RAB3C cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB3C
Entrez Gene ID	115827
Full Name	RAB3C, member RAS oncogene family
General protein information	Preferred Names RAB3C, member RAS oncogene family Names ras-related protein Rab-3C
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 5 Map Location: 5q11.2
Summary	This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Disorder MIM:	612829

mRNA and Protein(s)

mRNA	Protein	Name
NM_138453.3	NP_612462.1	ras-related protein Rab-3C isoform 1
NM_001317915.1	NP_001304844.1	ras-related protein Rab-3C isoform 2
NM_001317915.2	NP_001304844.1	ras-related protein Rab-3C isoform 2
NM_138453.4	NP_612462.1	ras-related protein Rab-3C isoform 1
NM_138453.2	NP_612462.1	ras-related protein Rab-3C

Pathways from BioSystems

Homologies

	RAB3C	XP_001103215.2
Bos taurus (cattle)	RAB3C	NP_789862.1
Pan troglodytes (chimpanzee)	RAB3C	XP_526915.3
Mus musculus (house mouse)	Rab3c	NP_076341.1
Rattus norvegicus (Norway rat)	Rab3c	NP_598220.1
Gallus gallus (chicken)	RAB3C	XP_003642996.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005255	XP_314172.1
Caenorhabditis elegans (roundworm)	rab-3	NP_001021973.1
Homo sapiens (human)	RAB3C	NP_612462.1
Canis lupus familiaris (dog)	RAB3C	XP_005617471.1
Danio rerio (zebrafish)	rab3c	NP_001002530.1
Drosophila melanogaster (fruit fly)	Rab3	NP_523687.1
Xenopus tropicalis (tropical clawed frog)	rab3c	XP_002938225.2

Gene Ontology
Bibliography

Related articles in PubMed

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Chang YC, Su CY, Chen MH, Chen WS, Chen CL, Hsiao M
Molecular cancer16(1)135(2017 Aug)

Identification and characterization of multiple novel Rab-myosin Va interactions.
Lindsay AJ, Jollivet F, Horgan CP, Khan AR, Raposo G, McCaffrey MW, Goud B
Molecular biology of the cell24(21)3420-34(2013 Nov)

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A, Turnbull C, Rahman N, , Fletcher O, Peto J, Gibson L, Dos Santos Silva I, Nevanlinna H, Muranen TA, Aittom?ki K, Blomqvist C, Czene K, Irwanto A, Liu J, Waisfisz Q, Meijers-Heijboer H, Adank M, , van der Luijt RB, Hein R, Dahmen N, Beckman L, Meindl A, Schmutzler RK, M?ller-Myhsok B, Lichtner P, Hopper JL, Southey MC, Makalic E, Schmidt DF, Uitterlinden AG, Hofman A, Hunter DJ, Chanock SJ, Vincent D, Bacot F, Tessier DC, Canisius S, Wessels LF, Haiman CA, Shah M, Luben R, Brown J, Luccarini C, Schoof N, Humphreys K, Li J, Nordestgaard BG, Nielsen SF, Flyger H, Couch FJ, Wang X, Vachon C, Stevens KN, Lambrechts D, Moisse M, Paridaens R, Christiaens MR, Rudolph A, Nickels S, Flesch-Janys D, Johnson N, Aitken Z, Aaltonen K, Heikkinen T, Broeks A, Veer LJ, van der Schoot CE, Gu?nel P, Truong T, Laurent-Puig P, Menegaux F, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Zamora MP, Perez JI, Pita G, Alonso MR, Cox A, Brock IW, Cross SS, Reed MW, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, Henderson BE, Schumacher F, Le Marchand L, Andrulis IL, Knight JA, Glendon G, Mulligan AM, , , Lindblom A, Margolin S, Hooning MJ, Hollestelle A, van den Ouweland AM, Jager A, Bui QM, Stone J, Dite GS, Apicella C, Tsimiklis H, Giles GG, Severi G, Baglietto L, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Brenner H, M?ller H, Arndt V, Stegmaier C, Swerdlow A, Ashworth A, Orr N, Jones M, Figueroa J, Lissowska J, Brinton L, Goldberg MS, Labr?che F, Dumont M, Winqvist R, Pylk?s K, Jukkola-Vuorinen A, Grip M, Brauch H, Hamann U, Br?ning T, , Radice P, Peterlongo P, Manoukian S, Bonanni B, Devilee P, Tollenaar RA, Seynaeve C, van Asperen CJ, Jakubowska A, Lubinski J, Jaworska K, Durda K, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Bogdanova NV, Antonenkova NN, D?rk T, Kristensen VN, Anton-Culver H, Slager S, Toland AE, Edge S, Fostira F, Kang D, Yoo KY, Noh DY, Matsuo K, Ito H, Iwata H, Sueta A, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Shu XO, Lu W, Gao YT, Cai H, Teo SH, Yip CH, Phuah SY, Cornes BK, Hartman M, Miao H, Lim WY, Sng JH, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Shen CY, Hsiung CN, Wu PE, Ding SL, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Blot WJ, Signorello LB, Cai Q, Zheng W, Deming-Halverson S, Shrubsole M, Long J, Simard J, Garcia-Closas M, Pharoah PD, Chenevix-Trench G, Dunning AM, Benitez J, Easton DF
Nature genetics45(4)353-61, 361e1-2(2013 Apr)

