PROKR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PROKR1
Entrez Gene ID	10887
Full Name	prokineticin receptor 1
Synonyms	GPR73,GPR73a,PK-R1,PKR1,ZAQ
General protein information	Preferred Names prokineticin receptor 1 Names prokineticin receptor 1 G protein-coupled receptor 73 G protein-coupled receptor ZAQ
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.3
Summary	This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016].
Disorder MIM:	607122

mRNA and Protein(s)

mRNA	Protein	Name
NM_138964.2	NP_620414.1	prokineticin receptor 1
NM_138964.3	NP_620414.1	prokineticin receptor 1
NM_138964.4	NP_620414.1	prokineticin receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PROKR1	NP_620414.1
Danio rerio (zebrafish)	prokr1a	NP_001166877.1
Pan troglodytes (chimpanzee)	PROKR1	XP_515526.3
Bos taurus (cattle)	PROKR1	NP_776755.1
Canis lupus familiaris (dog)	PROKR1	XP_538526.2
	PROKR1	XP_001094867.1
Mus musculus (house mouse)	Prokr1	NP_067356.2
Rattus norvegicus (Norway rat)	Prokr1	NP_620433.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.
Cao YL, Zhang ZF, Wang J, Miao MH, Xu JH, Shen YP, Chen AM, Du J, Yuan W
Journal of Zhejiang University. Science. B17(3)218-24(2016 Mar)

Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.
Heck D, Wortmann S, Kraus L, Ronchi CL, Sinnott RO, Fassnacht M, Sbiera S
Hormones & cancer6(5-6)225-36(2015 Dec)

Prokineticins in central and peripheral control of human reproduction.
Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T, Hoffmann P, Feige JJ, Benharouga M, Alfaidy N
Hormone molecular biology and clinical investigation24(2)73-81(2015 Nov)

Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.
Eddie SL, Childs AJ, Kinnell HL, Brown P, Jabbour HN, Anderson RA
The Journal of clinical endocrinology and metabolism100(9)E1197-205(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
Title: Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.

EG-VEGF and its receptor PKR1 might play a role in the pathogenesis of adrenocortical tumors and could serve as prognostic markers for this rare malignant disease.
Title: Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.

Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]
Title: Prokineticins in central and peripheral control of human reproduction.

Expression of PROK1 and PROKR1 was significantly higher in mid-gestation ovaries (17-20 wk) than at earlier gestations (8-11 and 14-16 wk).
Title: Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.

Study corroborates the clinical relevance of the EG-VEGF system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF and PROKR variants.
Title: Gene-gene interactions and risk of?recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms.

The following PROKR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROKR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01023	NM_138964.4 Latest version!	Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu01023	NM_138964.2	Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu01023	NM_138964.3	Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PROKR1 ( NM_138964.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620414.1 Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.

Price & Availability↑

CloneID	OHu01023
Clone ID Related Accession (Same CDS sequence)	NM_138964.2 , NM_138964.3 , NM_138964.4
Accession Version	NM_138964.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	prokineticin receptor 1
Comment

