk? P, Lyonnet S, de Pontual L, Murray SA, Bonnet D, Kingsmore SF, Amiel J, Bouvagnet P, Lo CW, Gordon CT
Nature genetics47(11)1260-3(2015 Nov)

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell24(3)305-17(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation.
Title: MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.

The following Mmp21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu39437	NM_001320216.1 Latest version!	Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu18004	NM_152944.1 Latest version!	Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$335.30 $479.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp21 ( NM_001320216.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001307145.1 Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu39437
Clone ID Related Accession (Same CDS sequence)	NM_001320216.1
Accession Version	NM_001320216.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-21 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC106860.2 and AC127348.4. On Feb 17, 2016 this sequence version replaced XM_006507560.2. Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC106860.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849379, SAMN01164131 [ECO:0000350] ##Evidence-Data-END##

ATGCTTGCTG CCTCTGTCTT GCGTCTGACA CTGCCGCTCT GCTGGCTAGT TGCACCCCAG 
CCCACCCAGC CTGAGAGGCT CTTCCACAGC CGGGACCGTT CGGACCTGGA GCCATCTCCC 
CTGAGCCAGG CCAAGCCCAT TGCTGACCTC CATGATGCTC AGAGCTTCCT ATTGAAATAT 
GGCTGGTCAG AGATACCTAG CCCAAAGGAG TCAGCAGGAG TCCCTGTGGG ATTCACCTTG 
GCTCAAGCTG TACGTAGATT CCAGAAGGCG AACAGACTGC CAGCCAGTGG GGAATTGGAC 
TCACCTACAC TGGCCGCTAT GAACAAGCCA CGCTGTGGGG TTCCTGACAC ACGGCTGCCC 
CCTCGGGCTG CCCTGCCAAC CCCACCAGCC CTGCTGACCT CTTTAGGTCT CCGGCCCAGG 
GCCAGACAAA AGCGCTTTCT TCAAATGCTG TTCCCCAAGC CAGATGGGCA ACAGGAGGAT 
GCCTCAGACA CTGGGGCCAG CAGGGCCTTC TCCAAGAAGA CACTGACCTG GAGGCTGGTG 
GGAGATGCCT ACAGCAGCCA ACTCTCTGGG GATGAGCAGA GGTACATCTT TAGACTGGCC 
TTCAGGATGT GGAGTGAGGT GACACCACTG GACTTCCGGG AGGACCGCAC TGCCCCTGGC 
ACCATGGTGG ACATAAAGCT GGGTTTTGGG AGAGGCCGGC ACCTGGGCTG TCCACGGGTG 
TTTGACGGGA GTGGACAGGA GTTTGCACAT GCCTGGCGCC TGGGTGAGAT CCACTTTGAT 
GACGACGAGC ACTTCACTCC TCTCTCCAGT GACACAGGCA TCAGCCTTCT CAAAGTAGCT 
GTCCATGAAA TTGGCCACGT CCTCGGATTG CCTCACACCT ACAGGGTGGG ATCCATAATG 
CAACCAAACT ACATTCCCCA GGAGCCTGCC TTTGAGTTGG ACTGGGCAGA CAGAAAAGCA 
ATTCAAAGAC TATATGGTTC GTGCAAGGGG TCATTTGATA CAGTGTTTGA CTGGATCCGC 
AAGGAGAGGA ACCAATATGG TGAGGTGAGG GTGAGATTCA ACACGTACTT CTTCCGCAAC 
AGCTGGTACT GGCTCTACGA AAACCGCAAC AACAGGACTC GCTACGGGGA CCCCCTCCAA 
ATCCTCACTG GCTGGCGTGG GATCCCCACG CAGAGCATCG ATGCCTACGT CCATGTCTGG 
TCATGGGGAA AAGACGAGCG CTACTTTTTC AAAGGTATTT GCATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307145.1
CDS	16..1263
Translation	MLAASVLRLTLPLCWLVAPQPTQPERLFHSRDRSDLEPSPLSQAKPIADLHDAQSFLLKYGWSEIPSPKESAGVPVGFTLAQAVRRFQKANRLPASGELDSPTLAAMNKPRCGVPDTRLPPRAALPTPPALLTSLGLRPRARQKRFLQMLFPKPDGQQEDASDTGASRAFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDRTAPGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWRLGEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWADRKAIQRLYGSCKGSFDTVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPTQSIDAYVHVWSWGKDERYFFKGICI