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)

The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
Zou L, Zhou J, Zhang J, Li J, Liu N, Chai L, Li N, Liu T, Li L, Xie Z, Liu H, Wan Y, Wu Y
Proceedings of the National Academy of Sciences of the United States of America106(37)15801-6(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation.
Title: The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

cloning, mapping, and characterization; expressed in the brain, placenta, and lung; maps to chromosome 5q13
Title: Cloning, mapping, and characterization of the human Rab3C gene.

The following RAB3C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB3C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16221	NM_138453.4 Latest version!	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu39430	NM_001317915.2 Latest version!	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu39430	NM_001317915.1	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu16221	NM_138453.3	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16221	NM_138453.2	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB3C ( NM_138453.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_612462.1 Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16221
Clone ID Related Accession (Same CDS sequence)	NM_138453.3 , NM_138453.4 , NM_138453.2
Accession Version	NM_138453.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	ras-related protein Rab-3C isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB485923.1, BC013033.2, AC008852.5 and H05600.1. On Dec 15, 2015 this sequence version replaced NM_138453.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.39163.1, SRR1660805.173752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACACG AAGCGCCCAT GCAGATGGCC TCTGCCCAAG ATGCCAGGTA CGGCCAGAAA 
GACTCCTCTG ATCAGAACTT TGACTACATG TTCAAATTAC TCATCATCGG CAATAGCAGT 
GTGGGGAAAA CATCTTTTCT ATTCCGTTAT GCAGATGACT CCTTTACATC TGCATTCGTC 
AGCACAGTTG GGATCGATTT CAAAGTAAAA ACTGTATTCA AAAATGAAAA GAGAATCAAG 
CTTCAGATTT GGGACACAGC AGGCCAGGAA AGATACAGGA CTATCACCAC AGCCTATTAT 
CGTGGAGCCA TGGGCTTTAT TTTAATGTAT GACATTACAA ATGAAGAATC CTTCAATGCA 
GTACAAGATT GGTCAACTCA AATCAAAACA TACTCTTGGG ACAATGCCCA AGTTATTCTG 
GTTGGGAACA AGTGTGACAT GGAAGACGAG CGGGTCATCT CAACTGAGCG AGGTCAACAT 
TTAGGAGAAC AGCTTGGGTT TGAGTTTTTT GAAACAAGTG CCAAGGACAA CATTAATGTC 
AAGCAGACAT TTGAGCGCCT TGTGGATATC ATCTGCGACA AAATGTCAGA GAGTTTGGAG 
ACTGATCCTG CCATCACTGC TGCAAAGCAG AACACGAGAC TCAAGGAAAC TCCTCCTCCA 
CCGCAGCCCA ACTGTGCCTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612462.1
CDS	166..849
Translation	MRHEAPMQMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC

Target ORF information:

RefSeq Version	NM_138453.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138453.3

ORF Insert Sequence:

ATGAGACACG AAGCGCCCAT GCAGATGGCC TCTGCCCAAG ATGCCAGGTA CGGCCAGAAA 
GACTCCTCTG ATCAGAACTT TGACTACATG TTCAAATTAC TCATCATCGG CAATAGCAGT 
GTGGGGAAAA CATCTTTTCT ATTCCGTTAT GCAGATGACT CCTTTACATC TGCATTCGTC 
AGCACAGTTG GGATCGATTT CAAAGTAAAA ACTGTATTCA AAAATGAAAA GAGAATCAAG 
CTTCAGATTT GGGACACAGC AGGCCAGGAA AGATACAGGA CTATCACCAC AGCCTATTAT 
CGTGGAGCCA TGGGCTTTAT TTTAATGTAT GACATTACAA ATGAAGAATC CTTCAATGCA 
GTACAAGATT GGTCAACTCA AATCAAAACA TACTCTTGGG ACAATGCCCA AGTTATTCTG 
GTTGGGAACA AGTGTGACAT GGAAGACGAG CGGGTCATCT CAACTGAGCG AGGTCAACAT 
TTAGGAGAAC AGCTTGGGTT TGAGTTTTTT GAAACAAGTG CCAAGGACAA CATTAATGTC 
AAGCAGACAT TTGAGCGCCT TGTGGATATC ATCTGCGACA AAATGTCAGA GAGTTTGGAG 
ACTGATCCTG CCATCACTGC TGCAAAGCAG AACACGAGAC TCAAGGAAAC TCCTCCTCCA 
CCGCAGCCCA ACTGTGCCTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB3C ( NM_138453.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_612462.1 Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16221
Clone ID Related Accession (Same CDS sequence)	NM_138453.3 , NM_138453.4 , NM_138453.2
Accession Version	NM_138453.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ras-related protein Rab-3C isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB485923.1, BC013033.2, AC008852.5 and H05600.1. On Nov 23, 2018 this sequence version replaced NM_138453.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.69935.1, SRR1660803.39163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000282878.6/ ENSP00000282878.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGACACG AAGCGCCCAT GCAGATGGCC TCTGCCCAAG ATGCCAGGTA CGGCCAGAAA 
GACTCCTCTG ATCAGAACTT TGACTACATG TTCAAATTAC TCATCATCGG CAATAGCAGT 
GTGGGGAAAA CATCTTTTCT ATTCCGTTAT GCAGATGACT CCTTTACATC TGCATTCGTC 
AGCACAGTTG GGATCGATTT CAAAGTAAAA ACTGTATTCA AAAATGAAAA GAGAATCAAG 
CTTCAGATTT GGGACACAGC AGGCCAGGAA AGATACAGGA CTATCACCAC AGCCTATTAT 
CGTGGAGCCA TGGGCTTTAT TTTAATGTAT GACATTACAA ATGAAGAATC CTTCAATGCA 
GTACAAGATT GGTCAACTCA AATCAAAACA TACTCTTGGG ACAATGCCCA AGTTATTCTG 
GTTGGGAACA AGTGTGACAT GGAAGACGAG CGGGTCATCT CAACTGAGCG AGGTCAACAT 
TTAGGAGAAC AGCTTGGGTT TGAGTTTTTT GAAACAAGTG CCAAGGACAA CATTAATGTC 
AAGCAGACAT TTGAGCGCCT TGTGGATATC ATCTGCGACA AAATGTCAGA GAGTTTGGAG 
ACTGATCCTG CCATCACTGC TGCAAAGCAG AACACGAGAC TCAAGGAAAC TCCTCCTCCA 
CCGCAGCCCA ACTGTGCCTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612462.1
CDS	135..818
Translation	MRHEAPMQMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC

Target ORF information:

RefSeq Version	NM_138453.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138453.4

ORF Insert Sequence:

ATGAGACACG AAGCGCCCAT GCAGATGGCC TCTGCCCAAG ATGCCAGGTA CGGCCAGAAA 
GACTCCTCTG ATCAGAACTT TGACTACATG TTCAAATTAC TCATCATCGG CAATAGCAGT 
GTGGGGAAAA CATCTTTTCT ATTCCGTTAT GCAGATGACT CCTTTACATC TGCATTCGTC 
AGCACAGTTG GGATCGATTT CAAAGTAAAA ACTGTATTCA AAAATGAAAA GAGAATCAAG 
CTTCAGATTT GGGACACAGC AGGCCAGGAA AGATACAGGA CTATCACCAC AGCCTATTAT 
CGTGGAGCCA TGGGCTTTAT TTTAATGTAT GACATTACAA ATGAAGAATC CTTCAATGCA 
GTACAAGATT GGTCAACTCA AATCAAAACA TACTCTTGGG ACAATGCCCA AGTTATTCTG 
GTTGGGAACA AGTGTGACAT GGAAGACGAG CGGGTCATCT CAACTGAGCG AGGTCAACAT 
TTAGGAGAAC AGCTTGGGTT TGAGTTTTTT GAAACAAGTG CCAAGGACAA CATTAATGTC 
AAGCAGACAT TTGAGCGCCT TGTGGATATC ATCTGCGACA AAATGTCAGA GAGTTTGGAG 
ACTGATCCTG CCATCACTGC TGCAAAGCAG AACACGAGAC TCAAGGAAAC TCCTCCTCCA 
CCGCAGCCCA ACTGTGCCTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB3C ( NM_138453.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_612462.1 Homo sapiens RAB3C, member RAS oncogene family (RAB3C), mRNA.