ATGGAGACCA CCATGGGGTT CATGGATGAC AATGCCACCA ACACTTCCAC CAGCTTCCTT 
TCTGTGCTCA ACCCTCATGG AGCCCATGCC ACTTCCTTCC CATTCAACTT CAGCTACAGC 
GACTATGATA TGCCTTTGGA TGAAGATGAG GATGTGACCA ATTCCAGGAC GTTCTTTGCT 
GCCAAGATTG TCATTGGGAT GGCCCTGGTG GGCATCATGC TGGTCTGCGG CATTGGAAAC 
TTCATCTTTA TCGCTGCCCT GGTCCGCTAC AAGAAACTGC GCAACCTCAC CAACCTGCTC 
ATCGCCAACC TGGCCATCTC TGACTTCCTG GTGGCCATTG TCTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTGCGCCA GCTCTCCTGG GAGCACGGCC ACGTCCTGTG CACCTCTGTC 
AACTACCTGC GCACTGTCTC TCTCTATGTC TCCACCAATG CCCTGCTGGC CATCGCCATT 
GACAGGTATC TGGCTATTGT CCATCCGCTG AGACCACGGA TGAAGTGCCA AACAGCCACT 
GGCCTGATTG CCTTGGTGTG GACGGTGTCC ATCCTGATCG CCATCCCTTC CGCCTACTTC 
ACCACCGAGA CGGTCCTCGT CATTGTCAAG AGCCAGGAAA AGATCTTCTG CGGCCAGATC 
TGGCCTGTGG ACCAGCAGCT CTACTACAAG TCCTACTTCC TCTTTATCTT TGGCATAGAA 
TTCGTGGGCC CCGTGGTCAC CATGACCCTG TGCTATGCCA GGATCTCCCG GGAGCTCTGG 
TTCAAGGCGG TCCCTGGATT CCAGACAGAG CAGATCCGCA AGAGGCTGCG CTGCCGCAGG 
AAGACGGTCC TGGTGCTCAT GTGCATCCTC ACCGCCTACG TGCTATGCTG GGCGCCCTTC 
TACGGCTTCA CCATCGTGCG CGACTTCTTC CCCACCGTGT TTGTGAAGGA GAAGCACTAC 
CTCACTGCCT TCTACATCGT CGAGTGCATC GCCATGAGCA ACAGCATGAT CAACACTCTG 
TGCTTCGTGA CCGTCAAGAA CGACACCGTC AAGTACTTCA AAAAGATCAT GTTGCTCCAC 
TGGAAGGCTT CTTACAATGG CGGTAAGTCC AGTGCAGACC TGGACCTCAA GACAATTGGG 
ATGCCTGCCA CCGAAGAGGT GGACTGCATC AGACTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620414.1
Translation	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK

Target ORF information:

RefSeq Version	NM_138964.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138964.2

ORF Insert Sequence:

ATGGAGACCA CCATGGGGTT CATGGATGAC AATGCCACCA ACACTTCCAC CAGCTTCCTT 
TCTGTGCTCA ACCCTCATGG AGCCCATGCC ACTTCCTTCC CATTCAACTT CAGCTACAGC 
GACTATGATA TGCCTTTGGA TGAAGATGAG GATGTGACCA ATTCCAGGAC GTTCTTTGCT 
GCCAAGATTG TCATTGGGAT GGCCCTGGTG GGCATCATGC TGGTCTGCGG CATTGGAAAC 
TTCATCTTTA TCGCTGCCCT GGTCCGCTAC AAGAAACTGC GCAACCTCAC CAACCTGCTC 
ATCGCCAACC TGGCCATCTC TGACTTCCTG GTGGCCATTG TCTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTGCGCCA GCTCTCCTGG GAGCACGGCC ACGTCCTGTG CACCTCTGTC 
AACTACCTGC GCACTGTCTC TCTCTATGTC TCCACCAATG CCCTGCTGGC CATCGCCATT 
GACAGGTATC TGGCTATTGT CCATCCGCTG AGACCACGGA TGAAGTGCCA AACAGCCACT 
GGCCTGATTG CCTTGGTGTG GACGGTGTCC ATCCTGATCG CCATCCCTTC CGCCTACTTC 
ACCACCGAGA CGGTCCTCGT CATTGTCAAG AGCCAGGAAA AGATCTTCTG CGGCCAGATC 
TGGCCTGTGG ACCAGCAGCT CTACTACAAG TCCTACTTCC TCTTTATCTT TGGCATAGAA 
TTCGTGGGCC CCGTGGTCAC CATGACCCTG TGCTATGCCA GGATCTCCCG GGAGCTCTGG 
TTCAAGGCGG TCCCTGGATT CCAGACAGAG CAGATCCGCA AGAGGCTGCG CTGCCGCAGG 
AAGACGGTCC TGGTGCTCAT GTGCATCCTC ACCGCCTACG TGCTATGCTG GGCGCCCTTC 
TACGGCTTCA CCATCGTGCG CGACTTCTTC CCCACCGTGT TTGTGAAGGA GAAGCACTAC 
CTCACTGCCT TCTACATCGT CGAGTGCATC GCCATGAGCA ACAGCATGAT CAACACTCTG 
TGCTTCGTGA CCGTCAAGAA CGACACCGTC AAGTACTTCA AAAAGATCAT GTTGCTCCAC 
TGGAAGGCTT CTTACAATGG CGGTAAGTCC AGTGCAGACC TGGACCTCAA GACAATTGGG 
ATGCCTGCCA CCGAAGAGGT GGACTGCATC AGACTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROKR1 ( NM_138964.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620414.1 Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.