Target ORF information:

RefSeq Version	NM_001320216.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320216.1

ORF Insert Sequence:

ATGCTTGCTG CCTCTGTCTT GCGTCTGACA CTGCCGCTCT GCTGGCTAGT TGCACCCCAG 
CCCACCCAGC CTGAGAGGCT CTTCCACAGC CGGGACCGTT CGGACCTGGA GCCATCTCCC 
CTGAGCCAGG CCAAGCCCAT TGCTGACCTC CATGATGCTC AGAGCTTCCT ATTGAAATAT 
GGCTGGTCAG AGATACCTAG CCCAAAGGAG TCAGCAGGAG TCCCTGTGGG ATTCACCTTG 
GCTCAAGCTG TACGTAGATT CCAGAAGGCG AACAGACTGC CAGCCAGTGG GGAATTGGAC 
TCACCTACAC TGGCCGCTAT GAACAAGCCA CGCTGTGGGG TTCCTGACAC ACGGCTGCCC 
CCTCGGGCTG CCCTGCCAAC CCCACCAGCC CTGCTGACCT CTTTAGGTCT CCGGCCCAGG 
GCCAGACAAA AGCGCTTTCT TCAAATGCTG TTCCCCAAGC CAGATGGGCA ACAGGAGGAT 
GCCTCAGACA CTGGGGCCAG CAGGGCCTTC TCCAAGAAGA CACTGACCTG GAGGCTGGTG 
GGAGATGCCT ACAGCAGCCA ACTCTCTGGG GATGAGCAGA GGTACATCTT TAGACTGGCC 
TTCAGGATGT GGAGTGAGGT GACACCACTG GACTTCCGGG AGGACCGCAC TGCCCCTGGC 
ACCATGGTGG ACATAAAGCT GGGTTTTGGG AGAGGCCGGC ACCTGGGCTG TCCACGGGTG 
TTTGACGGGA GTGGACAGGA GTTTGCACAT GCCTGGCGCC TGGGTGAGAT CCACTTTGAT 
GACGACGAGC ACTTCACTCC TCTCTCCAGT GACACAGGCA TCAGCCTTCT CAAAGTAGCT 
GTCCATGAAA TTGGCCACGT CCTCGGATTG CCTCACACCT ACAGGGTGGG ATCCATAATG 
CAACCAAACT ACATTCCCCA GGAGCCTGCC TTTGAGTTGG ACTGGGCAGA CAGAAAAGCA 
ATTCAAAGAC TATATGGTTC GTGCAAGGGG TCATTTGATA CAGTGTTTGA CTGGATCCGC 
AAGGAGAGGA ACCAATATGG TGAGGTGAGG GTGAGATTCA ACACGTACTT CTTCCGCAAC 
AGCTGGTACT GGCTCTACGA AAACCGCAAC AACAGGACTC GCTACGGGGA CCCCCTCCAA 
ATCCTCACTG GCTGGCGTGG GATCCCCACG CAGAGCATCG ATGCCTACGT CCATGTCTGG 
TCATGGGGAA AAGACGAGCG CTACTTTTTC AAAGGTATTT GCATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mmp21 ( NM_152944.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694423.1 Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18004
Clone ID Related Accession (Same CDS sequence)	NM_152944.1
Accession Version	NM_152944.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-21 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC106861.2 and AC127348.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AY124569.1, AF507967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGCTTGCTG CCTCTGTCTT GCGTCTGACA CTGCCGCTCT GCTGGCTAGT TGCACCCCAG 
CCCACCCAGC CTGAGAGGCT CTTCCACAGC CGGGACCGTT CGGACCTGGA GCCATCTCCC 
CTGAGCCAGG CCAAGCCCAT TGCTGACCTC CATGATGCTC AGAGCTTCCT ATTGAAATAT 
GGCTGGTCAG AGATACCTAG CCCAAAGGAG TCAGCAGGAG TCCCTGTGGG ATTCACCTTG 
