Exosc8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Exosc8
Entrez Gene ID	69639
Full Name	exosome component 8
Synonyms	2310032N20Rik,CIP3,mKIAA4013
General protein information	Preferred Names exosome component 8 Names exosome complex component RRP43 exosome complex exonuclease RRP43 ribosomal RNA-processing protein 43
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_027148.3	NP_081424.3	exosome complex component RRP43 isoform 2
NM_001163570.1	NP_001157042.1	exosome complex component RRP43 isoform 1

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	SPBC17D1.03c	NP_596385.1
Arabidopsis thaliana (thale cress)	AT1G60080	NP_176216.1
	EXOSC8	XP_001085228.1
Rattus norvegicus (Norway rat)	Exosc8	NP_001099902.1
Oryza sativa (rice)	Os11g0311300	NP_001067758.1
Xenopus tropicalis (tropical clawed frog)	exosc8	NP_001007919.1
Homo sapiens (human)	EXOSC8	NP_852480.1
Danio rerio (zebrafish)	exosc8	NP_001002865.1
Pan troglodytes (chimpanzee)	EXOSC8	XP_522661.2
Canis lupus familiaris (dog)	EXOSC8	XP_534492.2
Bos taurus (cattle)	EXOSC8	NP_001073074.1
Gallus gallus (chicken)	EXOSC8	XP_003640625.1
Mus musculus (house mouse)	Exosc8	NP_001157042.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012402	XP_320154.3

Gene Ontology
Bibliography

Related articles in PubMed

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Exosc8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Exosc8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03708	NM_027148.3 Latest version!	Mus musculus exosome component 8 (Exosc8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu09203	NM_001163570.1 Latest version!	Mus musculus exosome component 8 (Exosc8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Exosc8 ( NM_027148.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081424.3 Mus musculus exosome component 8 (Exosc8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu03708
Clone ID Related Accession (Same CDS sequence)	NM_027148.3
Accession Version	NM_027148.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	exosome complex component RRP43 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK220227.1. On Jul 25, 2009 this sequence version replaced NM_027148.2. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK220227.1, BC059089.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG GGTTCAAAAC TGTGGAGCCG CTGGAGTATT ACAGGAGATT TCTGAAGGAA 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAG CCACAACTGT CAACATAGGT 
TCAATCAGTA CAGCGGATGG CTCTGCTCTC GTGAAGCTGG GGAATACCAC GGTCATTTGT 
GGCGTTAAAG CAGAATTTGC AGCACCACCA GTAGATGCCC CCGATAGAGG ATATGTCGTC 
CCTAATGTGG ATCTACCACC GCTGTGTTCT TCGAGGTTCC GGACAGGACC TCCTGGGGAA 
GAGGCTCAAG TAACCAGCCA GTTCATTGCA GATGTCGTTG ACAACTCACA GGTGATTAAG 
AAAGAGGATT TATGCATTTC TCCAGGCAAG CTTGCTTGGG TTCTATACTG TGACCTCATT 
TGTCTAGACT ACGATGGGAA CATTTTGGAT GCCTGCACAT TTGCTTTGTT AGCAGCTTTA 
AAGAATGTAC AGTTGCCTGA AGTTACTATA AACGAAGAGA CTGCTTTAGC CGAAGTCAAT 
TTAAAGAAGA AAAGTTATTT GAATGTTAGA ACAAACCCAG TTGCTACTTC CTTTGCTGTG 
TTTGATGACA CTCTACTGAT AGTCGATCCT ACCGGCGAGG AGGAGCACCT GTCCACAGGA 
ACCCTAACCG TAGTCACGGA CGAGGACGGC AAGCTGTGCT GTCTTCACAA GCCAGGTGGG 
AGTGGGCTGA CTGGAGCTAA ACTTCAGGAC TGCATGAGTC GAGCGGTAAC GAGACACAAA 
GAAGTGAGCA AGCTACTGGA TGAAGTAATT CAGAGCATGA GACACAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081424.3
CDS	341..1171
Translation	MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRATTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPPVDAPDRGYVVPNVDLPPLCSSRFRTGPPGEEAQVTSQFIADVVDNSQVIKKEDLCISPGKLAWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNVRTNPVATSFAVFDDTLLIVDPTGEEEHLSTGTLTVVTDEDGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVSKLLDEVIQSMRHK

Target ORF information:

RefSeq Version	NM_027148.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus exosome component 8 (Exosc8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027148.3

ORF Insert Sequence:

ATGGCGGCTG GGTTCAAAAC TGTGGAGCCG CTGGAGTATT ACAGGAGATT TCTGAAGGAA 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAG CCACAACTGT CAACATAGGT 
TCAATCAGTA CAGCGGATGG CTCTGCTCTC GTGAAGCTGG GGAATACCAC GGTCATTTGT 
GGCGTTAAAG CAGAATTTGC AGCACCACCA GTAGATGCCC CCGATAGAGG ATATGTCGTC 
CCTAATGTGG ATCTACCACC GCTGTGTTCT TCGAGGTTCC GGACAGGACC TCCTGGGGAA 
GAGGCTCAAG TAACCAGCCA GTTCATTGCA GATGTCGTTG ACAACTCACA GGTGATTAAG 
AAAGAGGATT TATGCATTTC TCCAGGCAAG CTTGCTTGGG TTCTATACTG TGACCTCATT 
TGTCTAGACT ACGATGGGAA CATTTTGGAT GCCTGCACAT TTGCTTTGTT AGCAGCTTTA 
AAGAATGTAC AGTTGCCTGA AGTTACTATA AACGAAGAGA CTGCTTTAGC CGAAGTCAAT 
TTAAAGAAGA AAAGTTATTT GAATGTTAGA ACAAACCCAG TTGCTACTTC CTTTGCTGTG 
TTTGATGACA CTCTACTGAT AGTCGATCCT ACCGGCGAGG AGGAGCACCT GTCCACAGGA 
ACCCTAACCG TAGTCACGGA CGAGGACGGC AAGCTGTGCT GTCTTCACAA GCCAGGTGGG 
AGTGGGCTGA CTGGAGCTAA ACTTCAGGAC TGCATGAGTC GAGCGGTAAC GAGACACAAA 
GAAGTGAGCA AGCTACTGGA TGAAGTAATT CAGAGCATGA GACACAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Exosc8 ( NM_001163570.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001157042.1 Mus musculus exosome component 8 (Exosc8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09203
Clone ID Related Accession (Same CDS sequence)	NM_001163570.1
Accession Version	NM_001163570.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	exosome complex component RRP43 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK220227.1 and AA003291.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG GGTTCAAAAC TGTGGAGCCG CTGGAGTATT ACAGGAGATT TCTGAAGGAA 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAG CCACAACTGT CAACATAGGT 
TCAATCAGTA CAGCGGATGG CTCTGCTCTC GTGAAGCTGG GGAATACCAC GGTCATTTGT 
GGCGTTAAAG CAGAATTTGC AGCACCACCA GTAGATGCCC CCGATAGAGG ATATGTCGTG 
TTTCTTTCAG TCCCTAATGT GGATCTACCA CCGCTGTGTT CTTCGAGGTT CCGGACAGGA 
CCTCCTGGGG AAGAGGCTCA AGTAACCAGC CAGTTCATTG CAGATGTCGT TGACAACTCA 
CAGGTGATTA AGAAAGAGGA TTTATGCATT TCTCCAGGCA AGCTTGCTTG GGTTCTATAC 
TGTGACCTCA TTTGTCTAGA CTACGATGGG AACATTTTGG ATGCCTGCAC ATTTGCTTTG 
TTAGCAGCTT TAAAGAATGT ACAGTTGCCT GAAGTTACTA TAAACGAAGA GACTGCTTTA 
GCCGAAGTCA ATTTAAAGAA GAAAAGTTAT TTGAATGTTA GAACAAACCC AGTTGCTACT 
TCCTTTGCTG TGTTTGATGA CACTCTACTG ATAGTCGATC CTACCGGCGA GGAGGAGCAC 
CTGTCCACAG GAACCCTAAC CGTAGTCACG GACGAGGACG GCAAGCTGTG CTGTCTTCAC 
AAGCCAGGTG GGAGTGGGCT GACTGGAGCT AAACTTCAGG ACTGCATGAG TCGAGCGGTA 
ACGAGACACA AAGAAGTGAG CAAGCTACTG GATGAAGTAA TTCAGAGCAT GAGACACAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157042.1
CDS	341..1183
Translation	MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRATTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPPVDAPDRGYVVFLSVPNVDLPPLCSSRFRTGPPGEEAQVTSQFIADVVDNSQVIKKEDLCISPGKLAWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNVRTNPVATSFAVFDDTLLIVDPTGEEEHLSTGTLTVVTDEDGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVSKLLDEVIQSMRHK

Target ORF information:

RefSeq Version	NM_001163570.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus exosome component 8 (Exosc8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163570.1

ORF Insert Sequence:

ATGGCGGCTG GGTTCAAAAC TGTGGAGCCG CTGGAGTATT ACAGGAGATT TCTGAAGGAA 
AACTGCCGTC CTGATGGAAG AGAACTTGGT GAATTCAGAG CCACAACTGT CAACATAGGT 
TCAATCAGTA CAGCGGATGG CTCTGCTCTC GTGAAGCTGG GGAATACCAC GGTCATTTGT 
GGCGTTAAAG CAGAATTTGC AGCACCACCA GTAGATGCCC CCGATAGAGG ATATGTCGTG 
TTTCTTTCAG TCCCTAATGT GGATCTACCA CCGCTGTGTT CTTCGAGGTT CCGGACAGGA 
CCTCCTGGGG AAGAGGCTCA AGTAACCAGC CAGTTCATTG CAGATGTCGT TGACAACTCA 
CAGGTGATTA AGAAAGAGGA TTTATGCATT TCTCCAGGCA AGCTTGCTTG GGTTCTATAC 
TGTGACCTCA TTTGTCTAGA CTACGATGGG AACATTTTGG ATGCCTGCAC ATTTGCTTTG 
TTAGCAGCTT TAAAGAATGT ACAGTTGCCT GAAGTTACTA TAAACGAAGA GACTGCTTTA 
GCCGAAGTCA ATTTAAAGAA GAAAAGTTAT TTGAATGTTA GAACAAACCC AGTTGCTACT 
TCCTTTGCTG TGTTTGATGA CACTCTACTG ATAGTCGATC CTACCGGCGA GGAGGAGCAC 
CTGTCCACAG GAACCCTAAC CGTAGTCACG GACGAGGACG GCAAGCTGTG CTGTCTTCAC 
AAGCCAGGTG GGAGTGGGCT GACTGGAGCT AAACTTCAGG ACTGCATGAG TCGAGCGGTA 
ACGAGACACA AAGAAGTGAG CAAGCTACTG GATGAAGTAA TTCAGAGCAT GAGACACAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Exosc8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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