Price & Availability↑

CloneID	OHu01023
Clone ID Related Accession (Same CDS sequence)	NM_138964.2 , NM_138964.3 , NM_138964.4
Accession Version	NM_138964.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	prokineticin receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD636583.1 and BC100960.2. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2016 this sequence version replaced NM_138964.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC100960.2, AB084080.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGACCA CCATGGGGTT CATGGATGAC AATGCCACCA ACACTTCCAC CAGCTTCCTT 
TCTGTGCTCA ACCCTCATGG AGCCCATGCC ACTTCCTTCC CATTCAACTT CAGCTACAGC 
GACTATGATA TGCCTTTGGA TGAAGATGAG GATGTGACCA ATTCCAGGAC GTTCTTTGCT 
GCCAAGATTG TCATTGGGAT GGCCCTGGTG GGCATCATGC TGGTCTGCGG CATTGGAAAC 
TTCATCTTTA TCGCTGCCCT GGTCCGCTAC AAGAAACTGC GCAACCTCAC CAACCTGCTC 
ATCGCCAACC TGGCCATCTC TGACTTCCTG GTGGCCATTG TCTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTGCGCCA GCTCTCCTGG GAGCACGGCC ACGTCCTGTG CACCTCTGTC 
AACTACCTGC GCACTGTCTC TCTCTATGTC TCCACCAATG CCCTGCTGGC CATCGCCATT 
GACAGGTATC TGGCTATTGT CCATCCGCTG AGACCACGGA TGAAGTGCCA AACAGCCACT 
GGCCTGATTG CCTTGGTGTG GACGGTGTCC ATCCTGATCG CCATCCCTTC CGCCTACTTC 
ACCACCGAGA CGGTCCTCGT CATTGTCAAG AGCCAGGAAA AGATCTTCTG CGGCCAGATC 
TGGCCTGTGG ACCAGCAGCT CTACTACAAG TCCTACTTCC TCTTTATCTT TGGCATAGAA 
TTCGTGGGCC CCGTGGTCAC CATGACCCTG TGCTATGCCA GGATCTCCCG GGAGCTCTGG 
TTCAAGGCGG TCCCTGGATT CCAGACAGAG CAGATCCGCA AGAGGCTGCG CTGCCGCAGG 
AAGACGGTCC TGGTGCTCAT GTGCATCCTC ACCGCCTACG TGCTATGCTG GGCGCCCTTC 
TACGGCTTCA CCATCGTGCG CGACTTCTTC CCCACCGTGT TTGTGAAGGA GAAGCACTAC 
CTCACTGCCT TCTACATCGT CGAGTGCATC GCCATGAGCA ACAGCATGAT CAACACTCTG 
TGCTTCGTGA CCGTCAAGAA CGACACCGTC AAGTACTTCA AAAAGATCAT GTTGCTCCAC 
TGGAAGGCTT CTTACAATGG CGGTAAGTCC AGTGCAGACC TGGACCTCAA GACAATTGGG 
ATGCCTGCCA CCGAAGAGGT GGACTGCATC AGACTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620414.1
CDS	422..1603
Translation	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK

Target ORF information:

RefSeq Version	NM_138964.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138964.3

ORF Insert Sequence:

ATGGAGACCA CCATGGGGTT CATGGATGAC AATGCCACCA ACACTTCCAC CAGCTTCCTT 
TCTGTGCTCA ACCCTCATGG AGCCCATGCC ACTTCCTTCC CATTCAACTT CAGCTACAGC 
GACTATGATA TGCCTTTGGA TGAAGATGAG GATGTGACCA ATTCCAGGAC GTTCTTTGCT 
GCCAAGATTG TCATTGGGAT GGCCCTGGTG GGCATCATGC TGGTCTGCGG CATTGGAAAC 
TTCATCTTTA TCGCTGCCCT GGTCCGCTAC AAGAAACTGC GCAACCTCAC CAACCTGCTC 
ATCGCCAACC TGGCCATCTC TGACTTCCTG GTGGCCATTG TCTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTGCGCCA GCTCTCCTGG GAGCACGGCC ACGTCCTGTG CACCTCTGTC 
AACTACCTGC GCACTGTCTC TCTCTATGTC TCCACCAATG CCCTGCTGGC CATCGCCATT 
GACAGGTATC TGGCTATTGT CCATCCGCTG AGACCACGGA TGAAGTGCCA AACAGCCACT 
GGCCTGATTG CCTTGGTGTG GACGGTGTCC ATCCTGATCG CCATCCCTTC CGCCTACTTC 
ACCACCGAGA CGGTCCTCGT CATTGTCAAG AGCCAGGAAA AGATCTTCTG CGGCCAGATC 
TGGCCTGTGG ACCAGCAGCT CTACTACAAG TCCTACTTCC TCTTTATCTT TGGCATAGAA 
TTCGTGGGCC CCGTGGTCAC CATGACCCTG TGCTATGCCA GGATCTCCCG GGAGCTCTGG 
TTCAAGGCGG TCCCTGGATT CCAGACAGAG CAGATCCGCA AGAGGCTGCG CTGCCGCAGG 
AAGACGGTCC TGGTGCTCAT GTGCATCCTC ACCGCCTACG TGCTATGCTG GGCGCCCTTC 
TACGGCTTCA CCATCGTGCG CGACTTCTTC CCCACCGTGT TTGTGAAGGA GAAGCACTAC 
CTCACTGCCT TCTACATCGT CGAGTGCATC GCCATGAGCA ACAGCATGAT CAACACTCTG 
TGCTTCGTGA CCGTCAAGAA CGACACCGTC AAGTACTTCA AAAAGATCAT GTTGCTCCAC 
TGGAAGGCTT CTTACAATGG CGGTAAGTCC AGTGCAGACC TGGACCTCAA GACAATTGGG 
ATGCCTGCCA CCGAAGAGGT GGACTGCATC AGACTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROKR1 ( NM_138964.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_620414.1 Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.

Price & Availability↑

CloneID	OHu01023
Clone ID Related Accession (Same CDS sequence)	NM_138964.2 , NM_138964.3 , NM_138964.4
Accession Version	NM_138964.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	prokineticin receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC105054.6. On Nov 21, 2019 this sequence version replaced NM_138964.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: EF577399.1, BC100960.2 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGACCA CCATGGGGTT CATGGATGAC AATGCCACCA ACACTTCCAC CAGCTTCCTT 
TCTGTGCTCA ACCCTCATGG AGCCCATGCC ACTTCCTTCC CATTCAACTT CAGCTACAGC 
GACTATGATA TGCCTTTGGA TGAAGATGAG GATGTGACCA ATTCCAGGAC GTTCTTTGCT 
GCCAAGATTG TCATTGGGAT GGCCCTGGTG GGCATCATGC TGGTCTGCGG CATTGGAAAC 
TTCATCTTTA TCGCTGCCCT GGTCCGCTAC AAGAAACTGC GCAACCTCAC CAACCTGCTC 
ATCGCCAACC TGGCCATCTC TGACTTCCTG GTGGCCATTG TCTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTGCGCCA GCTCTCCTGG GAGCACGGCC ACGTCCTGTG CACCTCTGTC 
AACTACCTGC GCACTGTCTC TCTCTATGTC TCCACCAATG CCCTGCTGGC CATCGCCATT 
GACAGGTATC TGGCTATTGT CCATCCGCTG AGACCACGGA TGAAGTGCCA AACAGCCACT 
GGCCTGATTG CCTTGGTGTG GACGGTGTCC ATCCTGATCG CCATCCCTTC CGCCTACTTC 
ACCACCGAGA CGGTCCTCGT CATTGTCAAG AGCCAGGAAA AGATCTTCTG CGGCCAGATC 
TGGCCTGTGG ACCAGCAGCT CTACTACAAG TCCTACTTCC TCTTTATCTT TGGCATAGAA 
TTCGTGGGCC CCGTGGTCAC CATGACCCTG TGCTATGCCA GGATCTCCCG GGAGCTCTGG 
TTCAAGGCGG TCCCTGGATT CCAGACAGAG CAGATCCGCA AGAGGCTGCG CTGCCGCAGG 
AAGACGGTCC TGGTGCTCAT GTGCATCCTC ACCGCCTACG TGCTATGCTG GGCGCCCTTC 
TACGGCTTCA CCATCGTGCG CGACTTCTTC CCCACCGTGT TTGTGAAGGA GAAGCACTAC 
CTCACTGCCT TCTACATCGT CGAGTGCATC GCCATGAGCA ACAGCATGAT CAACACTCTG 
TGCTTCGTGA CCGTCAAGAA CGACACCGTC AAGTACTTCA AAAAGATCAT GTTGCTCCAC 
TGGAAGGCTT CTTACAATGG CGGTAAGTCC AGTGCAGACC TGGACCTCAA GACAATTGGG 
ATGCCTGCCA CCGAAGAGGT GGACTGCATC AGACTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620414.1
CDS	431..1612
Translation	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK

Target ORF information:

RefSeq Version	NM_138964.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138964.4

ORF Insert Sequence:

ATGGAGACCA CCATGGGGTT CATGGATGAC AATGCCACCA ACACTTCCAC CAGCTTCCTT 
TCTGTGCTCA ACCCTCATGG AGCCCATGCC ACTTCCTTCC CATTCAACTT CAGCTACAGC 
GACTATGATA TGCCTTTGGA TGAAGATGAG GATGTGACCA ATTCCAGGAC GTTCTTTGCT 
GCCAAGATTG TCATTGGGAT GGCCCTGGTG GGCATCATGC TGGTCTGCGG CATTGGAAAC 
TTCATCTTTA TCGCTGCCCT GGTCCGCTAC AAGAAACTGC GCAACCTCAC CAACCTGCTC 
ATCGCCAACC TGGCCATCTC TGACTTCCTG GTGGCCATTG TCTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTGCGCCA GCTCTCCTGG GAGCACGGCC ACGTCCTGTG CACCTCTGTC 
AACTACCTGC GCACTGTCTC TCTCTATGTC TCCACCAATG CCCTGCTGGC CATCGCCATT 
GACAGGTATC TGGCTATTGT CCATCCGCTG AGACCACGGA TGAAGTGCCA AACAGCCACT 
GGCCTGATTG CCTTGGTGTG GACGGTGTCC ATCCTGATCG CCATCCCTTC CGCCTACTTC 
ACCACCGAGA CGGTCCTCGT CATTGTCAAG AGCCAGGAAA AGATCTTCTG CGGCCAGATC 
TGGCCTGTGG ACCAGCAGCT CTACTACAAG TCCTACTTCC TCTTTATCTT TGGCATAGAA 
TTCGTGGGCC CCGTGGTCAC CATGACCCTG TGCTATGCCA GGATCTCCCG GGAGCTCTGG 
TTCAAGGCGG TCCCTGGATT CCAGACAGAG CAGATCCGCA AGAGGCTGCG CTGCCGCAGG 
AAGACGGTCC TGGTGCTCAT GTGCATCCTC ACCGCCTACG TGCTATGCTG GGCGCCCTTC 
TACGGCTTCA CCATCGTGCG CGACTTCTTC CCCACCGTGT TTGTGAAGGA GAAGCACTAC 
CTCACTGCCT TCTACATCGT CGAGTGCATC GCCATGAGCA ACAGCATGAT CAACACTCTG 
TGCTTCGTGA CCGTCAAGAA CGACACCGTC AAGTACTTCA AAAAGATCAT GTTGCTCCAC 
TGGAAGGCTT CTTACAATGG CGGTAAGTCC AGTGCAGACC TGGACCTCAA GACAATTGGG 
ATGCCTGCCA CCGAAGAGGT GGACTGCATC AGACTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.
Journal of Zhejiang University. Science. B17(3)218-24(2016 Mar)
Cao YL,Zhang ZF,Wang J,Miao MH,Xu JH,Shen YP,Chen AM,Du J,Yuan W

Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.
Hormones & cancer6(5-6)225-36(2015 Dec)
Heck D,Wortmann S,Kraus L,Ronchi CL,Sinnott RO,Fassnacht M,Sbiera S

Prokineticins in central and peripheral control of human reproduction.
Hormone molecular biology and clinical investigation24(2)73-81(2015 Nov)
Traboulsi W,Brouillet S,Sergent F,Boufettal H,Samouh N,Aboussaouira T,Hoffmann P,Feige JJ,Benharouga M,Alfaidy N

Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.
The Journal of clinical endocrinology and metabolism100(9)E1197-205(2015 Sep)
Eddie SL,Childs AJ,Kinnell HL,Brown P,Jabbour HN,Anderson RA

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PROKR1 cDNA ORF clone, Homo sapiens(human)

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