GCTCAAGCTG TACGTAGATT CCAGAAGGCG AACAGACTGC CAGCCAGTGG GGAATTGGAC 
TCACCTACAC TGGCCGCTAT GAACAAGCCA CGCTGTGGGG TTCCTGACAC ACGGCTGCCC 
CCTCGGGCTG CCCTGCCAAC CCCACCAGCC CTGCTGACCT CTTTAGGTCT CCGGCCCAGG 
GCCAGACAAA AGCGCTTTCT TCAAATGCTG TTCCCCAAGC CAGATGGGCA ACAGGAGGAT 
GCCTCAGACA CTGGGGCCAG CAGGGCCTTC TCCAAGAAGA CACTGACCTG GAGGCTGGTG 
GGAGATGCCT ACAGCAGCCA ACTCTCTGGG GATGAGCAGA GGTACATCTT TAGACTGGCC 
TTCAGGATGT GGAGTGAGGT GACACCACTG GACTTCCGGG AGGACCGCAC TGCCCCTGGC 
ACCATGGTGG ACATAAAGCT GGGTTTTGGG AGAGGCCGGC ACCTGGGCTG TCCACGGGTG 
TTTGACGGGA GTGGACAGGA GTTTGCACAT GCCTGGCGCC TGGGTGAGAT CCACTTTGAT 
GACGACGAGC ACTTCACTCC TCTCTCCAGT GACACAGGCA TCAGCCTTCT CAAAGTAGCT 
GTCCATGAAA TTGGCCACGT CCTCGGATTG CCTCACACCT ACAGGGTGGG ATCCATAATG 
CAACCAAACT ACATTCCCCA GGAGCCTGCC TTTGAGTTGG ACTGGGCAGA CAGAAAAGCA 
ATTCAAAGAC TATATGGTTC GTGCAAGGGG TCATTTGATA CAGTGTTTGA CTGGATCCGC 
AAGGAGAGGA ACCAATATGG TGAGGTGAGG GTGAGATTCA ACACGTACTT CTTCCGCAAC 
AGCTGGTACT GGCTCTACGA AAACCGCAAC AACAGGACTC GCTACGGGGA CCCCCTCCAA 
ATCCTCACTG GCTGGCGTGG GATCCCCACG CAGAGCATCG ATGCCTACGT CCATGTCTGG 
TCATGGGGAA AAGACGAGCG CTACTTTTTC AAAGGAAGCC AATACTGGAG ATATGACAGT 
GAGAATGACC AGGCACACAC AGAAGACGAA CAAGGAAGGA GCTACCCTAA ACTGATCTCA 
GAAGGATTCC CTGGCATCCC CAGCCCCCTG GACACGGCCT TTTACGATCG GAGGCAGCAG 
TTAATTTACT TCTTCAAGGA GTCTCTAGTA TTTGCATTTG ATGTCAACCG AAACCAAGTA 
CTTAATTCTT ATCCAAAGAA GATGAGCCAA GTGTTTCCAG CAATAATGCC TCAAAACCAC 
CCATTCAGAA ACCTCGATTC AGCGTACTAC TCCTATGCAC ACAACTCCAT CTTCTTCTTC 
AAAGGCAACT CGTACTGGAA AGTAGTTAGT GACAAGGACA AACAGCAGAA CACCCGGCTG 
CCTCTGAATG GCTTATTTCC AAAAAAACCT GTTTCCGAGA AGTGGTTTGA TGTTTGTGAT 
GTTCACACCT CTACCCTGAA CATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694423.1
CDS	16..1722
Translation	MLAASVLRLTLPLCWLVAPQPTQPERLFHSRDRSDLEPSPLSQAKPIADLHDAQSFLLKYGWSEIPSPKESAGVPVGFTLAQAVRRFQKANRLPASGELDSPTLAAMNKPRCGVPDTRLPPRAALPTPPALLTSLGLRPRARQKRFLQMLFPKPDGQQEDASDTGASRAFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDRTAPGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWRLGEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWADRKAIQRLYGSCKGSFDTVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPTQSIDAYVHVWSWGKDERYFFKGSQYWRYDSENDQAHTEDEQGRSYPKLISEGFPGIPSPLDTAFYDRRQQLIYFFKESLVFAFDVNRNQVLNSYPKKMSQVFPAIMPQNHPFRNLDSAYYSYAHNSIFFFKGNSYWKVVSDKDKQQNTRLPLNGLFPKKPVSEKWFDVCDVHTSTLNM

