exosc8 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	exosc8
Entrez Gene ID	323016
Full Name	exosome component 8
Synonyms	wu:fb79a10,zgc:110381
General protein information	Preferred Names exosome component 8 Names exosome complex component RRP43 Opa-interacting protein 2 (3' exoribonuclease family)
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002865.1	NP_001002865.1	exosome complex component RRP43

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	SPBC17D1.03c	NP_596385.1
Arabidopsis thaliana (thale cress)	AT1G60080	NP_176216.1
	EXOSC8	XP_001085228.1
Rattus norvegicus (Norway rat)	Exosc8	NP_001099902.1
Oryza sativa (rice)	Os11g0311300	NP_001067758.1
Xenopus tropicalis (tropical clawed frog)	exosc8	NP_001007919.1
Homo sapiens (human)	EXOSC8	NP_852480.1
Danio rerio (zebrafish)	exosc8	NP_001002865.1
Pan troglodytes (chimpanzee)	EXOSC8	XP_522661.2
Canis lupus familiaris (dog)	EXOSC8	XP_534492.2
Bos taurus (cattle)	EXOSC8	NP_001073074.1
Gallus gallus (chicken)	EXOSC8	XP_003640625.1
Mus musculus (house mouse)	Exosc8	NP_001157042.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012402	XP_320154.3

Gene Ontology
Bibliography

Related articles in PubMed

Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes.
Ribas L, Liew WC, D?az N, Sreenivasan R, Orb?n L, Piferrer F
Proceedings of the National Academy of Sciences of the United States of America114(6)E941-E950(2017 Feb)

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Giunta M, Edvardson S, Xu Y, Schuelke M, Gomez-Duran A, Boczonadi V, Elpeleg O, M?ller JS, Horvath R
Human molecular genetics25(14)2985-2996(2016 07)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.
Boczonadi V, M?ller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, L?tzkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochm?ller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R
Nature communications54287(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation
Title: Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.

down-regulation induced a specific increase in AU-rich element-containing messenger RNAs encoding myelin proteins
Title: EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

The following exosc8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the exosc8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa32604	NM_001002865.1 Latest version!	Danio rerio exosome component 8 (exosc8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

exosc8 ( NM_001002865.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001002865.1 Danio rerio exosome component 8 (exosc8), mRNA.

Price & Availability↑

CloneID	ODa32604
Clone ID Related Accession (Same CDS sequence)	NM_001002865.1
Accession Version	NM_001002865.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	exosome complex component RRP43
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648725.1. On May 27, 2009 this sequence version replaced NM_001105147.1. ##Evidence-Data-START## Transcript exon combination :: AY648725.1, BC152248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCTG GTTTTAAAAC CGCAGAGCCT CTTGAATATC ACCGGAGCTT TCTGAAAGAA 
AACTGTCGTC CAGATGGAAG GGAGTTGGGA GAGTTTAGAC CCACGACGTT AAATATTAAC 
TCCATATCTA CAGCCGATGG ATCAGCACTG GTGAAAATTG GAAACACTAC CGTGATCTGT 
GGGATAAAAG CTGAATTGGC TGTGCCGCCA TCTGAGGCTC AGAATAAAGG ATATTTAGTC 
CCAAATGTAG ATCTGCCCCC GCTGTGCTCG TCCAGATTCA GAGCTGGTCC ACCAGGAGAA 
CAGGCACAGG CTGCCAGCCA GTTCATCGCA GATGTCATCG AAAGTTCCGA TTTAATAAAT 
TTGGAGGAAC TGTGCATTGA AAAAGCTAAG CTTTGTTGGG TGCTGTACTG TGATATTATG 
TGTTTGGATT ACGATGGGAA CTTACTTGAC GCCTGCATCA CAGTTCTGCT GGCAGCTTTA 
AAAACCGCAC AACTCCCTGA AGTCACCATA AACAAAGAGA CAGATCTAGC AGAAGTTGAC 
ATTGAGAAGA AGAGGCGCTT GAAGATCAAC CGGCACCCAG TCGGCTCATC GTTTGCAGTA 
TTTGATGACT CCATCATTAT AGTTGACCCC ACGGCGGAAG AGGAAAGCTT GTCTACAGCA 
TTAATGACTG TGGTGACGGA TGAGGAGGAT AGACTCTGTG CAGTTCACAA ACCAGGTGGG 
ACATCGTTAT CCGGCGAGAA GCTACAACAC TGCATAAACA GAGCCCTCAC AAGAAACAAA 
GAGATCAGAA AACTGCTGGA CAAAGTCCAC GAGAGCACGA AGACCATGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002865.1
CDS	25..858
Translation	MAAGFKTAEPLEYHRSFLKENCRPDGRELGEFRPTTLNINSISTADGSALVKIGNTTVICGIKAELAVPPSEAQNKGYLVPNVDLPPLCSSRFRAGPPGEQAQAASQFIADVIESSDLINLEELCIEKAKLCWVLYCDIMCLDYDGNLLDACITVLLAALKTAQLPEVTINKETDLAEVDIEKKRRLKINRHPVGSSFAVFDDSIIIVDPTAEEESLSTALMTVVTDEEDRLCAVHKPGGTSLSGEKLQHCINRALTRNKEIRKLLDKVHESTKTMK