Price & Availability↑

CloneID	OHu16221
Clone ID Related Accession (Same CDS sequence)	NM_138453.3 , NM_138453.4 , NM_138453.2
Accession Version	NM_138453.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ras-related protein Rab-3C
Comment

ATGAGACACG AAGCGCCCAT GCAGATGGCC TCTGCCCAAG ATGCCAGGTA CGGCCAGAAA 
GACTCCTCTG ATCAGAACTT TGACTACATG TTCAAATTAC TCATCATCGG CAATAGCAGT 
GTGGGGAAAA CATCTTTTCT ATTCCGTTAT GCAGATGACT CCTTTACATC TGCATTCGTC 
AGCACAGTTG GGATCGATTT CAAAGTAAAA ACTGTATTCA AAAATGAAAA GAGAATCAAG 
CTTCAGATTT GGGACACAGC AGGCCAGGAA AGATACAGGA CTATCACCAC AGCCTATTAT 
CGTGGAGCCA TGGGCTTTAT TTTAATGTAT GACATTACAA ATGAAGAATC CTTCAATGCA 
GTACAAGATT GGTCAACTCA AATCAAAACA TACTCTTGGG ACAATGCCCA AGTTATTCTG 
GTTGGGAACA AGTGTGACAT GGAAGACGAG CGGGTCATCT CAACTGAGCG AGGTCAACAT 
TTAGGAGAAC AGCTTGGGTT TGAGTTTTTT GAAACAAGTG CCAAGGACAA CATTAATGTC 
AAGCAGACAT TTGAGCGCCT TGTGGATATC ATCTGCGACA AAATGTCAGA GAGTTTGGAG 
ACTGATCCTG CCATCACTGC TGCAAAGCAG AACACGAGAC TCAAGGAAAC TCCTCCTCCA 
CCGCAGCCCA ACTGTGCCTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612462.1
Translation	MRHEAPMQMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC

Target ORF information:

RefSeq Version	NM_138453.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138453.2

ORF Insert Sequence:

ATGAGACACG AAGCGCCCAT GCAGATGGCC TCTGCCCAAG ATGCCAGGTA CGGCCAGAAA 
GACTCCTCTG ATCAGAACTT TGACTACATG TTCAAATTAC TCATCATCGG CAATAGCAGT 
GTGGGGAAAA CATCTTTTCT ATTCCGTTAT GCAGATGACT CCTTTACATC TGCATTCGTC 
AGCACAGTTG GGATCGATTT CAAAGTAAAA ACTGTATTCA AAAATGAAAA GAGAATCAAG 
CTTCAGATTT GGGACACAGC AGGCCAGGAA AGATACAGGA CTATCACCAC AGCCTATTAT 
CGTGGAGCCA TGGGCTTTAT TTTAATGTAT GACATTACAA ATGAAGAATC CTTCAATGCA 
GTACAAGATT GGTCAACTCA AATCAAAACA TACTCTTGGG ACAATGCCCA AGTTATTCTG 
GTTGGGAACA AGTGTGACAT GGAAGACGAG CGGGTCATCT CAACTGAGCG AGGTCAACAT 
TTAGGAGAAC AGCTTGGGTT TGAGTTTTTT GAAACAAGTG CCAAGGACAA CATTAATGTC 
AAGCAGACAT TTGAGCGCCT TGTGGATATC ATCTGCGACA AAATGTCAGA GAGTTTGGAG 
ACTGATCCTG CCATCACTGC TGCAAAGCAG AACACGAGAC TCAAGGAAAC TCCTCCTCCA 
CCGCAGCCCA ACTGTGCCTG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB3C ( NM_001317915.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001304844.1 Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu39430
Clone ID Related Accession (Same CDS sequence)	NM_001317915.1 , NM_001317915.2
Accession Version	NM_001317915.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-03
Organism	Homo sapiens(human)
Product	ras-related protein Rab-3C isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX375794.2, AC034250.7, BX394661.2, BC013033.2, AC008852.5 and H05600.1. On Dec 15, 2015 this sequence version replaced XM_005248418.3. Transcript Variant: This variant (2) uses a different first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.149575.1, SRR3476690.279138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT ATGGAAAGAT GGCCTCTGCC CAAGATGCCA GGTACGGCCA GAAAGACTCC 
TCTGATCAGA ACTTTGACTA CATGTTCAAA TTACTCATCA TCGGCAATAG CAGTGTGGGG 
AAAACATCTT TTCTATTCCG TTATGCAGAT GACTCCTTTA CATCTGCATT CGTCAGCACA 
GTTGGGATCG ATTTCAAAGT AAAAACTGTA TTCAAAAATG AAAAGAGAAT CAAGCTTCAG 
ATTTGGGACA CAGCAGGCCA GGAAAGATAC AGGACTATCA CCACAGCCTA TTATCGTGGA 
GCCATGGGCT TTATTTTAAT GTATGACATT ACAAATGAAG AATCCTTCAA TGCAGTACAA 
GATTGGTCAA CTCAAATCAA AACATACTCT TGGGACAATG CCCAAGTTAT TCTGGTTGGG 
AACAAGTGTG ACATGGAAGA CGAGCGGGTC ATCTCAACTG AGCGAGGTCA ACATTTAGGA 
GAACAGCTTG GGTTTGAGTT TTTTGAAACA AGTGCCAAGG ACAACATTAA TGTCAAGCAG 
ACATTTGAGC GCCTTGTGGA TATCATCTGC GACAAAATGT CAGAGAGTTT GGAGACTGAT 
CCTGCCATCA CTGCTGCAAA GCAGAACACG AGACTCAAGG AAACTCCTCC TCCACCGCAG 
CCCAACTGTG CCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304844.1
CDS	210..887
Translation	MELYGKMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC

Target ORF information:

RefSeq Version	NM_001317915.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317915.1

ORF Insert Sequence:

ATGGAGCTGT ATGGAAAGAT GGCCTCTGCC CAAGATGCCA GGTACGGCCA GAAAGACTCC 
TCTGATCAGA ACTTTGACTA CATGTTCAAA TTACTCATCA TCGGCAATAG CAGTGTGGGG 
AAAACATCTT TTCTATTCCG TTATGCAGAT GACTCCTTTA CATCTGCATT CGTCAGCACA 
GTTGGGATCG ATTTCAAAGT AAAAACTGTA TTCAAAAATG AAAAGAGAAT CAAGCTTCAG 
ATTTGGGACA CAGCAGGCCA GGAAAGATAC AGGACTATCA CCACAGCCTA TTATCGTGGA 
GCCATGGGCT TTATTTTAAT GTATGACATT ACAAATGAAG AATCCTTCAA TGCAGTACAA 
GATTGGTCAA CTCAAATCAA AACATACTCT TGGGACAATG CCCAAGTTAT TCTGGTTGGG 
AACAAGTGTG ACATGGAAGA CGAGCGGGTC ATCTCAACTG AGCGAGGTCA ACATTTAGGA 
GAACAGCTTG GGTTTGAGTT TTTTGAAACA AGTGCCAAGG ACAACATTAA TGTCAAGCAG 
ACATTTGAGC GCCTTGTGGA TATCATCTGC GACAAAATGT CAGAGAGTTT GGAGACTGAT 
CCTGCCATCA CTGCTGCAAA GCAGAACACG AGACTCAAGG AAACTCCTCC TCCACCGCAG 
CCCAACTGTG CCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB3C ( NM_001317915.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001304844.1 Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 2, mRNA.