Target ORF information:

RefSeq Version	NM_152944.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152944.1

ORF Insert Sequence:

ATGCTTGCTG CCTCTGTCTT GCGTCTGACA CTGCCGCTCT GCTGGCTAGT TGCACCCCAG 
CCCACCCAGC CTGAGAGGCT CTTCCACAGC CGGGACCGTT CGGACCTGGA GCCATCTCCC 
CTGAGCCAGG CCAAGCCCAT TGCTGACCTC CATGATGCTC AGAGCTTCCT ATTGAAATAT 
GGCTGGTCAG AGATACCTAG CCCAAAGGAG TCAGCAGGAG TCCCTGTGGG ATTCACCTTG 
GCTCAAGCTG TACGTAGATT CCAGAAGGCG AACAGACTGC CAGCCAGTGG GGAATTGGAC 
TCACCTACAC TGGCCGCTAT GAACAAGCCA CGCTGTGGGG TTCCTGACAC ACGGCTGCCC 
CCTCGGGCTG CCCTGCCAAC CCCACCAGCC CTGCTGACCT CTTTAGGTCT CCGGCCCAGG 
GCCAGACAAA AGCGCTTTCT TCAAATGCTG TTCCCCAAGC CAGATGGGCA ACAGGAGGAT 
GCCTCAGACA CTGGGGCCAG CAGGGCCTTC TCCAAGAAGA CACTGACCTG GAGGCTGGTG 
GGAGATGCCT ACAGCAGCCA ACTCTCTGGG GATGAGCAGA GGTACATCTT TAGACTGGCC 
TTCAGGATGT GGAGTGAGGT GACACCACTG GACTTCCGGG AGGACCGCAC TGCCCCTGGC 
ACCATGGTGG ACATAAAGCT GGGTTTTGGG AGAGGCCGGC ACCTGGGCTG TCCACGGGTG 
TTTGACGGGA GTGGACAGGA GTTTGCACAT GCCTGGCGCC TGGGTGAGAT CCACTTTGAT 
GACGACGAGC ACTTCACTCC TCTCTCCAGT GACACAGGCA TCAGCCTTCT CAAAGTAGCT 
GTCCATGAAA TTGGCCACGT CCTCGGATTG CCTCACACCT ACAGGGTGGG ATCCATAATG 
CAACCAAACT ACATTCCCCA GGAGCCTGCC TTTGAGTTGG ACTGGGCAGA CAGAAAAGCA 
ATTCAAAGAC TATATGGTTC GTGCAAGGGG TCATTTGATA CAGTGTTTGA CTGGATCCGC 
AAGGAGAGGA ACCAATATGG TGAGGTGAGG GTGAGATTCA ACACGTACTT CTTCCGCAAC 
AGCTGGTACT GGCTCTACGA AAACCGCAAC AACAGGACTC GCTACGGGGA CCCCCTCCAA 
ATCCTCACTG GCTGGCGTGG GATCCCCACG CAGAGCATCG ATGCCTACGT CCATGTCTGG 
TCATGGGGAA AAGACGAGCG CTACTTTTTC AAAGGAAGCC AATACTGGAG ATATGACAGT 
GAGAATGACC AGGCACACAC AGAAGACGAA CAAGGAAGGA GCTACCCTAA ACTGATCTCA 
GAAGGATTCC CTGGCATCCC CAGCCCCCTG GACACGGCCT TTTACGATCG GAGGCAGCAG 
TTAATTTACT TCTTCAAGGA GTCTCTAGTA TTTGCATTTG ATGTCAACCG AAACCAAGTA 
CTTAATTCTT ATCCAAAGAA GATGAGCCAA GTGTTTCCAG CAATAATGCC TCAAAACCAC 
CCATTCAGAA ACCTCGATTC AGCGTACTAC TCCTATGCAC ACAACTCCAT CTTCTTCTTC 
AAAGGCAACT CGTACTGGAA AGTAGTTAGT GACAAGGACA AACAGCAGAA CACCCGGCTG 
CCTCTGAATG GCTTATTTCC AAAAAAACCT GTTTCCGAGA AGTGGTTTGA TGTTTGTGAT 
GTTCACACCT CTACCCTGAA CATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Journal of medical genetics52(12)840-7(2015 Dec)
Perles Z,Moon S,Ta-Shma A,Yaacov B,Francescatto L,Edvardson S,Rein AJ,Elpeleg O,Katsanis N