Target ORF information:

RefSeq Version	NM_001002865.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio exosome component 8 (exosc8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002865.1

ORF Insert Sequence:

ATGGCGGCTG GTTTTAAAAC CGCAGAGCCT CTTGAATATC ACCGGAGCTT TCTGAAAGAA 
AACTGTCGTC CAGATGGAAG GGAGTTGGGA GAGTTTAGAC CCACGACGTT AAATATTAAC 
TCCATATCTA CAGCCGATGG ATCAGCACTG GTGAAAATTG GAAACACTAC CGTGATCTGT 
GGGATAAAAG CTGAATTGGC TGTGCCGCCA TCTGAGGCTC AGAATAAAGG ATATTTAGTC 
CCAAATGTAG ATCTGCCCCC GCTGTGCTCG TCCAGATTCA GAGCTGGTCC ACCAGGAGAA 
CAGGCACAGG CTGCCAGCCA GTTCATCGCA GATGTCATCG AAAGTTCCGA TTTAATAAAT 
TTGGAGGAAC TGTGCATTGA AAAAGCTAAG CTTTGTTGGG TGCTGTACTG TGATATTATG 
TGTTTGGATT ACGATGGGAA CTTACTTGAC GCCTGCATCA CAGTTCTGCT GGCAGCTTTA 
AAAACCGCAC AACTCCCTGA AGTCACCATA AACAAAGAGA CAGATCTAGC AGAAGTTGAC 
ATTGAGAAGA AGAGGCGCTT GAAGATCAAC CGGCACCCAG TCGGCTCATC GTTTGCAGTA 
TTTGATGACT CCATCATTAT AGTTGACCCC ACGGCGGAAG AGGAAAGCTT GTCTACAGCA 
TTAATGACTG TGGTGACGGA TGAGGAGGAT AGACTCTGTG CAGTTCACAA ACCAGGTGGG 
ACATCGTTAT CCGGCGAGAA GCTACAACAC TGCATAAACA GAGCCCTCAC AAGAAACAAA 
GAGATCAGAA AACTGCTGGA CAAAGTCCAC GAGAGCACGA AGACCATGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes.
Proceedings of the National Academy of Sciences of the United States of America114(6)E941-E950(2017 Feb)
Ribas L,Liew WC,D?az N,Sreenivasan R,Orb?n L,Piferrer F

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Human molecular genetics25(14)2985-2996(2016 07)
Giunta M,Edvardson S,Xu Y,Schuelke M,Gomez-Duran A,Boczonadi V,Elpeleg O,M?ller JS,Horvath R

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.
Nature communications54287(2014 Jul)
Boczonadi V,M?ller JS,Pyle A,Munkley J,Dor T,Quartararo J,Ferrero I,Karcagi V,Giunta M,Polvikoski T,Birchall D,Princzinger A,Cinnamon Y,L?tzkendorf S,Piko H,Reza M,Florez L,Santibanez-Koref M,Griffin H,Schuelke M,Elpeleg O,Kalaydjieva L,Lochm?ller H,Elliott DJ,Chinnery PF,Edvardson S,Horvath R

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exosc8 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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