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CloneID	OHu39430
Clone ID Related Accession (Same CDS sequence)	NM_001317915.1 , NM_001317915.2
Accession Version	NM_001317915.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	ras-related protein Rab-3C isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034250.7, BX375794.2, BX394661.2, BC013033.2, AC008852.5 and H05600.1. On May 31, 2019 this sequence version replaced NM_001317915.1. Transcript Variant: This variant (2) uses a different first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.149575.1, SRR3476690.279138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT ATGGAAAGAT GGCCTCTGCC CAAGATGCCA GGTACGGCCA GAAAGACTCC 
TCTGATCAGA ACTTTGACTA CATGTTCAAA TTACTCATCA TCGGCAATAG CAGTGTGGGG 
AAAACATCTT TTCTATTCCG TTATGCAGAT GACTCCTTTA CATCTGCATT CGTCAGCACA 
GTTGGGATCG ATTTCAAAGT AAAAACTGTA TTCAAAAATG AAAAGAGAAT CAAGCTTCAG 
ATTTGGGACA CAGCAGGCCA GGAAAGATAC AGGACTATCA CCACAGCCTA TTATCGTGGA 
GCCATGGGCT TTATTTTAAT GTATGACATT ACAAATGAAG AATCCTTCAA TGCAGTACAA 
GATTGGTCAA CTCAAATCAA AACATACTCT TGGGACAATG CCCAAGTTAT TCTGGTTGGG 
AACAAGTGTG ACATGGAAGA CGAGCGGGTC ATCTCAACTG AGCGAGGTCA ACATTTAGGA 
GAACAGCTTG GGTTTGAGTT TTTTGAAACA AGTGCCAAGG ACAACATTAA TGTCAAGCAG 
ACATTTGAGC GCCTTGTGGA TATCATCTGC GACAAAATGT CAGAGAGTTT GGAGACTGAT 
CCTGCCATCA CTGCTGCAAA GCAGAACACG AGACTCAAGG AAACTCCTCC TCCACCGCAG 
CCCAACTGTG CCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304844.1
CDS	246..923
Translation	MELYGKMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC

Target ORF information:

RefSeq Version	NM_001317915.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB3C, member RAS oncogene family (RAB3C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317915.2

ORF Insert Sequence:

ATGGAGCTGT ATGGAAAGAT GGCCTCTGCC CAAGATGCCA GGTACGGCCA GAAAGACTCC 
TCTGATCAGA ACTTTGACTA CATGTTCAAA TTACTCATCA TCGGCAATAG CAGTGTGGGG 
AAAACATCTT TTCTATTCCG TTATGCAGAT GACTCCTTTA CATCTGCATT CGTCAGCACA 
GTTGGGATCG ATTTCAAAGT AAAAACTGTA TTCAAAAATG AAAAGAGAAT CAAGCTTCAG 
ATTTGGGACA CAGCAGGCCA GGAAAGATAC AGGACTATCA CCACAGCCTA TTATCGTGGA 
GCCATGGGCT TTATTTTAAT GTATGACATT ACAAATGAAG AATCCTTCAA TGCAGTACAA 
GATTGGTCAA CTCAAATCAA AACATACTCT TGGGACAATG CCCAAGTTAT TCTGGTTGGG 
AACAAGTGTG ACATGGAAGA CGAGCGGGTC ATCTCAACTG AGCGAGGTCA ACATTTAGGA 
GAACAGCTTG GGTTTGAGTT TTTTGAAACA AGTGCCAAGG ACAACATTAA TGTCAAGCAG 
ACATTTGAGC GCCTTGTGGA TATCATCTGC GACAAAATGT CAGAGAGTTT GGAGACTGAT 
CCTGCCATCA CTGCTGCAAA GCAGAACACG AGACTCAAGG AAACTCCTCC TCCACCGCAG 
CCCAACTGTG CCTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Molecular cancer16(1)135(2017 Aug)
Chang YC,Su CY,Chen MH,Chen WS,Chen CL,Hsiao M

Identification and characterization of multiple novel Rab-myosin Va interactions.
Molecular biology of the cell24(21)3420-34(2013 Nov)
Lindsay AJ,Jollivet F,Horgan CP,Khan AR,Raposo G,McCaffrey MW,Goud B