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.
Nature genetics47(11)1363-9(2015 Nov)
Akawi N,McRae J,Ansari M,Balasubramanian M,Blyth M,Brady AF,Clayton S,Cole T,Deshpande C,Fitzgerald TW,Foulds N,Francis R,Gabriel G,Gerety SS,Goodship J,Hobson E,Jones WD,Joss S,King D,Klena N,Kumar A,Lees M,Lelliott C,Lord J,McMullan D,O'Regan M,Osio D,Piombo V,Prigmore E,Rajan D,Rosser E,Sifrim A,Smith A,Swaminathan GJ,Turnpenny P,Whitworth J,Wright CF,Firth HV,Barrett JC,Lo CW,FitzPatrick DR,Hurles ME,

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Nature genetics47(11)1260-3(2015 Nov)
Guimier A,Gabriel GC,Bajolle F,Tsang M,Liu H,Noll A,Schwartz M,El Malti R,Smith LD,Klena NT,Jimenez G,Miller NA,Oufadem M,Moreau de Bellaing A,Yagi H,Saunders CJ,Baker CN,Di Filippo S,Peterson KA,Thiffault I,Bole-Feysot C,Cooley LD,Farrow EG,Masson C,Schoen P,Deleuze JF,Nitschk? P,Lyonnet S,de Pontual L,Murray SA,Bonnet D,Kingsmore SF,Amiel J,Bouvagnet P,Lo CW,Gordon CT

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Nature521(7553)520-4(2015 May)
Li Y,Klena NT,Gabriel GC,Liu X,Kim AJ,Lemke K,Chen Y,Chatterjee B,Devine W,Damerla RR,Chang C,Yagi H,San Agustin JT,Thahir M,Anderton S,Lawhead C,Vescovi A,Pratt H,Morgan J,Haynes L,Smith CL,Eppig JT,Reinholdt L,Francis R,Leatherbury L,Ganapathiraju MK,Tobita K,Pazour GJ,Lo CW

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Cancer cell24(3)305-17(2013 Sep)
Nagamachi A,Matsui H,Asou H,Ozaki Y,Aki D,Kanai A,Takubo K,Suda T,Nakamura T,Wolff L,Honda H,Inaba T

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Mmp21 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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