EXOSC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EXOSC8
Entrez Gene ID	11340
Full Name	exosome component 8
Synonyms	CIP3,EAP2,OIP2,PCH1C,RRP43,Rrp43p,bA421P11.3,p9
General protein information	Preferred Names exosome component 8 Names exosome complex component RRP43 CBP-interacting protein 3 OIP-2 Opa interacting protein 2 exosome complex exonuclease RRP43 ribosomal RNA-processing protein 43
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q13.3
Summary	This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009].
Disorder MIM:	606019
Disorder Html:	Pontocerebellar hypoplasia, type 1C, 616081 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_006719763.1	XP_006719826.1	exosome complex component RRP43 isoform X1
NM_181503.2	NP_852480.1	exosome complex component RRP43
NM_181503.3	NP_852480.1	exosome complex component RRP43

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	SPBC17D1.03c	NP_596385.1
Arabidopsis thaliana (thale cress)	AT1G60080	NP_176216.1
	EXOSC8	XP_001085228.1
Rattus norvegicus (Norway rat)	Exosc8	NP_001099902.1
Oryza sativa (rice)	Os11g0311300	NP_001067758.1
Xenopus tropicalis (tropical clawed frog)	exosc8	NP_001007919.1
Homo sapiens (human)	EXOSC8	NP_852480.1
Danio rerio (zebrafish)	exosc8	NP_001002865.1
Pan troglodytes (chimpanzee)	EXOSC8	XP_522661.2
Canis lupus familiaris (dog)	EXOSC8	XP_534492.2
Bos taurus (cattle)	EXOSC8	NP_001073074.1
Gallus gallus (chicken)	EXOSC8	XP_003640625.1
Mus musculus (house mouse)	Exosc8	NP_001157042.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012402	XP_320154.3

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Giunta M, Edvardson S, Xu Y, Schuelke M, Gomez-Duran A, Boczonadi V, Elpeleg O, M?ller JS, Horvath R
Human molecular genetics25(14)2985-2996(2016 07)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation
Title: Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.

homozygous missense mutations cause progressive and lethal neurological disease
Title: EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.
Title: A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.

The following EXOSC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12606	NM_181503.3 Latest version!	Homo sapiens exosome component 8 (EXOSC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu47079	XM_006719763.1 Latest version!	Homo sapiens exosome component 8 (EXOSC8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu12606	NM_181503.2	Homo sapiens exosome component 8 (EXOSC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EXOSC8 ( NM_181503.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_852480.1 Homo sapiens exosome component 8 (EXOSC8), mRNA.

Price & Availability↑

CloneID	OHu12606
Clone ID Related Accession (Same CDS sequence)	NM_181503.2 , NM_181503.3
Accession Version	NM_181503.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	exosome complex component RRP43
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138706.9, BM697343.1, BC020773.1 and BU687776.1. This sequence is a reference standard in the RefSeqGene project. On Mar 3, 2009 this sequence version replaced NM_181503.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.136975.1, SRR1660809.70193.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG GGTTCAAAAC CGTGGAACCT CTGGAGTATT ACAGGAGATT TCTGAAAGAG 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAA CCACAACTGT CAACATCGGT 
TCAATTAGTA CCGCAGATGG TTCTGCTTTA GTGAAGTTGG GAAATACTAC AGTAATCTGT 
GGAGTTAAAG CAGAATTTGC AGCACCATCA ACAGATGCCC CTGATAAAGG ATACGTTGTT 
CCTAATGTGG ATCTACCACC CCTGTGTTCA TCGAGATTCC GGTCTGGACC TCCTGGAGAA 
GAGGCCCAAG TGGCTAGCCA GTTCATTGCA GATGTCATTG AAAATTCACA GATAATTCAG 
AAAGAGGACT TATGCATTTC TCCAGGAAAG CTTGTCTGGG TTCTATACTG TGATCTCATT 
TGCCTCGACT ACGATGGAAA CATTTTGGAT GCCTGCACAT TTGCTTTGCT AGCGGCTTTA 
AAAAATGTAC AGTTGCCTGA AGTTACTATA AATGAAGAAA CTGCTTTAGC AGAAGTTAAT 
TTAAAGAAGA AAAGTTATTT GAATATTAGA ACTCATCCAG TTGCAACTTC CTTTGCTGTG 
TTTGATGACA CTTTGCTTAT AGTTGACCCT ACTGGAGAGG AGGAACATCT GGCAACAGGA 
ACCTTAACAA TAGTAATGGA TGAGGAAGGC AAACTCTGTT GTCTTCACAA ACCAGGTGGA 
AGTGGGCTAA CTGGAGCTAA ACTTCAGGAC TGTATGAGCC GAGCAGTTAC AAGACACAAA 
GAAGTTAAAA AACTGATGGA TGAAGTAATT AAGAGTATGA AACCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852480.1
CDS	266..1096
Translation	MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK

Target ORF information:

RefSeq Version	NM_181503.2
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 8 (EXOSC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181503.2

ORF Insert Sequence:

ATGGCGGCTG GGTTCAAAAC CGTGGAACCT CTGGAGTATT ACAGGAGATT TCTGAAAGAG 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAA CCACAACTGT CAACATCGGT 
TCAATTAGTA CCGCAGATGG TTCTGCTTTA GTGAAGTTGG GAAATACTAC AGTAATCTGT 
GGAGTTAAAG CAGAATTTGC AGCACCATCA ACAGATGCCC CTGATAAAGG ATACGTTGTT 
CCTAATGTGG ATCTACCACC CCTGTGTTCA TCGAGATTCC GGTCTGGACC TCCTGGAGAA 
GAGGCCCAAG TGGCTAGCCA GTTCATTGCA GATGTCATTG AAAATTCACA GATAATTCAG 
AAAGAGGACT TATGCATTTC TCCAGGAAAG CTTGTCTGGG TTCTATACTG TGATCTCATT 
TGCCTCGACT ACGATGGAAA CATTTTGGAT GCCTGCACAT TTGCTTTGCT AGCGGCTTTA 
AAAAATGTAC AGTTGCCTGA AGTTACTATA AATGAAGAAA CTGCTTTAGC AGAAGTTAAT 
TTAAAGAAGA AAAGTTATTT GAATATTAGA ACTCATCCAG TTGCAACTTC CTTTGCTGTG 
TTTGATGACA CTTTGCTTAT AGTTGACCCT ACTGGAGAGG AGGAACATCT GGCAACAGGA 
ACCTTAACAA TAGTAATGGA TGAGGAAGGC AAACTCTGTT GTCTTCACAA ACCAGGTGGA 
AGTGGGCTAA CTGGAGCTAA ACTTCAGGAC TGTATGAGCC GAGCAGTTAC AAGACACAAA 
GAAGTTAAAA AACTGATGGA TGAAGTAATT AAGAGTATGA AACCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC8 ( NM_181503.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_852480.1 Homo sapiens exosome component 8 (EXOSC8), mRNA.

Price & Availability↑

CloneID	OHu12606
Clone ID Related Accession (Same CDS sequence)	NM_181503.2 , NM_181503.3
Accession Version	NM_181503.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	exosome complex component RRP43
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020773.1, AL138706.9 and BU687776.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_181503.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.117613.1, SRR1803613.75381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000389704.4/ ENSP00000374354.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCTG GGTTCAAAAC CGTGGAACCT CTGGAGTATT ACAGGAGATT TCTGAAAGAG 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAA CCACAACTGT CAACATCGGT 
TCAATTAGTA CCGCAGATGG TTCTGCTTTA GTGAAGTTGG GAAATACTAC AGTAATCTGT 
GGAGTTAAAG CAGAATTTGC AGCACCATCA ACAGATGCCC CTGATAAAGG ATACGTTGTT 
CCTAATGTGG ATCTACCACC CCTGTGTTCA TCGAGATTCC GGTCTGGACC TCCTGGAGAA 
GAGGCCCAAG TGGCTAGCCA GTTCATTGCA GATGTCATTG AAAATTCACA GATAATTCAG 
AAAGAGGACT TATGCATTTC TCCAGGAAAG CTTGTCTGGG TTCTATACTG TGATCTCATT 
TGCCTCGACT ACGATGGAAA CATTTTGGAT GCCTGCACAT TTGCTTTGCT AGCGGCTTTA 
AAAAATGTAC AGTTGCCTGA AGTTACTATA AATGAAGAAA CTGCTTTAGC AGAAGTTAAT 
TTAAAGAAGA AAAGTTATTT GAATATTAGA ACTCATCCAG TTGCAACTTC CTTTGCTGTG 
TTTGATGACA CTTTGCTTAT AGTTGACCCT ACTGGAGAGG AGGAACATCT GGCAACAGGA 
ACCTTAACAA TAGTAATGGA TGAGGAAGGC AAACTCTGTT GTCTTCACAA ACCAGGTGGA 
AGTGGGCTAA CTGGAGCTAA ACTTCAGGAC TGTATGAGCC GAGCAGTTAC AAGACACAAA 
GAAGTTAAAA AACTGATGGA TGAAGTAATT AAGAGTATGA AACCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852480.1
CDS	21..851
Translation	MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK

Target ORF information:

RefSeq Version	NM_181503.3
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 8 (EXOSC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181503.3

ORF Insert Sequence:

ATGGCGGCTG GGTTCAAAAC CGTGGAACCT CTGGAGTATT ACAGGAGATT TCTGAAAGAG 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAA CCACAACTGT CAACATCGGT 
TCAATTAGTA CCGCAGATGG TTCTGCTTTA GTGAAGTTGG GAAATACTAC AGTAATCTGT 
GGAGTTAAAG CAGAATTTGC AGCACCATCA ACAGATGCCC CTGATAAAGG ATACGTTGTT 
CCTAATGTGG ATCTACCACC CCTGTGTTCA TCGAGATTCC GGTCTGGACC TCCTGGAGAA 
GAGGCCCAAG TGGCTAGCCA GTTCATTGCA GATGTCATTG AAAATTCACA GATAATTCAG 
AAAGAGGACT TATGCATTTC TCCAGGAAAG CTTGTCTGGG TTCTATACTG TGATCTCATT 
TGCCTCGACT ACGATGGAAA CATTTTGGAT GCCTGCACAT TTGCTTTGCT AGCGGCTTTA 
AAAAATGTAC AGTTGCCTGA AGTTACTATA AATGAAGAAA CTGCTTTAGC AGAAGTTAAT 
TTAAAGAAGA AAAGTTATTT GAATATTAGA ACTCATCCAG TTGCAACTTC CTTTGCTGTG 
TTTGATGACA CTTTGCTTAT AGTTGACCCT ACTGGAGAGG AGGAACATCT GGCAACAGGA 
ACCTTAACAA TAGTAATGGA TGAGGAAGGC AAACTCTGTT GTCTTCACAA ACCAGGTGGA 
AGTGGGCTAA CTGGAGCTAA ACTTCAGGAC TGTATGAGCC GAGCAGTTAC AAGACACAAA 
GAAGTTAAAA AACTGATGGA TGAAGTAATT AAGAGTATGA AACCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC8 ( XM_006719763.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719826.1 Homo sapiens exosome component 8 (EXOSC8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu47079
Clone ID Related Accession (Same CDS sequence)	XM_006719763.1
Accession Version	XM_006719763.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	exosome complex component RRP43 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGAGGGC GGGCCAGGGA CCTTTCGTCG CGTCCCCACC TTGGCATTTC CCGTGGCGTG 
AGCGGCCCCG GCATCCGTGT CGAAAGTGCG GCGGCGGAAC AGGCGCGCAG GAGAGGAGCG 
GCGCAGGCGC AGACGCGCGG GCGGGAAGAT GGCGGCTGGG TTCAAAAAGA GAACTGCCGT 
CCTGATGGAA GAGAACTTGG TGAATTCAGA ACCACAACTG TCAACATCGG TTCAATTAGT 
ACCGCAGATG GTTCTGCTTT AGTGAAGTTG GGAAATACTA CAGTAATCTG TGGAGTTAAA 
GCAGAATTTG CAGCACCATC AACAGATGCC CCTGATAAAG GATACGTTGT TCCTAATGTG 
GATCTACCAC CCCTGTGTTC ATCGAGATTC CGGTCTGGAC CTCCTGGAGA AGAGGCCCAA 
GTGGCTAGCC AGTTCATTGC AGATGTCATT GAAAATTCAC AGATAATTCA GAAAGAGGAC 
TTATGCATTT CTCCAGGAAA GCTTGTCTGG GTTCTATACT GTGATCTCAT TTGCCTCGAC 
TACGATGGAA ACATTTTGGA TGCCTGCACA TTTGCTTTGC TAGCGGCTTT AAAAAATGTA 
CAGTTGCCTG AAGTTACTAT AAATGAAGAA ACTGCTTTAG CAGAAGTTAA TTTAAAGAAG 
AAAAGTTATT TGAATATTAG AACTCATCCA GTTGCAACTT CCTTTGCTGT GTTTGATGAC 
ACTTTGCTTA TAGTTGACCC TACTGGAGAG GAGGAACATC TGGCAACAGG AACCTTAACA 
ATAGTAATGG ATGAGGAAGG CAAACTCTGT TGTCTTCACA AACCAGGTGG AAGTGGGCTA 
ACTGGAGCTA AACTTCAGGA CTGTATGAGC CGAGCAGTTA CAAGACACAA AGAAGTTAAA 
AAACTGATGG ATGAAGTAAT TAAGAGTATG AAACCCAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719826.1
CDS	286..1227
Translation	MRGRARDLSSRPHLGISRGVSGPGIRVESAAAEQARRRGAAQAQTRGREDGGWVQKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK

Target ORF information:

RefSeq Version	XM_006719763.1
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 8 (EXOSC8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719763.1

ORF Insert Sequence:

ATGCGAGGGC GGGCCAGGGA CCTTTCGTCG CGTCCCCACC TTGGCATTTC CCGTGGCGTG 
AGCGGCCCCG GCATCCGTGT CGAAAGTGCG GCGGCGGAAC AGGCGCGCAG GAGAGGAGCG 
GCGCAGGCGC AGACGCGCGG GCGGGAAGAT GGCGGCTGGG TTCAAAAAGA GAACTGCCGT 
CCTGATGGAA GAGAACTTGG TGAATTCAGA ACCACAACTG TCAACATCGG TTCAATTAGT 
ACCGCAGATG GTTCTGCTTT AGTGAAGTTG GGAAATACTA CAGTAATCTG TGGAGTTAAA 
GCAGAATTTG CAGCACCATC AACAGATGCC CCTGATAAAG GATACGTTGT TCCTAATGTG 
GATCTACCAC CCCTGTGTTC ATCGAGATTC CGGTCTGGAC CTCCTGGAGA AGAGGCCCAA 
GTGGCTAGCC AGTTCATTGC AGATGTCATT GAAAATTCAC AGATAATTCA GAAAGAGGAC 
TTATGCATTT CTCCAGGAAA GCTTGTCTGG GTTCTATACT GTGATCTCAT TTGCCTCGAC 
TACGATGGAA ACATTTTGGA TGCCTGCACA TTTGCTTTGC TAGCGGCTTT AAAAAATGTA 
CAGTTGCCTG AAGTTACTAT AAATGAAGAA ACTGCTTTAG CAGAAGTTAA TTTAAAGAAG 
AAAAGTTATT TGAATATTAG AACTCATCCA GTTGCAACTT CCTTTGCTGT GTTTGATGAC 
ACTTTGCTTA TAGTTGACCC TACTGGAGAG GAGGAACATC TGGCAACAGG AACCTTAACA 
ATAGTAATGG ATGAGGAAGG CAAACTCTGT TGTCTTCACA AACCAGGTGG AAGTGGGCTA 
ACTGGAGCTA AACTTCAGGA CTGTATGAGC CGAGCAGTTA CAAGACACAA AGAAGTTAAA 
AAACTGATGG ATGAAGTAAT TAAGAGTATG AAACCCAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Human molecular genetics25(14)2985-2996(2016 07)
Giunta M,Edvardson S,Xu Y,Schuelke M,Gomez-Duran A,Boczonadi V,Elpeleg O,M?ller JS,Horvath R

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

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EXOSC8 cDNA ORF clone, Homo sapiens(human)

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