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Nature genetics45(4)353-61, 361e1-2(2013 Apr)
Michailidou K,Hall P,Gonzalez-Neira A,Ghoussaini M,Dennis J,Milne RL,Schmidt MK,Chang-Claude J,Bojesen SE,Bolla MK,Wang Q,Dicks E,Lee A,Turnbull C,Rahman N,,Fletcher O,Peto J,Gibson L,Dos Santos Silva I,Nevanlinna H,Muranen TA,Aittom?ki K,Blomqvist C,Czene K,Irwanto A,Liu J,Waisfisz Q,Meijers-Heijboer H,Adank M,,van der Luijt RB,Hein R,Dahmen N,Beckman L,Meindl A,Schmutzler RK,M?ller-Myhsok B,Lichtner P,Hopper JL,Southey MC,Makalic E,Schmidt DF,Uitterlinden AG,Hofman A,Hunter DJ,Chanock SJ,Vincent D,Bacot F,Tessier DC,Canisius S,Wessels LF,Haiman CA,Shah M,Luben R,Brown J,Luccarini C,Schoof N,Humphreys K,Li J,Nordestgaard BG,Nielsen SF,Flyger H,Couch FJ,Wang X,Vachon C,Stevens KN,Lambrechts D,Moisse M,Paridaens R,Christiaens MR,Rudolph A,Nickels S,Flesch-Janys D,Johnson N,Aitken Z,Aaltonen K,Heikkinen T,Broeks A,Veer LJ,van der Schoot CE,Gu?nel P,Truong T,Laurent-Puig P,Menegaux F,Marme F,Schneeweiss A,Sohn C,Burwinkel B,Zamora MP,Perez JI,Pita G,Alonso MR,Cox A,Brock IW,Cross SS,Reed MW,Sawyer EJ,Tomlinson I,Kerin MJ,Miller N,Henderson BE,Schumacher F,Le Marchand L,Andrulis IL,Knight JA,Glendon G,Mulligan AM,,,Lindblom A,Margolin S,Hooning MJ,Hollestelle A,van den Ouweland AM,Jager A,Bui QM,Stone J,Dite GS,Apicella C,Tsimiklis H,Giles GG,Severi G,Baglietto L,Fasching PA,Haeberle L,Ekici AB,Beckmann MW,Brenner H,M?ller H,Arndt V,Stegmaier C,Swerdlow A,Ashworth A,Orr N,Jones M,Figueroa J,Lissowska J,Brinton L,Goldberg MS,Labr?che F,Dumont M,Winqvist R,Pylk?s K,Jukkola-Vuorinen A,Grip M,Brauch H,Hamann U,Br?ning T,,Radice P,Peterlongo P,Manoukian S,Bonanni B,Devilee P,Tollenaar RA,Seynaeve C,van Asperen CJ,Jakubowska A,Lubinski J,Jaworska K,Durda K,Mannermaa A,Kataja V,Kosma VM,Hartikainen JM,Bogdanova NV,Antonenkova NN,D?rk T,Kristensen VN,Anton-Culver H,Slager S,Toland AE,Edge S,Fostira F,Kang D,Yoo KY,Noh DY,Matsuo K,Ito H,Iwata H,Sueta A,Wu AH,Tseng CC,Van Den Berg D,Stram DO,Shu XO,Lu W,Gao YT,Cai H,Teo SH,Yip CH,Phuah SY,Cornes BK,Hartman M,Miao H,Lim WY,Sng JH,Muir K,Lophatananon A,Stewart-Brown S,Siriwanarangsan P,Shen CY,Hsiung CN,Wu PE,Ding SL,Sangrajrang S,Gaborieau V,Brennan P,McKay J,Blot WJ,Signorello LB,Cai Q,Zheng W,Deming-Halverson S,Shrubsole M,Long J,Simard J,Garcia-Closas M,Pharoah PD,Chenevix-Trench G,Dunning AM,Benitez J,Easton DF

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
PLoS genetics9(1)e1003225(2013)
Lauc G,Huffman JE,Pu?i? M,Zgaga L,Adamczyk B,Mu?ini? A,Novokmet M,Pola?ek O,Gornik O,Kri?ti? J,Keser T,Vitart V,Scheijen B,Uh HW,Molokhia M,Patrick AL,McKeigue P,Kol?i? I,Luki? IK,Swann O,van Leeuwen FN,Ruhaak LR,Houwing-Duistermaat JJ,Slagboom PE,Beekman M,de Craen AJ,Deelder AM,Zeng Q,Wang W,Hastie ND,Gyllensten U,Wilson JF,Wuhrer M,Wright AF,Rudd PM,Hayward C,Aulchenko Y,Campbell H,Rudan I

The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America106(37)15801-6(2009 Sep)
Zou L,Zhou J,Zhang J,Li J,Liu N,Chai L,Li N,Liu T,Li L,Xie Z,Liu H,Wan Y,Wu Y

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RAB3C cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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