Rab3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab3
Entrez Gene ID	36127
Full Name	CG7576 gene product from transcript CG7576-RA
Synonyms	AAF58762,CG7576,DRAB3,DRab3,DmRab3,Dmel\CG7576,Drab3,P25228,Rab3A,dm-Rab3,drab3,rab3
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 47B7-47B7

mRNA and Protein(s)

mRNA	Protein	Name
NM_001370044.1	NP_001356961.1	Rab3, isoform B
NM_078963.3	NP_523687.1	Rab3, isoform A

Pathways from BioSystems

Homologies

	RAB3C	XP_001103215.2
Bos taurus (cattle)	RAB3C	NP_789862.1
Pan troglodytes (chimpanzee)	RAB3C	XP_526915.3
Mus musculus (house mouse)	Rab3c	NP_076341.1
Rattus norvegicus (Norway rat)	Rab3c	NP_598220.1
Gallus gallus (chicken)	RAB3C	XP_003642996.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005255	XP_314172.1
Caenorhabditis elegans (roundworm)	rab-3	NP_001021973.1
Homo sapiens (human)	RAB3C	NP_612462.1
Canis lupus familiaris (dog)	RAB3C	XP_005617471.1
Danio rerio (zebrafish)	rab3c	NP_001002530.1
Drosophila melanogaster (fruit fly)	Rab3	NP_523687.1
Xenopus tropicalis (tropical clawed frog)	rab3c	XP_002938225.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that the Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
Title: Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.

Findings suggest that Rab3 controls the distribution of active zone components via a vesicle docking mechanism that is consistent with standard Rab protein function.
Title: Mutational Analysis of Rab3 Function for Controlling Active Zone Protein Composition at the Drosophila Neuromuscular Junction.

High-resolution crystal structures of Drosophila Rab2 and Rab3 in complex with GMPPNP and magnesium.
Title: Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.

Rab3 regulates basal synaptic strength and short-term plasticity at the level of release probability at individual sites.
Title: Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons.

The data of this study defined roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity.
Title: Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release.

The following Rab3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa12903	NM_078963.3 Latest version!	Drosophila melanogaster Rab3, transcript variant A (Rab3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa12903	NM_001370044.1 Latest version!	Drosophila melanogaster Rab3, transcript variant B (Rab3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab3 ( NM_001370044.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001356961.1 Drosophila melanogaster Rab3, transcript variant B (Rab3), mRNA.

Price & Availability↑

CloneID	OFa12903
Clone ID Related Accession (Same CDS sequence)	NM_001370044.1 , NM_078963.3
Accession Version	NM_001370044.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Rab3, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCGAGTG GCGGAGACCC CAAGTGGCAG AAGGATGCCG CCGACCAGAA CTTTGACTAC 
ATGTTCAAGC TGCTCATCAT TGGCAACTCC AGCGTGGGCA AGACCAGCTT CCTCTTCCGC 
TACGCCGACG ATAGCTTCAC ATCCGCCTTC GTCTCCACGG TGGGCATTGA CTTTAAGGTG 
AAGACCGTAT TTCGGCACGA TAAGCGCGTG AAACTCCAGA TCTGGGACAC TGCTGGACAG 
GAGCGGTACA GAACTATCAC CACAGCCTAC TACCGAGGAG CGATGGGTTT CATCCTAATG 
TACGATGTCA CTAATGAGGA CAGTTTTAAC TCGGTTCAGG ATTGGGTGAC ACAGATCAAA 
ACGTATTCGT GGGACAATGC CCAGGTGATC CTGGTGGGCA ACAAGTGCGA CATGGAGGAC 
CAGCGGGTAA TCAGCTTCGA ACGTGGTCGC CAGTTGGCCG ATCAATTGGG TGTTGAGTTC 
TTCGAGACCT CTGCCAAGGA GAACGTCAAC GTCAAGGCTG TTTTCGAGCG TTTGGTGGAC 
ATCATCTGCG ATAAGATGTC CGAGAGCCTG GACGCGGATC CGACGTTAGT AGGCGGTGGC 
CAGAAGGGCC AGAGGTTGAC GGATCAGCCG CAGGGCACGC CTAATGCCAA CTGCAATTGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356961.1
CDS	620..1282
Translation	MASGGDPKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGGQKGQRLTDQPQGTPNANCNC

Target ORF information:

RefSeq Version	NM_001370044.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Rab3, transcript variant B (Rab3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001370044.1

ORF Insert Sequence:

ATGGCGAGTG GCGGAGACCC CAAGTGGCAG AAGGATGCCG CCGACCAGAA CTTTGACTAC 
ATGTTCAAGC TGCTCATCAT TGGCAACTCC AGCGTGGGCA AGACCAGCTT CCTCTTCCGC 
TACGCCGACG ATAGCTTCAC ATCCGCCTTC GTCTCCACGG TGGGCATTGA CTTTAAGGTG 
AAGACCGTAT TTCGGCACGA TAAGCGCGTG AAACTCCAGA TCTGGGACAC TGCTGGACAG 
GAGCGGTACA GAACTATCAC CACAGCCTAC TACCGAGGAG CGATGGGTTT CATCCTAATG 
TACGATGTCA CTAATGAGGA CAGTTTTAAC TCGGTTCAGG ATTGGGTGAC ACAGATCAAA 
ACGTATTCGT GGGACAATGC CCAGGTGATC CTGGTGGGCA ACAAGTGCGA CATGGAGGAC 
CAGCGGGTAA TCAGCTTCGA ACGTGGTCGC CAGTTGGCCG ATCAATTGGG TGTTGAGTTC 
TTCGAGACCT CTGCCAAGGA GAACGTCAAC GTCAAGGCTG TTTTCGAGCG TTTGGTGGAC 
ATCATCTGCG ATAAGATGTC CGAGAGCCTG GACGCGGATC CGACGTTAGT AGGCGGTGGC 
CAGAAGGGCC AGAGGTTGAC GGATCAGCCG CAGGGCACGC CTAATGCCAA CTGCAATTGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rab3 ( NM_078963.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523687.1 Drosophila melanogaster Rab3, transcript variant A (Rab3), mRNA.

Price & Availability↑

CloneID	OFa12903
Clone ID Related Accession (Same CDS sequence)	NM_001370044.1 , NM_078963.3
Accession Version	NM_078963.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Rab3, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_078963.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCGAGTG GCGGAGACCC CAAGTGGCAG AAGGATGCCG CCGACCAGAA CTTTGACTAC 
ATGTTCAAGC TGCTCATCAT TGGCAACTCC AGCGTGGGCA AGACCAGCTT CCTCTTCCGC 
TACGCCGACG ATAGCTTCAC ATCCGCCTTC GTCTCCACGG TGGGCATTGA CTTTAAGGTG 
AAGACCGTAT TTCGGCACGA TAAGCGCGTG AAACTCCAGA TCTGGGACAC TGCTGGACAG 
GAGCGGTACA GAACTATCAC CACAGCCTAC TACCGAGGAG CGATGGGTTT CATCCTAATG 
TACGATGTCA CTAATGAGGA CAGTTTTAAC TCGGTTCAGG ATTGGGTGAC ACAGATCAAA 
ACGTATTCGT GGGACAATGC CCAGGTGATC CTGGTGGGCA ACAAGTGCGA CATGGAGGAC 
CAGCGGGTAA TCAGCTTCGA ACGTGGTCGC CAGTTGGCCG ATCAATTGGG TGTTGAGTTC 
TTCGAGACCT CTGCCAAGGA GAACGTCAAC GTCAAGGCTG TTTTCGAGCG TTTGGTGGAC 
ATCATCTGCG ATAAGATGTC CGAGAGCCTG GACGCGGATC CGACGTTAGT AGGCGGTGGC 
CAGAAGGGCC AGAGGTTGAC GGATCAGCCG CAGGGCACGC CTAATGCCAA CTGCAATTGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523687.1
CDS	620..1282
Translation	MASGGDPKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGGQKGQRLTDQPQGTPNANCNC

Target ORF information:

RefSeq Version	NM_078963.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Rab3, transcript variant A (Rab3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078963.3

ORF Insert Sequence:

ATGGCGAGTG GCGGAGACCC CAAGTGGCAG AAGGATGCCG CCGACCAGAA CTTTGACTAC 
ATGTTCAAGC TGCTCATCAT TGGCAACTCC AGCGTGGGCA AGACCAGCTT CCTCTTCCGC 
TACGCCGACG ATAGCTTCAC ATCCGCCTTC GTCTCCACGG TGGGCATTGA CTTTAAGGTG 
AAGACCGTAT TTCGGCACGA TAAGCGCGTG AAACTCCAGA TCTGGGACAC TGCTGGACAG 
GAGCGGTACA GAACTATCAC CACAGCCTAC TACCGAGGAG CGATGGGTTT CATCCTAATG 
TACGATGTCA CTAATGAGGA CAGTTTTAAC TCGGTTCAGG ATTGGGTGAC ACAGATCAAA 
ACGTATTCGT GGGACAATGC CCAGGTGATC CTGGTGGGCA ACAAGTGCGA CATGGAGGAC 
CAGCGGGTAA TCAGCTTCGA ACGTGGTCGC CAGTTGGCCG ATCAATTGGG TGTTGAGTTC 
TTCGAGACCT CTGCCAAGGA GAACGTCAAC GTCAAGGCTG TTTTCGAGCG TTTGGTGGAC 
ATCATCTGCG ATAAGATGTC CGAGAGCCTG GACGCGGATC CGACGTTAGT AGGCGGTGGC 
CAGAAGGGCC AGAGGTTGAC GGATCAGCCG CAGGGCACGC CTAATGCCAA CTGCAATTGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Rab3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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